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Study on friction performance and mechanism of slipper pair under different paired materials in high-pressure axial piston pump

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Friction 2020年第5期8卷 957-969页

作者： Huaichao WU limei zhao Siliang NI Yongyong HE School of Mechanical Engineering Guizhou UniversityGuiyang 550025China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

High-pressure axial piston pumps operate in high-speed and high-pressure environments. The contact state of the slipper against the swashplate can easily change from an oil film lubrication to a mixed oil film/asperity contact, or even dry friction. To improve the dry friction performance of slipper pairs and to avoid their potentially rapid failure, this study examined the effects of material matching on the dry friction performance of the slipper pair for high-pressure axial piston pumps. A FAIAX6 friction and wear tester was developed, and the dry friction coefficients of the slipper pairs matched with different materials were studied using this tester. Based on the thermo-mechanical coupling of the slipper pair with the working process, the contact surface temperatures of the slipper pairs matched with different materials were calculated and analyzed for the same working conditions. Following this, the effects of the material properties on the temperature increase at the slipper sliding contact surfaces were revealed. The reliabilities of the temperature calculations and analysis results were verified through orthogonal tests of slipper pairs matched with different materials. The results indicate that the influence of the material density on the friction coefficient is greater than that of the Poisson's ratio or the elastic modulus, and that the slipper material chosen should have a high thermal conductivity, low density, and low specific heat, whereas the swashplate material should be high in specific heat, density, and thermal conductivity;in addition, the slipper pair should be a type of hard material to match the type of soft material applied;that is, the hardness of the swashplate material should be greater than that of the slipper material.

关键词： axial piston pump slipper pair material matching dry friction temperature

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Preparation and in vitro-in vivo evaluation of intestinal retention pellets of Berberine chloride to enhance hypoglycemic and lipid-lowing efficacy

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Asian Journal of Pharmaceutical Sciences 2019年第5期14卷 559-568页

作者： Guofei Li Mingming zhao Xianying Su Lin Song limei zhao Shengjing Hospital of China Medical University Shenyang110004China Northeast Pharmaceutical Science&Technology Development Co. Ltd.Shenyang110027China

Berberine chloride(BBR) is a pharmacokinetic profile of drug with poor bioavailability but good therapeutic efficacy,which is closely related to the discovery of BBR intestinal *** major aim of this paper is to develop BBR intestinal retention type sustained-release pellets and evaluate their in vivo and in vitro behaviors base on the aspect of local action on intestinal tract. Here,wet milling technology is used to improve dissolution and dissolution rate of BBR by decreasing the particle size and increasing the wettability. The pellets are prepared by liquid layer deposition technology,and then the core pellets are coated with Eudragit~?L30 D-55 and Eudragit~?NE30 D aqueous dispersion. The prepared pellets show high drug loading capacity,and the drug loading up to 93%. Meanwhile,it possesses significant sustained drug release effect in purified water which is expected to improve the pharmacokinetic behavior of BBR. The pharmacokinetics results demonstrate that the halflife of BBR was increased significantly from 24 h to 36 h and the inter-and intra-subject variability are decreased compared to commercial BBR tablets. The retention test results indicate that the pellet size and Eudragit~?NE30 D plays an important role in retention time of the pellet,and it is found that the pellets with small particle size and high Eudragit~?NE30 D coating content can stay longer in the intestine than the pellets with large particle size. All in all,BBR intestinal retention type pellets are prepared successfully in this study,and the pellets show satisfactory in vivo and in vitro behaviors.

关键词： BBR Pellets Sustained release Intention Pharmacokinetics

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Tribological properties of novel palygorskite nanoplatelets used as oil-based lubricant additives

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Friction 2021年第2期9卷 332-343页

作者： Kunpeng WANG Huaichao WU Hongdong WANG Yuhong LIU Lv YANG limei zhao School of Mechanical Engineering Guizhou UniversityGuiyang 550025China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

Layered palygorskite(PAL),commonly called attapulgite,is a natural inorganic clay mineral composed of magnesium *** this study,an aqueous miscible organic solvent treatment method is adopted to prepare molybdenum-dotted palygorskite(Amo-PMo)nanoplatelets,which greatly improved the specific surface area of PAL and the dispersion effect in an oil-based lubricant *** layered structure and size were confirmed using transmission electron microscopy(TEM)and atomic force *** a tribological test lubricated with three additives(PAL,organic molybdenum(SN-Mo),and Amo-PMo),it was found that the sample of 0.5 wt%Amo-PMo exhibited the best tribological properties with a coefficient of friction of ***,the resulting wear scar diameter and wear volume of the sliding ball surface were 63%and 49.6%of those lubricated with base oil,*** excellent lubricating performance and self-repairing ability were mainly attributed to the generated MoS2 adsorbed on the contact surfaces during the tribochemical reaction,thereby effectively preventing the direct collision between asperities on sliding solid ***,as-prepared Amo-PMo nanoplatelets show great potential as oil-based lubricant additives,and this study enriches the existing application of PAL in industry.

关键词： palygorskite(PAL) layered material lubricant additive wear tribofilm

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SmMYB2 promotes salvianolic acid biosynthesis in the medicinal herb Salvia miltiorrhiza

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Journal of Integrative Plant Biology 2020年第11期62卷 1688-1702页

作者： Changping Deng Yao Wang Fenfen Huang Sunjie Lu limei zhao Xingyuan Ma Guoyin Kai Laboratory of Medicinal Plant Biotechnology College of PharmacyZhejiang Chinese Medical UniversityHangzhou 310053China State Key Laboratory of Bioreactor Engineering School of BiotechnologyEast China University of Science and TechnologyShanghai 200237China Institute of Plant Biotechnology School of Life SciencesShanghai Normal UniversityShanghai 200234China

MYB transcription factors play vital roles in plant growth and *** phytohormone methyl jasmonate(MeJA)promotes phenolic acid accumulation in the medicinal herb Salvia miltiorrhiza,but the regulatory mechanism is poorly ***,we identified the MeJA-responsive R2R3-MYB transcription factor gene 5mMYB2 from a transcriptome library produced from MeJAtreated ***'/horr/ifza hairy ***/VIYB2 expression was tightly correlated with the expression of key salvianolic acid biosynthetic genes including CYP^8Ai^.5mMYB2 was highly expressed in the periderm of *** and SmMYB2 localized to the *** Sml\AYB2 in *** hairy roots significantly increased the levels of salvianolic acids(including rosmarinic acid and salvianolic acid B)by upregulating salvianolic acid biosynthetic genes such as ***2 binds to the MYB-binding motifs in the promoter of CYP98A14,as confirmed by a dual-luciferase assay and electrophoretic mobility shift *** contents were significantly higher in Sm/ViyB2-overexpressing hairy root lines than the control,primarily due to the increased expression of CHI,DFR,and *** findings reveal the novel regulatory role of SmMYB2 in MeJA-mediated phenolic acid biosynthesis,providing a useful target gene for metabolic engineering and shedding light on the salvianolic acid regulatory network.

关键词： roots phenolic expressing

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The Realization of Common Prosperity through Relative Poverty Alleviation:Gradient Development and Optimization

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Contemporary Social Sciences 2022年第5期7卷 1-15页

作者： zhao limei Research Institute of Rural Development Sichuan Academy of Social Sciences Sichuan Academy of Social SciencesChengduSichuan 610074China

Relative poverty alleviation is explicitly consistent with common *** poverty alleviation,which is part of the modernization of national governance capacity,is both an objective requirement of effective poverty alleviation and an inevitable approach to the realization of common *** alleviation of relative poverty and the realization of common prosperity are intrinsically coupled because they feature overlapping time sequences,monistic values,superimposed fields,similar systems,and homogeneous *** relationship between the two is essentially symbiotic,coexistent,and ***,how to effectively alleviate relative poverty and build a dynamic long-term mechanism for relative poverty alleviation will be one of the major challenges for China to tackle before it can make more obvious and substantial progress toward common prosperity for all by *** paper proposes relevant countermeasures and suggestions,which mainly concern the building of a dynamic,multi-dimensional mechanism for relative poverty alleviation and a coordinated mode for the two *** aim is to achieve a balanced integration of the academic logic,social logic,and policy logic.

关键词： relative poverty alleviation common prosperity coordinated advancement

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LC-MS/MS Method for the Quantitation of Cefotetan in Human Plasma and Its Application to Pharmacokinetic Study

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Chemical Research in Chinese Universities 2014年第6期30卷 900-904页

作者： SHI Meiyun YIN Lei CAI Lanlan WANG Can LIU Xidong zhao Sen SUN Yantong FAWCETT J. Paul zhao limei YANG Yan GU Jingkai College of Life Science Jilin University Changchun 130012 t~ R. China Clinical Pharmacology Center Research Institute of Translational Medicine the First Hospital of Jilin University Changchun 130061 1~ R. China" School of Pharmaceutical Sciences dilin University Changchun 130021 P. R. China School of Pharmacy University of Otago Dunedin 9054 New Zealand The Second Clinical Hospital Affiliated to Chinese Medical University Shenyang 110004 P. R. China

A rapid and sensitive liquid chromatography-tandem mass spectrometry（LC-MS/MS） method for the de- termination of cefotetan in human plasma was developed and validated. After the protein precipitation of sample with acetonitrile, the analyte and internal standard（IS）, tramadol, were separated on a Zorbax XDB C8 column using ace- tonitrile/1%（volume fraction） formic acid（volume ratio 35：65, pH=2.5） as mobile phase at a flow rate of 1.0 mL/min with a 1 ： 1 split. The detection was performed by electrospray ionization with positive ion mode, followed by multiple reaction monitoring of the transitions for cefotetan at m/z 576.3→460.2（quantifier） and m/z 576.3→432.2（qualifier） and for IS at m/z 264.1→58.1. Cefotetan and IS were eluted at 1.86 and 1.87 rain, respectively. The assay was linear over the concentration range of 0.1-100 gg/mL for 20 μL of human plasma only with intra- and inter-day preci- sions（expressed as the relative standard deviation） of less than 6.62% and accuracies（as relative error） of ＋1.31%. The method was applied to the pharmacokinetic study of a l-h intravenous infusion of 1.0 g of cefotetan disodium for human volunteers（n=6）.

关键词： Cefotetan Liquid chromatography-tandem mass spectrometry(LC-MS/MS) Pharmacokinetics Humanplasma

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MALE STERILITY 3 encodes a plant homeodomain-finger protein for male fertility in soybean

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Journal of Integrative Plant Biology 2022年第5期64卷 1076-1086页

作者： Jingjing Hou Weiwei Fan Ruirui Ma Bing Li Zhihui Yuan Wenxuan Huang Yueying Wu Quan Hu Chunjing Lin Xingqi zhao Bao Peng limei zhao Chunbao Zhang Lianjun Sun State Key Laboratory of Agrobiotechnology Beijing Key Laboratory for Crop Genetic Improvementand College of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Soybean Research Institute the National Engineering Research Center for SoybeanJilin Academy of Agricultural SciencesChangchun 130033China Jiamusi Branch of Heilongjiang Academy of Agricultural Sciences Jiamusi 154007China

Male-sterile plants are used in hybrid breeding to improve yield in soybean(Glycine max(L.)Merr.).Developing the capability to alter fertility under different environmental conditions could broaden germplasm resources and simplify hybrid ***,molecular mechanisms potentially underlying such a system in soybean were ***,using positional cloning,we identified a gene,MALE STERILITY 3(MS3),which encodes a nuclear-localized protein containing a plant homeodomain(PHD)-finger domain.A spontaneous mutation in ms3 causing premature termination of MS3 translation and partial loss of the *** analysis indicated that MS3 knockout resulted in nonfunctional pollen and no selfpollinated pods,and RNA-seq analysis revealed that MS3 affects the expression of genes associated with carbohydrate ***,the fertility of mutant ms3 can restore under longd *** mutant could thus be used to create a new,more stable photoperiod-sensitive genic male sterility line for two-line hybrid seed production,with significant impact on hybrid breeding and production.

关键词： fertility restoration male sterililty PHD-finger photoperiod soybean

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Study on the Algorithms for Shaping a Team’s Internal Complex Scientific Research Networks

Study on the Algorithms for Shaping a Team’s Internal Compl...

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第26届中国控制与决策会议

作者： limei zhao School of Information Management Heilongjiang University

ISBN: (纸本)9781479937097

The purpose of this paper is to analyze team members’ complex scientific research relationships and shape the team’s internal complex scientific research networks. The social network analysis method and fuzzy method are used to analyze team members’ scientific research relationships on the basis of their cross-citations, collaborations, co-words, bibliographic coupling and co-citations. The team members’ roles in the scientific research processes are defined and the algorithms for shaping a team’s internal five kinds of complex scientific research networks are presented, rather than just presenting the algorithms for shaping one kind of network. It is found that there are complex relations among those networks, and the algorithms presented in this paper may lay a unified theoretic analysis framework to build a team’s internal complex scientific research networks and analyze those networks’ structures.

关键词： Team’s internal scientific research networks Social network analysis Shaping algorithms

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Bibliometric analysis and visualization on International Mobile Library Research Output,2007-2016

Bibliometric analysis and visualization on International Mob...

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第30届中国控制与决策会议

作者： limei zhao Luyao Shen Information Management School Heilongjiang University Information Resources Management Center Heilongjiang University

Bibliometrics analysis of published research output is performed on the mobile library field for the period of 2007-2016, based on research data retrieved from the Science Citation index and Social Sciences Citation Index databases. A number of 772 mobile library related articles in the period are identified in this research. On the basis of the above data source, combined with the softwares of GEPHI and VOSviewer, co-word analysis and visualization are employed from the viewpoint of the bibliometrics analysis method, in order that the number evolution pattern of research outputs, prominent authors and their research paradigms, institutions contributing to the field, and content analysis based on co-word method are conducted in the paper, to reveal the research status and future trend in mobile library field.

关键词： Bibliometrics mobile library research trend research outputs

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科学数据共享伦理秩序建构研究

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现代情报 2024年第11期44卷 118-127页

作者：赵丽梅黑龙江大学信息管理学院黑龙江哈尔滨150080 黑龙江大学信息资源管理研究中心黑龙江哈尔滨150080

[目的/意义]科学数据共享伦理秩序建构,旨在强化共享参与主体行为的正当性与合理性,规范共享过程与规约主体间际关系。科学数据共享是新型数据赋权场域,数据共享风险及不确定性增强,为避免数据共享及重用伦理失序问题,科学数据共享伦理... 详细信息

[目的/意义]科学数据共享伦理秩序建构,旨在强化共享参与主体行为的正当性与合理性,规范共享过程与规约主体间际关系。科学数据共享是新型数据赋权场域,数据共享风险及不确定性增强,为避免数据共享及重用伦理失序问题,科学数据共享伦理秩序建构亟不可待。[方法/过程]在阐释科学数据伦理秩序内涵与属性的基础上,论证科学数据共享伦理秩序建构的实然基础与应然要求,系统论述科学数据共享伦理秩序的建构进路。[结果/结论]科学数据共享伦理秩序建构需要遵循理念公平、过程公正与结果正义的基本价值准则,以制度契约保障有效性、以激励机制确保可实施性、以平台互惠共生治理逻辑实现可控性。

关键词：科学数据共享伦理秩序制度契约激励机制共生治理

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