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Gastroenterology & Hepatology Research 2022年第2期4卷 10-15页

作者： zhao-chun chi Department of Gastroenterology Qingdao MunicipalHospitalQingdao 266011Shandong ProvinceChina

The incidence of metabolic-associated fatty liver disease(MAFLD)is the highest among chronic liver disease worldwide,accounting for one-fourth to one-third of the world population and seriously affecting people's *** is a multi-systemic disease,which is closely related to the occurrence and prognosis of many *** an increase in research,studies have shown that MAFLD is associated with hepatitis virus infection,and this interaction affects the prognosis of the *** paper thus reviews the recent research progress in this field.

关键词： metabolic associated fatty liver disease viral hepatitis hepatitis virus pathogenesis prognosis

the Study of Hepatitis B Virus Reactivation

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国际感染病学（电子版） 2014年第4期3卷 187-192页

作者： zhao-chun chi Department of Gastroenterology Qingdao Municipal Hospital Affiliated Hospital of College Pharmacy of Ocean University of china

Hepatitis B virus(HBV) reactivation after chemotherapy or immunosuppressive therapy is a cause of liver-related morbidity and mortality. Not all chronic hepatitis B patients will lead to HBV reactivation. The incidence is 0.3%-30.2% according to the reports. The mechanism of HBV reactivation is still unclear, but it is believed that the viral load is increasing due to the suppression of immune response. No uniform diagnostic criteria are available. HBV reactivation can be confirmed by an increase of serum HBV DNA level. Recently, awareness of reactivation of occult HBV has been improved, especially in HBV endemic area. Preemptive antiviral therapy was the best approach to prevent the HBV reactivation. HBV reactivation can lead to acute hepatitis, severe hepatitis and acute liver failure. Therefore, it is worthy of great attention and further study. Antiviral therapy is safe and effective to prevent HBV reactivation.

关键词： HBV reactivation Occult HBV infection Chemotherapy Hepatectomy Immunosuppressive

Research progress on the correlation between metabolic-associated fatty liver disease and cardiovascular disease

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Gastroenterology & Hepatology Research 2022年第2期4卷 1-9页

作者： zhao-chun chi Department of Gastroenterology Qingdao MunicipalHospitalQingdao 266011Shandong ProvinceChina

Metabolisc-associated fatty liver disease(MAFLD)is a multi-system disease in which cardiovascular disease plays an important role and is considered the main cause of ***,cardiovascular disease events in young patients with MAFLD have attracted extensive *** article reviews the research progress on the correlation between MAFLD and cardiovascular disease.

关键词： non-alcoholic fatty liver disease metabolic-associated fatty liver disease extrahepatic complications cardiovascular disease

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Mechanism, current status, and prospects of MSC and its extracellular vesicles in the treatment of IBD

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Gastroenterology & Hepatology Research 2023年第4期5卷 26-34页

作者： zhao-chun chi Department of Gastroenterology Qingdao Municipal HospitalQingdao 266011China

The etiology of inflammatory bowel disease(IBD)is multifaceted,involving genetic susceptibility,immune dysregulation,alterations in the gut microbiota,and environmental *** intrinsic and extrinsic factors can disrupt the intestinal mucosal barrier,leading to chronic nonspecific inflammation,local structural changes,and gastrointestinal ***,due to a lack of effective treatments,recurrent inflammation and microcirculatory disturbances could result in complications such as intestinal fistulas,strictures,obstructions,perforations,gastrointestinal bleeding,sepsis,etc.,thereby increasing the risk of intestinal cell carcinoma and *** the overall incidence of IBD remains at 0.5%in North America and Europe,its annual incidence is increasing in Asia,Africa,and South America,resulting in a growing number of patients and warning significant *** research has highlighted mesenchymal stem cell(MSC)therapy as an innovative treatment option for IBD due to its capacity to modulate inflammatory immune responses and promote tissue regeneration.A current preclinical study has shown a promising result,with systemic administration of MSCs in patients with reduced intestinal inflammation and no intestinal *** addition,in a new study,the use of mesenchymal stem cell-derived exosomes(MSC-EXOs)was successful,a type derived from mesenchymal stem cells,was successful,especially in patients with refractory anal ***,MSC therapy has become a preferred approach in IBD treatment,showcasing the potential application prospects for stem cell-based therapy in ***,clinical research in this field still needs to refine strategies and further explore to lay a solid foundation.

关键词： therapy Inflammatory bowel disease MSC-derived exosomes mesenchymal stem cells therapeutic mechanisms mesenchymal stem cell-derived extracellular vesicles prospects

Research progress in gastric cancer caused by Helicobacter pylori

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Gastroenterology & Hepatology Research 2022年第4期4卷 17-22页

作者： zhao-chun chi Department of Gastroenterology Qingdao Municipal HospitalQingdao 266011China

Helicobacter pylori(***)infection is the most prevalent cause of gastric *** to recent studies,the likelihood of developing gastric cancer can be significantly increased by subtle microbial differences and has hereditary *** and gastric mucosal begetter cells have a complex relationship because of their ability to recombine epithelial cells and activate stem *** antecedent and stem cells can be directly influenced by cell-associated ***,which can colonize gastric *** balance between ***’s activities as a symbiont or pathogen can be changed by external and natural factors,such as calories count and gastrointestinal microbiota,which provides information for determining its full carcinogenic potential.

关键词： helicobacter pylori gastric cancer pathogenesis H.pylori virulence

Research of the eradication of Helicobacter pylori to prevent gastric cancer

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Gastroenterology & Hepatology Research 2023年第1期5卷 1-5页

作者： zhao-chun chi Department of Gastroenterology Qingdao Municipal HospitalQingdao 266011China

Gastric cancer(GC)is primarily caused by Helicobacter pylori(***).Approximately 50%of chinese people have ***,and *** is responsible for 90%of stomach cancer *** far,the best method of preventing the development of stomach cancer is the inhibition of *** incidence and fatality rates of stomach cancer can be considerably reduced by population-based *** eradication.

关键词： prevention gastric cancer metachronous occurrence epigenetic chemoprevention

Rheumatologic manifestations of hepatic diseases

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 32-37页

作者： zhao-chun chi Su-Zhen Ma the Division of Gastroenterologr, Department of Medicine, People’s Hospital, Qingdao 266001, china the Department of Infectious Diseases, Qingdao University College of Medicine, Qingdao 266012, china Division of Gastroenterology Department of Medicine People's Hospital Qingdao 266001 China.

A possible link is suggested between hepatic diseases and rheumatic disease. Polyarthralgia and polyarthritis may be seen during the prodromal period of acute viral hepatitis, especially in hepatitis B virus (HBV). The symptoms of arthritis, mild, localized or generalized, mostly involve the small joints of hands. Joint symptoms frequently precede the onset of jaundice, no residual joint deformities. Circulating immune complexes are believed to play a causative role in the development of vasculitis and arthritis. Hemochromatosis is an antosomal recessive disorder of iron. About 43%-81% of patients with hemochromatosis have arthritis. The common extrahepatic manifestations of autoimmune hepatitis are arthralgia and skin rash. The reported prevalence of symptomatic inflammatory arthropathy in patients with primary biliary cirrhosis ranges from 4% to 50%. Skeletal involvement with Wilson's disease is common. Such patients may complain of pain and stiffness, mainly in the knee, wrist, or other large joints. Shwachman's syndrome is a disorder of pancreatic exocrine. Symmetric bone lesions have been reported in 10% to 15% of patients. They are involved predominantly at the femoral neck. Rheumatic symptoms are seen in one third of adult patients with cystic fibrosis and arthritis in 2.5% to 12% of patients. The arthritis caused by pancreatic panniculitis is usually symmetrical and involves the small joints of the hand, wrist, and feet, but may involve such larger joints as the elbow, ankle, and knee.

关键词： hepatic diseases rheumatologic manifestation

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炎症与肿瘤相关性研究进展与展望

世界华人消化杂志 2024年第1期32卷 23-40页

作者：池肇春青岛市市立医院消化内科山东省青岛市266011

在过去的十年中,有明确的证据表明,炎症在肿瘤发生中起着关键作用.肿瘤外源性炎症是由许多因素引起的,包括细菌和病毒感染、自身免疫性疾病、肥胖、吸烟和过度饮酒等,所有这些因素都会增加癌症风险并刺激恶性进展.相反,癌症固有或癌症... 详细信息

在过去的十年中,有明确的证据表明,炎症在肿瘤发生中起着关键作用.肿瘤外源性炎症是由许多因素引起的,包括细菌和病毒感染、自身免疫性疾病、肥胖、吸烟和过度饮酒等,所有这些因素都会增加癌症风险并刺激恶性进展.相反,癌症固有或癌症引发的炎症可由癌症启动突变触发,并可通过炎症细胞的募集和激活促进恶性进展.外源性和内源性炎症均可导致免疫抑制,从而为肿瘤发展提供了首选的机遇.研究证实,慢性炎症与肿瘤发生的各个步骤有关,包括细胞转化、促进、存活、增殖、侵袭、血管生成和转移.最近的研究成果对炎症和癌症之间的分子和细胞回路有了新的认识.已经初步确定了两种途径:在内在途径中,导致肿瘤的遗传事件启动炎症相关程序的表达,引导炎症微环境的构建;在外在途径中,炎症条件促进癌症的发展.本文综述炎症与肿瘤相关的最新进展与展望.

关键词：慢性炎症氧化应激肿瘤细胞因子免疫细胞衰老感染肥胖基因不稳定

代谢相关脂肪性肝病与病毒感染疾病相关性研究进展

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世界华人消化杂志 2022年第18期30卷 783-794页

作者：池肇春青岛市市立医院消化内科山东省青岛市266011

代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)是当前世界上发病率最高的慢性肝病,其发病率约占世界人口的1/4-1/3,严重影响人民健康.MAFLD又是一种多系统疾病,与众多疾病的发生和预后密切相关.随着研究的深入,... 详细信息

代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)是当前世界上发病率最高的慢性肝病,其发病率约占世界人口的1/4-1/3,严重影响人民健康.MAFLD又是一种多系统疾病,与众多疾病的发生和预后密切相关.随着研究的深入,研究显示MAFLD也与病毒感染疾病相关,相互作用影响疾病预后.本文就对这方面的近年研究进展进行评述.

关键词：代谢相关脂肪性肝病病毒感染疾病发病机制预后

代谢相关脂肪性肝病肝外并发症研究进展与现状

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世界华人消化杂志 2022年第1期30卷 1-16页

作者：池肇春青岛市市立医院消化内科山东青岛266011

代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)是作为描述这种疾病的一个更合适的总括述语,新的定义将代谢功能障碍列为肝病的重要病因,论证了MAFLD的高异质性,加快了向新治疗的转化路径.MAFLD的肝外并发症其发... 详细信息

代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)是作为描述这种疾病的一个更合适的总括述语,新的定义将代谢功能障碍列为肝病的重要病因,论证了MAFLD的高异质性,加快了向新治疗的转化路径.MAFLD的肝外并发症其发生率和相关疾病,远远超过肝病本身,严重威脅着人类健康.鉴于当前人们对其严重性认识不足,且对肝外并发病的疾病范围、发病机制、诊断的研究还不完善,尤其当前对其缺乏有效的药物治疗,有鉴于此本文就MAFLD肝外并发症研究现状与进展作一介绍与述评,与广大读者共享.

关键词：非酒精性脂肪性肝病代谢相关脂肪性肝病肝外并发症