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Perturbation to Symmetries and Adiabatic Invariants of Nonholonomic System in Terms of Quasi-coordinates

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Communications in Theoretical Physics 2005年第5X期44卷 773-778页

作者： CHEN Xiang-Wei zhao Yong-hong LI yan-Min Department of Physics Shangqiu Teachers College Shangqiu 476000 China

Based on the theory of Lie symmetries and conserved quantities, the exact invariants and adiabatic invariants of nonholonomic system in terms of quasi-coordinates are studied. The perturbation to symmetries for the nonholonomic system in terms of quasi-coordinates under small excitation is discussed. The concept of high-order adiabatic invariant is presented, and the forms of exact invariants and adiabatic invariants as well as the conditions for their existence are given. Then the corresponding inverse problem is studied.

关键词： nonholonomic system in terms of quasi-coordinates perturbation exact invariant adiabatic invariant

Analgesic and anti-inflammatory activity of Cotinus coggygria *** in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 225-235页

作者： Kai Lu Chong-Yu yang zhao-hong yan Department of Anesthesiology Qiantang Campus Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310018China Department of Anesthesiology 3201 HospitalHanzhong723000China Department of Anesthesiology The Second Affiliated Hospital of the Chinese People’s Liberation Army Air Force Medical UniversityXi’an710038China

Objective:To assess the analgesic and anti-inflammatory effects of standardized extract of Cotinus coggygria(***)in different animal ***:*** extracts(25,50,and 100 mg/kg)were administered to rats and mice(n=6)during hot plate,tail-flick,acetic acid-induced writhing,and formalin tests to determine its analgesic *** anti-inflammatory activity of *** extracts was evaluated by histamine and carrageenan-induced paw edema,cotton pellet-induced granuloma,and acetic acid-induced peritoneal capillary dye leakage ***:*** extracts(50 and 100 mg/kg)significantly alleviated thermal and chemical-induced pain in rodents(P<0.05).It also demonstrated notable anti-inflammatory properties by mitigating histamine and carrageenan-induced paw edema,granuloma deposits,and vascular permeability(P<0.05).Moreover,*** extracts remarkably reduced TNF-α,IL-1β,IL-6,COX-2,and oxidative stress in rat paws(P<0.05).Carrageenan-induced histological aberrations in hind paw tissues were effectively(P<0.05)mitigated by treatment with *** ***:*** *** show analgesic and anti-inflammatory effects via inhibition of COX-2 and inflammatory and oxidative mediators.

关键词： Antioxidant Carrageenan Cotinus coggygria Scop. Anti-inflammatory Analgesic Pain TNF-α Fustin

Text Mining of Rheumatoid Arthritis and Diabetes Mellitus to Understand the Mechanisms of Chinese Medicine in Different Diseases with Same Treatment

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Chinese Journal of Integrative Medicine 2018年第10期24卷 777-784页

作者： zhao Ning ZHENG Guang LI Jian zhao hong-yan LU Cheng JIANG Miao ZHANG Chi GUO hong-tao LU Ai-ping Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences School of Information Science and Engineering Lanzhou University School of Basic Medical Sciences Beijing University of Chinese Medicine Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences School of Chinese Medicine Hong Kong Baptist University

Objective： To identify the commonalities between rheumatoid arthritis （RA） and diabetes mellitus （DM） to understand the mechanisms of Chinese medicine （CM） in different diseases with the same treatment. Methods： A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identified via text mining was used as the intervention. Results： Similarities were identified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Conclusion： Commonalities between the biological activities involved in RA and DM were identified through text mining, and both RA and DM might be responsive to the same intervention at a specific stage.

关键词： text mining rheumatoid arthritis diabetes mellitus different diseases with same treatment Chinese medicine

The differential effects of prostate stromal cells derived from different zones on prostate cancer epithelial cells under the action of sex hormones

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Asian Journal of Andrology 2011年第6期13卷 798-805页

作者： Qi Jiang Bang-Min Han Fu-Jun zhao yan hong Shu-Jie Xia Department of Urology Shanghai First People＇s Hospital Institute of Urology Shanghai Jiao Tong University Shanghai 200080 China

It is well known that prostate cancer （PCa） occurs predominantly in the peripheral zone （PZ）, whereas benign prostatic hyperplasia （BPH） typically develops in the transition zone. To identify possible mechanisms underlying zonal differences, we compared the effects of prostate stromal cells derived from the peripheral zone （PZsc） and the transition zone （TZsc） on a PCa epithelial cell line （PC3） in the presence of sex hormones. First, we observed that androgen receptor （AR） mRNA was more highly expressed in PZsc than TZsc when the cells were treated with dihydrotestosterone （DHT） and β-oestradiol （E2）（P〈0.05）. By ELISA, we looked for differences in the secretion of peptide growth factors from PZsc and TZsc. We found that keratinocyte growth factor （KGF） secretion increased with increasing concentrations of DHT （P〉0.01） and was higher in PZsc than TZsc. Under treatment with DHT plus E2, PZsc secreted more transforming growth factor-β1 （TGF-β1） than TZsc, but this pattern was reversed when the cells were treated with E2 only. With increasing concentrations of DHT, insulin-like growth factor-1 （IGF-1） secretion increased in PZsc but decreased in TZsc. To further characterize the effects of PZsc and TZsc on PC3 cells, we developed a coculture model and performed MTT assays, Western blot analysis and real-time RT-PCR. We found that PZsc promoted PC3 cell proliferation and progression better than TZsc, particularly when treated with 10 nmoll^- 1 DHT plus 10 nmoll^-1 E2. In conclusion, our data suggest that PZsc may have a greater capacity to induce PCa development and progression than TZsc via growth factors regulated by sex hormones. These findings provide possible mechanisms underlying zonal differences in prostate diseases, which may aid the search for novel therapeutic targets for PCa.

关键词： androgen growth factor oestrogen prostate cancer stromal cell

Heat Flux Through Slag Film and Its Crystallization Behavior

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Journal of Iron and Steel Research International 2008年第4期15卷 7-11,20页

作者： TANG Ping XU Chu-shao WEN Guang-hua zhao yan-hong QI Xin College of Materials Science and Engineering Chongqing University Chongqing 400044 China

An experimental apparatus for simulating copper mold is used to quantify the heat flux through the slag film and to obtain a solid slag for further determining its crystallization behavior. The result indicates that both the chemical composition of the mold powder and the cooling rate have an important influence on the heat flux through the slag film. With increasing the binary basicity, the heat flux of slag film decreases at first, reaches the minimum at the basicity of 1.4, and then increases, indicating that the maximum binary basicity is about 1.4 for selecting ＂mild cooling＂ mold powder. The heat transfer through the slag film can be specified in terms of the crystalline ratio and the thickness of the slag film. Recrystallization of the solid slag occurs and must be considered as an important factor that may influence the heat transfer through the solid slag layer.

关键词： continuous casting mold powder slag film heat flux crystallization

Microbial Community Dynamics During Biogas Slurry and Cow Manure Compost

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Journal of Integrative Agriculture 2013年第6期12卷 1087-1097页

作者： zhao hong-yan LI Jie LIU Jing-jing Lü Yu-cai WANG Xiao-fen CUI Zong-jun College of Agronomy and Biotechnology/Center of Biomass Engineering China Agricultural University Agronomy of yanbian University Alan G. MacDiarmid Research Institute of Renewable Energy China Three Gorges University

This study evaluated the microbial community dynamics and maturation time of two compost systems： biogas slurry compost and cow manure compost, with the aim of evaluating the potential utility of a biogas slurry compost system. Denaturing gradient gel electrophoresis （DGGE）, gene clone library, temperature, C/N ratio, and the germination index were employed for the investigation, cow manure compost was used as the control. Results showed that the basic strip and dominant strips of the DGGE bands for biogas slurry compost were similar to those of cow manure compost, but the brightness of the respective strips for each system were different. Shannon-Weaver indices of the two compost systems differed, possessing only 22% similarity in the primary and maturity stages of the compost process. Using bacterial 16S rRNA gene clone library analysis, 88 bacterial clones were detected. Further, 18 and 13 operational taxonomic units （OTUs） were present in biogas slurry and cow manure compost, respectively. The 18 OTUs of the biogas slurry compost belonged to nine bacterial genera, of which the dominant strains were Bacillus sp. and Carnobacterium sp.; the 13 OTUs of the cow manure compost belonged to eight bacterial genera, of which the dominant strains were Psychrobacter sp., Pseudomonas sp., and Clostridium sp. Results demonstrated that the duration of the thermophilic phase （more than 50°C） for biogas slurry compost was 8 d less than the according duration for cow manure compost, and the maturation times for biogas slurry and cow manure compost were 45 and 60 d, respectively. It is an effective biogas slurry assimilate technology by application of biogas slurry as nitrogen additives in the manufacture of organic fertilizer.

关键词： biogas slurry fermentation compost denaturing gradient gel electrophoresis (DGGE) gene clone library maturity

Features of Climate Change in Northwest China during 1961-2010

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Advances in Climate Change Research 2013年第1期4卷 12-19页

作者： SUN Lan-Dong ZHANG Cun-Jie zhao hong-yan LIN Jing-Jing QU Wen Institute of Arid Meteorology China Meteorological Administration Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province/Key Open Laboratory of Arid Climate Change and Disaster Reduction China Meteorological Administration National Climate Center China Meteorological Administration

In this study, observational data from 141 meteorological stations in Northwest China, including temperature, precipitation, dust storm, gale days and wind speed, were analyzed statistically to gain insight of the features of basic climate index and extreme climate events. The results showed that the annual mean temperature and seasonal mean temperature rose significantly, and the rising rate of the annual mean temperature is 0.27℃ per decade; the extreme high temperature days have increased; the interdecadal change of annual precipitation is marked, and the precipitation in winter and summer increased slightly, while decreased slightly in spring and autumn. The annual precipitation increased in the area west of the Yellow River, whereas decreased in the area east of the river. The drought had an increasing trend. There were 17 droughts during 1961-2010, and 10 droughts from 1991 to 2010. The number of droughts in spring and autumn increased, while decreased in summer.

关键词： climate index extreme climate event drought Northwest China

Mutation of DNA polymerase p in esophageal carcinoma of different regions

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World Journal of Gastroenterology 2005年第30期11卷 4618-4622页

作者： Guo-Qiang zhao Tao Wang Qin zhao Qin zhao, hong-yan yang, Xiao-Hui Tan, Zi-Ming Dong hong-yan yang Xiao-Hui Tan Zi-Ming Dong Basic Medical College Zhengzhou University Zhengzhou 450052 Henan Province China

AIM： To observe the variation of DNA polymerase β （polβ） in esophageal carcinoma. METHODS： Thirty specimens containing adjacent normal epithelial tissues were collected from patients in Linzhou region （a high risk area for esophageal squamous carcinoma） and 25 specimens were from a non-high risk area. Total RNA was extracted from the samples and reverse transcription polymerase chain reaction （RT-PCR） was performed. PCR products were cloned and sequenced to investigate the po1β gene with DNASIS and OMIGA. Statistical significance was evaluated using the X^2 test. RESULTS： High-inddence area group： Polβ gene variation was detected in 13 of 30 esophageal carcinoma tissue specimens, and only one variation was found in 30 corresponding adjacent normal tissue specimens. Non high-incidence area group： po1β gene variation was detected in 5 of 25 esophageal carcinoma tissue specimens, and no variation was found in 25 corresponding adjacent normal tissue specimens. The incidence of po1β gene variation observed in the high-incidence area group was significantly higher than in the non-high incidence area group. Two mutation hot spots （454-466 and 648-670 nt） and a 58 bp deletion （177-234 nt） were found. CONCLUSION： Variations of polβ perform different functions between the high-incidence areas and the other areas, and may play a more important role in the high-incidence areas.

关键词： DNA polymerase β Esophageal carcinoma Gene mutation

Misdiagnosis of scalp angiosarcoma: A case report

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World Journal of Clinical Cases 2023年第13期11卷 3099-3104页

作者： zhao-hong yan Zhen-Lan li Xiao-Wei Chen Ya-Wen Lian Li-Xin Liu Hao-yang Duan Department of Rehabilitation Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Plastic and Aesthetic Surgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Angiosarcoma is a rare malignant *** to the lack of specific clinical manifestations of this disease,it is difficult to achieve early diagnosis and start early *** SUMMARY A 78-year-old male patient was admitted to the hospital because of a bump on his head that did not heal for 4 *** patient was diagnosed with a refractory head *** patient underwent neoplasm resection and skin grafting surgery in the Plastic *** neoplasm was sent for pathological examination during the *** final pathological results were confirmed scalp *** Our research suggests that pathological examination should be performed for refractory ulcers of the scalp,and physical factor therapy should be used with caution before the diagnosis is clear.

关键词： Scalp angiosarcoma Refractory head wound Pathological examination Case report