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Extreme Heat Exposure Induced Acute Kidney Injury through NLRP3 Inflammasome Activation in Mice

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Environment & Health 2024年第8期2卷 563-571页

作者： Jiahui Wang Kunyi Wang Xinnu Shi Zhoufan Hu Lisha zhao Kan Chen Lu Zhang ran Li Guoqing Zhang Cuiqing Liu School of Public Health Zhejiang Chinese Medical UniversityHangzhou 310053China Zhejiang International Science and Technology Cooperation Base of Air Pollution and Health Hangzhou 310053China Department of Clinical Nutrition West China HospitalSichuan UniversityChengdu 610041China

Climate change has resulted in a marked increase in heat extremes that carry a severe risk for morbidity and *** is sensitive to heat stimulation,and acute kidney injury(AKI)is the early *** this study,we investigated the adverse effects of heat extremes and their underlying mechanism.A total of 16 wild-type C57BL/6N mice were randomly divided into groups of control(exposed to 22±0.5°C)and heat(exposed to 39.5±0.5°C until the core body temperature reached the maximum).First,extreme heat exposure induced AKI evidenced by kidney dysfunction and morphological *** addition,heat exposure suppressed expression of molecules for mitochondrial energetics and fatty acid beta-oxidation and disturbed the balance of oxidative stress in the ***,heat exposure enhanced the protein levels in the upstream signaling pathway for NLRP3 inflammasome formation,followed by NLRP3 inflammasome activation and inflammatory cytokine *** findings demonstrated that acute extreme heat exposure may induce AKI through the NLRP3 inflammasome formation and activation.

关键词： Extreme Heat Acute Kidney Injury NLRP3 Inflammation Mitochondrial Oxidative Stress

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高盐低pH值法提取玉米基因组DNA的研究

玉米科学 2009年第1期17卷 59-61,70页

作者：许理文王凤格赵久然易红梅北京市农林科学院玉米研究中心北京100097 首都师范大学生命科学学院北京100037

优化建立了基于玉米叶片的高盐低pH值法提取玉米基因组DNA,经琼脂糖电泳检测表明,提取的DNA主带清晰、无降解现象、质量好,满足基于SSR标记的5色荧光电泳检测系统。此方法比目前提取植物基因组DNA常用的CTAB法和SDS法具有成本低、步骤... 详细信息

优化建立了基于玉米叶片的高盐低pH值法提取玉米基因组DNA,经琼脂糖电泳检测表明,提取的DNA主带清晰、无降解现象、质量好,满足基于SSR标记的5色荧光电泳检测系统。此方法比目前提取植物基因组DNA常用的CTAB法和SDS法具有成本低、步骤简单、不使用酚、氯仿、异戊醇等有毒有机试剂的优点,是提取玉米基因组DNA的一种较好的方法。

关键词：玉米 DNA提取高盐低pH值法

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关于玉米品种DUS测试的几点思考

玉米科学 2005年第3期13卷 126-129页

作者：王凤格赵久然邢锦丰郭景伦北京市农林科学院玉米研究中心北京100089

针对玉米品种DUS测试中存在的实际问题,从标准品种、测试性状、对照品种、繁殖材料提供、特异性、分子标记等方面进行了全面分析,并对部分问题提出了相应的解释或解决方法。

关键词：玉米新品种保护 DUS测试

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结冰风洞小流量发动机进气部件防冰试验技术

航空动力学报 2024年第4期39卷 1-7页

作者：冉林熊建军赵照易贤中国空气动力研究与发展中心结冰与防除冰重点实验室四川绵阳621000 中国空气动力研究与发展中心空气动力学国家重点实验室四川绵阳621000

为满足国产航空发动机小流量进气防冰试验的需求,基于结冰风洞的发动机进气模拟系统,分析了典型小流量发动机进气部件的进气特征,开展了小流量发动机进气模拟方法研究。提出采用水环真空泵解决了大流阻进气导致吸气管道压力大幅度降低问... 详细信息

为满足国产航空发动机小流量进气防冰试验的需求,基于结冰风洞的发动机进气模拟系统,分析了典型小流量发动机进气部件的进气特征,开展了小流量发动机进气模拟方法研究。提出采用水环真空泵解决了大流阻进气导致吸气管道压力大幅度降低问题,在此基础上,优化了发动机进气模拟系统,建立了在结冰风洞开展小流量发动机进气部件防冰试验的流程,并应用于某型号小流量发动机进气部件防冰试验。结果表明:发动机进气模拟系统满足小流量发动机进气部件防冰试验要求,进气流量控制精度达到±0.05 kg/s(±0.33%FS),试验过程中的流量变化可用于辨别防冰效果。相关研究为发动机进气模拟系统设计、优化和小流量发动机进气部件的防冰特性考核提供了参考依据。

关键词：结冰风洞发动机进气模拟系统小流量发动机进气部件防冰试验进气流量

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大型结冰风洞热气供气防除冰试验技术

航空动力学报 2024年第5期39卷 11-17页

作者：赵照熊建军冉林易贤中国空气动力研究与发展中心结冰与防除冰重点实验室四川绵阳621000

在结冰风洞建立热气供气防除冰试验系统是开展热气防除冰试验的主要手段,为满足我国一系列国产飞机防除冰系统设计与结冰适航审定需求,中国空气动力研究与发展中心依托3 m×2 m大型结冰风洞开展了热气供气防除冰试验技术研究,自主研制... 详细信息

在结冰风洞建立热气供气防除冰试验系统是开展热气防除冰试验的主要手段,为满足我国一系列国产飞机防除冰系统设计与结冰适航审定需求,中国空气动力研究与发展中心依托3 m×2 m大型结冰风洞开展了热气供气防除冰试验技术研究,自主研制了热气供气防除冰试验系统。设计并研制了数字阀流量控制单元、电加热器单元、流量控制单元等试验子系统,建立了试验流程与方法,构建了完善的多路热气供气防除冰试验技术,并对某小型航空发动机进气道部件开展了双路防除冰试验验证,试验结果表明:热气供气防除冰试验系统可模拟真实压气机引出的热气,具备多路热气供气试验能力,温度控制精度可达±1℃,流量控制精度可达±1%,性能指标优异,为下一步我国飞行器防除冰试验系统设计与适航审定提供了有力支撑。

关键词：大型结冰风洞多路热气供气防除冰试验技术飞行器适航审定

Resilient control of flexible hypersonic vehicles against unmatched distributed faults

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Chinese Journal of Aeronautics 2024年第5期37卷 60-70页

作者： Dong zhao Wenjing REN School of Artificial Intelligence Anhui UniversityHefei 230601China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China

This paper studies a robust fault compensation and vibration suppression problem of flexible hypersonic *** controlled plant is represented by a cascade system composed of a nonlinear Ordinary Differential Equation(ODE)and an Euler-Bernoulli Beam Equation(EBBE),in which the vibration dynamics is coupled with the rigid dynamics and suffers from distributed faults.A state differential transformation is introduced to transfer distributed faults to an EBBE boundary and a longitudinal dynamics is refined by utilizing T-S fuzzy IF-THEN rules.A novel T-S fuzzy based fault-tolerant control algorithm is developed and related stability conditions are *** robust exponential stability and well-posedness are proved by using the modified l_(0)-semigroup based Lyapunov direct approach.A simulation study on the longitudinal dynamics of flexible hypersonic vehicles effectively verifies the validity of the developed theoretical results.

关键词： Flexible hypersonic vehicles ODE-EBBE cascade Robust exponential stability Unmatched distributed fault compensation Vibration suppression

“甜味糯”新型鲜食玉米及其代表品种京科糯768的选育

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植物遗传资源学报 2023年第1期24卷 317-324页

作者：徐丽史亚兴席胜利俞嫒年卢柏山赵久然北京市农林科学院玉米研究所/玉米DNA指纹及分子育种北京市重点实验室北京100097

本研究阐述了“甜味糯”新型鲜食糯玉米极其代表品种的培育。通过对糯质玉米的种质创新和改良提升,实现果穗上的所有籽粒都是糯质,在适采期内,糯质籽粒糖度值平均可达到12度以上,显著高于普通糯玉米,带有明显的甜味,形成“糯中有甜”的... 详细信息

本研究阐述了“甜味糯”新型鲜食糯玉米极其代表品种的培育。通过对糯质玉米的种质创新和改良提升,实现果穗上的所有籽粒都是糯质,在适采期内,糯质籽粒糖度值平均可达到12度以上,显著高于普通糯玉米,带有明显的甜味,形成“糯中有甜”的特殊口感品质。北京市农林科学院鲜食玉米创新团队从2011年开始“甜味糯”种质创新和品种培育工作,利用创新集成的“大群体、严选择、单株配合力测定”以及“优系聚合”等育种方法,并通过大量田间表型鉴选和籽粒糖度、口感品质等鉴定评价,创制选育出“甜味糯”新型玉米优良自交系ZN3。以ZN3为骨干亲本,组配育成京科糯768等“甜味糯”新型鲜食糯玉米系列新品种,鲜籽粒糖度达14度以上,具有籽粒甜度高、口感品质好、高产稳产、多抗广适、采收期长等综合优点。京科糯768被评为“全国十大优秀糯玉米品种”,于2021年通过四大生态区国审,适宜在全国鲜食玉米生态区种植。“甜味糯”玉米将是我国未来鲜食糯玉米的一个重要发展方向。

关键词：甜味糯鲜食玉米 ZN3 京科糯768

H-and J-aggregation of conjugated small molecules in organic solar cells

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Journal of Energy Chemistry 2024年第6期93卷 174-192,I0005页

作者： Qiaoqiao zhao Feng He State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353ShangdongChina Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055GuangdongChina Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055GuangdongChina

As H-and J-aggregation receive more and more attention in the research of organic solar cells(OSCs),especially in small molecular systems,deep understanding of aggregation behavior is needed to guide the design of conjugated small molecular structure and the fabrication process of OSC *** this end,this review is ***,the review firstly introduced the basic information about H-and J-aggregation of conjugated small molecules in ***,the characteristics of H-and J-aggregation and the methods to identify them were ***,it reviewed the research progress of H-and J-aggregation of conjugated small molecules in OSCs,including the factors influencing H-and J-aggregation in thin film and the effects of H-and J-aggregation on OPV performance.

关键词： H-aggregation J-aggregation Organic solar cells Small molecules Efficiency Stability

A novel Bayesian-based INS/GNSS integrated positioning method with both adaptability and robustness in urban environments

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Chinese Journal of Aeronautics 2024年第6期37卷 205-218页

作者： Zhe YANG Hongbo zhao School of Electronics and Information Engineering Beihang UniversityBeijing 100191China

Achieving higher accuracy positioning results in urban environments at a lower cost has been an important pursuit in areas such as autonomous driving and intelligent *** Inertial Navigation System and Global Navigation Satellite System(INS/GNSS)integrated navigation systems have been an important means of fulfilling the above quest due to the complementary error characteristics between INS and *** complex urban driving environment requires the system sufficiently adaptive to keep up with the time-varying measurement noise and sufficiently robust to cope with measurement outliers and prior ***,many efforts lack a balance between adaptability and *** this paper,a novel positioning method with both adaptability and robustness is proposed by coupling the Mahalanobis distance method,the Variational Bayesian method and the student’s t-distribution in one process(M-VBt method).This method is robust against non-Gaussian noise and priori uncertainties,plus adaptive against measurement noise uncertainty and time-varying *** field test results show that the M-VBt method(especially the Mahalanobis distance part)has significantly improved the system performance in the complex urban driving environment.

关键词： Urban environments Mahalanobis distance Adaptability Robustness Integrated navigation