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Engineering biomimetic epigenetic nanoinducer improves cancer immunotherapy

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Science China Chemistry 2021年第12期64卷 2055-2056页

作者： yuliang zhao National Center for Nanoscience and Technology Beijing100190China

Immunotherapy such as immune checkpoint blockade(ICB)and adoptive cell transfer is a revolutionary advance in the field of cancer therapy by providing clinical benefits in longterm tumor growth control and recurrence *** progress is also being made in the other immunotherapeutic strategies including anticancer vaccines and cytokine supplementary therapies.

关键词： cancer clinical immunotherapy

Solidifying framework nucleic acids

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Science China Chemistry 2018年第12期61卷 1481-1482页

作者： yuliang zhao Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Excellence Center for Nanosciences Chinese Academy of SciencesNational Center for Nanosciences and Technology of China

Living organisms have developed their unique strategies during the natural evolution for building hard tissues with minerals,including silica,calcium carbonate,calcium phosphate,and ferric oxide [1].Such biomineralized materials generally have complex hierarchical structures with excellent mechanical *** bioinspired approaches have led to the creation of well-defined synthetic structural materials ranging from micro to macro scales,the rational design of discrete biomimetic structures at the nanoscale remains a grand challenge.

关键词： Solidifying framework nucleic acids

Bottom-up construction of highly ordered mesoporous graphene frameworks

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Science Bulletin 2015年第22期60卷 1962-1963页

作者： yuliang zhao National Center for Nanosciences and Technology of China

Graphene,a two-dimensional(2D)sheet of carbon atoms,has attracted increasingly greater attention since its first isolation in 2004[1].Apart from the excellent electrical conductivity,graphene also possesses an exceptionally high specific surface area(*2,630 m2/g),which makes it particularly suitable for applications in electrochemical energy storage devices such as lithium-ion batteries(LIBs)and supercapacitors[2,3].However,graphene sheets

关键词：石墨有序介孔框架碳原子导电性表面积二维分离

Sensing system for mimicking cancer cell–drug interaction

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Science Bulletin 2015年第13期60卷 1218-1219页

作者： yuliang zhao National Center for Nanosciences and Technology of China

Biomarker discovery for early detection and therapy of diseases has been blooming for the past two *** the identification of new biomarkers,research and development of sensing platforms has started to become more urge... 详细信息

关键词：传感系统药物相互作用癌细胞生物标志物模拟实验室

2D graphdiyne materials:challenges and opportunities in energy field

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Science China Chemistry 2018年第7期61卷 765-786页

作者： Yurui Xue yuliang Li Jin Zhang Zhongfan Liu yuliang zhao CAS Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190China Center for Nanochemistry College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China National Center for Nanoscience and Technology Chinese Academy of SciencesBeijing 100190China

Graphdiyne(GDY),a novel two-dimensional(2D)carbon allotrope featuring one-atom-thick planar layers of sp andhybridized carbon network,is a rapidly rising star on the horizon of materials *** of its unparalleled structural,electronic,chemical and physical properties,it has been receiving unprecedented increases from fundamental studies to practical applications,particularly the field of energetic *** this review,we aim at providing an up-to-date comprehensive overview on the state-of-the-art research into GDY,from theoretical studies to the key achievements in the development of new GDY-based energetic materials for energy storage and *** reviewing the state-of-the-art achievements,we aim to address the benefits and issues of GDY-based materials,as well as highlighting the existing key challenges and future opportunities in this exciting field.

关键词： graphdiyne semiconductor two-dimensional carbon materials nanostructure

Nanotechnology in the programmed cell therapy:nowhere to escape of cancer

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Science Bulletin 2016年第1期61卷 45-47页

作者： Jinxia Li yuliang zhao CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanosciences and Technology

For lymphomas,the transport of chemotherapeutic drugs usually meets physical barriers to the lymph nodes where disseminated tumor cells frequently *** new findings show that autologous T cells as live vectors combined with nanotechnology-based drug delivery can provide a novel opportunity for the improved chemotherapy toward lymphomas.

关键词：纳米技术细胞疗法程序性癌症化疗药物肿瘤细胞淋巴瘤淋巴结

Estimating Design Loads with Environmental Contour Approach Using Copulas for an Offshore Jacket Platform

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Journal of Ocean University of China 2020年第5期19卷 1029-1041页

作者： zhao yuliang LIU Dahui DONG Sheng College of Engineering Ocean University of ChinaQingdao 266100China CIMC Offshore Engineering Institute Co. Ltd.Yantai 264670China

Jacket-type offshore platforms are widely used for oil, gas field, and energy development in shallow water. The design of a jacket structure is highly dependent on target environmental variables. This study focuses on a strategy to estimate design loads for offshore jacket structures based on an environmental contour approach. In addition to the popular conditional distribution model, various classes of bivariate copulas are adopted to construct joint distributions of environmental variables. Analytical formulations of environmental contours based on various models are presented and discussed in this study. The design loads are examined by dynamic response analysis of jacket platform. Results suggest that the conditional model is not recommended for use in estimating design loads in sampling locations due to poor fitting results. Independent copula produces conservative design loads and the extreme response obtained using the conditional model are smaller than those determined by copulas. The suitability of a model for contour construction varies with the origin of wave data. This study provides a reference for the design load estimation of jacket structures and offers an alternative procedure to determine the design criteria for offshore structures.

关键词： design loads jacket platform joint probability distribution conditional model copula theory environmental contour method

Probabilistic Methods for Reliability Assessment of Floating Structures Based on Extreme Wave Simulation

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Journal of Ocean University of China 2022年第2期21卷 291-305页

作者： zhao yuliang CHU Xinjie DONG Sheng College of Engineering Ocean University of ChinaQingdao 266100China Drilling Technology Research Institute of Shengli Petroleum Engineering Corporation Limited SINOPECDongying 257017China

With the increasing application of floating platforms in deep waters and harsh environments,a proper assessment of the reliability of floating structures is important to ensure that these structures can operate safely during their design *** study outlines a practical methodology for reliability analysis of a semi-submersible platform based estimating the probability distribution of the extreme response in rough sea conditions(survival conditions).The Constrained NewWave(CNW)theory combined with Monte Carlo simulations was first applied to simulate the random wave surface elevation process in the time domain.A Gumbel distribution was the best fitting to describe the dynamically sensitive extreme response statistics under extreme waves(drift and mooring tension).The derived probability distribution of the extreme response was subsequently used in estimation of the associated limit state func-tion,and a reliability analysis of the floating structure was conducted using the Monte Carlo method.A semi-submersible platform in a water depth of 1500 m subjected to extreme wave loads was used to demonstrate the efficiency of the proposed *** probability of failure of the semi-submersible when considering mooring lines tension is greater than considering drift.

关键词： reliability assessment floating structure Constrained NewWave theory Monte Carlo simulation extreme response

A smart DNA nanodevice for ATP-activatable bioimaging and photodynamic therapy

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Science China Chemistry 2020年第10期63卷 1490-1497页

作者： Bei Liu Rui Ma Jian zhao yuliang zhao Lele Li School of Science Minzu University of ChinaBeijing 100081China CAS Key Laboratoty for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China GBA Research Innovation Institute for Nanotechnology Guangdong 510700China

Rational design of activatable photosensitizers for controlled generation of singlet oxygen remains a challenge for precise photodynamic therapy(PDT).Herein,we present an aptamer-based nanodevice for adenosine 5′-triphosphate(ATP)-activatable bioimaging and *** nanodevice is constructed by modifying ATP-responsive duplex DNA units and polyethylene glycol on the surface of a gold nanoparticle(AuNP)through the thiolate-Au *** DNA units were designed by the hybridization of the ATP aptamer strand with a methylene blue(MB)-modified complementary DNA(cDNA).The close proximity of MB to the surface of AuNP results in the low photodynamic activity of MB(OFF state).Once internalized into cancer cells,the ATP-binding induced conformation switch of aptamer strand leads to the release of the MB-bearing DNA strand from AuNPs,resulting in the activatable generation of singlet oxygen under light irradiation(ON state).We demonstrate that the DNA nanodevice represents a promising platform for ATP-responsive bioimaging and specific PDT in vitro and in *** work highlights a potential way for specific tumor diagnosis and therapy.

关键词： DNA nanotechnology ATP-activatable photodynamic therapy bioimaging