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Neural Regeneration Research 2011年第5期6卷 325-329页

作者： Zhihua Li Qingzan zhao hua Zhang Xiuhua ren Mingfu Zhou Weidong Zang Department of Human Anatomy Basic Medical College Zhengzhou University Z.hengzhou 450052 Henan Province China

Inflammation plays an important role in the pathogenesis of Parkinson＇s disease （PD） through the over-activation of microglia. Epidemiological studies show that smoking is associated with a lower incidence of PD. This study hypothesized that the neuroprotective effect of nicotine is mediated by modulating the activation of microglia via cytokine release. This study found that nicotine pretreatment suppressed the lipopolysaccharide-induced inflammatory reaction in the nervous system, especially microglia activation and interleukin-6 production. The inhibitory effects of 100 pmol/L nicotine were stronger compared with 1 and 10 iJmol/L nicotine. These findings indicate that nicotine significantly decreases the production of proinflammatory interleukin-6 in mixed glia or microglia-enriched cultures, and plays an inhibitory effect on the lipopolysaccharide-induced inflammatory reaction.

关键词： nicotine glia cytokine lipopolysaccharides Parkinson's disease

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu Song Gu Fulong Chen Zhe zhao Peng Liu Daoben hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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2型糖尿病合并高血压对自主及周围神经病变的影响研究

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中国全科医学 2013年第7期16卷 752-754页

作者：张永红赵仁华薛元明云南省第一人民医院内分泌科云南省昆明市650032

目的探讨2型糖尿病合并高血压对自主及周围神经病变的影响。方法选取2型糖尿病患者156例,根据高血压诊断标准,分为2型糖尿病合并高血压组76例与2型糖尿病未合并高血压组80例。选取同期在我院进行体检的健康体检者60例作为对照组。对3组... 详细信息

目的探讨2型糖尿病合并高血压对自主及周围神经病变的影响。方法选取2型糖尿病患者156例,根据高血压诊断标准,分为2型糖尿病合并高血压组76例与2型糖尿病未合并高血压组80例。选取同期在我院进行体检的健康体检者60例作为对照组。对3组研究对象进行一般资料收集、自主及周围神经功能检查。结果 (1)3组研究对象的心率变异性(HRV)各参数比较,差异均有统计学意义(P0.05)。结论 2型糖尿病合并高血压可能对自主神经功能有一定影响,对周围神经功能影响不大。并发高血压的2型糖尿病患者应尽早进行自主神经功能检查,积极控制血糖和血压。

关键词：糖尿病,2型高血压自主神经功能周围神经功能

Transforming waste particles into valuable adsorbents via amyloid-mediated molecular engineering

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Science China Chemistry 2025年第01期 317-328页

作者： Qingmin Yang Jian zhao Yujia Zhang Xingyu Zhou Hao ren Bowen Hu Zhongli Lei Lixin Chen Peng Yang School of Material and Chemical Engineering Bengbu University Anhui Provincial Engineering Laboratory of Silicon-Based Materials School of Chemistry and Chemical Engineering Northwestern Polytechnical University Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical EngineeringShaanxi Normal University Xi'an Key Laboratory of Polymeric Soft Matter School of Chemistry and Chemical Engineering Shaanxi Normal University International Joint Research Center on Functional Fiber and Soft Smart Textile School of Chemistry and Chemical EngineeringShaanxi Normal University

The high-value utilization of industrial solid waste using a facile and eco-friendly process is of great interest and significance in reducing environmental pollution and developing a green circular economy. Herein, we propose an amyloid-mediated molecular engineering strategy to transform particulate waste into valuable adsorbents for metal ions. Our method has the advantage of aqueous solution fabrication under mild conditions without the use of high-temperature hydrothermal methods and toxic chemical reagents. Amyloid-mediated molecular engineering manipulates the phase transition of bovine serum albumin(BSA)on particulate waste surfaces, resulting in a remarkable ～3.1 times improvement in the adsorption capacity of fly ash, a typical industrial solid waste for gold ions after modification with the phase-transitioned BSA(PTB). The resultant adsorption ability was 69–1,980 times higher than those of conventional and emerging adsorbent materials such as ion exchange resins, activated carbon(AC), covalent organic frameworks(COFs), and metal-organic frameworks(MOFs). We further demonstrated the application of our PTB-modified materials in the recovery of precious metals from low-grade gold ore and electronic waste leachates. Consequently, this strategy could increase the value of waste materials nearly 27 times. In addition, this method is generally extendable to other conventional industrial adsorbents such as resin, clay, and Al2O3, and enhances their adsorption capabilities at least twofold. Overall, this work provides a simple and green approach for improving the adsorption performance of solid particles, and is expected to develop into a universal strategy for transforming waste particles into high-value-added products.

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao Wenjie ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

人骨髓间充质干细胞脑内注射给予食蟹猴的长期毒性研究

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毒理学杂志 2010年第2期24卷 89-93页

作者：李岩高虹李秦朱华韩钦安沂华赵春华王任直秦川中国医学科学院实验动物研究所北京100050 中国医学科学院基础医学研究所北京市神经外科研究所北京协和医院神经外科

目的研究人骨髓间充质干细胞(BMSC)脑内注射给予食蟹猴的长期毒性,为临床试验提供依据。方法24只食蟹猴随机分为对照组(生理盐水)、低剂量组(3×105个细胞/kg)和高剂量组(2.5×106个细胞/kg),每只动物脑内基底节外囊区域定向注射人BMSC2... 详细信息

目的研究人骨髓间充质干细胞(BMSC)脑内注射给予食蟹猴的长期毒性,为临床试验提供依据。方法24只食蟹猴随机分为对照组(生理盐水)、低剂量组(3×105个细胞/kg)和高剂量组(2.5×106个细胞/kg),每只动物脑内基底节外囊区域定向注射人BMSC2次,间隔3周。注射后观察动物的一般毒性反应,并进行体重、体温、神经功能、心电图、血液学和血液生化学、体液免疫(IgG、IgM)、细胞免疫(CD3、CD4、CD8)、尿液、脑脊液(一般性状、细胞计数、葡萄糖、蛋白质和氯化物含量)及组织病理学等指标测定。结果病理结果显示食蟹猴脑内基底节外囊区域注射人BMSC后,注射部位大脑局部出现组织坏死及炎症反应,对照组、低剂量组和高剂量组的损伤程度和范围呈递增趋势,随着时间推移,各组脑组织病变基本修复,残存少量瘢痕组织。其他各项检测指标均未见有生物学意义的显著改变。结论在本试验条件下,2.5×106/kg的剂量范围内,人BMSC食蟹猴脑内基底节外囊区域注射仅对注射局部大脑组织产生一定的病理损伤,损伤可随着时间推移逐渐修复。

关键词：骨髓间充质干细胞长期毒性脑内注射食蟹猴

2型糖尿病足部振动感觉损伤相关危险因素分析

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中华内分泌代谢杂志 2009年第6期25卷 601-603页

作者：周怡昆薛元明张永红赵仁华苏恒马杉牛奔云南省第一人民医院(昆明医学院附属昆华医院)内分泌代谢科昆明650032

目的研究2型糖尿病足部振动感觉损伤相关危险因素。方法用振动感觉分析仪对3270名2型糖尿病患者行振动感觉检查，分为振动感觉减退的研究组及无振动感觉减退的对照组，测定尿蛋白、血脂、体重指数、血糖、HbA1c、血清果糖胺、C肽、血压... 详细信息

目的研究2型糖尿病足部振动感觉损伤相关危险因素。方法用振动感觉分析仪对3270名2型糖尿病患者行振动感觉检查，分为振动感觉减退的研究组及无振动感觉减退的对照组，测定尿蛋白、血脂、体重指数、血糖、HbA1c、血清果糖胺、C肽、血压等及眼底检查。结果研究组年龄平均为（59±12）岁，病程≥5年、24h尿蛋白定量≥300mg／d、有糖尿病视网膜病变、足部症状及男性比例均高于对照组，空腹血清C肽（0．56±0．45）nmol／L、餐后2hC肽（1．81±0．95）nmol／L均低于对照组[（0．65±0．56）和（2．14±0．82）nmol／L，P〈0．05]。Logistic回归分析显示，足部症状、24h尿蛋白定量、糖尿病病程与振动感觉减退明显相关。结论24h尿蛋白量、糖尿病病程、足部症状是2型糖尿病振动感觉损伤的危险因素。

关键词：糖尿病 2型振动感觉危险因素

Entanglement Transfer via Heisenberg Interaction in a Four-Qubit System

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Communications in Theoretical Physics 2007年第4期47卷 621-624页

作者： ren Feng-hua WANG zhao-Ming School of Computer Engineering Qingdao Technological University Qingdao 266033 China Department of Physics Beijing Institute of Technology Beijing 100081 China

We investigate the entanglement transfer in a four-qubit system and calculate the concurrence between any two qubits in different initial states. We show that both the pure entangled state and mixed entangled state can be transferred. For some special coupling constants and some evolution time, entanglement can be completely transferred from one pair particles to another.

关键词： entanglement transfer Heisenberg interaction

Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies

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Cancer Biology & Medicine 2021年第4期18卷 981-991页

作者： hua zhao Hao Wang Qiuru Zhou Xiubao ren Department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China

Tertiary lymphoid structures(TLSs)are ectopic immune cell aggregations that develop in peripheral tissues in response to a wide range of chronic inflammatory conditions,including infection,autoimmune disease,and *** the tumor microenvironment(TME),the structures of TLSs,including B-cell-and T-cell-enriched areas indicate that the TLSs might be the local site during the initiation and maintenance of humoral and cellular immune responses against *** studies have evaluated the expression of TLSs in different cancer patients and their association with prognoses of cancer *** was shown that welldeveloped TLSs characterized by mature B cells synthesized tumor specific antibodies,which were considered as specific markers for a good ***,there are still some immunosuppressive factors existing in the TLSs that may affect anti-tumor *** factors include dysfunctional B cells,regulatory T cells,and T follicular regulatory *** complexity and heterogeneity of the TLS composition may affect the function and activity of TLSs;it is therefore essential to fully understand the function and influencing factors in *** has been reported that checkpoint inhibitors and vaccines are currently being developed to reprogram the TME by establishing mature TLSs to improve cancer *** this review,we focused on recent advances in TLSs in human solid tumors,including structural characteristics and classes,antitumor mechanisms,immunosuppressive factors,and TLSbased therapeutic approaches.

关键词： Tertiary lymphoid structure tumor microenvironment immunotherapy B cells T cells