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In vitro cartilage production using an extracellular matrix-derived scaffold and bone marrow-derived mesenchymal stem cells

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Chinese Medical Journal 2013年第16期126卷 3130-3137页

作者： zhao Yan-hong YANG Qiang xia Qun PENG Jiang LU shi-bi GUO Quan-yi ma Xin-long XU Bao-shan HU yong-cheng zhao Bin ZHANG Li WANG Ai-yuan XU Weng-jing MIAO jun LIU Yue Institute of Orthopedics Chinese People's Liberation Army GeneralHospital Beijing 100853 China Stomatological Hospital of Tianjin Medical University Tianjin300070 China Department of Spine Surgery Tianjin Hospital Tianjin 300211 China Tianjin Medical University Tianjin 300211 China

Background Cartilage repair is a challenging research area because of the limited healing capacity of adult articular *** had previously developed a natural,human cartilage extracellular matrix （ECM）-derived scaffold for in vivo cartilage tissue engineering in nude ***,before these scaffolds can be used in clinical applications in vivo,the in vitro effects should be further *** We produced cartilage in vitro using a natural cartilage ECM-derived *** scaffolds were fabricated by combining a decellularization procedure with a freeze-drying technique and were characterized by scanning electron microscopy （SEM）,micro-computed tomography （micro-CT）,histological staining,cytotoxicity assay,biochemical and biomechanical *** being chondrogenically induced,the induction results of BMSCs were analyzed by histology and *** attachment and viability assessment of the cells on scaffolds were analyzed using SEM and LIVE/DEAD ***-scaffold constructs cultured in vitro for 1 week and 3 weeks were analyzed using histological and immunohistochemical *** SEM and micro-CT revealed a 3-D interconnected porous *** majority of the cartilage ECM was found in the scaffold following the removal of cellular debris,and stained positive for safranin O and collagen Ⅱ.Viability staining indicated no cytotoxic effects of the *** analysis showed that collagen content was （708.2±44.7）μg/mg,with GAG （254.7±25.9） μg/*** testing showed the compression moduli （E） were （1.226±0.288） and （0.052±0.007） MPa in dry and wet conditions,*** canine bone marrow-derived stem cells （BMSCs） were induced down a chondrogenic pathway,labeled with PKH26,and seeded onto the *** staining of the cell-scaffold constructs indicated that chondrocyte-like cells were derived from seeded BMSCs and excreted *** cell-scaffold constructs contained pink,smooth

关键词： bone marrow-derived mesenchymal stem cells cartilage tissue engineering extracellular matrix in vitro scaffold

Compressive performance of innovative reinforced pillars in closed/abandoned mines

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Journal of Central South University 2024年第8期31卷 2780-2793页

作者： LI Jian BAI Jin-wen FENG Guo-rui WANG shan-yong zhao hong-chao MI Jia-chen PAN Rui-kai shi Xu-dong ma jun-biao College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of shanxi Province for Mine Rock Strata Control and Disaster Prevention Taiyuan University of TechnologyTaiyuan 030024China shanxi-Zheda Institute of Advanced materials and Chemical Engineering Taiyuan 030024China Department of Mining Engineering Shanxi Institute of EnergyJinzhong 030600China Priority Research Centre for Geotechnical Science and Engineering School of Engineeringthe University of NewcastleCallaghanNSW 2308Australia School of Geology and Mining Engineering Xinjiang UniversityUrumqi 830000China

Pillar is closely related to the stability and reliability of underground spaces in closed/abandoned *** present research introduced a new technique to strengthen square cement mortar columns via fiber-reinforced polymer(FRP)strips to verify the strengthening effect of FRP on *** to a fully wrapped FRP jacket,the advantages of FRP strip are cost-effective and easy-to-construct.A series of compression tests as well as theoretical analysis were carried out to explore the mechanical behavior of square cement mortar specimens partially strengthened with FRP *** results verified the effectiveness of FRP strips in enhancing the stress and strain of cement *** from unconfined cement mortar specimens,these FRP-strengthened cement mortar specimens are featured with the double-peaked behaviors,mainly attributed to the stress state transformation from a one-dimensional to a three-dimensional stress *** also indicated that the enhancement of stress increased with the FRP strip ***,the brittle-ductile transition ductile failure characteristics were also observed in FRP-confined cement mortar *** ultimate ductility of the cement mortar specimen decreases gradually with the growth of the FRP strip *** main contribution of this research is to enrich the strengthening techniques for residual pillars.

关键词： fiber-reinforced polymer uniaxial compression partially strengthening double-peaked behaviors brittle-ductile transition

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

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Signal Transduction and Targeted Therapy 2022年第1期7卷 228-242页

作者： Jin-Lan Zhang Yu-Huan Li Lu-Lu Wang hong-Qi Liu Shuai-Yao Lu yong Liu Ke Li Bin Liu Su-Yun Li Feng-Min Shao Kun Wang Ning Sheng Rui Li Jin-Jin Cui Pei-Chun Sun Chun-xia ma Bo Zhu Zhe Wang Yuan-Hao Wan shi-shan Yu yongsheng Che Chao-Yang Wang Chen Wang Qiangqian Zhang Li-Min zhao xiao-Zhong Peng Zhenshun Cheng jun-Biao Chang Jian-Dong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medical Biology Chinese Academy of Medical Science and Peking Union Medical CollegeKunming 650031 YunnanChina Genuine Biotech.Inc. Pingdingshan 467000 HenanChina Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan Research Center for Infectious Diseases and CancerWuhan 430071 HubeiChina The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000 HenanChina Department of Internal Medicine Henan Provincial Peoples HospitalZhengzhou 450003 HenanChina Henan Key Laboratory of Organic Functional Molecule and Drug Innovation School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007 HenanChina National Clinical Research Center for Respiratory Diseases Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China School of Chemistry Zhengzhou UniversityZhengzhou 450001 HenanChina

Azvudine(FNC)is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase(RdRp).Recently,we discovered FNC an agent against SARS-CoV-2,and have taken it into Phase III trial for COVID-19 *** monophosphate analog inhibited SARS-CoV-2 and HCoV-OC43 coronavirus with an EC_(50) between 1.2 and 4.3 μM,depending on viruses or cells,and selective index(SI)in 15-83 *** administration of FNC in rats revealed a substantial thymus-homing feature,with FNC triphosphate(the active form)concentrated in the thymus and peripheral blood mononuclear cells(PBMC).Treating SARS-CoV-2 infected rhesus macaques with FNC(0.07 mg/kg, qd,orally)reduced viral load,recuperated the thymus,improved lymphocyte profiles,alleviated in flammation and orga n damage,and lessened grou nd・glass opacities in chest *** gle-cell seque ncing suggested the promotion of thymus function by FNC.A randomized,single-arm clinical trial of FNC on compassionate use(n=31)showed that oral FNC(5 mg,qd)cured all COVID-19 patients,with 100%viral ribonucleic acid negative conversion in 3.29±2.22 days(range:1-9 days)and 100%hospital discharge rate in 9.00±4.93 days(range:2-25 days).The side-effect of FNC is minor and transient dizziness and nausea in 16.12%(5/31)***,FNC might cure COVID-19 through its anti-SARS-CoV-2 activity concentrated in the thymus,followed by promoted immunity.

关键词： patients inhibited concentrated

Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan hong-tao Yang Yue-yi Deng Wei Li Ya-ni He zhao-hui Ni yong-li Zhan shan Lin Zhi-yong Guo jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang xiao-hong Cheng Li-qun He Ping Luo shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang hong-yu Chen Wen-hu Liu hong-li Lin Meng Liang Lu ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou jun-zhou Fu Qiang He Guang-yan Cai xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein *** with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine *** a superiority threshold of 15%,neither was statistically ***,serum creatinine and serum albumin from the baseline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： ma Yan ZHU Dong shan CHEN Ren Bo shi Nan Nan LIU Si hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN hong CHEN Li Ying FENG Qiao GUO Tuan mao HOU yong HU Gui Fen HU xiao Mei HU Yun hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI xiao LI Chun Yan LI Min Qing LI Qun Tang LI xian yong LIU hong De LIU Jin Ping LIU Zhang ma Yu Ting maO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping xiaO Yan Hua XIE Hai jun XU hong Ming XU Shou Fang XUE Rui xia YANG Chun YANG Kai jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song zhao Shu Sen zhao Wan Ying ZHENG Kai ZHOU Ying Chun ZHU jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： xiao-Dong Song Fei Yang Hua-yong Wu Jing Zhang De-Cheng Li Feng Liu Yu-Guo zhao Jin-Ling Yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long Ying Lu Yue-Yu Sui Qiu-Bing Wang Ke-Ning Wu Feng-Rong Zhang Ming-Kui Zhang Zhou shi Wan-Zhu ma Gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-Gang Yuan Yang-Zhu Zhang jun-Ping Bai Jia-Ying Chen Jie Chen Yin-jun Chen Yun-Zhong Dong Chun-Lan Han Ling Li Li-Ming Liu Jian-jun Pan Fu-Peng Song Fu-jun Sun Deng-Feng Wang Tian-Wei Wang xiang-Hua Wei hong-Qi Wu xia zhao Qing Zhou Gan-Lin Zhang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification

Towards the full realization of the RIBLL2 beam line at the HIRFL-CSR complex

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Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-Hua Sun Jian-Wei zhao Xue-Heng Zhang Li-Na Sheng Zhi-Yu Sun Isao Tanihata Satoru Terashima yong Zheng Li-Hua Zhu Li-Min Duan Liu-Chun He Rong-Jiang Hu Guang-Shuai Li Wen-Jian Lin Wei-Ping Lin Chuan-Ye Liu Zhong Liu Chen-Gui Lu Xin-Wen ma Li-jun mao Yi Tian Feng Wang Meng Wang shi-Tao Wang Jia-Wen xia xiao-Dong Xu Hu-shan Xu Zhi-Guo Xu Jian-Cheng Yang Da-Yu Yin You-Jin Yuan Wen-Long Zhan Yu-Hu Zhang xiao-hong Zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFL-CSR 横梁建筑群排队原子核物理学家试验性世界

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-Xin Hao Lu Feng Hugh RAJones Jian Li Jing Xu Li-yong Liu Teng-Fei Song Jian-Feng Wang Hua-Lin Chen Yan-Jie Xue Huang Shen yong-Heng zhao zhao-xiang Qi Jian-Rong shi Yuan Tian Zheng Wang xia Wang Jin-Liang Hou Jin-Ming Bai Ji Yang Xu Zhou yong-Qiang Yao Jia Yin Ali Esamdin Guang-Xin Pu Peng Wei Chun-Hai Bai Guo-Jie Feng Lu ma Xuan Zhang Yu Liu Chong Pei Zhi-xia Shen Yun-Ying Jiang Jian-Feng Tian xian-Qun Zeng Zhi-Gang Hou Xu Yang jun-Bo Zhang shi-Long Liao Dong-Wei Fan Yun-Fei Xu Jian-Ping Xiong Tai-Sheng Yan Xi Zhang Chang-Hua Li Yi-Han Tao Si-Cheng Yu Zhi-Song Cao hong-Shuai Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 march 10 to 2019 march *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma(2022 version)

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Journal of Clinical and Translational Hepatology 2023年第7期11卷 1553-1564页

作者： Han Wang jun Chen Xin Zhang xia Sheng xiao-Yan Chang Jie Chen Min-shan Chen Hui Dong Guang-Jie Duan He-Ping Hu Zhi-yong Huang Wei-Dong Jia xiao-Qing Jiang Dong Kuang shan-shan Li Zeng-shan Li Chang-Li Lu Shu-Kui Qin Xue-shan Qiu Li-Juan Qu Chun-Kui Shao Feng Shen Guo-Ming shi Su-Sheng shi Yu-jun shi Hui-Chuan Sun xiao-Dong Teng Bin Wang Zhan-Bo Wang Tian-Fu Wen Jia-Mei Yang Qiao-Qiao Yang Sheng-Long Ye hong-Fang Yin Zhen-Gang Yuan Jing-Ping Yun Feng-Lin Zang hong-Qi Zhang Li-hong Zhang Jing-Min zhao Jian Zhou Wei-Xun Zhou Jia Fan xiao-Ping Chen Wan Yee Lau Yuan Ji Wen-Ming Cong Chinese Society of Liver Cancer of Chinese Anti-Cancer Association Digestive Disease Group of Chinese Society of Pathology,Chinese Medical Association Chinese Society of Pathology of Chinese Anti-Cancer Association Hepatic Surgery Group of Chinese Society of Surgery,Chinese Medical Association Biliary Tract Tumor Committee of China Anti-Cancer Association Chinese Society of Clinical Oncology IDepartment of Pathology Eastern Hepatobilary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology the Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsuChina Department of Pathology Zhongshan HospitalFudan UniversityShanghaiChina Department of Pathology Minhang HospitalFudan Uni-versityShanghaiChina Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sci-ences and Peking Union Medical CollegeBeijingChina Department of Liver Surgery Sun Yat-Sen University Cancer CenterGuangzhouGuangdongChina Department of Pathology The First Affiliated HospitalArmy Medical UniversityChongqingChina Department of Hepatobiliary Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghaiChina Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWu-hanHubeiChina Department of General Surgery The First Affliated Hospital of USTCDivision of Life Science and Medi-cineUniversity of Science and Technology of ChinaHefeiAnhuiChina Department of Biliary Surgery I Eastern Hepatobil-iary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Pathology The First Afiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenanChina Department of Pathology Xijing Hospi-talAir Force Medical UniversityXi'anShaanxiChina Department of Pathology West China HospitalSichuan UniversityChengduSichuanChina Cancer Center of Jinling Hospital Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Pathology The First Affiliated HospitalChina Medical UniversityShenyangLiaoningChina Department of Pathology The 900 Hospital of the Chinese People's Liberation Army Joint Logistics TeamFuzhouFujianChina Department of Pathology The Third Affiliated HospitalSun Yat-Sen UniversityGuangz

Intrahepatic cholangiocarcinoma(iCCA)can originate from the large bile duct group(segment bile ducts and area bile ducts),small bile duct group(septal bile ducts and interlobular bile ducts),and terminal bile duct group(bile ductules and canals of Hering)of the intrahepatic biliary tree,which can be histopathological corresponding to large duct type iCCA,small duct type iCCA and iCCA with ductal plate malformation pattern,and cholangiolocarcinoma,*** challenge in pathological diagnosis of above subtypes of iCCA falls in the distinction of cellular morphologies,tissue structures,growth patterns,invasive behaviors,immunophenotypes,molecular mutations,and surgical *** these reasons,this expert consensus provides nine recommendations as a reference for standardizing and refining the diagnosis of pathological subtypes of iCCA,mainly based on the 5th edition of the World Health Organization Classification of Tumours of the Digestive System.

关键词： Intrahepatic cholangiocarcinoma Pathology Histological type Immunohistochemistry Molecular variation