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Exploring the effect and mechanisms of Epimedium on diabetic testicular injury using network pharmacology,molecular docking,and cell experiments

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TMR Modern Herbal Medicine 2024年第2期7卷 19-27页

作者： Jun-Jun Wei Qiong-Yao Xu zhao-wen pan Yi-Wei Tu Wei Yu Lan Huang wen-Liang Zha College of Pharmacy Hubei University of Science and TechnologyXianning 437100China Xianning Medical College Hubei University of Science and TechnologyXianning 437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China

Background:Studying the potential targets and mechanisms of Epimedium for anti-diabetic testicular injury using network pharmacology,molecular docking,and cell ***:Acquisition of major components and targets of Epimedium was based on TCMSP,TCMID,and Symmap databases and retrieval of diabetic testicular injury targets by OMIM,GeneCards,Pharmgkb,and Drugbank *** targets were obtained from the Venny 2.1.0 database and input SRTING data to construct a protein-protein interaction(PPI)network,and key targets were screened in Cytoscape 3.8.0 *** the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of intersecting targets were conducted through the DAVID ***,AutoDock software was used to verify docking between the main components and the core target *** addition,a Cell Counting Kit-8(CCK-8)assay was used to determine the survival effect of quercetin,the main component of Epimedium,on TM4 sertoli-like cells exposed to palmitic acid(PA).Results:Quercetin,kaempferol and luteolin in epimedium were identified as the main components in the treatment of diabetic testicular *** has core target proteins including MMP9,AKT1,and *** biological process mainly involves the regulation of the apoptotic signaling *** key pathways of KEGG are the AGE-RAGE signaling pathway in diabetic complications,PI3K-Akt and MAPK signaling *** docking results showed that quercetin had the strongest binding ability to ***,PA-challenged cells had a lower survival rate,which was alleviated by the administration of ***:Our findings suggest that Epimedium attenuates diabetes mellitus(DM)-induced testicular injury through AGE-RAGE,PI3K-Akt and MAPK signaling *** insights offer a potential therapeutic strategy for managing DM-induced testicular injury,will be the basis for future clinical research.

关键词： Epimedium diabetic testicular injury network pharmacology molecular docking

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Aeroengine thrust estimation and embedded verification based on improved temporal convolutional network

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Chinese Journal of Aeronautics 2024年第1期37卷 106-117页

作者： Wanzhi MENG Zhuorui pan Sixin wen pan QIN Ximing SUN Key Laboratory of Intelligent Control and Optimization for Industrial Equipment of Ministry of Education Dalian University of TechnologyDalian 116024China School of Control Science and Engineering Dalian University of TechnologyDalian 116024China

Thrust estimation is a significant part of aeroengine thrust control *** traditional estimation methods are either low in accuracy or large in *** further improve the estimation effect,a thrust estimator based on Multi-layer Residual Temporal Convolutional Network(M-RTCN)is *** solve the problem of dead Rectified Linear Unit(ReLU),the proposed method uses the Gaussian Error Linear Unit(GELU)activation function instead of ReLU in residual *** the overall architecture of the multi-layer convolutional network is adjusted by using residual connections,so that the network thrust estimation effect and memory consumption are further ***,the comparison with seven other methods shows that the proposed method has the advantages of higher estimation accuracy and faster convergence ***,six neural network models are deployed in the embedded controller of the micro-turbojet *** Hardware-in-the-Loop(HIL)testing results demonstrate the superiority of M-RTCN in terms of estimation accuracy,memory occupation and running ***,an ignition verification is conducted to confirm the expected thrust estimation and real-time performance.

关键词： Thrust estimation Temporal convolutional network Embedded deployment Hardware-in-the-loop testing Ignition verification

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Embedded high-quality ternary GaAs_(1−x)Sb_(x) quantum dots in GaAs nanowires by molecular-beam epitaxy

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Journal of Semiconductors 2024年第8期45卷 18-24页

作者： Xiyu Hou Lianjun wen Fengyue He Ran Zhuo Lei Liu Hailong Wang Qing Zhong Dong pan Jianhua zhao State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

Semiconductor quantum dots are promising candidates for preparing high-performance single photon sources.A basic requirement for this application is realizing the controlled growth of high-quality semiconductor quantum ***,we report the growth of embedded GaAs_(1−x)Sb_(x) quantum dots in GaAs nanowires by molecular-beam *** is found that the size of the GaAs_(1−x)Sb_(x) quantum dot can be well-defined by the GaAs *** dispersive spectroscopy analyses show that the antimony content x can be up to 0.36 by tuning the growth *** GaAs_(1−x)Sb_(x) quantum dots exhibit a pure zinc-blende *** addition,we have developed a new technology to grow GaAs passivation layers on the sidewalls of the GaAs_(1−x)Sb_(x) quantum *** from the traditional growth process of the passivation layer,GaAs passivation layers can be grown simultaneously with the growth of the embedded GaAs_(1−x)Sb_(x) quantum *** spontaneous GaAs passivation layer shows a pure zinc-blende phase due to the strict epitaxial relationship between the quantum dot and the passivation *** successful fabrication of embedded high-quality GaAs_(1−x)Sb_(x) quantum dots lays the foundation for the realization of GaAs_(1−x)Sb_(x)-based single photon sources.

关键词： semiconductor quantum dot nanowire GaAs_(1−x)Sb_(x) molecular-beam epitaxy

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Characteristics of orthorhombic anisotropic seismic response induced by horizontal in situ stress in vertical transversely isotropic media

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Science China Earth Sciences 2024年第7期67卷 2291-2310页

作者： Xinpeng pan Chengxu LU Zhizhe zhao Jianxin LIU School of Geoscience and Info-Physics Central South UniversityChangsha 410083China Hunan Key Labraory of Nonferrous Resources and Geological Disaster Exploration Central South University Changsha 410083China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring(Central South University) Ministry of EducationChangsha 410083China PowerChina Zhongnan Engineering Corporation Limited Changsha 410014China

Sedimentary strata typically exhibit the characteristics of transverse isotropy(VTI)with a vertical axis of ***,fractures in sedimentary strata tend to produce anisotropic closure due to horizontal in situ stress,resulting in pronounced orthorhombic anisotropy in VTI media under such stress conditions and influencing the propagation behavior of seismic *** studies have primarily focused on the elastic wave velocity anisotropy induced by applied stress in isotropic background media,neglecting the impact of VTI background media on the anisotropy induced by horizontal in situ stress and the response characteristics of seismic wave *** address these gaps,we first establish the effective elastic stiffness tensor of VTI media under horizontal in situ stress using nonlinear acoustoelastic ***,we derive the accurate and linearized approximate equations for P-wave seismic reflectivity of VTI media under horizontal in situ stress,based on wave equations and scattering theory,***,we compare and analyze the characteristics of orthorhombic anisotropic seismic response induced by horizontal in situ stress at various types of elastic reflection *** results demonstrate that the linearized approximation of the seismic reflection response characteristics closely aligns with the accurate equations under conditions of small stress below 10 MPa,effectively capturing the azimuth-dependent orthorhombic anisotropy induced by horizontal in situ stress in VTI *** results of this study also provide a novel theoretical approach and valuable insights into the seismic prediction of in situ stress.

关键词： Horizontal in situ stress Nonlinear acoustoelastic theory Linear slip theory Orthorhombic anisotropy Stress seismic prediction

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Novel stacking models based on SMOTE for the prediction of rockburst grades at four deep gold mines

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Underground Space 2024年第6期19卷 169-188页

作者： Peng Xiao Zida Liu Guoyan zhao Pengzhi pan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China School of Resources and Safety Engineering Central South UniversityChangsha 410083China

Rockburst is a frequently encountered hazard during the production of deep gold *** prediction of rockburst is an important measure to prevent rockburst in gold *** study considers seven indicators to evaluate rockburst at four deep gold *** research and rock tests were performed at two gold mines in China to collect these seven indicators and rockburst *** collected database was oversampled by the synthetic minority oversampling technique(SMOTE)to balance the categories of rockburst *** models combining tree-based models and logistic regression(LR)were established by the balanced *** datasets from another two deep gold mines were implemented to verify the applicability of the predictive *** stacking model combining extremely randomized trees and LR based on SMOTE(SMOTE-ERT-LR)was the best model,and it obtained a training accuracy of 100%and an evaluation accuracy of 100%.Moreover,model evaluation suggested that SMOTE can enhance the prediction performance for weak rockburst,thereby improving the overall ***,sensitivity analysis was performed for *** results indicated that the SMOTE-ERT-LR model can achieve satisfactory performance when only depth,maximum tangential stress index,and linear elastic energy index were available.

关键词： Rockburst prediction Gold mine Stacking model SMOTE

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Galerkin-based quasi-smooth manifold element(QSME)method for anisotropic heat conduction problems in composites with complex geometry

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 137-154页

作者： pan WANG Xiangcheng HAN Weibin wen Baolin WANG Jun LIANG School of Civil Engineering Central South UniversityChangsha 410083China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China School of Science Harbin Institute of TechnologyShenzhen 518055Guangdong ProvinceChina

The accurate and efficient analysis of anisotropic heat conduction problems in complex composites is crucial for structural design and performance evaluation. Traditional numerical methods, such as the finite element method(FEM), often face a trade-off between calculation accuracy and efficiency. In this paper, we propose a quasi-smooth manifold element(QSME) method to address this challenge, and provide the accurate and efficient analysis of two-dimensional(2D) anisotropic heat conduction problems in composites with complex geometry. The QSME approach achieves high calculation precision by a high-order local approximation that ensures the first-order derivative *** results demonstrate that the QSME method is robust and stable, offering both high accuracy and efficiency in the heat conduction analysis. With the same degrees of freedom(DOFs), the QSME method can achieve at least an order of magnitude higher calculation accuracy than the traditional FEM. Additionally, under the same level of calculation error, the QSME method requires 10 times fewer DOFs than the traditional FEM. The versatility of the proposed QSME method extends beyond anisotropic heat conduction problems in complex composites. The proposed QSME method can also be applied to other problems, including fluid flows, mechanical analyses, and other multi-field coupled problems, providing accurate and efficient numerical simulations.

关键词： anisotropic heat conduction quasi-smooth manifold element(QSME) composite with complex geometry numerical simulation finite element method(FEM)

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Limits of Uneven Battery Power in Modular Multilevel Converter-based Battery Energy Storage Systems

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 686-695页

作者： Yao pan Xiaofeng Sun Wei zhao Xin Li Yao Cai Institute of Electrical Engineering Yanshan UniversityQinhuangdao 066004China

For modular multilevel converter-based battery energy storage systems (MMC-BESS), uneven power among batteries of SMs will be deduced by battery aging, battery fault, etc., which will degrade performance and even lead to system failure. For maintaining the balance of capacitor voltage, this paper analyzes the limits of the uneven power of batteries, which are presented as the current limits in this paper. According to analysis, an analytical method is proposed that only the dc and fundamental frequency components of the arm current are used to calculate current limits. With the current limits it is able to evaluate the reasonability of power distribution among batteries. Meanwhile, increase of fundamental frequency component will enhance the current limits, and the dc component determines the size relationship between the absolute values of the upper and lower current limits. Finally, simulation model and experiment prototype are built for verifying the theoretical analysis and current limits calculation method, and satisfactory results are provided.

关键词： Arm current balance of capacitor voltage current limits MMC-BESS uneven power

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Lithospheric strength of the Anatolian plateau and implications for strong earthquake activity in Turkey

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Geodesy and Geodynamics 2024年第3期15卷 209-218页

作者： Yuhang pan Shi Chen wen Shi Institute of Geophysics China Earthquake AdministrationBeijing 100081China Beijing Baijiatuan Earth Science National Observation and Research Station Beijing 100095China

On February 6, 2023, the doublet earthquake including two main shocks with magnitudes M_(W)7.8 and M_(W)7.5, occurred near the western side of the East Anatolian Fault at the southeast boundary of the Anatolian Plateau in Turkey. Based on the WGM2012 Bouguer gravity anomaly data and the Etopo1topography data, this study first introduced a joint inversion of admittance and coherence functions and used the Bayesian optimal parameter estimation method to obtain the effective elastic thickness Teand loading ratio F of the lithosphere for various tectonic units in the Anatolian Plateau. Secondly, we discussed the characteristics and influencing factors of the lithospheric mechanical strength and analyzed its relationship with seismic activity. The lithospheric mechanical strength of the Anatolian Plateau showed clear lateral heterogeneity and a "weak-strong-weak" spatial pattern from east to west,reflecting various tectonic processes. At last, the strong seismic activity was found where the lithospheric strength was low in the Anatolian Plate. We also incorporated GPS strain rate and other results to investigate the tectonic background and primary causes of the M_(W)7.8 and M_(W)7.5 doublet earthquakes in Turkey. The results have a good insight into urban safety design in the Turkish region, including postdisaster rehabilitation, earthquake hazard assessment, and loss reduction.

关键词： Effective elastic thickness Anatolian plateau Turkey doublet earthquakes Bayesian optimization

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Multi-layer quasi-zero-stiffness meta-structure for high-efficiency vibration isolation at low frequency

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1189-1208页

作者： Jiahao ZHOU Jiaxi ZHOU Hongbin pan Kai WANG Changqi CAI Guilin wen College of Mechanical and Vehicle Engineering Hunan UniversityChangsha410082China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body The Ministry of Science and TechnologyChangsha410082China School of Mechanical Engineering Zhejiang Sci-Tech UniversityHangzhou310018China School of Mechanical Engineering Yanshan UniversityQinhuangdao066004Hebei ProvinceChina

An easily stackable multi-layer quasi-zero-stiffness(ML-QZS)meta-structure is proposed to achieve highly efficient vibration isolation performance at low ***,the distributed shape optimization method is used to design the unit cel,i.e.,the single-layer QZS(SL-QZS)***,the stiffness feature of the unit cell is investigated and verified through static ***,the unit cells are stacked one by one along the direction of vibration isolation,and thus the ML-QZS meta-structure is ***,the dynamic modeling of the ML-QZS vibration isolation metastructure is conducted,and the dynamic responses are obtained from the equations of motion,and verified by finite element(FE)***,a prototype of the ML-QZS vibration isolation meta-structure is fabricated by additive manufacturing,and the vibration isolation performance is evaluated *** results show that the vibration isolation performance substantially enhances when the number of unit cells *** importantly,the ML-QZS meta-structure can be easily extended in the direction of vibration isolation when the unit cells are properly ***,the ML-FQZS vibration isolation meta-structure should be a fascinating solution for highly efficient vibration isolation performance at low frequency.

关键词： quasi-zero stiffness(QZS) meta-structure high efficiency low frequency vibration isolation

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Effect of Wave Nonlinearity on the Instantaneous Seabed Liquefaction

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China Ocean Engineering 2024年第1期38卷 93-103页

作者： WANG zhao-jun SUI Ti-ti ZHANG Chi pan Jun-ning Key Laboratory of Port Waterway and Sedimentation Engineering of the Ministry of TransportNanjing Hydraulic Research InstituteNanjing 210024China Key Laboratory of Coastal Disaster and Protection(Hohai University) Ministry of EducationNanjing 210098China The National Key Laboratory of Water Disaster Prevention Nanjing 210098China

The nonlinear variation of wave is commonly seen in nearshore area,and the resulting seabed response and liquefaction are of high concern to coastal *** this study,an analytical formula considering the nonlinear wave skewness and asymmetry is adopted to provide wave pressure on the seabed *** liquefaction depth attenuation coefficient and width growth coefficient are defined to quantitatively characterize the nonlinear effect of wave on seabed *** on the 2D full dynamic model of wave-induced seabed response,a detailed parametric study is carried out in order to evaluate the influence of the nonlinear variation of wave loadings on seabed ***,new empirical prediction formulas are proposed to fast predict the maximum liquefaction under nonlinear *** indicate that(1)Due to the influence of wave nonlinearity,the vertical transmission of negative pore water pressure in the seabed is hindered,and therefore,the amplitude decreases significantly.(2)In general,with the increase of wave nonlinearity,the liquefaction depth of seabed decreases *** under asymmetric and skewed wave loading,the attenuation of maximum seabed liquefaction depth is the most significant among all the nonlinear wave ***,highly skewed wave can cause the liquefaction depth of seabed greater than that under linear wave.(3)The asymmetry of wave pressure leads to the increase of liquefaction width,whereas the influence of skewedness is not significant.(4)Compared with the nonlinear waveform,seabed liquefaction is more sensitive to the variation of nonlinear degree of wave loading.

关键词： nonlinear wave seabed response seabed liquefaction numerical simulation liquefaction prediction

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