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Chronic Diseases and Translational Medicine 2017年第1期3卷 -页

作者： Hao-Xin Shen Hu-Wei Song Xin-Jian Xu Zuo-Yi Jiao Zhen-yu Ti zhao-yu li Bin Ren Chen Chen li Ma Ya-ling zhao Guan-Jun Zhang Jian-Cang Ma Xi-lin Geng Xiao-Di Zhang Jing-Sen Shi lin Wang Zhi-Min Geng Department of Hepatobiliary Surgery First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of General Surgery First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Hepatobiliary Surgery Second Affiliated Hospital of Lanzhou University Lanzhou Gansu 730030 China Department of Hepatobiliary Surgery Lanzhou General Hospital of Lanzhou Military Region Lanzhou Gansu 730050 China Department of Hepatobiliary Surgery General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Hepatobiliary Surgery Affiliated Hospital of Qinghai University Xining Qinghai 810001 China Faculty of Public Health School of Medicine Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Pathology First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of General Surgery Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710004 China Department of Hepatobiliary Surgery Shaanxi People's Hospital Xi'an Shaanxi 710068 China Department of Hepatobiliary Surgery Shaanxi Nuclear Industry 215 Hospital Xianyang Shaanxi 712000 China

Objective: To analyze the clinical epidemiological characteristics of patients with gallbladder carcinoma recruited from 17 hospitals in five northwestern provinces of China (Shaanxi Province, Gansu Province, Qinghai Province, Ningxia Hui Autonomous Region, and Xinjiang Uygur Autonomous Region) from 2009 to 2013, and to summarize the clinical diagnosis and treatment data of gallbladder carcinoma. Methods: Clinical information of 2379 patients with gallbladder carcinoma from 17 hospitals in five northwestern provinces of China was retrospectively collected and analyzed using the 'Questionnaire for Gallbladder Carcinoma Patients in Northwestern Area of China.' All information was verified with EpiData software and analyzed with SPSS 13.0 software. Results: (1) Gallbladder carcinoma accounted for 2.7% (2379/86,609) of all biliary tract diseases during the study period, which was significantly higher than that from 1986 to 1998 (P linical manifestations, 81.2% (1527/1881) were positive in those receiving B ultrasound examinations and 90.7% (1567/1727) were positive in those undergoing computed tomography, and 64.5% (1124/1742) of patients with gallbladder carcinoma were positive for carbohydrate antigen (CA) 19-9. (5) The pathological type of gallbladder carcinoma was mainly moderately and poorly differentiated adenocarcinoma with a high degree of malignancy. At admission, 55.1% (1091/1981) of patients had stage Ⅳ cancer among patients with TNM staging information; 55.9% (1331/2379) had lymphatic metastasis, 29.7% (706/2379) had bile duc

关键词： Gallbladder carcinoma Epidemiology Incidence Risk factor Northwestern China

水化硅酸钙晶种对CaO-SiO_2-H_2O蒸压体系强度的影响及其机理分析

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材料导报 2017年第14期31卷 122-126,137页

作者：张海东韦江雄赵志广余其俊李方贤华南理工大学材料科学与工程学院广州510640 广东省建筑材料低碳技术工程技术研究中心广州510640

选取石灰与无定形二氧化硅为原料,利用水热合成法在不同热工条件下制备了水化硅酸钙晶种,研究水化硅酸钙晶种对硅酸盐蒸压制品强度的影响。通过化学分析法探讨了不同蒸压时间下水化硅酸钙晶种对粉煤灰反应程度的影响;利用X射线衍射(XRD... 详细信息

选取石灰与无定形二氧化硅为原料,利用水热合成法在不同热工条件下制备了水化硅酸钙晶种,研究水化硅酸钙晶种对硅酸盐蒸压制品强度的影响。通过化学分析法探讨了不同蒸压时间下水化硅酸钙晶种对粉煤灰反应程度的影响;利用X射线衍射(XRD)、电子扫描电镜(SEM-EDS)和压汞法(MIP)分析了晶种对不同蒸压时间下CaO-SiO_2-H_2O体系水化产物种类及形貌的影响。研究结果表明:采用钙硅物质的量比为1.0、水热合成温度低于150℃时制备的水化硅酸钙晶种提高CaO-SiO_2-H_2O蒸压体系强度最明显,水化硅酸钙晶种的掺入促进了粉煤灰中SiO_2快速溶出以及水石榴石的分解,提高了水化产物含量;水化硅酸钙晶种的加入可以细化孔结构,使孔结构分布均匀,增加50nm以下的无害孔及少害孔数量,减少大于200nm的多害孔数量。

关键词：水化硅酸钙晶种蒸压硅酸盐制品粉煤灰水化程度

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang li Xuechun Chen Wen zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan li Xi liu Wenping liang yu li liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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制度化信任与和谐警民关系建设探析

湖南警察学院学报 2012年第2期24卷 143-147页

作者：赵玉丽南京森林警察学院江苏南京210094

从类型学的角度来说,警民关系可以划分为具有陌生人特征的制度化信任关系与具有熟人特征的人格化信任关系,二者在构建和谐警民关系中是相互补充,共同起作用的。不过,在当代的复杂社会中,制度化信任在警民信任关系建设中具有更为基础的... 详细信息

从类型学的角度来说,警民关系可以划分为具有陌生人特征的制度化信任关系与具有熟人特征的人格化信任关系,二者在构建和谐警民关系中是相互补充,共同起作用的。不过,在当代的复杂社会中,制度化信任在警民信任关系建设中具有更为基础的地位。通过典型案例的调查分析我们可以发现,我国当前的警民信任危机主要体现为"制度化信任危机"。因此,增进我国警民间的信任关系也必须从制度建设入手,在吸纳当前公安机关所采取的有益经验的同时进行制度创新,加强民众对于地方公安机关的组织与法律约束力的信任力度,建立起一套系统的制度化信任体系。

关键词：警民关系制度化信任人格化信任警民信任危机

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马克斯·韦伯的社会科学研究方法论探析

安徽工业大学学报（社会科学版） 2010年第6期27卷 68-70页

作者：赵玉丽南京森林警察学院治安管理系江苏南京210094

韦伯的研究方法包含着三个有机的组成部分,即价值关联、理想类型和价值中立。韦伯方法论学说的意义在于:从方法论的整体主义走向个体主义,从寻求社会规律本质上的因果关系到发现个别社会现象的多因果关系,从追求社会科学功用的全能期望... 详细信息

韦伯的研究方法包含着三个有机的组成部分,即价值关联、理想类型和价值中立。韦伯方法论学说的意义在于:从方法论的整体主义走向个体主义,从寻求社会规律本质上的因果关系到发现个别社会现象的多因果关系,从追求社会科学功用的全能期望到有意识的自我限制。

关键词：马克斯.韦伯社会科学研究方法

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秩序转型视角下的社会控制体制建设探析

北京人民警察学院学报 2012年第4期 -页

作者：赵玉丽南京森林警察学院南京210094

社会控制的建设不应陷入“为控制而控制”的恶性循环,而是必须置于社会秩序建设的整体视野之中.从福山、哈耶克、韦伯等人所阐发的社会秩序构成理论视角进行观察,可以发现,我国当前的社会控制体制有着控制范围过大,“理性化”程度不高... 详细信息

社会控制的建设不应陷入“为控制而控制”的恶性循环,而是必须置于社会秩序建设的整体视野之中.从福山、哈耶克、韦伯等人所阐发的社会秩序构成理论视角进行观察,可以发现,我国当前的社会控制体制有着控制范围过大,“理性化”程度不高及控制权力缺乏制约等局限.为了构建良好的社会秩序,必须对我国当前的社会控制体制进行相应的改革.

关键词：社会秩序构成理论社会控制体制正义规则

美国基础研究经费投入与管理对我国未来的经验借鉴

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未来与发展 2013年第11期36卷 31-34+24页

作者：赵立雨西安理工大学经济与管理学院

基础研究是整个科技创新活动的基础和源泉。通过对美国基础研究投入情况总结与分析,为我国基础研究经费投入及绩效评估工作提供借鉴。本文系统分析了美国联邦政府基础研究投入与执行、基础研究经费管理经验,结合我国实际情况,提出了加... 详细信息

基础研究是整个科技创新活动的基础和源泉。通过对美国基础研究投入情况总结与分析,为我国基础研究经费投入及绩效评估工作提供借鉴。本文系统分析了美国联邦政府基础研究投入与执行、基础研究经费管理经验,结合我国实际情况,提出了加大基础研究投入力度、充分发挥政府的引导和支持作用、构建有效的协调机制和加强基础研究经费绩效评估等相关政策建议,对我国未来基础研究经费管理提供经验借鉴。

关键词：美国基础研究投入管理绩效评估经验借鉴

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等值反磁通瞬变电磁法在浅部岩溶探测中的应用研究——以惠州市龙门县某地区为例

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地下水 2024年第3期46卷 141-142,269页

作者：赵玉立天津华北地质勘查局核工业二四七大队天津301800

传统瞬变电磁法受关断时间和互感的过渡过程影响,存在较大浅部盲区;新近发展迅速的等值反磁通瞬变电磁法从理论和仪器上实现了纯二次场的观测,大大提高了浅部区域的探测精度。为研究等值反磁通瞬变电磁法在100 m以浅岩溶探测的应用效果... 详细信息

传统瞬变电磁法受关断时间和互感的过渡过程影响,存在较大浅部盲区;新近发展迅速的等值反磁通瞬变电磁法从理论和仪器上实现了纯二次场的观测,大大提高了浅部区域的探测精度。为研究等值反磁通瞬变电磁法在100 m以浅岩溶探测的应用效果,以惠州市龙门县某岩溶发育区为靶区,开展了方法有效性研究,取得主要成果与结论:(1)界定的土石界面和圈定的岩溶发育区与已知钻孔揭露情况吻合较好,验证了基于等磁反磁通瞬变电磁法在100 m以浅岩溶探测的有效性;(2)反映区内岩溶具有一定连通性,岩溶大小约1~20 m,岩溶主要发育于20~40 m及60 m以下埋深。研究结果一方面有效圈定了研究区100 m以浅岩溶发育区,对后续桥梁工程的安全建设具有重要意义;另一方面等值反磁通瞬变电磁法具有施工便捷、采集高效、抗干扰强等优势,未来有望在城市浅部空间探测领域实现更大作为。

关键词：瞬变电磁法等磁反磁通岩溶勘察浅部盲区惠州市龙门县