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不同类型的一体化编码对青年人和老年人在联结记忆任务中项目再认的影响

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心理学报 2024年第8期56卷 1015-1030页

作者：王宝玺王雪静金朝晖程琛向玲江西师范大学心理学院南昌330022 中共新疆生产建设兵团委员会党校五家渠831300

使用脑电探究不同的一体化对联结记忆任务中项目再认的影响及其相关的神经机制。两个实验分别使用复合词和定义操作自下而上和自上而下一体化。青年人的行为结果发现两种一体化的联结再认相当,项目再认也无显著差异。脑电结果发现复合... 详细信息

使用脑电探究不同的一体化对联结记忆任务中项目再认的影响及其相关的神经机制。两个实验分别使用复合词和定义操作自下而上和自上而下一体化。青年人的行为结果发现两种一体化的联结再认相当,项目再认也无显著差异。脑电结果发现复合词减少了顶区新/旧效应,定义缺失额区新/旧效应,说明青年人依据较少的神经活动达到相当的行为表现,支持“只有收益”观点。老年人的结果发现两种一体化都能提高联结再认,但对项目再认的影响不同。复合词在促进联结再认时也促进了项目再认,脑电结果发现仅在复合词下存在额区新/旧效应,显示复合词促进项目再认可能是源于熟悉性的增加,支持“只有收益”的观点。定义在促进联结再认时损害了项目再认,脑电结果发现定义缺失额区新/旧效应,显示定义对项目再认的损害可能源于熟悉性的缺失,支持“收支平衡”的观点。这些结果表明一体化促进还是损害老年人项目再认取决于自下而上和自上而下的一体化对认知资源的需求情况。

关键词：一体化项目再认复合词定义记忆老化

Stabilization of Fe^0 nanoparticles with silica fume for enhanced transport and remediation of hexavalent chromium in water and soil

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Journal of Environmental Sciences 2011年第7期23卷 1211-1218页

作者： Yongchao Li Tielong Li zhaohui jin College of Environmental Science and Engineering Nankai University Tianjin 300071 China Key Laboratory of Pollution Processes and Environmental Criteria Ministry of Education of China

Effective in situ remediation of Cr（VI） in groundwater requires the successful delivery of reactive iron particles to the subsurface. Fe 0 nanoparticles （20–110 nm diameter） supported on silica fume were synthesized by borohydride reduction of an aqueous iron salt in the presence of a support material. The experimental result showed that attachment of Fe 0 nanoparticles on the commercial available sub-micrometer silica fume prevented them from aggregation while maintaining the particle reactivity. When the Fe 0 concentration was 0.4 g/L, 88.00% of 40 mg/L Cr（VI） was removed by silica fume-supported Fe 0 nanoparticles （SF-Fe 0 ） in 120 min, 22.55% higher than unsupported Fe 0 . Furthermore, transport experiments confirmed that almost all unsupported Fe 0 was retained, whereas 51.50% and 38.29% of SF-Fe 0 were eluted from the vertical and horizontal sand column, respectively. Additionally, the effect of solution ionic strength on the transport ability of SF-Fe 0 was evaluated. The result showed that increase in the salt concentration led to a decrease in the mobility and also the divalent ion Ca 2＋ had a greater effect than that of monovalent ion Na ＋ .

关键词： silica fume Fe 0 nanoparticles stability Cr(VI) removal transport

金朝晖教授基于“络以通为用”理论治疗慢性咳嗽临证经验

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中国民族民间医药 2024年第16期33卷 86-88页

作者：仄志敏金朝晖湖南中医药大学第一中医临床学院湖南长沙410007

金朝晖经过长期临床实践的积累,基于叶天士“络以通为用”理论,认为慢性咳嗽以肺络瘀虚为发病之本,邪积肺络为病机之关键,虚实夹杂为病理特点,确立补虚通络法为主要治则。按照因人而异的理论,采取辨证与辨病相结合的方式,临证时根据患... 详细信息

金朝晖经过长期临床实践的积累,基于叶天士“络以通为用”理论,认为慢性咳嗽以肺络瘀虚为发病之本,邪积肺络为病机之关键,虚实夹杂为病理特点,确立补虚通络法为主要治则。按照因人而异的理论,采取辨证与辨病相结合的方式,临证时根据患者具体情况,配合调补肺脾、祛风、化痰、活血等方法治疗,在临床诊疗中每获良效。并附验案1则佐证。

关键词：慢性咳嗽叶天士络脉中医药金朝晖

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Systemic treatment for hepatocellular carcinoma

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Chronic Diseases and Translational Medicine 2018年第3期4卷 148-155页

作者： Manushi Aggarwal Abeer Arain zhaohui jin Carle Cancer Center Carle Foundation Hospital509 W.University AvenueUrbanaIL 61801USA Department of Internal Medicine University of Illinois College of Medicine at Urbana-ChampaignUrbanaIL 61801USA

Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality worldwide. Treatment options for patients with advanced stage HCC remain a great challenge. However, novel agents especially small molecule tyrosine kinase inhibitor and innovative immunotherapy demonstrate new promising therapeutic options for these patients. This review article summarizes systemic treatment options evaluated in HCC focusing on the most recently published data and ongoing studies.

关键词： Hepatocellular carcinoma Systemic treatment Immunotherapy Tyrosine kinase inhibitor

Bonding Strength of Ni/Ni3Al Interface with Different Lattice Misfit

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Journal of Materials Science & Technology 2003年第z1期19卷 26-28页

作者： Ping PENG Caixing ZHENG Shaochang HAN zhaohui jin Rui YANG Zhuangqi HU Materials Science and Engineering College Hunan University Changsha 410082 China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China Materials Science and Engineering College Hunan University Changsha 410082 China Materials Science and Engineering College Hunan University Changsha 410082 China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China Titanium Alloy Laboratory Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China

The interfacial binding covalent bond density (CBD) and the local environmental total bond order (LTBO) of the Ni/Ni3Alinterface with different lattice misfits (δ) were calculated by using first-principles discrete variation Xα method. It was foundthat the effects of lattice misfits on the electronic structures of incoherent Ni/Ni3Al interface were very obvious. On one hand,less than -0.6% negative lattice misfit can promote the binding strength of γ/γ′ interface. On the other hand, the totalbonding strength of γ/γ′ interface decreases with increasing δ. Therefore, the magnitude and sign of lattice misfit must becarefully controlled for balancing the high temperature creep strength of Ni-base single crystal superalloy and the structuralstability of γ/γ′interface when one designs a new Ni-base single crystal superalloy.

关键词： γ/γ′ interface, lattice misfit, DV-Xα method, first-principles calculation

Preparation and properties of CdS/Au composite nanorods and hollow Au tubes

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Chinese Science Bulletin 2010年第10期55卷 921-926页

作者： YANG zhaohui CHU HaiBin jin Zhong ZHOU WeiWei LI Yan Beijing National Laboratory for Molecular Sciences Key Laboratory for the Physics and Chemistry of Nanodevices College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

1-dimensional (1D) metal-semiconductor nano-scale composite superstructures based on Au nanoparticles and CdS nanorods were *** outer surface of CdS nanorods was modified with mercapto-ethylamine (MEA) in *** the aid of MEA,dense and uniform Au nanoparticles were deposited onto the external wall of CdS nanorods through in situ chemical reduction of *** Au nanoparticles induced further electroless deposition and a continuous layer of Au was formed on CdS *** hollow Au tubes were obtained after the inner CdS cores were etched by ***-Vis,FL,XPS,EDX,TEM and SEM measurements were carried out to characterize the produced *** quenching of the defect emission of CdS in CdS-nanorod/Au-nanoparticle hybrid superstructures was detected,which was ascribed to the energy transfer from the exciton of CdS to surface plasma resonance level of Au.

关键词： CdS纳米棒金纳米粒子纳米复合材料硫化镉空心表面等离子体共振光电子能谱性能

G-Eco-AAc/OTF复合层导电水凝胶的制备及在柔性传感领域的应用

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山西化工 2024年第6期44卷 3-7页

作者：高子健孙晟宇金朝辉孙健吉林化工学院石油化工学院吉林吉林132022

导电水凝胶作为一种高性能聚合物材料,被广泛应用于柔性传感器与储能设备等领域。然而,大多数导电水凝胶均为单层结构,且力学性能较弱。而复合层水凝胶可以通过各层之间的结合,进行力学性能上的互补。因此,需要从水凝胶的结构上进行设计... 详细信息

导电水凝胶作为一种高性能聚合物材料,被广泛应用于柔性传感器与储能设备等领域。然而,大多数导电水凝胶均为单层结构,且力学性能较弱。而复合层水凝胶可以通过各层之间的结合,进行力学性能上的互补。因此,需要从水凝胶的结构上进行设计,使其具有优异的力学性能,并具有更多功能。在此,通过原位聚合的方式,将石墨烯层、Ecoflex弹性体和AAc/OTF水凝胶进行聚合,制备了一款兼具黏附性能、力学拉伸性能和导电性能的复合层水凝胶G-Eco-AAc/OTF。由于水凝胶表面羧基、羟基和磺酸基团的存在,该水凝胶材料展示了良好的黏附性。将G-Eco-AAc/OTF复合层导电水凝胶应用于运动传感领域,可对手指、手腕、肘部和膝盖处进行信号的监测,并且测试结果稳定。这为下一代可穿戴柔性传感设备奠定了基础。

关键词：复合层水凝胶传感器黏附性能力学拉伸性能导电性能

我国静脉用药调配中心智能化建设的现状及趋势:基于CiteSpace的可视化分析

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中国医院药学杂志 2024年第10期44卷 1228-1234页

作者：许政坛倪恒凡王曼曼蔡琪张琳阳浩李健金朝辉四川大学华西医院临床药学部四川成都610041

目的:利用CiteSpace软件对我国静脉用药调配中心(pharmacy intravenous admixture service,PIVAS)近二十多年智能化建设发展情况进行可视化研究。方法:计算机检索中国知网、万方、维普数据库发表的关于PIVAS智能化建设情况的相关文献,运... 详细信息

目的:利用CiteSpace软件对我国静脉用药调配中心(pharmacy intravenous admixture service,PIVAS)近二十多年智能化建设发展情况进行可视化研究。方法:计算机检索中国知网、万方、维普数据库发表的关于PIVAS智能化建设情况的相关文献,运用NoteExpress、CiteSpace软件对文献的发文量、作者、机构、关键词等进行可视化分析。结果:共纳入文献121篇,统计年度发文量最多的是2021年(23篇);统计关键词241个,对关键词分析共形成12个聚类,排名前5的关键词分别为静脉用药调配中心、信息化、自动化、静脉用药集中调配中心、智能化;统计PIVAS智能化建设发文机构,以河北省人民医院和苏州大学附属第一医院发文量最多(6篇);统计作者350名,发文量最多的作者为庞国勋(7篇);统计期刊60个,以《中国药房》及《海峡药学》发文量最高(12篇);统计中国PIVAS智能化建设应用情况,使用智能化设备可明显降低调配差错,提高工作效率,应用效果较好。结论:中国PIVAS智能化发展速度快,通过采用信息化管理及自动化设备搭建智能化服务平台,可显著提高工作效率、优化工作流程,且有效推动药学服务创新,是未来现代化医疗机构PIVAS建设发展的方向。

关键词：静脉用药调配中心智能化建设可视化分析

Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma

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Chinese Chemical Letters 2020年第2期31卷 494-500页

作者： Yang Zhou Aiping Fang Fazhan Wang Huili Li Quansheng jin Lingjing Huang Chunmei Fu Jun Zeng zhaohui jin Xiangrong Song State Key Laboratory of Biotherapy and Cancer Center/Department of Pharmacy West China Hospitaland Collaborative Innovation Center for BiotherapySichuan UniversityChengdu 610041China West China School of Pharmacy Sichuan UniversityChengdu 610041China

Nowadays,tremendous researches have been focused on the core-shell lipid-polymer nanoparticles(LPNs) due to the advantages of both liposomes and polymer *** this work,LPNs were applied to encapsulate brinzolamide(Brz-LPNs) for achieving sustained drug release,improving drug corneal permeation and enhancing drug topical therapeutic *** structure of Brz-LPNs was composed of poly(lactic-co-glycolic) acid(PLGA) nanocore which encapsulated Brz(Brz-NPs) and lipid shell around the ***-LPNs were prepared by a modified thin-film dispersion *** the parameters optimization of Brz-LPNs,optimal Brz-LPNs showed an average particle size of151.23±1.64 nm with a high encapsulation efficiency(EE) of 86.7%±2.28%.The core-shell structure of Brz-LPNs were confirmed by transmission electronic microscopy(TEM).Fourier transformed infrared spectra(FTIR) analysis proved that Brz was successfully entrapped into ***-LPNs exhibited obvious sustained release of Brz,compared with AZOPT^■ and ***,the corneal accumulative permeability of Brz-LPNs significantly increased compared to the commercial available formulation(AZOPT^■) in ***,Brz-LPNs(1 mg/mL Brz) showed a more sustained and effective intraocular pressure(IOP) reduction than Brz-LPs(1 mg/mL) and AZOPT^■(10 mg/mL Brz) in *** conclusion,Brz-LPNs,as promising ocular drug delivery systems,are well worth developing in the future for glaucoma treatment.

关键词： Core-shell lipid-polymer nanoparticles Ocular drug delivery system Sustained release Corneal permeation Intraocular pressure