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自血穴位注射疗法联合中医护理在咳嗽变异性哮喘护理中的应用

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护理研究 2021年第20期35卷 3739-3741页

作者：赵立美山西省中医院山西030000

目的:探讨自血穴位注射疗法联合中医护理在咳嗽变异性哮喘护理中的应用效果。方法:将158例咳嗽变异性哮喘病人随机分为两组各79例,对照组病人实施常规西医治疗与护理模式,观察组病人实施自血穴位注射疗法联合中医护理模式。比较两组病... 详细信息

目的:探讨自血穴位注射疗法联合中医护理在咳嗽变异性哮喘护理中的应用效果。方法:将158例咳嗽变异性哮喘病人随机分为两组各79例,对照组病人实施常规西医治疗与护理模式,观察组病人实施自血穴位注射疗法联合中医护理模式。比较两组病人血清免疫球蛋白E(IgE)、白介素⁃13(IL⁃13)、呼出气体一氧化氮(FeNO)、最小诱发累积剂量(Dmin)、PEF变异率、中医症状评分及临床疗效。结果:干预后观察组病人中医症状评分[(5.3±1.2)分]低于对照组[(11.8±2.9)分],治疗有效率(94.9%)高于对照组(77.2%),两组比较差异均有统计学意义(P<0.001);干预后观察组病人的IgE、IL⁃13、FeNO、Dmin及PEF变异率均优于对照组,两组比较差异有统计学意义(P<0.001)。结论:自血穴位注射联合中医护理模式有助于缓解咳嗽变异性哮喘病人的症状,抑制气道反应与气道炎症,提升免疫功能,并改善临床疗效。

关键词：咳嗽变异性哮喘自血疗法穴位注射中医护理气道反应免疫功能

数字经济背景下数字服务税规则的分析与反思——基于常设机构与利润归属规则视角

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南方金融 2021年第7期 82-90页

作者：赵利梅华东政法大学经济法学院上海201620

经济数字化时代下,税收征收地与价值创造地的错配加剧了税基侵蚀与利润转移,数字化商业活动的收入定性和利润归属问题深刻影响着各国税收征管权的实施。为应对数字经济给国际税收秩序带来的挑战,部分国家率先展开对数字服务税的探索,旨... 详细信息

经济数字化时代下,税收征收地与价值创造地的错配加剧了税基侵蚀与利润转移,数字化商业活动的收入定性和利润归属问题深刻影响着各国税收征管权的实施。为应对数字经济给国际税收秩序带来的挑战,部分国家率先展开对数字服务税的探索,旨在扩大常设机构范围,同时将用户参与嵌套进价值创造体系中,以此赋予来源地国对数字经济价值创造的税收征管权,然而单边的税收举措无法真正解决国际税收困境。目前正值数字经济国际税收征管秩序的重铸阶段,我国可从联结度问题出发,完善数字化常设机构定义,改进剩余利润分配法与部分分配法相结合的利润分配方案,在建立国际税收新秩序过程中掌握属于自己的话语权。

关键词：数字经济国际税收协调数字服务税常设机构显著数字存在

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反应挤出制备高熔体强度PP

合成树脂及塑料 2008年第5期25卷 12-17页

作者：郭玉文赵丽梅中国石油化工股份有限公司北京燕山分公司树脂应用研究所北京102500

采用反应挤出方法制备高熔体强度聚丙烯,通过凝胶渗透色谱仪、差示扫描量热仪、偏光显微镜等究了改性产品的结构与性能,并进行挤出发泡应用实验。结果表明:采用特殊的过氧化物引发剂和支化促进剂,与丙烯基础树脂共混后通过双螺杆挤出机... 详细信息

采用反应挤出方法制备高熔体强度聚丙烯,通过凝胶渗透色谱仪、差示扫描量热仪、偏光显微镜等究了改性产品的结构与性能,并进行挤出发泡应用实验。结果表明:采用特殊的过氧化物引发剂和支化促进剂,与丙烯基础树脂共混后通过双螺杆挤出机熔融连续反应挤出,可以直接制备具有长链支化结构的聚丙烯,熔体强度高300%;挤出发泡试样泡孔均匀,发泡倍率达到50倍,具有较好的可发性能。

关键词：聚丙烯熔体强度反应挤出长链支化结构

Trichinella spiralis calreticulin inhibits the complement classical pathway activation by interaction with human complement C1q

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Trichinella spiralis calreticulin inhibits the complement cl...

中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： limei zhao Shuai Shao Yi Chen Jing Yang Xinping Zhu Department of Parasitology School of Basic Medical Sciences Capital Medical University

Objective To explore the role of Trichinella spiralis calreticulin(Ts-CRT) in host immune attack by interference with the complement function, therefore deeply clarifying the mechanisms of *** evading from complement killing Methods Recombinant Ts-CRT(r Ts-CRT) was expressed and its ability to bind calcium was assessed using "Stains-all". The expression pattern and distribution of Ts-CRT were detected by Western blot and confocal immunofluorescence. The binding between r Ts-CRT and C1 q was determined by ELISA, Far Western blot and co-immunoprecipitation. The activation products of C4/C3 deposition were detected with ELISA and the complement-mediated lysis of sheep erythrocytes was investigated with hemolysis assay. The effect of r Ts-CRT on C1 q interacting with its receptor on THP-1-derived macrophages was examined by cell immunofluorescence staining and the C1q-induced chemotaxis of macrophages was determined by Transwell. Results The results of "Stains-all" suggested that r Ts-CRT had the ability to bind Ca2+. ELIAS and expressed all the developmental stages. Far Western blot and co-immunoprecipitation experiments showed that r Ts-CRT was able to bind human C1 q. The interaction of rT s-CRT and C1 q significantly reduced C4 and C3 deposition to the activator Ig M. The C1q-dependent lysis of sensitized sheep erythrocytes was also inhibited by r Ts-CRT. rT s-CRT also inhibited C1 q interacting with its receptor on THP-1-derived M2 phenotype macrophage and suppressed C1q-induced macrophages chemotaxis. Conclusion These findings suggest that Ts-CRT plays an important role in the immune evasion by inhibiting the initial stage of host complement activation.

关键词： Trichinella spiralis calrecitulin complement C1q immune evasion complement attack

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基于区块链理念的科学数据溯源研究

科技管理研究 2021年第23期41卷 200-204页

作者：赵丽梅黑龙江大学信息管理学院黑龙江大学信息资源管理研究中心黑龙江哈尔滨150080

科学数据溯源不仅可以维护科学数据生产主体的权益,而且可以保障科学研究的有效性,因此科学数据溯源对于科学数据的有效管理与利用具有重要意义。鉴于传统溯源方法存在信息不能及时对称、监管不能及时到位等效率低下的情况,提出基于区... 详细信息

科学数据溯源不仅可以维护科学数据生产主体的权益,而且可以保障科学研究的有效性,因此科学数据溯源对于科学数据的有效管理与利用具有重要意义。鉴于传统溯源方法存在信息不能及时对称、监管不能及时到位等效率低下的情况,提出基于区块链理念的科学数据溯源体系。在分析科学数据溯源内涵的基础上,论述基于区块链的科学数据溯源的可行性和必要性,从溯源内容、溯源平台以及融合私有链和联盟链的运行模式等3个维度提出基于区块链的科学数据溯源实施方案。

关键词：区块链科学数据科学数据溯源

A Population Pharmacokinetic-pharmacogenetic Modelof Lamotrigine in Chinese Children with Epilepsy

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A Population Pharmacokinetic-pharmacogenetic Modelof Lamotri...

Electronics workbench在电子技术仿真实验中的运用

第八届全国治疗药物监测学术年会

作者： Yanan Chen Shansen Xu Zhanyou Wang Mingming zhao Huanxin Wang Tong Lu limei zhao Department of Pharmacy Shengjing Hospital of China Medical University Institute of Health Sciences Key Laboratory of Medical Cell Biology of Ministry of EducationChina Medical University School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University

Objective:This study aimed to establish a population pharmacokinetic（PPK） model of LTG in Chinese children with epilepsy and to evaluate the effects of genetic variationscomprehensivelyin metabolizingenzymes, transporters, and a transcriptional regulator on ***: 385 steady-state plasmaconcentrationswere obtained from 179 children（mean age 10.72 ± 3.05 years, mean body weight 46.23 ± 17.77 kg） with epilepsyduring therapeutic drug monitoring（TDM）.These patients were divided into the PPK-model group（n=121） and the PPK-validation group（n=58） and were genotyped for UGT1A4, UGT2B7, ABCB1, ABCG2,SLC22A1,and HNF4α. PPK analysis was performed by non-linear mixed effects modeling（NONMEM）.Results: In the final model, apparent clearance（CL/F） of LTG was estimated to be 1.48 L/h;500 mg valproic acid, oxcarbazepine, and UGT2B7-161 TT genotype changed the CL/F by –46.2,+31.1 and –21.8%, respectively. Body weight was also identified as a significant covariate affecting LTG CL/***: A population pharmacokinetic-pharmacogenetic model of LTG in Chinese children with epilepsy was successfully established with NONMEM. Genotyping for UGT2B7-161C＞T may be useful in titrating the optimal LTG dose.

关键词： lamotrigine Chinese children population pharmacokinetics genetic polymorphisms

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中国远程教育 2001年第12期 58-59页

作者：赵丽梅宁波广播电视大学电子信息技术与工程系

ElectronicsWorkbench是电子线路仿真分析平台综合了SPICE和Protel的全部功能,较好解决了系统测试问题及波形分析问题,在电子设计自动化方面获得广泛应用。将其引入电子技术仿真实验教学旨在摸索远程实验可行的解决方案。

关键词： EWB 电子电路仿真分析远程实验

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数字电路仿真实验及其设计示例

中国远程教育 2003年第11期 59-62页

作者：赵丽梅宁波广播电视大学电子信息技术与工程系

利用电子线路仿真分析平台Electronics Workbench(简称EWB)在组合逻辑电路及时序逻辑电路实验课的仿真分析中需要进行验证性实验的设计。组合逻辑电路:七段译码显示电路,8线-3线优先编码器功能测试;利用EWB所提供的字发生器(Word genera... 详细信息

利用电子线路仿真分析平台Electronics Workbench(简称EWB)在组合逻辑电路及时序逻辑电路实验课的仿真分析中需要进行验证性实验的设计。组合逻辑电路:七段译码显示电路,8线-3线优先编码器功能测试;利用EWB所提供的字发生器(Word generator)及显示仪器中的发光元件测试RS、JK、D触发器的功能,仿真分析数据的串行—并行转换,二分频的验证;利用74160采用复位法及置位法接成七进制计数器与采用74190置位法接成七进制计数器进行比较分析,明确复位法与置位法的区别,搞清置位法中预置数操作与时钟脉冲有关与无关设计设计方法的不同。

关键词： EWB 数字电路仿真分析实验设计

Development of a simple and rapid method to measure the free fraction of lamotrigine in plasma using HPLC:applications for therapeutic drug monitoring

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Journal of Chinese Pharmaceutical Sciences 2018年第12期27卷 832-839页

作者： Huanxin Wang Yaxin Sun Shansen Xu Tong Lu Yanan Chen limei zhao Department of Pharmacy Shengjing Hospital of China Medical University Shenyang110004 Liaoning Province China

Lamotrigine (LTG) is a widely used antiepileptic drug (AED) for the treatment of new-onset, as well as refractory epilepsy. Due to the narrow treatment window and large individual variability in the pharmacokinetics and pharmacodynamics of LTG, therapeutic drug monitoring (TDM) is necessary in clinical practice to guide dose adjustments. Individual differences and drug combinations can also affect protein binding rate, which further affects the unbound concentration of LTG. The unbound fraction is more closely related to adverse reactions and therapeutic efficacy than total concentration. Therefore, it may be more meaningful to determine the unbound LTG concentration in plasma than the total *** LTG in plasma was extracted by ultrafiltration. High-performance liquid chromatography (HPLC) was used to measure unbound LTG concentration. This method was validated by studies of its selectivity, linearity, lower limit of quantification (LLOQ), accuracy, precision, recovery, and *** method was validated over a linear range of 0.2 to 10.0 μg·mL–1, and its LLOQ was 0.2 μg·mL–1. The method’s relative standard deviations (RSDs) for intra-day and inter-day precision were less than 15%, and its accuracy (RE) was ±4.69%. The recoveries of unbound LTG at three different concentrations satisfied the requirements for the analysis of biological samples, and no significant degradation of LTG was observed under different storage conditions.A simple HPLC method showed good performance when used to measure unbound LTG concentration. This method might be used to study the relationship between unboundLTG concentrations and its effectiveness according to TDM.

关键词： Lamotrigine Unbound concentration Ultrafiltration HPLC Therapeutic drug monitoring