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Global and national burden of atherosclerosis from 1990 to 2019:trend analysis based on the Global Burden of Disease Study 2019

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Chinese Medical Journal 2023年第20期136卷 2442-2450页

作者： Weihua Chen zeya Li Yu zhao Yitian Chen Rongchong Huang Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100053China Department of Cardiology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian 364000China

Background:Atherosclerosis-related diseases represent significant health issues among adults globally.Despite their widespread impact,comprehensive data concerning the global and national burden and trends of these diseases remain sparse.Our objective is to examine the trends in the burden of atherosclerosis among adults from 1990 to 2019 at both global and national levels.Methods:We reported the average annual percentage changes(AAPCs)in prevalence,incidence,mortality,and disabilityadjusted life years(DALYs)of atherosclerosis-related diseases(ischemic heart disease[IHD],ischemic stroke,and peripheral arterial disease[PAD])at the global and national levels among individuals based on a trend analysis of the Global Burden of Diseases Study(GBD)2019.We further analyzed these global trends as a function of age,gender,and the social development index.We also used joinpoint regression analysis to identify the year with the most substantial changes in global trends.Results:Globally,the AAPC of IHD incidence rose from 1990 to 2019(0.20;95%confidence interval[CI],0.12-0.28),with substantial surges in 1995,2001,2005,2010,and 2017.Conversely,AAPC of IHD mortality rates exhibited a different trend until a rise in 2014.The AAPC of incidence rates of ischemic stroke and PAD also escalated during the same period,with respective 0.43(95%CI,0.39-0.48)and 0.13(95%CI,0.06-0.21).For ischemic stroke,both incidence and mortality soared in 2014,while PAD incidence declined in 1994 and 1998,then sharply climbed in 2016.Nationally,the Northern Mariana Islands experienced the steepest increase in IHD and PAD incidence and mortality between 1990 and 2019.China saw a significant rise in ischemic stroke incidence,whereas the highest mortality rate increase occurred in Timor-Leste.By sociodemographic index(SDI)quintile,low-middle-,middle-,and high-middle-SDI countries all showed upward trends in IHD,ischemic stroke,and PAD incidence.Simultaneously,IHD and ischemic stroke mortality rates,as well as DALYs,dropped in the low-,high-middle-,and hi

关键词： Atherosclerosis Disability-adjusted life years(DALYs) Global Disease Burden 2019 Incidence Mortality

Lanthanum doped octacalcium phosphate/polylactic acid scaffold fabricated by 3D printing for bone tissue engineering

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Journal of Materials Science & Technology 2022年第23期118卷 229-242页

作者： zeya Xu Bin Lin Chaoqian zhao Yanjin Lu Tingting Huang Yan Chen Jungang Li Rongcan Wu Wenge Liu Jinxin Lin Key Laboratory of Optoelectronic Materials Chemical and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences155 West Yangqiao RoadFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Orthopedics Department Fujian Medical University Union HospitalFuzhou 350001China

Lanthanum(La)has tremendous potential in the treatment and prevention of bone diseases especially osteoporosis and metabolic disorders.However,controlling its distribution and keeping the release of La^(3+)ions sustained and steady in the body is still a big challenge.In this study,we prepared La-OCP powders via co-precipitation method,and further prepared La-OCP/PLA porous scaffolds by 3 D printing.La^(3+)was successfully introduced into the OCP crystal structure and substituted Ca^(2+)at the Ca-5 and Ca-8 sites.In particular,some La^(3+)ions were deposited on the crystal surface in the form of nanoparticles.Both octacalcium phosphate(OCP,Ca_(8)H_(2)(PO_(4))_6·5 H_(2)O)crystals and nanoparticles played as the carriers for La^(3+)ions.The La-OCP/PLA scaffolds displayed obvious mineralization effects and sustained release of La^(3+).The scaffolds contained a uniform structure with rough micro surface topography which acted as a suitable pathway for BMSCs cells to adhere,grow and proliferation.At a certain La^(3+)concentration,the extracts from La-OCP/PLA scaffolds increased the expression of osteogenesis-related genes,thus promoting the osteogenic differentiation of BMSCs.Moreover,the extracts regulated the immune responses.The experiment in vivo proved that La-OCP/PLA porous scaffolds were safe and could enhance bone defect regeneration in vivo.These findings suggest that 3 D printed La-OCP/PLA porous scaffolds have promising potentials in bone tissue engineering.

关键词： Lanthanum Octacalcium phosphate Scaffold 3D printing Bone tissue engineering Polylactic acid

Selective substitution induced anomalous phonon stiffening within quasi-one-dimensional P–P chains in SiP2

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Nano Research 2023年第1期16卷 1107-1114页

作者： Xueting Dai Feng Qin Caiyu Qiu Ling Zhou Junwei Huang Fanghua Cheng Xiangyu Bi Caorong Zhang zeya Li Ming Tang Shengqiang Wu Xiaoxu zhao Yangfan Lu Huiyang Gou Hongtao Yuan National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210000China School of Materials Science and Engineering Peking UniversityBeijing 100871China College of Materials Science and Engineering National Engineering Research Center for Magnesium AlloysChongqing UniversityChongqing 400030China Center for High Pressure Science and Technology Advanced Research Beijing 100094China

Light-matter interactions in low-dimensional quantum-confined structures can dominate the optical properties of the materials and lead to optoelectronic applications.In anisotropic layered silicon diphosphide(SiP2)crystal,the embedded quasi-onedimensional(1D)phosphorus–phosphorus(P–P)chains directly result in an unconventional quasi-1D excitonic state,and a special phonon mode vibrating along the P–P chains,establishing a unique 1D quantum-confined system.Alloying SiP2 with the homologous element serves as an effective way to study the properties of these excitons and phonons associated with the quasi-1D P–P chains,as well as the strong interaction between these quasiparticles.However,the experimental observation and the related optical spectral understanding of SiP2 with isoelectronic dopants remain elusive.Herein,with the photoluminescence and Raman spectroscopy measurements,we demonstrate the redshift of the confined excitonic peak and the stiffening of the phonon vibration mode■of a series of Si(P1−xAsx)2 alloys with increasing arsenic(As)compositions.This anomalous stiffening of■is attributed to the selective substitution of As atoms for P atoms within the P–P chains,which is confirmed via our scanning transmission electron microscopy investigation.Such optical spectra evolutions with selective substitution pave a new way to understand the 1D quantum confinement in semiconductors,offering opportunities to explore quasi-1D characteristics in SiP2 and the resulting photonic device application.

关键词： SiP2 quasi-one-dimensional structure Raman photoluminescence phosphide

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与先天性上睑下垂相关的致病基因研究进展

中华实验外科杂志 2019年第5期36卷 978-982页

作者：张泽亚赵延勇中国医学科学院整形外科医院北京100144

先天性上睑下垂为临床较常见疾病,手术为其首选治疗方式。导致先天性上睑下垂症状的致病基因较多。至今相关突变位点已被发现上百个。近些年,越来越多与先天性上睑下垂症状相关的其它基因在一些医学综合征中得到研究。现对可导致先天性... 详细信息

先天性上睑下垂为临床较常见疾病,手术为其首选治疗方式。导致先天性上睑下垂症状的致病基因较多。至今相关突变位点已被发现上百个。近些年,越来越多与先天性上睑下垂症状相关的其它基因在一些医学综合征中得到研究。现对可导致先天性上睑下垂的相关基因的研究进展进行综述,为临床诊疗提供思路。

关键词：先天性上睑下垂综合征基因

凝胶注模工艺制备三维多孔Li1.3Al0.3Ti1.7（PO4）3固态电解质

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硅酸盐学报 2019年第10期47卷 1351-1356页

作者：黄泽亚赵伟然汪长安清华大学材料科学与工程学院新型陶瓷与精细工艺国家重点实验室

三维多孔固态电解质是连续型复合电解质的骨架部分。采用共沉淀法制备Li1.3Al0.3Ti1.7(PO4)3固态电解质粉体,再通过凝胶注模工艺合成了Li1.3Al0.3Ti1.7(PO4)3多孔坯体,并在不同温度下烧结,比较了烧结体的物相组成、显微形貌、收缩率、... 详细信息

三维多孔固态电解质是连续型复合电解质的骨架部分。采用共沉淀法制备Li1.3Al0.3Ti1.7(PO4)3固态电解质粉体,再通过凝胶注模工艺合成了Li1.3Al0.3Ti1.7(PO4)3多孔坯体,并在不同温度下烧结,比较了烧结体的物相组成、显微形貌、收缩率、孔隙率、电导率和激活能。结果表明:在900℃以上烧结,坯体发生明显的致密化,并且产生更多的杂相,其致密度升高而电导率降低。在800℃烧结的样品,孔隙率在50%以上,具有6.94×10–5 S/cm的电导率,激活能为0.27 eV。所得多孔坯具有较高的孔隙率和电导率,使其适合作为三维有机–无机复合固态电解质的陶瓷框架。

关键词：固态电解质离子电导率凝胶注模磷酸钛铝锂

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基于有限元的蒸压加气混凝土墙开裂分析

工程建设 2017年第3期49卷 40-41页

作者：赵泽亚华南理工大学土木与交通学院广州510000

蒸压加气混凝土墙体(ACC)作为一种轻质高强环保的围护结构是传统砖墙优质的替代物。但由于过低的抗拉强度,在各种复杂受力工况下,蒸压加气混凝土墙板易于开裂,进而影响建筑美观以及其保温抗渗性能。本文采用Abaqus有限元软件建立了一面... 详细信息

蒸压加气混凝土墙体(ACC)作为一种轻质高强环保的围护结构是传统砖墙优质的替代物。但由于过低的抗拉强度,在各种复杂受力工况下,蒸压加气混凝土墙板易于开裂,进而影响建筑美观以及其保温抗渗性能。本文采用Abaqus有限元软件建立了一面由蒸压加气混凝土砖堆砌而成的墙体模型,分析了其在风荷载与梁挠度变形作用下的应力分布以及裂缝扩展情况。给实际工程的裂缝防护措施提供理论依据。

关键词：蒸压加气混凝土砌块墙体开裂 Abaqus有限元抗风

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铁路隧道洞渣环境危害识别与处理研究

铁路节能环保与安全卫生 2020年第2期10卷 10-13页

作者：刘珺赵泽亚中国铁道科学研究院集团有限公司节能环保劳卫研究所北京100081

修建山区铁路桥隧比高,地质条件复杂,合理处置隧道洞渣是一项重要的环境保护工作。通过对隧道洞渣环境危害类型的分析,总结提出洞渣环境危害的常规和快速检测方法。对不能综合利用的洞渣,根据其类型及环境危害检测结果,选择合适的弃渣... 详细信息

修建山区铁路桥隧比高,地质条件复杂,合理处置隧道洞渣是一项重要的环境保护工作。通过对隧道洞渣环境危害类型的分析,总结提出洞渣环境危害的常规和快速检测方法。对不能综合利用的洞渣,根据其类型及环境危害检测结果,选择合适的弃渣场进行堆置处理。特殊弃渣应根据其危害特性选择适宜的处理方法,以防止产生环境危害和污染。

关键词：隧道洞渣环境危害环境监测

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加强化学实验室安全管理的思考

铁路节能环保与安全卫生 2023年第1期13卷 61-64页

作者：姜坤赵泽亚刘珺中国铁道科学研究院集团有限公司节能环保劳卫研究所北京100081

化学实验室涉及种类庞杂的化学药品及各种各样的实验仪器,一旦实验人员工作过程失慎,易造成人员伤亡及经济损失。通过研究已发生的实验室安全事故典型案例,结合实际工作,从安全管理责任制、安全管理制度、实验人员安全意识与安全培训、... 详细信息

化学实验室涉及种类庞杂的化学药品及各种各样的实验仪器,一旦实验人员工作过程失慎,易造成人员伤亡及经济损失。通过研究已发生的实验室安全事故典型案例,结合实际工作,从安全管理责任制、安全管理制度、实验人员安全意识与安全培训、化学试剂库安全管理及实验室设施等对易导致化学实验室安全事故发生的主要风险点进行识别分析,提出实验室安全管理路径与措施,即健全实验室安全责任制、完善实验室安全管理制度、加强实验室人员安全培训和试剂库管理、构建安全考核体系。

关键词：化学实验室安全管理风险识别

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我国科技期刊评价发展脉络及研究展望

科技进步与对策 2013年第16期30卷 125-128页

作者：杨泽亚赵迎红武汉大学新闻学院湖北武汉430072 武汉理工大学湖北武汉430070

基于我国科技期刊评价发展历程,将我国的期刊评价模式划分为政府主导、行业主导和专业研究机构主导3种模式,并根据期刊研究中的文献计量学应用,将我国的期刊评价研究分为3个阶段,进而提出我国科技期刊评价研究的不足及未来展望。

关键词：科技期刊评价发展历程主导模式研究方向