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TCERG1L hypermethylation is a risk factor of diabetic retinopathy in Chinese children with type 1 diabetes

International Journal of Ophthalmology(English edition) 2024年第3期17卷 537-544页

作者： yu Qian Ying Xiao Qiu-Rong Lin zhao-yu xiang Li-Pu Cui Jia-Qi Sun Si-Cong Li Xin-Ran Qin Hai-Dong Zou Chen-Hao Yang Pei-Yao Jin Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai First People’s HospitalShanghai 200080China Shanghai Eye Diseases Prevention&Treatment Center Shanghai Eye HospitalShanghai 200040China National Clinical Research Center for Eye Diseases Shanghai Clinical Research Center for Eye DiseasesShanghai Key Clinical SpecialtyShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology Children’s Hospital of Fudan UniversityShanghai 201102China

●AIM:To identify the differential methylation sites(DMS)and their according genes associated with diabetic retinopathy(DR)development in type 1 diabetes(T1DM)children.●METHODS:This study consists of two surveys.A total of 40 T1DM children was included in the first *** no participant has DR,retina thinning was used as a surrogate indicator for *** lowest 25%participants with the thinnest macular retinal thickness were included into the case group,and the others were *** DNA methylation status was assessed by the Illumina methylation 850K array BeadChip assay,and compared between the case and control *** DMS with a potential role in diabetes were *** second survey included 27 T1DM children,among which four had *** methylation patterns of the four DMS identified by 850K were compared between participants with and without DR by pyrosequencing.●RESULTS:In the first survey,the 850K array revealed 751 sites significantly and differentially methylated in the case group comparing with the controls(|Δβ|>0.1 and Adj.P0.05)between participants with and without DR.●CONCLUSION:The hypermethylation of the TCERG1L gene is a risk factor for DR development in Chinese children with T1DM.

关键词： DNA methylation 850K array pyrosequencing diabetic retinopathy type 1 diabetes children

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Treatment of coke plant wastewater by SND fixed biofilm hybrid system

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Journal of Environmental Sciences 2007年第2期19卷 153-159页

作者： QI Rong YANG Kun yu zhao-xiang Department of Chemistry Tongji University Shanghai 200092 China

In this article, coke plant wastewater was treated by a simultaneous nitrifying and denitrifying （SND） fixed biofilm hybrid system. The results showed that suitable parameters of the system were important for the performance of the bio-degradation system. The chemical oxygen demand （COD） removal efficiency in this system was satisfactory, higher than 94%, and ammonia nitrogen was higher than 95%. The effluent COD concentration could meet the discharge standard, except for very few situations. The results showed that a sufficient carbon source was important for making ammonia nitrogen concentration meet the discharge standard. Then the TiN removal efficiency in this system can be brought higher than 94%. Dissolved oxygen （DO） is very important to the performance of the SND bio-degradation system, and the suitable DO is about 3.5-4.0 mg/L at the forepart of reactor. In addition, the performance of the system was almost not affected by pH value. The results show that the system is feasible to treat coke plant wastewater.

关键词： coke plant wastewater SND fixed biofilm ammonia nitrogen COD carbon source

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个性化心理灵活性指数中文版在大学生和乳腺癌患者中的信效度检验

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中国临床心理学杂志 2024年第4期32卷 882-886页

作者：赵迪李国鹏赵香玉高怡明覃瑞马清华厉萍山东大学护理与康复学院济南250012 山东省肿瘤防治研究院(山东省肿瘤医院) 山东第一医科大学(山东省医学科学院)乳腺外科济南250017

目的:对个性化心理灵活性指数(personalized psychological flexibility index,PPFI)进行汉化,并在大学生和乳腺癌患者中进行信效度检验。方法:对三组样本(包括大学生和乳腺癌患者)施测,采用接纳与行动问卷第二版、广泛性焦虑障碍量表... 详细信息

目的:对个性化心理灵活性指数(personalized psychological flexibility index,PPFI)进行汉化,并在大学生和乳腺癌患者中进行信效度检验。方法:对三组样本(包括大学生和乳腺癌患者)施测,采用接纳与行动问卷第二版、广泛性焦虑障碍量表、患者健康问卷、弗莱堡正念调查表和心理弹性量表作为效标工具。结果:中文版PPFI项目质量良好,量表共15个条目,包括回避、接纳、掌控三个维度。验证性因子分析一阶3因子模型拟合良好(χ^(2)/df=2.383,RMSEA=0.054,SRMR=0.056,CFI=0.960,TLI=0.947)。中文版PPFI及各维度与接纳与行动问卷、抑郁和焦虑等指标呈显著负相关(r=-0.14~-0.49),与正念和心理弹性呈显著正相关(r=0.23~0.64)。总量表内部一致性系数在大学生和乳腺癌患者中分别为0.88和0.83,重测信度为0.54。各维度的内部一致性系数为0.75~0.89,重测信度为0.36~0.56。结论:中文版个性化心理灵活性指数(PPFI)在中国大学生和乳腺癌患者中具有较好的信度和效度。

关键词：心理灵活性信度效度大学生乳腺癌

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Image Field Deformation of LAMOST due to Differential Atmospheric Refraction

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Chinese Journal of Astronomy and Astrophysics 2006年第4期6卷 495-502页

作者： Jin-Ling Li Bo Zhang Yong yu zhao-xiang Qi Ming zhao Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030

A vectorial expression of the image field deformation of LAMOST due to the differential atmospheric refraction is presented. The calculated results are compared with those from previous analyses based on the traditional spherical trigonometric formulas. It is demonstrated that different tangential displacements of star images during the observation tracking given by various authors are simply due to different reference points adopted. It is pointed out that the observational celestial pole is the center of the apparent diurnal motion, that, by referring to the observational celestial pole, the effect of the differential refraction on the image field of LAMOST during the 1.5-hour tracking period is approximately equivalent to a constant rotation of - 13.65″ for all declination belts. It is therefore unnecessary to design a particular tracking velocity for each observation, and this will be obviously advantageous to the observation implementation. If the maximum tracking error of the fibers is 0.2″, then the fibers are required to be able to re-position during observational tracking for sky regions south of declination ＋20° and north of declination ＋60°.

关键词： telescopes -- atmospheric effects -- methods: analytical-- methods: statistical-- astrometry

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杜仲籽粕水解肽的滋味评价及在乳饮料中的应用

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中国调味品 2024年第10期49卷 31-38页

作者：葛珍珍赵玉翔许明月胡乔乔张亦楠赵光远纵伟郑州轻工业大学食品与生物工程学院郑州450002 郑州轻工业大学冷链食品加工与安全控制教育部重点实验室郑州450002

以杜仲籽粕水解液为原料,添加全脂乳粉、复合稳定剂(羧甲基纤维素钠、黄原胶)、白砂糖、维生素C进行调配,在单因素实验的基础上,以感官评分和离心沉淀率为考察指标,利用Box-Behnken响应面法优化乳饮料的最优配方。最优配方为水解液添加... 详细信息

以杜仲籽粕水解液为原料,添加全脂乳粉、复合稳定剂(羧甲基纤维素钠、黄原胶)、白砂糖、维生素C进行调配,在单因素实验的基础上,以感官评分和离心沉淀率为考察指标,利用Box-Behnken响应面法优化乳饮料的最优配方。最优配方为水解液添加量20%、全脂乳粉添加量2.20%、复合稳定剂添加量0.12%,由此配方得到的乳饮料感官评分为(83.85±2.26)分,离心沉淀率为(3.08±0.12)%,且乳饮料色泽通透,风味协调,组织均匀,通过电子舌分析可知酸味、甜味物质是造成乳饮料呈味差异的主要物质,杜仲籽粕水解肽对其滋味特征的影响较小。

关键词：杜仲籽粕水解肽乳饮料工艺优化滋味

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Reduction of unactivated alkyl chlorides enabled by light-induced single electron transfer

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Science China Chemistry 2024年第2期67卷 471-481页

作者： Lei Dai zhao-Fei Zhang xiang-yu Chen School of Chemical Sciences University of the Chinese Academy of SciencesBeijing100049China Institute of Chemistry Chinese Academy of SciencesBeijing100190China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou256606China

Alkyl chlorides are abundant and easily accessible starting ***,due to the high reduction potentials associated with unactivated alkyl chlorides,achieving their single electron reduction remains a persistent *** challenge has spurred the exploration of efficient activation methods to overcome this *** recent years,photocatalysis has emerged as a mild and potent tool for the single electron reduction of unactivated alkyl chlorides,opening up new possibilities in this *** the rapid advancements in this area,a comprehensive review that provides a conceptual understanding of this emerging field,with a specific focus on reaction design and catalytic mechanisms,would be timely and highly ***,we present an overview of various synthetic techniques for photoinduced single electron reduction of unactivated alkyl ***,we also discuss the limitations of the present methods and future directions that lie ahead in this field.

关键词： photocatalysis unactivated alkyl chlorides single electron transfer radical reactions

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北京地区医疗机构科技成果转化的PEST-SWOT分析

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医院管理论坛 2024年第3期41卷 75-78页

作者：金彦梁公文申占龙赵翔宇北京大学人民医院

目的探讨医疗机构科技成果转化工作策略。方法通过专利数据库、文献检索分析北京地区医疗机构近年来的专利及转化情况,结合政策文本进行PEST-SWOT分析。结果北京地区医疗机构专利申请、授权增多,进行成果转化的优势和机会明显,也存... 详细信息

目的探讨医疗机构科技成果转化工作策略。方法通过专利数据库、文献检索分析北京地区医疗机构近年来的专利及转化情况,结合政策文本进行PEST-SWOT分析。结果北京地区医疗机构专利申请、授权增多,进行成果转化的优势和机会明显,也存在一定的劣势与威胁,转化率需要提升。结论医疗机构应顺应政策要求,发挥资源优势,加强产业融合,提升成果价值和知识产权运营能力,完善转化机制。

关键词：医疗机构知识产权 PEST-SWOT分析成果转化

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Hydrodynamic Performance of An Integrated System of Breakwater and A Multi-Chamber OWC Wave Energy Converter

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China Ocean Engineering 2024年第4期38卷 543-556页

作者： NING De-zhi ZHANG xiang-yu WANG Rong-quan zhao Ming State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Dalian Key Laboratory of Offshore Renewable Energy Dalian University of TechnologyDalian 116024China School of Computing Engineering and MathematicsUniversity of Western SydneyPenrith NSW 2751Australia

A multi-chamber oscillating water column wave energy converter(OWC-WEC)integrated to a breakwater is *** hydrodynamic characteristics of the device are analyzed using an analytical model based on the linear potential flow theory.A pneumatic model is employed to investigate the relationship between the air mass flux in the chamber and the turbine *** effects of chamber width,wall draft and wall thickness on the hydrodynamic performance of a dual-chamber OWC-WEC are *** results demonstrate that the device,with a smaller front wall draft and a wider rear chamber exhibits a broader effective frequency *** device with a chamber-width-ratio of 1:3 performs better in terms of power ***,results from the analysis of a triplechamber OWC-WEC demonstrate that reducing the front chamber width and increasing the rearward chamber width can improve the total performance of the *** the number of chambers from 1 to 2 or 3 can widen the effective frequency bandwidth.

关键词： oscillating water column power extraction efficiency potential flow theory wave energy converter multi-chamber

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Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-yue Cai Weiming Shi zhao-Hui Jin Zhi-xiang yu Jin-Xin zhao Jian-Min yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

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An integrative mathematical model of microwave ion thruster for mHz-frequency thrust noise analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 121-136页

作者： xiang NIU Hui LIU Daren yu Plasma Propulsion Laboratory Harbin Institute of TechnologyHarbin 150001China

Many high-precision space missions need thrusters to produce thrust with low noise to compensate for disturbances and ensure satellite platform stability. Microwave ion thruster is characterized with a wide thrust range and potential for these missions. A cost-effective and accurate mathematical model is crucial for mHz-frequency thrust noise analysis and feedback controller design. The Particle-In-Cell(PIC) and global models are two common simulation tools. The PIC model is characterized with high accuracy but huge computation cost, which is difficult to analyze long-time performance characteristics. Now, the global model is only used for the discharge chamber with low accuracy and cannot reflect ion extraction properties. In this paper, an integrative mathematical model is built for a 1-cm microwave ion thruster and can reflect ion beamlet divergence and impingement on the Accelerator Grid(AG). Simulation results show good agreement with experiments at 0.06 sccm. However, the model demonstrates worse consistency with experiments when the flux increases to 0.1 sccm, which may be because the influence of neutral gas on the Electron Cyclotron Resonance(ECR) is not considered in the model. A long-time(1000 s) simulation is conducted with this model under 35 μN. It takes 3 hrs, and the thrust noise reaches 1 μN/Hz^(0.5) at 1 mHz.

关键词： Electric propulsion Microwave ion thruster Integrative model Sheath property Ion beamlet divergence Thrust noise Plasma

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