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The Multifaceted Roles of TAM Receptors during Viral Infection

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Virologica Sinica 2021年第1期36卷 1-12页

作者： zhao-yang wang Pei-Gang wang Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100093China

Tyro3,Axl,and Mertk(TAM)receptors play multiple roles in a myriad of physiological and pathological processes,varying from promoting the phagocytic clearance of apoptotic cells,sustaining the immune and inflammatory homeostasis,maintaining the blood-brain barrier(BBB)integrity and central nervous system(CNS)homeostasis,to mediating cancer malignancy and *** arrest-specific protein 6(Gas6)and protein S(Pros1)are the two ligands that activate TAM ***,TAM receptors have been reported to mediate cell entry and infection of multitudinous enveloped viruses in a manner called apoptotic ***,TAM receptors are revitalized during viral entry and infection,which sequesters innate immune and inflammatory responses,facilitating viral replication and immune ***,accumulating evidence have now proposed that TAM receptors are not required for the infection of these viruses in *** addition,TAM receptors protect mice against the CNS infection of neuroinvasive viruses and relieve the brain lesions during *** protective effects are achieved through maintaining BBB integrity,attenuating proinflammatory cytokine production,and promoting neural cell *** receptors also regulate the programmed cell death modes of virus-infected cells,which have profound impacts on the pathogenesis and outcome of ***,we systematically review the functionalities and underlying mechanisms of TAM receptors and propose the potential application of TAM agonists to prevent severe viral encephalitis.

关键词： Axl Tyro3 Mertk Virus Infection

Gold-Hydrogen Nanoclusters:Atom-Precise Model to Unveil Catalytic Mechanism and Growth Process of Gold Nanoparticles

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Chinese Journal of Chemistry 2020年第6期38卷 663-664页

作者： zhao-yang wang Shuang-Quan Zang College of Chemistry Zhengzhou UniversityZhengzhouHenan 450001China

Gold nanoclusters show high catalytic performance in various chemical reactions including the hydrogenation and hydrogen evolution *** involved gold clusters is the ideal model to investigate the hydrogen-gold cluster interactions,the influence of H atoms on the electronic structures of the gold clusters,the particle growth process,and the catalytic *** paper highlights the pioneering experimental and theoretical works in the gold-hydrogen cluster studies,and overviews the existing challenges.

关键词： mechanism. clusters cluster

Detecting Anomalous Bus-Driving Behaviors from Trajectories

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Journal of Computer Science & Technology 2020年第5期35卷 1047-1063页

作者： zhao-yang wang Bei-Hong Jin Tingjian Ge Tao-Feng Xue State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Computer Science University of Massachusetts LowellLowellMA 01854U.S.A.

In urban transit systems,discovering anomalous bus-driving behaviors in time is an important technique for monitoring the safety risk of public transportation and improving the satisfaction of *** paper proposes a two-phase approach named Cygnus to detect anomalous driving behaviors from bus trajectories,which utilizes collected sensor data of smart phones as well as subjective assessments from bus passengers by crowd *** optimizing support vector machines,Cygnus discovers the anomalous bus trajectory candidates in the first phase,and distinguishes real anomalies from the candidates,as well as identifies the types of driving anomalies in the second *** improve the anomaly detection performance and robustness,Cygnus introduces virtual labels of trajectories and proposes a correntropy-based policy to improve the robustness to noise,combines the unsupervised anomaly detection and supervised classification,and further refines the classification procedure,thus forming an integrated and practical *** experiments are conducted on real-world bus *** experimental results demonstrate that Cygnus detects anomalous bus-driving behaviors in an effective,robust,and timely manner.

关键词： anomaly detection bus trajectory crowd sensing bus-driving safety

Mixed-cation chiral perovskites displaying warm-white circularly polarized luminescence

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Science China Chemistry 2023年第5期66卷 1425-1434页

作者： Hua-Li Liu Hua-yang Ru Meng-En Sun zhao-yang wang Shuang-Quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China

Chiral perovskites with exceptional structural flexibility and optoelectrical properties are regarded as promising materials for optoelectronic and spintronic ***,the effects of achiral organic ligands on the chiroptical activity of chiral perovskites have been rarely ***,we present four one-dimensional lead bromide perovskites R-/S-(AMP)_(2)Pb_(3)Br_(10)(1-R and 1-S)with mono-cation and R-/S-AMP(DMA)Pb Br_(5)(2-R and 2-S)with mixed-cation templated by chiral R-/S-2-aminomethylpyrrolidine(R-/S-AMP)and achiral dimethylammonium(DMA).All four compounds demonstrate broadband emissions from self-trapped excitons(STEs).Derived from the stronger chirality transfer synergistically induced by achiral DMA,amplified bathochromically-shifted circular dichroism signals and strong warm-white circularly polarized emissions have been observed in 2-R and *** mixed-cation structural engineering provides a new route toward developing chiral perovskites for optoelectronic applications.

关键词： chiral perovskites achiral cations chirality transfer circular dichroism circularly polarized luminescence

Effects of recrystallization on the low cycle fatigue behavior of directionally solidified superalloy DZ40M

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Rare Metals 2008年第4期27卷 425-428页

作者： zhao yang wang Lei LI Hongyun YU Teng LIU yang Key Laboratory of the Ministry of Education of China for Anisotropy and Texture of Materials Northeastern University Shenyang 110004 China

The effects of recrystallization on low cycle fatigue behavior were investigated on directionally solidified Co-base superalloy DZ40M. Optical microscopy and SEM were used to examine the microstructure and fracture surface of the specimens. The mechanical testing results demonstrated that the low cycle fatigue property of DZ40M significantly decreased with the partial recrystallization. Fatigue cracks initiate near the carbides and the grain boundaries with slip-bands. Both the fatigue crack initiation and propagation can be accelerated with the occurrences of recrystallized grain boundaries.

关键词： Co-base superalloy low cycle fatigue recrystallization crack initiation crack propagation

Axial length/corneal radius of curvature ratio and refractive development evaluation in 3-to 4-year-old children: the Shanghai Pudong Eye Study

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 1021-1026页

作者： Ke-Ke zhao Yuan yang Hong wang Lu Li zhao-yang wang Fan Jiang Ji-Fang Qu Shanghai Children’s Medical Center Shanghai Jiao Tong University School of MedicineShanghai 200127China Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China

AIM: To measure and analysis axial length(AL)/corneal radius of curvature(CRC) ratio and other refractive parameters, provide a medical reference range for refractive development evaluation and earlier visual impairment screening of 3 to 4 y kindergarten ***: Between April and June 2017, a total of 4350 participants aged 3-to 4-year-old(8700 eyes) from 10 cluster random sampling kindergartens in Shanghai, Pudong District were involved. According to the measurement and analysis of the unaided visual acuity(VA), AL, CRC, AL/CRC ratio, astigmatism and other refractive parameters, the data distribution and reference range were ***: Uncorrected VA of examined children was 0.23±0.08(logMAR, mean±SD) [95% confidence interval(CI) range ≤0.36];AL was 22.10±0.79 mm(95%CI 20.55-23.65);CRC was 7.86±0.26 mm(95%CI, 7.35-8.37);AL/CRC ratio was 2.81±0.12(95%CI, 2.57-3.05). The median of astigmatism was-0.5 D, a total of 56.3% had astigmatism -1.50 D;71% were astigmatism with the rule. Eye-specific analyses were conducted. Statistical difference of VA was in right and left eyes. There were no significant differences between two eyes of AL, CRC, AL/CRC ratio and astigmatism(P>0.05).CONCLUSION: VA and AL/CRC ratio reference could be used to assess refractive development in children and screening uncorrected refractive errors or amblyopia. Astigmatism needs to be considered in the diagnosis.

关键词： children axial length/corneal radius of curvature ratio refractive development visual impairment reference

Axl Alleviates Neuroinflammation and Delays Japanese Encephalitis Progression in Mice

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Virologica Sinica 2021年第4期36卷 667-677页

作者： zhao-yang wang Zi-Da Zhen Dong-Ying Fan Pei-Gang wang Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100093China

Japanese encephalitis virus(JEV)is a mosquito-borne flavivirus,which causes the most commonly diagnosed viral encephalitis named Japanese encephalitis(JE)in the world with an unclear ***,a receptor tyrosine kinase from TAM family,plays crucial role in many inflammatory *** have previously discovered that Axl deficiency resulted in more severe body weight loss in mice during JEV infection,which we speculate is due to the anti-inflammatory effect of Axl during ***,the role of Axl in regulating the neuroinflammation and brain damage during JE has not been investigated *** this study,by using Axl deficient and heterozygous control mice,we discovered that Axl deficient mice displayed accelerated JE progression and exacerbated brain damage characterized by increased neural cell death,extended infiltration of inflammatory cells,and enhanced production of pro-inflammatory cytokines,in comparison to control ***,consistent with our previous report,Axl deficiency had no impact on the infection and target cell tropism of JEV in *** together,our results suggest that Axl plays an anti-inflammatory and neuroprotective role during the pathogenesis of JE.

关键词： Axl Japanese encephalitis virus(JEV) Inflammation Cytokine

Traumatic endophthalmitis and the outcome after vitrectomy in young children

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 406-411页

作者： Ya-Li Zhou Yi-Xiao wang Teng-Teng Yao Yuan yang zhao-yang wang Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China

AIM:To explore the traumatic endophthalmitis in young children and the outcome of pars plana vitrectomy(PPV).METHODS:Twenty-two eyes of 22 cases of young children consecutive pediatric traumatic endophthalmitis treated and followed up between September 2014 and May 2018 were *** humor or vitreous samples were taken for bacterial culture and sensitivity *** antibiotics(norvancomycin and ceftazidime)injection,combined with 23-gauge PPV,were administered in 22 *** oil(SO;5000 centistoke)tamponade or perfluoropropane gas(C3F8)was used in all *** outcome measures were best-corrected visual acuity(BCVA)and retinal attachment,the ratio of penetrating injury,and the existence of intraocular foreign ***:The mean age of patients was 6.9±2.2(range,3-10)*** injured eyes suffered from penetrating ocular injury with retained intraocular foreign body in one *** culture was positive in only 2 *** mean follow-up time was 21.1±4.7(range,12-30)*** the primary PPV,intravitreal antibiotics was administrated in all eyes,SO in 18 eyes,and C3F8 in 4 *** secondary operation of SO removal and C3F8 endotamponade was performed in 16 eyes and a second SO endotamponade due to emulsification of the oil and retinal detachment(RD)was operated in 7 eyes underwent 3 to 11.5 mo after primary PPV.A third operation was done in 7 *** final intraocular pressure(IOP)was 8.9±1.8(range,6.9-11.4)mm *** final BCVAs were 20/200 or better in 5,counting fingers in 2,and light perception to hand movement in 8 ***(66.7%)had retinal injury exhibited worse BCVA(P=0.019,Fisher’s exact test).Eyes underwent SO tamponade exhibited worse final BCVA than that with C3F8 in the primary PPV(P=0.026,Fisher’s exact test).CONCLUSION:Traumatic endophthalmitis in children is generally more severe and associated with more complicated surgical *** patients have retinal injury need multiple operations and the final BCVA is poor

关键词： pediatric penetrating eye injury traumatic endophthalmitis pars plana vitrectomy

Differences and similarities in radial growth of Betula species to climate change

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Journal of Forestry Research 2024年第2期35卷 176-187页

作者： Di Liu yang An zhao Li Zhihui wang Yinghui zhao Xiaochun wang Center for Ecological Research Key Laboratory of Sustainable Forest Ecosystem ManagementMinistry of EducationCollege of ForestryNortheast Forestry UniversityHarbin 150040People’s Republic of China Changan Park in Shijiazhuang Shijiazhuang 050000People’s Republic of China Shijiazhuang Landscape Greening Engineering Project Construction Center Shijiazhuang 050000People’s Republic of China Heilongjiang Institute of Meteorological Science Harbin 150030People’s Republic of China School of Life Qufu Normal UniversityQufu 273100People’s Republic of China

Betula platyphylla and Betula costata are important species in mixed broadleaved-Korean pine(Pinus koraiensis)***,the specific ways in which their growth is affected by warm temperatures and drought remain *** address this issue,60 and 62 tree-ring cores of *** and *** were collected in Yichun,*** dendrochronological methods,the response and adaptation of these species to climate change were examined.A“hysteresis effect”was found in the rings of both species,linked to May–September moisture conditions of the previous *** growth of *** was positively correlated with the standardized precipitation-evapotranspiration index(SPEI),the precipitation from September to October of the previous year,and the relative humidity in October of the previous *** of *** is primarily restricted by moisture conditions from September to *** contrast,*** growth is mainly limited by minimum temperatures in May–June of both the previous and current *** droughts,*** had a faster recovery rate compared to *** the context of rising temperatures since 1980,the correlation between *** growth and monthly SPEI became positive and strengthened over time,while the growth of *** showed no conspicuous *** findings suggest that the growth of *** is already affected by warming temperatures,whereas *** may become limited if warming continues or *** change could disrupt the succession of these species,possibly accelerating the succession of pioneer *** results of this research are of great significance for understanding how the growth changes of birch species under warming and drying conditions,and contribute to understanding the structural adaptation of mixed broadleaved-Korean pine(Pinus koraiensis)forests under climate change.

关键词： Tree rings Betula platyphylla Betula costata Climate response Moving correlation Extreme drought