检索结果-南通市图书馆

SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo

引用

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1205-1216页

作者： hui Cui Di Sun Sheng Meng Tian-Ju Ma Zi Ye zhao-hui li Medical School of Chinese PLA Beijing 100089China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To explore the effect of silent information regulator factor 2-related enzyme 1(SIRT1)on modulating apoptosis of human lens epithelial cells(HLECs)and alleviating lens opacification of rats through suppressing endoplasmic reticulum(ER)***:HLECs(SRA01/04)were treated with varying concentrations of tunicamycin(TM)for 24h,and the expression of SIRT1 and C/EBP homologous protein(CHOP)was assessed using real-time quantitative polymerase chain reaction(RT-PCR),Western blotting,and *** morphology and proliferation was evaluated using an inverted microscope and cell counting kit-8(CCK-8)assay,*** the SRA01/04 cell apoptosis model,which underwent siRNA transfection for SIRT1 knockdown and SRT1720 treatment for its activation,the expression levels of SIRT1,CHOP,glucose regulated protein 78(GRP78),and activating transcription factor 4(ATF4)were *** potential reversal of SIRT1 knockdown effects by 4-phenyl butyric acid(4-PBA;an ER stress inhibitor)was *** vivo,age-related cataract(ARC)rat models were induced by sodium selenite injection,and the protective role of SIRT1,activated by SRT1720 intraperitoneal injections,was evaluated through morphology observation,hematoxylin and eosin(H&E)staining,Western blotting,and ***:SIRT1 expression was downregulated in TMinduced SRA01/04 ***,in SRA01/04 cells,both cell apoptosis and CHOP expression increased with the rising doses of *** stress was stimulated by TM,as evidenced by the increased GRP78 and ATF4 in the SRA01/04 cell apoptosis *** of SIRT1 by siRNA knockdown increased ER stress activation,whereas SRT1720 treatment had opposite results.4-PBA partly reverse the adverse effect of SIRT1 knockdown on *** vivo,SRT1720 attenuated the lens opacification and weakened the ER stress activation in ARC rat ***:SIRT1 plays a protective role against TM-induced apoptosis in HLECs and slows the progression of cataract in

关键词： silent information regulator factor 2-related enzyme 1 endoplasmic reticulum stress apoptosis human lens epithelial cells cataract

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Detection of Novel BEST1 Variations in Autosomal Recessive Bestrophinopathy Using Third-generation Sequencing

引用

Current Medical Science 2024年第2期44卷 419-425页

作者： Jia-xun li ling-rui MENG Bao-ke HOU Xiao-lu HAO Da-jiang WANG ling-hui QU zhao-hui li Lei ZHANG Xin JIN Department of Senior Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China Department of Ophthalmology the 74th Army Group HospitalGuangzhou 510318China

Objective:Autosomal recessive bestrophinopathy(ARB),a retinal degenerative disease,is characterized by central visual loss,yellowish multifocal diffuse subretinal deposits,and a dramatic decrease in the light peak on *** potential pathogenic mechanism involves mutations in the BEST1 gene,which encodes Ca2+-activated Cl−channels in the retinal pigment epithelium(RPE),resulting in degeneration of RPE and *** this study,the complete clinical characteristics of two Chinese ARB families were ***:Pacific Biosciences(PacBio)single-molecule real-time(SMRT)sequencing was performed on the probands to screen for disease-causing gene mutations,and Sanger sequencing was applied to validate variants in the patients and their family ***:Two novel mutations,c.202T>C(chr11:61722628,p.Y68H)and c.867+97G>A,in the BEST1 gene were identified in the two Chinese ARB *** novel missense mutation BEST1 c.202T>C(p.Y68H)resulted in the substitution of tyrosine with histidine in the N-terminal region of transmembrane domain 2 of *** novel variant,BEST1 c.867+97G>A(chr11:61725867),located in intron 7,might be considered a regulatory variant that changes allele-specific binding affinity based on motifs of important transcriptional ***:Our findings represent the first use of third-generation sequencing(TGS)to identify novel BEST1 mutations in patients with ARB,indicating that TGS can be a more accurate and efficient tool for identifying mutations in specific *** novel variants identified further broaden the mutation spectrum of BEST1 in the Chinese population.

关键词： autosomal recessive bestrophinopathy BEST1 gene third-generation sequencing mutation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial intelligence in the anterior segment of eye diseases

引用

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1743-1751页

作者： Yao-Hong liu lin-Yu li Si-Jia liu li-Xiong Gao Yong Tang zhao-hui li Zi Ye School of Medicine Nankai UniversityTianjin 300071China Medical School of Chinese PLA Beijing 100039China Department of Ophthalmology Chinese PLA General HospitalBeijing 100039China Chinese PLA General Hospital Medicine Innovation Research Department Beijing 100039China

Ophthalmology is a subject that highly depends on imaging *** intelligence(AI)technology has great potential in medical imaging analysis,including image diagnosis,classification,grading,guiding treatment and evaluating *** combination of the two can realize mass screening of grass-roots eye health,making it possible to seek medical treatment in the mode of“first treatment at the grass-roots level,two-way referral,emergency and slow treatment,and linkage between the upper and lower levels”.On the basis of summarizing the AI technology carried out by scholars and their teams all over the world in the field of ophthalmology,quite a lot of studies have confirmed that machine learning can assist in diagnosis,grading,providing optimal treatment plans and evaluating prognosis in corneal and conjunctival diseases,ametropia,lens diseases,glaucoma,iris diseases,*** paper systematically shows the application and progress of AI technology in common anterior segment ocular diseases,the current limitations,and prospects for the future.

关键词： artificial intelligence anterior segment ocular disease ametropia glaucoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families

引用

当代医学科学（英文） 2024年第4期44卷 820-826页

作者： Xiao-lu HAO Ran CHEN Wei liU Bao-ke HOU ling-hui QU zhao-hui li Da-jiang WANG Xin JIN Hou-bin HUANG Senior Department of Opthalmology the Third Medical Center of Chinese PLA General HospitalBeijing 100039China Bolin Eye Care Group Beijing 100098China Department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanya 572000China Department of Ophthalmology the74th Army Group HospitalGuangzhou 510318China

Objective:To examine the clinical phenotype and genetic deficiencies present in Chinese aniridia families with PAX6 haplotype ***:A comprehensive questionnaire and ophthalmological assessments were administered to both affected patients and unaffected *** clinical feature analysis included the evaluation of visual acuity,intraocular pressure,slit-lamp anterior segment examination,fundus photography,and spectral domain optical coherence *** identify the mutation responsible for aniridia,targeted next-generation sequencing was used as a beneficial ***:A total of 4 mutations were identified,consisting of two novel frameshift mutations(c.314delA,p.K105Sfs*33 and c.838_845dup AACACACC,p.S283Tfs*85),along with two recurring nonsense mutations(c.307C＞T,p.R103X and c.619A＞T,p.K207*).Complete iris absence,macular foveal hypoplasia,and nystagmus were consistent in these PAX6 haplotype-deficient Chinese aniridia families,while corneal lesions,cataracts,and glaucoma exhibited heterogeneity both among the families and within the same ***:In our study,two novel PAX6 mutations associated with aniridia were identified in Chinese families,which expanded the phenotypic and genotypic spectrum of PAX6 *** also analyzed the clinical characteristics of PAX6 haplotype deficiency in Chinese aniridia families.

关键词： PAX6 aniridia genotype haplotype deficiency mutation phenotype

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

轻钢龙骨防火组合楼板梁板节点连接试验研究

引用

工程抗震与加固改造 2024年第5期46卷 37-43页

作者：赵更歧贺黎博赵会丽闫海峰倪克李可郑州大学水利与土木工程学院河南郑州450001 河南测绘职业学院河南郑州450015 河南交通职业技术学院河南郑州450003

轻钢龙骨防火组合楼板是一种新型的装配式楼板,因为自重较小,同时具有较大的承载力,板底板顶附层为防火楼板,具有较好的防火能力,该种楼板作为简支板直接放置于工字钢梁上,支座处无法传递负弯矩,因此在梁顶支座处会出现一条通缝,严重影... 详细信息

轻钢龙骨防火组合楼板是一种新型的装配式楼板,因为自重较小,同时具有较大的承载力,板底板顶附层为防火楼板,具有较好的防火能力,该种楼板作为简支板直接放置于工字钢梁上,支座处无法传递负弯矩,因此在梁顶支座处会出现一条通缝,严重影响使用效果,同时简支板体系也不符合抗震规范的要求。本文提出一种新的支座处梁板节点连接方式,目的是通过合理连接,实现支座处能够传递负弯矩,由简支变为固结。试验采用液压千斤顶对试件施加静荷载,对11个全比例节点连接试件进行研究,考虑连接件搭接长度、连接件厚度、连接所用的自攻螺钉(螺栓)的数量,以及连接件尺寸对梁板连接节点承载力和挠度的影响,并对节点连接件与C型轻钢龙骨之间的变形协调能力做出了分析。研究表明,本文提出的以Z型钢为连接件的梁板节点连接方法安全可靠,可实现该新型楼板的双跨以及多跨连接。

关键词：轻钢龙骨防火楼板梁板节点试验研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The quasitriangular structures of biproduct Hopf algebras

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 149-157页

作者： zhao li-hui zhao Wen-zheng Department of Mathematics Zhejiang University Hangzhou 310027 China Department of Mathematics Henan Normal University Xinxiang 453002 China

The construction of the biproduct of Hopf algebras, which consists of smash product and the dual notion of smash coproduct, was first formulated by Radford. In this paper we study the quasitriangular structures over biproduct Hopf algebras B*H. We show the necessary and sufficient conditions for biproduct Hopf algebras to be quasitriangular. For the case when they are, we determine completely the unique formula of the quasitriangular structures. And so we find a way to construct solutions of the Yang-Baxter equation over biproduct Hopf algebras in the sense of (Majid, 1990).

关键词： Hopf algebra Quasitriangular structure Biproduct

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Verifying Contextual Refinement with Ownership Transfer

引用

Journal of Computer Science & Technology 2021年第6期36卷 1342-1366页

作者： zhao-hui li Xin-Yu Feng School of Computer Science and Technology University of Science and Technology of ChinaHefei 230026China Department of Computer Science and Technology Nanjing UniversityNanjing 210023China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China

Contextual refinement is a compositional approach to compositional verification of concurrent *** has been much work designing program logics to prove the contextual refinement between the object implementation and its abstract ***,these program logics for contextual refinement verification cannot support objects with resource ownership transfer,which is a common pattern in many concurrent objects,such as the memory management module in OS kernels,which transfers the allocated memory block between the object and *** this paper,we propose a new approach to give abstract and implementation independent specifications to concurrent objects with ownership *** also design a program logic to verify contextual refinement of concurrent objects *** abstract *** have successfully applied our logic to verifying an implementation of the memory management module,where the implementation is an appropriately simplified version of the original version from a real-world preemptive OS kernel.

关键词： contextual refinement program logic concurrent object ownership transfer verification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

L-R smash products for multiplier Hopf algebras

引用

Applied Mathematics(A Journal of Chinese Universities) 2008年第1期23卷 83-90页

作者： zhao li-hui LU Di-ming FANG Xiao-li Dept. of Math. Zhejiang Univ. Hangzhou 310027 China. Dept. of Math. NIT Zhejiang Univ. Ningbo 315100 China.

The theory of L-R smash product is extended to multiplier Hopf algebras and a sufficient condition for L-R smash product to be regular multiplier Hopf algebras is given. In particular, the result of the paper implies ... 详细信息

关键词： multiplier Hopf algebral bimodule bialgebra L-R smash product.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of cooling parameters on the microstructure and properties of Mo-bearing and Cr-bearing steels

引用

International Journal of Minerals,Metallurgy and Materials 2011年第5期18卷 551-556页

作者： Xiang-dong Huo Yu-qian li Yu-tao zhao Hai-wang Zhang zhao-hui li School of Material Science and Engineering Jiangsu University Zhenjiang 212013 China Technology Center of Handan Iron and Steel Corp. Handan 056002 China

To develop low-cost low carbon bainitic steel,Mo-bearing and Cr-bearing steels were melted in a vacuum induction furnace and were researched by thermal simulation and hot rolling at the *** the cooling rate increases from 0.2 to 50°C/s,the transformation temperatures of two steels lie between 650 and 400°C,and the final microstructures of them change from quasi-polygonal ferrite and granular bainite to lath *** with cooling in air or by interrupted cooling,Mo-bearing and Cr-bearing steel plates cooled by sprayed water boast higher strength and superior toughness,for large-size islands are responsible for the poor mechanical *** to Mo,Cr is effective to isolate the bainitic reaction in low carbon steel,and the bainitic microstructure can also be obtained in Cr-bearing steel cooled at a wide range of cooling rate.

关键词： low carbon steel bainite phase transformations chromium microstructure mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Postoperative efficacy,safety,predictability,and visual quality of implantable collamer lens implantation versus small incision lenticule extraction in myopic eyes:a Meta-analysis

引用

International Journal of Ophthalmology(English edition) 2023年第3期16卷 442-452页

作者： Hong-Yu li Zi Ye zhao-hui li Medical School of Chinese PLA Beijing 100853China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To compare the postoperative efficacy,safety,predictability,and visual quality of implantable collamer lens(ICL)implantation versus small incision lenticule extraction(SMILE)in myopia ***:Pub Med,EMBASE,Web of Science,Cochrane library and several Chinese databases were searched at May 2021 to select relevant studies in comparison of clinical outcomes between ICL implantation and SMILE for *** primary outcomes were efficacy,safety,and *** the secondary outcomes were postoperative higher-order ocular aberrations(HOAs),modulation transfer function cutoff frequency(MTF),objective scatter index(OSI),contrast sensitivity and a quality of vision(Qo V)***:A total of 1036 eyes from 10 studies,of which 503 eyes underwent ICL implantation and 533 eyes underwent SMILE,were enrolled in this *** results revealed that ICL group had a better safety index and post-corrected distance visual acuity(CDVA)(P=0.007,line(P=0.007)than the SMILE *** significant differences were found in comparison of the other primary *** the longterm follow-up(>6mo),ICL group had a lower total HOA,coma,and spherical aberration than SMILE group(P=0.003,lity for correcting high ***,ICL group is relatively safer and also has better visual quality in comparison of SMILE group.

关键词： implantable collamer lens small incision lenticule extraction myopia refractive surgery Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：