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Immunotherapy for Alzheimer’s disease:targetingβ-amyloid and beyond

Translational Neurodegeneration 2022年第1期11卷 690-706页

作者： Chenghuan Song Jiyun Shi Pingao zhang Yongfang zhang Jianrong Xu Lanxue zhao Rui zhang Hao Wang Hongzhuan Chen Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Universities Collaborative Innovation Center for Translational Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education Shanghai Jiao Tong University School of MedicineShanghai 200025China Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Clinical Pharmacy Institute of Interdisciplinary Integrative Medicine ResearchShuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China.

Alzheimer’s disease(AD)is the most common neurodegenerative disease in the elderly worldwide.However,the complexity of AD pathogenesis leads to discrepancies in the understanding of this disease,and may be the main reason for the failure of AD drug development.Fortunately,many ongoing preclinical and clinical studies will continually open up avenues to unravel disease mechanisms and guide strategies for AD diagnosis and drug development.For example,immunotherapeutic strategies targeting amyloid-β(Aβ)and tau proteins were once deemed almost certainly effective in clinical treatment due to the excellent preclinical results.However,the repeated failures of clinical trials on vaccines and humanized anti-Aβand anti-tau monoclonal antibodies have resulted in doubts on this strategy.Recently,a new anti-Aβmonoclonal antibody(Aducanumab)has been approved by the US Food and Drug Administration,which brings us back to the realization that immunotherapy strategies targeting Aβmay be still promising.Meanwhile,immunotherapies based on other targets such as tau,microglia and gut-brain axis are also under development.Further research is still needed to clarify the forms and epitopes of targeted proteins to improve the accuracy and effectiveness of immunotherapeutic drugs.In this review,we focus on the immunotherapies based on Aβ,tau and microglia and their mechanisms of action in AD.In addition,we present up-to-date advances and future perspectives on immunotherapeutic strategies for AD.

关键词： Alzheimer’s disease Immunotherapy Vaccine Antibody Drug development

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The synthesis of carbon microspheres film composed of nano-onions and its application as flexible supercapacitors

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Carbon Energy 2021年第3期3卷 509-518页

作者： Miao zhang Naiqin zhao Xifei Li Tianjin International Joint Research Centre of Surface Technology for Energy Storage Materials School of Physics and Materials ScienceTianjin Normal UniversityTianjinChina Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjinChina

Flexible electrodes with superior mechanical and electrochemical properties are essential for flexible supercapacitors.A convenient and scalable colloidal film-assisted chemical vapor deposition(CF-CVD)method is developed for the one-step fabrication of the carbon microspheres films composed of carbon nano-onions(CMS-CNO films).The influence of growth conditions(such as growth temperature,time,and gas ratio)during CF-CVD process on the carbon structures and the growth mechanism of the CMS-CNO films have been investigated.By controlling the growth conditions,the controllable preparation of CMS-CNO films is realized.Such binder-free films can be used for the assembly of flexible supercapacitors,and unique architecture can achieve excellent performance.Benefitting from the composite of nano-micro zero dimensional structures,the performance of the film in supercapacitors is remarkably improved.At the current density of 5 mA cm^(-2),the area-specific capacity can be 903 mF cm^(-2).When the current density is increased to 500 mA cm^(-2),the area-specific capacity can be increased to 729 mF cm^(-2).This simple and low-cost preparation process and the superb electrochemical performance suggest great potential applications of CMS-CNO films in flexible supercapacitors.

关键词： carbon nano-onions composite films flexible supercapacitors

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Association between physical activity energy expenditure and cardiometabolic risk factor clustering among Chinese adults in 2015

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Sports Medicine and Health Science 2022年第2期4卷 105-111页

作者： Xiaorong Chen Mei zhang Limin Wang Zhengjing Huang Wenrong zhang Jing wu National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

To understand the association between cardiometabolic risk factor(CMRF)clustering and physical activity(PA)levels,we included 86520 Chinese adults aged 18–64 years having at least one CMRF(hypertension,diabetes,dyslipidemia,or obesity)from the China Chronic Disease and Nutrition Surveillance survey in 2015,a nationally and provincially representative investigation with a multistage clustering sampling design.Self-reported PA information was collected with the Global Physical Activity Questionnaire through face-to-face interviews.In view of the obesity epidemic in CMRF patients,PA energy expenditure(PAEE)per kilogram body weight was used,and was defined into four categories:(i)inactivity:0 kJ/kg/day;(ii)low activity:0–5 kJ/kg/day;(iii)moderate activity:6–11 kJ/kg/day;and(iv)vigorous activity:≥12 kJ/kg/day.The estimated weighted prevalence(95%confidence interval[CI])of having 1,2,3,and 4 CMRFs was 60.57%(59.48%–61.67%),28.10%(27.40%–28.79%),9.82%(9.22%–15.42%)and 1.50%(1.37%–1.63%),respectively.The rate(95%CI)of inactivity,low activity,moderate activity,and vigorous activity was 34.52%(32.69%–36.35%),22.22%(21.37%–23.37%),15.98%(15.38%–16.58%)and 27.28%(26.02%–28.53%),respectively.For those having 2,3 and 4 CMRFs(compared to those having 1 CMRF),the adjusted odds ratio(95%CI)for moderate activity and vigorous activity were 0.91(0.85–0.98)and 0.92(0.85–0.99),0.87(0.80–0.95)and 0.84(0.77–0.92),and 0.77(0.67–0.89)and 0.85(0.72–1.00),respectively.In conclusion,CMRF clustering was a pandemic among Chinese adults in 2015 and was inversely associated with PA level.PAEE(in kJ/kg/day)may be introduced into PA management practice,especially for populations with high body weight.

关键词： Physical activity Energy expenditure Cardiometabolic risk factors

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低引气缓凝型聚羧酸减水剂的性能研究

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混凝土 2012年第9期 43-46页

作者：赵苏吴娇颖张晓沈阳建筑大学材料科学与工程学院辽宁沈阳110168 辽宁省建设科学研究院辽宁沈阳110005

经分子设计并合成低引气缓凝型聚羧酸减水剂。试验表明低引气缓凝型聚羧酸减水剂在较小的掺量下,具有较好的分散性,保塑性好,减水率高,有一定的低引气作用,缓凝效果明显,对混凝土抗压强度有较好的影响,并且具有较强的适应性。掺入低引... 详细信息

经分子设计并合成低引气缓凝型聚羧酸减水剂。试验表明低引气缓凝型聚羧酸减水剂在较小的掺量下,具有较好的分散性,保塑性好,减水率高,有一定的低引气作用,缓凝效果明显,对混凝土抗压强度有较好的影响,并且具有较强的适应性。掺入低引气缓凝型聚羧酸减水剂的水泥试样,水泥水化温度峰有明显的推迟现象,峰值也有明显的降低。扫描电镜可以观察到硬化水泥净浆的孔隙小、孔隙分布比较均匀,表明低引气缓凝型聚羧酸减水剂的分子结构、性能和微观形貌有着紧密的联系。

关键词：聚羧酸减水剂低引气缓凝作用结构与性能

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微波溶剂热法快速合成CoSb_(3)纳米粉体的工艺研究

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现代化工 2022年第11期42卷 145-149,154页

作者：吴章平关春龙赵志伟赵小苗陈倩倩史丽萍河南工业大学材料科学与工程学院河南郑州450007 哈尔滨工业大学特种环境复合材料技术国防科技重点实验室黑龙江哈尔滨150001

以CoCl_(2)和SbCl_(3)为前驱物、NaBH_(4)为还原剂、无水乙醇和聚乙二醇(200)为溶剂,采用微波溶剂热法合成了CoSb_(3)纳米粉体,并考察了反应温度、前驱物的摩尔比以及保温时间对CoSb_(3)纳米粉体的影响。通过XRD、SEM、TEM、激光粒度仪... 详细信息

以CoCl_(2)和SbCl_(3)为前驱物、NaBH_(4)为还原剂、无水乙醇和聚乙二醇(200)为溶剂,采用微波溶剂热法合成了CoSb_(3)纳米粉体,并考察了反应温度、前驱物的摩尔比以及保温时间对CoSb_(3)纳米粉体的影响。通过XRD、SEM、TEM、激光粒度仪分别对样品的物相、形貌、晶粒尺寸进行表征。结果表明,当反应温度分别为210、230℃和250℃时,样品的主相分别为CoSb、CoSb_(2)和CoSb_(3)。在250℃保温10 min时,产物同时存在CoSb_(3)、CoSb_(2)、Sb三相;保温时间延长至20 min,CoSb_(2)和Sb相含量减少,产物中主相为CoSb_(3)相;保温时间延长至30 min可得到高纯CoSb_(3)相。通过Rietveld精修法对CoSb_(3)产物进行定量分析,CoSb_(3)相质量分数在90.9%以上。CoSb_(3)样品的晶体形貌为小颗粒球状,晶粒分布均匀,平均晶粒尺寸为33 nm。

关键词：微波溶剂热法纳米粉体热电材料方钴矿 CoSb_(3)

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噁唑烷酮类抗菌药物研究进展

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药学学报 2022年第11期57卷 3276-3291页

作者：胡宇华赵欣彤李天磊吴松张文轩中国医学科学院、北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室北京100050

利奈唑胺是第一个由FDA批准上市的噁唑烷酮类抗菌药,能有效地治疗各类革兰阳性菌感染,适应症包括血液感染、皮肤及软组织感染、社区及医院获得性肺炎等,已逐渐成为临床上常用的抗菌药物之一。除了随后上市的磷酸泰地唑胺(tedizolid phos... 详细信息

利奈唑胺是第一个由FDA批准上市的噁唑烷酮类抗菌药,能有效地治疗各类革兰阳性菌感染,适应症包括血液感染、皮肤及软组织感染、社区及医院获得性肺炎等,已逐渐成为临床上常用的抗菌药物之一。除了随后上市的磷酸泰地唑胺(tedizolid phosphate,TR701)和康泰唑胺(contezolid,MRX-I),目前还有多个噁唑烷酮类抗感染候选药物处于临床研究。本文对已上市和处于临床试验的噁唑烷酮抗菌药物做了简要的介绍,并对近期噁唑烷酮类药物的结构优化研究进展进行了总结。

关键词：抗耐药菌感染噁唑烷酮类抗菌药结构优化构效关系成药性评价

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High temperature creep mechanisms of a single crystal superalloy: A phasefield simulation and microstructure characterization

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Progress in Natural Science:Materials International 2020年第3期30卷 366-370页

作者： Ronghai wu Yunsong zhao Yanfei Liu Xing Ai School of Mechanics Civil Engineering and Architecture Northwestern Polytechnical University Beijing Institute of Aeronautical Materials AECC Sichuan Gas Turbine Establishment AECC Hunan Aviation Power Plant Research Institute

The high temperature creep behavior of a single crystal Ni-based superalloy was studied by combined experimental and numerical methods. The creep test results showed that the creep curves exhibited a three-stage feature. The qualitative explanations for each stage of the creep curves were carried out based on the microstructure characterizations of γ/γ′ phases and dislocations. An elastoplasticity incorporated phase-field model was developed to provide quantitative understanding on directional coarsening(rafting) of γ′ phase. The simulation results showed that the directionality of γ′ coarsening was induced by both dislocation activity in γchannels and elastic inhomogeneity between γ and γ’ phases, therein the dislocation activity played a major role.This findings provide new insights into the design of novel single crystal superalloys with improved creep properties.

关键词： Creep mechanism Dislocation activity Phase-field method Single crystal superalloy

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Analytic Mechanism for the Cumulative Effect of Wind Power Fluctuations from Single Wind Farm to Wind Farm Cluster

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CSEE Journal of Power and Energy Systems 2022年第5期8卷 1290-1301页

作者： Gang Mu Fangze wu Xiaoping zhang Ziheng Fu Bai Xiao Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Ministry of Education(Northeast Electric Power University)Jilin 132012China Department of Electronic Electrical and Systems EngineeringSchool of EngineeringUniversity of BirminghamBirmingham B152TTU.K

The use of wind power is rapidly growing worldwide as a means of reducing carbon emissions for the energy sector.China has the world’s largest wind power installation and multiple large-scale wind farm clusters,each comprising dozens of wind farms.For the planning and operation of the power system,it is important to understand the power fluctuation characteristics of wind farm clusters.Several studies demonstrate that the relative power fluctuation of a wind farm cluster is less than that of a single wind farm.Is this decreasing trend a random occurrence or does it have a regular pattern?This scientific question is addressed by investigating the mechanism of the cumulative effect of a wind farm cluster.In this study,a cumulative model is proposed by examining the spatiotemporal relationships of wind power variations and wind farm dispersion.Structural gain function and critical cumulative frequency are defined as the foundations to analytically describing the cumulative effect.By investigating the cumulative effect mechanism,the relationship between power fluctuation and spatiotemporal parameters of the wind farm cluster are revealed.The power fluctuation of a cluster can be predicted using the cumulative model even before it is completely built.The mechanism of the cumulative effect is validated on the basis of the data of two actual wind farm clusters.

关键词： Analytic mechanism cumulative effect evolution regularity wind farm cluster wind power fluctuation

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Experimental and theoretical study on N-hydroxyphthalimide and its derivatives catalyzed aerobic oxidation of cyclohexylbenzene

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Chinese Journal of Chemical Engineering 2022年第4期35卷 124-130页

作者： Yufei Yang Jieyi Ma Junyan wu Weixia Zhu Yadong zhang School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Jiyuan Research Institute Zhengzhou UniversityJiyuan 459000China

The liquid phase oxidation of cyclohexylbenzene(CHB)is a new green synthetic approach to cyclohexylbenzene-1-hydroperoxide(CHBHP),a key intermediate for preparing phenol and cyclohexanone.In this work,aryl-substituted(Cl and Br)derivatives of N-hydroxyphthalimide(NHPI)were synthesized and their catalytic performances for CHB oxidation were studied.In addition,geometric optimization and transition state search were performed using DFT calculations.Both experimental and theoretical studies have proven that chloro-substitution on NHPI can significantly improve its catalytic effects on the oxidation of CHB by oxygen.Compared with NHPI,CHB conversion and selectivity of CHBHP over Cl;NHPI were increased by 10.47%and 13.24%.The strategy of aryl-substituting NHPI with halogen atoms proposed in this study would provide a potential way to the development of new NHPI-based catalysts for aerobic oxidation reactions.

关键词： N-hydroxyphthalimide Aryl-substituted derivative Cyclohexylbenzene Oxidation Radical

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基于Halcon的多目摄像机标定技术

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现代电子技术 2015年第23期38卷 137-140页

作者：张芝贤赵远方武旭娟沈阳航空航天大学辽宁沈阳110136

对双目立体视觉摄像机标定方法进行了分析,通过Halcon标定板快速求出双目摄像机的内参和外参。在此基础上进行扩展,分别对相邻的摄像机进行双目标定,通过刚性转换,借助Halcon平台丰富的函数算子,最后把8个摄像机统一到惟一的世界坐标系... 详细信息

对双目立体视觉摄像机标定方法进行了分析,通过Halcon标定板快速求出双目摄像机的内参和外参。在此基础上进行扩展,分别对相邻的摄像机进行双目标定,通过刚性转换,借助Halcon平台丰富的函数算子,最后把8个摄像机统一到惟一的世界坐标系,达到多目标定的效果。实验证实了多目标定的可行性与正确性,突破了以往多数仅以双目摄像机系统进行三维测量的格局,为在特定情况下不能显示在惟一双目摄像机系统视野范围内的目标物体进行测量打下了坚实基础。

关键词： Halcon标定板多目标定刚性转换三维测量

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