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A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertility

Asian Journal of Andrology 2023年第5期25卷 643-645页

作者： Si-Yi zhao Lan-Lan Meng zhao-li du Yue-Qiu Tan Wen-Bin He Xiong Wang The First Clinical College of Guangzhou Medical University Guangzhou 511436China National Engineering and Research Center of Human Stem Cells and Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410008China Reproductive and Genetic Hospital of CITIC-Xiangya and Clinical Research Center For Reproduction and Genetics in Hunan Province Changsha 410008China Yinfeng Gene Technology Co. Ltd.Jinan 250000China Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000China

Male infertility is a major reproductive disorder,which is clinically characterized by highly heterogeneous phenotypes of abnormal sperm count or *** date,five male patients with biallelic loss-of-function(LOF)variants of PARN-like ribonuclease domain-containing exonuclease 1(PNLDC1)have been reported to experience infertility with nonobstructive *** aim of this study was to identify the genetic cause of male infertility with oligo-astheno-teratozoospermia(OAT)in a patient from a Chinese Han ***-exome and Sanger sequencing analyses identified a homozygous LOF variant(NM_173516.2,c.l42C>T,***48Ter)in *** and eosin staining revealed that the spermatozoa of the patient with OAT had an irregular head phenotype,including microcephaly,head tapering,and ***,peanut agglutinin staining of the spermatozoa revealed a complete or partial loss of the ***,the disomy rate of chromosomes in the patient’s spermatozoa was significantly increased compared with that of a fertile control *** reported an LOF variant of the PNLDC1 gene responsible for OAT.

关键词： loss-of-function variant male infertility oligo-astheno-teratozoospermia PARN-like ribonuclease domain-containing exonuclease 1

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Seismic and vibration control of segmented isolation layer in underground structure-diaphragm wall system

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Underground Space 2024年第6期19卷 72-86页

作者： Zhidong Gao Mingbo li Mi zhao Xiuli du Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China Department of Hydraulic Engineering Tsinghua UniversityBeijing 100084China

In this paper,a seismic and vibration reduction measure of subway station is developed by setting a segmented isolation layer between the sidewall of structure and the diaphragm *** segmented isolation layer consists of a rigid layer and a flexible *** rigid layer is installed at the joint section between the structural sidewall and slab,and the flexible layer is installed at the remaining sections.A diaphragm wall-segmented isolation layer-subway station structure system is *** and vibration control performance of the diaphragm wall-segmented isolation layer-subway station structure system is evaluated by the detailed numerical ***,a three-dimensional nonlinear time-history analysis is carried out to study the seismic response of the station structure by considering the effect of different earthquake motions and stiffness of segmented isolation ***,the vibration response of site under training loading is also studied by considering the influence of different train velocities and stiffness of the segmented isolation *** results demonstrate that the diaphragm wall-segmented isolation layer-subway station structure system can not only effectively reduce the lateral deformation of station structure,but also reduce the tensile damage of the roof *** the other hand,the developed reduction measure can also significantly reduce the vertical peak displacements of site under training loading.

关键词： Subway station Diaphragm wall Segmented isolation layer Seismic response Train vibration

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Broadband intelligent programmable metasurface with polarization-modulated self-adaptive electromagnetic functionality switching

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Photonics Research 2024年第7期12卷 1395-1409页

作者： XIMING li RUI XU XIAOFENG SUN YUAN zhao zhao YANG GUOHONG du College of Electronic Engineering Chengdu University of Information TechnologyChengdu 610225China

Programmable metasurfaces have received a great deal of attention due to their ability to dynamically manipulate electromagnetic(EM) waves. Despite the rapid growth, most of the existing metasurfaces require manual control to switch among different functionalities, which poses severe limitations on practical applications. Here, we put forth an intelligent metasurface that has self-adaptive EM functionality switching in broadband without human participation. It is equipped with polarization discrimination antennas(PDAs) and feedback components to automatically adjust functionalities for the different incident polarization information.

关键词： equipped adjust polarization

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Experimental study on out-of-plane seismic performance of precast composite sidewalls of utility tunnel with grouting-sleeve joints

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Underground Space 2024年第3期16卷 1-17页

作者： Zilan Zhong Guangfan li Jinqiang li Jiaxu Shen Mi zhao Xiuli du Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China

The precast composite reinforced concrete wall with the advantages of fewer joints,superior impermeability and rapid construction provides an efficient and environmental friendly alternative in the construction of underground utility tunnels in the last few *** investigate the seismic performance of precast concrete composite walls of utility tunnels with grouting-sleeve connection under out-ofplane loads,a series of quasi-static cyclic tests were performed on the full-scale sidewall specimens with different axial compression ratios in this *** experimental results including the failure modes,crack distributions,and the influence of different connections on the out-of-plane seismic performance of precast concrete composite wall were carefully examined and compared with those from the cyclic tests of the cast-in-place sidewalls of the utility *** test results show that the seismic performance of the precast concrete composite sidewall specimen,such as the hysteresis curves,the ultimate bearing capacity,stiffness degradation pattern and the ductility ratio,is basically the same as that of the cast-in-place specimen,indicating that the seismic performance of the prefabricated structure is equivalent to that of the cast-in-place ***,the grouting-sleeves of the joints can effectively transfer the reinforcement stress until the failure of the precast concrete composite sidewall specimens,which exhibits excellent out-of-plane ductility and serviceability.

关键词： Precast concrete composite walls Cyclic response Seismic performance Grouting sleeve Failure mechanism

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Numerical Study on the Aerodynamic and Fluid−Structure Interaction of An NREL-5MW Wind Turbine

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China Ocean Engineering 2024年第3期38卷 363-378页

作者： zhao Mi YU Wan-li WANG Pi-guang QU Yang du Xiu-li Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China

A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic *** this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.

关键词： computational fluid dynamics methods(CFD) tower shadow effect aerodynamic performance fluidstructure interaction space flow field

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Microfluidic separation of particles by synergistic effect of geometry-induced hydrodynamics and magnetic field

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Chinese Chemical Letters 2024年第2期35卷 380-385页

作者： du Qiao Hongxia li Weiping Zhu lili Zhu Danyang zhao Honglin li Key Laboratory for Precision & Non-traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116023China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China lingang Lab Shanghai 200031China

Microfluidic combined with magnetic field have been demonstrated to be the promising solutions for fast and low-damage particles ***,the difficulties in the precise layout of magnets and accurate prediction of particle trajectories lead to under and over separation of target particles.A novel particle separation lab-on-chip(LOC)prototype integrated with microstructures and micropolar arrays is designed and ***,a numerical model for the separation of magnetic particles by the synergistic effect of geometry-induced hydrodynamics and magnetic field is *** effect of geometry and magnetic field layout on particle deflection is systematically analyzed to implement accurate prediction of particle *** is found that the separation efficiency of magnetic particles increased from 50.2%to 91.7%and decreased from 88.6%to 85.7%in the range of depth factors from 15µm to 27µm and width factors from 30µm to 60µm,*** particular,the combined effect of the offset distance of permanent magnets and the distance from the main flow channel exhibits a significant difference from the conventional ***,the developed LOC prototype was generalized for extension to arbitrary *** work provides a new insight and robust method for the microfluidic separation of magnetic particles.

关键词： Microfluidic Particle separation Synergistic effect Hydrodynamics Magnetic field Numerical calculation

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Considerations of advanced aqueous batteries recycling:A perspective

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Journal of Energy Chemistry 2024年第6期93卷 46-54,I0002页

作者： Yun zhao Yuqiong Kang Hao du Feiyu Kang Baohua li Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055GuangdongChina

*** Battery technology,serving as a basis for a rechargeable society,has developed rapidly over a century[1].The progress can be roughly divided into three stages,with the initial two mainly focusing on aqueous battery *** to 1859,research primarily focused on the conceptualization of batteries and the development of primary(non-rechargeable)cells[2].In the subsequent150 years,rechargeable battery technology emerged。

关键词： battery Battery primarily

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Performance Design of High-Temperature Chloride Salts as Thermal Energy Storage Material

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Journal of Thermal Science 2024年第2期33卷 479-490页

作者： zhao Le WANG Jingyao CUI liu li Baorang du Xiaoze WU Hongwei Key Laboratory of Power Station Energy Transfer Conversion and System(North China Electric Power University) Ministry of EducationBeijing102206China School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou730050China School of Physics Engineering and Computer ScienceUniversity of HertfordshireHatfieldAL109ABUK

The chloride salts have great potential used as high-temperature thermal energy storage(TES) medium for the concentrated solar power *** this study,liCl,KCl and CaCl_(2) were selected as energy storage materials in order to further broaden the working temperature of ternary chloride salt and improve its energy storage *** new high-temperature energy storage ternary chloride composed of liCl,KCl,and CaCl_(2) was developed based on the phase diagram generated by *** components of liCl-KCl-CaCl_(2) with the mass ratio of 37.85%-53.38%-8.77%,30.90%-13.82%-55.28% and 1.78%-18.61%-79.61% were developed,of which the corresponding melting temperature(T_(m)) 340.93,433.57 and 626.85℃,respectively,was obtained *** that T_(m) of the third group of salts was too high,only the first two groups of salts were *** test showed that the actual melting point was only 0.46% and 1.64% different from the melting point predicted by *** thermal properties of the two ternary chloride salts were also *** solid and liquid-specific heat of ternary salts was determined by DSC using sapphire as the standard *** vapor pressure and decomposition temperature of ternary chloride salts were *** results showed that the vapor pressure of salt 1 was almost constant below 650℃ by ***,the TG results showed that the upper working temperature of salt 1 was 650℃ under the air *** addition,the ternary chloride salts after short-term cycling still exhibited excellent thermal properties,which revealed that these good thermal properties make them have broad application prospects in high-temperature thermal energy storage systems.

关键词： chloride salts thermal energy storages thermal properties thermal stability

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Investigation of stress distribution and damage behavior caused by forced installation of a composite bolted joint with a hole-location error

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Chinese Journal of Aeronautics 2024年第1期37卷 201-217页

作者： Chinan liU Yuan li Yi CHENG An’an zhao Kunpeng du Yue SHI Ximing li Hui CHENG School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China AVIC Xi’an Aircraft Industry Group Company LTD Xi’an 710089China

In this paper,the influence of forced installation caused by a hole-location error on the 3D stress distribution and damage of a composite bolted joint is *** analytical model of stress distributed on composite holes is promoted,in view of non-uniform extrusion caused by forced *** first,non-uniform extrusion of the hole edge caused by forced installation is *** to the contact state,expression of hole deformation is ***,based on Hertz theory,the maximum extrusion load is obtained with help of deformation *** constructing an elastic foundation beam model,3D stress distributed on a hole could be analyzed according to the extrusion ***,stress distribution predicted by the above analytical method is compared with that provided by FE considering composite ***,a forced installation experiment is carried out to analyze the damage distribution of the *** show that a central-symmetrically distributed stress is introduced by the hole-location *** an increment of the error,strength of composite decreases due to extrusion ***,stress presents a concave distribution on the *** the hole-location error exceeding 3%,stress decreases gradually due to failure of *** of holes does not exhibit a centrosymmetric *** damage is mainly distributed on the entrance of the hole at the lower sheet.

关键词： Hole-location error Composite joint Forced installation Stress distribution Damage

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Surface Defect Detection and Evaluation Method of Large Wind Turbine Blades Based on an Improved Deeplabv3+Deep Learning Model

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Structural durability & Health Monitoring 2024年第5期18卷 553-575页

作者： Wanrun li Wenhai zhao Tongtong Wang Yongfeng du Institution of Earthquake Protection and Disaster Mitigation Lanzhou University of TechnologyLanzhou730050China International Research Base on Seismic Mitigation and Isolation of GANSU Province Lanzhou University of TechnologyLanzhou730050China Disaster Prevention and Mitigation Engineering Research Center of Western Civil Engineering Lanzhou University of TechnologyLanzhou730050China

The accumulation of defects on wind turbine blade surfaces can lead to irreversible damage,impacting the aero-dynamic performance of the *** address the challenge of detecting and quantifying surface defects on wind turbine blades,a blade surface defect detection and quantiﬁcation method based on an improved Deeplabv3+deep learning model is ***,an improved method for wind turbine blade surface defect detection,utilizing Mobilenetv2 as the backbone feature extraction network,is proposed based on an original Deeplabv3+deep learning model to address the issue of limited ***,through integrating the concept of pre-trained weights from transfer learning and implementing a freeze training strategy,signiﬁcant improvements have been made to enhance both the training speed and model training accuracy of this deep learning ***,based on segmented blade surface defect images,a method for quantifying blade defects is *** method combines image stitching algorithms to achieve overall quantiﬁcation and risk assessment of the entire *** results show that the improved Deeplabv3+deep learning model reduces training time by approximately 43.03%compared to the original model,while achieving mAP and MIoU values of 96.87%and 96.93%,***,it demonstrates robustness in detecting different surface defects on blades across different *** application of a blade surface defect quantiﬁcation method enables the precise quantiﬁcation of dif-ferent defects and facilitates the assessment of risk levels associated with defect measurements across the entire *** method enables non-contact,long-distance,high-precision detection and quantiﬁcation of surface defects on the blades,providing a reference for assessing surface defects on wind turbine blades.

关键词： Structural health monitoring computer vision blade surface defects detection Deeplabv3+ deep learning model

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