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A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2324-2340页

作者： Xin Wang Qian Liu Hai-tao Yu Jia-zhao xie Jun-ning zhao Zhi-ting Fang Min Qu Yao Zhang Ying Yang Jian-Zhi Wang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Fundamental Medicine Wuxi School of MedicineJiangnan UniversityWuxiJiangsu 214122China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and PreventionHubei Provincial Academy of Preventive MedicineWuhan 430000China Endocrine Department of Liyuan Hospital Key Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease(AD);however,the fundamental mechanism is *** this study,we found a substantial decline in isocitrate dehydrogenase 3β(IDH3β)levels,a critical tricarboxylic acid cycle enzyme,in AD patients and AD-transgenic mice’s *** investigations demonstrated that the knockdown of IDH3βinduced oxidation-phosphorylation uncoupling,leading to reduced energy metabolism and lactate *** resulting increased lactate,a source of lactyl,was found to promote histone lactylation,thereby enhancing the expression of paired-box gene 6(PAX6).As an inhibitory transcription factor of IDH3β,the elevated PAX6 in turn inhibited the expression of IDH3β,leading to tau hyperphosphorylation,synapse impairment,and learning and memory deficits resembling those seen in *** AD-transgenic mice,upregulating IDH3βand downregulating PAX6 were found to improve cognitive functioning and reverse AD-like ***,our data suggest that impaired oxidative phosphorylation accelerates AD progression via a positive feedback inhibition loop of IDH3β-lactate-PAX6-IDH3β.Breaking this loop by upregulating IDH3βor downregulating PAX6 attenuates AD neurodegeneration and cognitive impairments.

关键词： metabolism Alzheimer impaired

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Multi-objective optimization design of spherical transducer

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Chinese Journal of Acoustics 2024年第1期43卷 113-131页

作者： ZHANG Xi LI Hongguang zhao xie XIONG Hanlin MENG Guang State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240 Kunming Shipbuilding Equipment Research and Test Center Kunming 650051

In order to solve the mixed nonlinear multi-objective optimization problem of discrete/continuous variables of the spherical transducer under the multi-constraint conditions, the electrical-mechanical-acoustic model of the spherical transducer is built based on the equivalent circuit theory. The multi-objective optimization mathematical model of the spherical transducer is constructed. The transmitting sound level, input electric power and mass are taken as the optimization objective functions, and the material property parameters, structural size parameters, frequency range and input voltage are taken as the design variables. Besides, the physical properties such as piezoelectric ceramic depolarization,structural strength limit, power capacity and the value of design variables are taken as constraints. The multi-objective optimization design of the spherical transducer is carried out by using the non-dominated sorting genetic algorithm-II(NSGA-II), and the Pareto front solution set is obtained. The effectiveness of the optimization results is verified by experiments. The results show that the transducer prototype designed and manufactured by the multi-objective optimization method reduces the input power by 32.8% and the mass by 27.4% under the premise of meeting the requirements of the transmitting sound level. The results are of great value to the optimization design of transmitting transducer under severe conditions.

关键词： optimization sorting sound

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Correction:A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimerlike pathology

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3537-3540页

作者： Xin Wang Qian Liu Hai-tao Yu Jia-zhao xie Jun-ning zhao Zhi-ting Fang Min Qu Yao Zhang Ying Yang Jian-Zhi Wang Department of Pathophysiology School of Basic Medicine Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Fundamental Medicine Wuxi School of Medicine Jiangnan University Wuxi Jiangsu 214122 China Co-innovation Center of Neuroregeneration Nantong University Nantong 226000 China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and Prevention Hubei Provincial Academy of Preventive Medicine Wuhan 430000 China Endocrine Department of Liyuan Hospital Key Laboratory of Ministry of Education of China for Neurological Disorders Tongji Medical College Huazhong University of Science and Technology Wuhan 430077 China

After online publication of the article',the authors noticed that,owing to authors'oversight in layer placement within the illustration,Golgi staining images representing both the 5xFAD group and,the 5xFAD+IDH3β_grou... 详细信息

关键词： illustration representing noticed

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Lung cancer metastasis-induced distal esophageal segmental spasm confirmed by individualized peroral endoscopic myotomy:A case report

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3321-3327页

作者： Hong Shi Su-Yu Chen zhao-Fei xie Li-Lin Lin Yan Jiang Department of Endoscopy Center Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFujian Branch of Fudan University Shanghai Cancer CenterFuzhou 350014Fujian ProvinceChina

BACKGROUND Peroral endoscopic myotomy(POEM)has been widely performed as a standard treatment for achalasia;however,its efficacy and safety for treating distal esophageal segmental spasms induced by cancer metastasis remain *** SUMMARY A 72-year-old male was referred to our hospital and complained of progressive dysphagia for two *** revealed a 2 cm long segment esophageal stenosis with intact mucosa and normal *** tomography showed a right upper lung mass,and pathology of the right pleural effusion confirmed the diagnosis of right upper lung adenocarcinoma with multiple rib and mediastinal lymph node metastases and right malignant pleural *** POEM was performed first to alleviate dysphagia,and the final diagnosis was changed to esophageal muscle metastasis arising from lung *** treatment,the patient could eat soft solid food and received multiple rounds of pembrolizumab-combination *** patient’s progression-free survival was approximately 16 *** stable disease was obtained during the 24-month *** The incidence of distal esophageal segmental spasms induced by muscular metastasis arising from lung adenocarcinoma is extremely *** POEM can effectively improve a patient’s nutritional status before subsequent chemotherapy can be combined with immune checkpoint inhibitors.

关键词： Peroral endoscopic myotomy Distal esophageal segmental spasm Lung cancer Esophageal metastasis Case report

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清代杨柳青年画仕女服饰溯源与构建规律分析

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服装学报 2024年第4期9卷 324-331页

作者：王雪婷谢朝南开大学文学院天津300071

为探索清代杨柳青年画中的仕女服饰来源与构建规律,以清代杨柳青年画中的仕女服饰为研究对象,选取研究样本69例,通过对图像资料的研究,溯源辨析服饰形制,归类统计服饰搭配方式,并以袖宽与绲边宽度为例探析清代杨柳青年画的仕女服饰构建... 详细信息

为探索清代杨柳青年画中的仕女服饰来源与构建规律,以清代杨柳青年画中的仕女服饰为研究对象,选取研究样本69例,通过对图像资料的研究,溯源辨析服饰形制,归类统计服饰搭配方式,并以袖宽与绲边宽度为例探析清代杨柳青年画的仕女服饰构建特征与风格流变现象。研究认为,清代杨柳青年画的仕女服饰将清代女性常服、古装与传统戏曲服装混用搭配,且年画艺人基于构建逻辑将这些超越时代与现实意义的服饰元素组合成“理想仕女原型”,给人尽善尽美的视觉感受,呼应集体审美共识。

关键词：杨柳青年画仕女服饰服饰形制服饰搭配方式

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肺动静脉畸形致急性脑梗死一例

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中国现代神经疾病杂志 2024年第5期24卷 398-402页

作者：解燕昭韩凝赵景茹魏娜首都医科大学附属北京天坛医院神经病学中心 100070 河北省人民医院神经内科石家庄050051

患者女性,70岁,主因突发性意识丧失伴右侧肢体无力、言语不能34小时,于2021年6月10日下午16∶00收入首都医科大学附属北京天坛医院。患者入院前1天6∶00突发意识丧失致跌倒,急诊至当地医院,体格检查无法配合,仅可见右侧肢体无自主活动,... 详细信息

患者女性,70岁,主因突发性意识丧失伴右侧肢体无力、言语不能34小时,于2021年6月10日下午16∶00收入首都医科大学附属北京天坛医院。患者入院前1天6∶00突发意识丧失致跌倒,急诊至当地医院,体格检查无法配合,仅可见右侧肢体无自主活动,头部CT未见脑出血,发病后2小时美国国立卫生研究院卒中量表(NIHSS)评分20分,遂予rt-PA静脉溶栓(0.90 mg/kg),意识转清,NIHSS评分降至9分,右侧肢体肌力3级,有自主活动,但无法言语;发病后6小时再次出现意识障碍,复查头部CT仍无脑出血,遂转至我院急诊(6月9日17∶00)。

关键词：动静脉畸形肺动脉肺静脉脑梗死病例报告

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High-quality genome assemblies for two Australimusa bananas(Musa spp.)and insights into regulatory mechanisms of superior fiber properties

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Plant Communications 2024年第1期5卷 245-261页

作者： Run Zhou Shuo Wang Ni Zhan Weidi He Guiming Deng Tongxin Dou Xi-Tong Zhu Wen-zhao xie Yu-Yu Zheng Chunhua Hu Fangcheng Bi Huijun Gao Tao Dong Siwen Liu Chunyu Li Qiaosong Yang Lingqiang Wang Jia-Ming Song Jiangbo Dang Qigao Guo Ganjun Yi Ling-Ling Chen Ou Sheng Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China

Bananas(Musa spp.)are monocotyledonous plants with high genetic diversity in the Musaceae family that are cultivated mainly in tropical and subtropical *** fruits are a popular food,and the plants themselves have diverse *** genetic groups(genomes)are thought to have contributed to current banana cultivars:Musa acuminata(A genome),Musa balbisiana(B genome),Musa schizocarpa(S genome),and species of the Australimusa section(T genome).However,the T genome has not been effectively ***,we present the high-quality TT genomes of two representative accessions,Abaca(Musa textilis),with high-quality naturalfiber,and Utafun(Musa troglodytarum,Fe’i group),with abundant *** the Abaca and Utafun assemblies comprise 10 pseudochromosomes,and their total genome sizes are 613 Mb and 619 Mb,*** genome analysis revealed that the larger size of the T genome is likely attributable to rapid expansion and slow removal of *** with those of Musa AA or BB accessions or sisal(Agava sisalana),Abacafibers exhibit superior mechanical properties,mainly because of their thicker cell walls with a higher content of cellulose,lignin,and *** of MusaCesA cellulose synthesis genes peaks earlier in Abaca than in AA or BB accessions during plant development,potentially leading to earlier cellulose accumulation during secondary cell wall *** Abaca-specific expressed gene MusaMYB26,which is directly regulated by MusaMYB61,may be an important regulator that promotes precocious expression of secondary cell wall ***,MusaWRKY2 and MusaNAC68,which appear to be involved in regulating expression of MusaLAC and MusaCAD,may at least partially explain the high accumulation of lignin in *** work contributes to a better understanding of banana domestica-tion and the diverse genetic resources in the Musaceae family,thus providing resources for Musa genetic improvement.

关键词： Australimusa bananas T genome Musaceae evolution structural variations fiber

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4种药剂对灵川县红火蚁的田间防治效果

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湖北植保 2024年第3期 22-23,27页

作者：谢钊尔灵川县农业科学研究所广西灵川541299

为筛选适宜的红火蚁防治药剂,在灵川县对4种登记用于红火蚁防治的杀虫剂进行田间效果对比试验。结果表明,0.6%高效氯氰菊酯粉剂对蚁巢和工蚁的速效性最好,药后5 d防治效果高达80.0%和83.9%;0.1%茚虫威饵剂有较好的持效性,药后30 d仍均有... 详细信息

为筛选适宜的红火蚁防治药剂,在灵川县对4种登记用于红火蚁防治的杀虫剂进行田间效果对比试验。结果表明,0.6%高效氯氰菊酯粉剂对蚁巢和工蚁的速效性最好,药后5 d防治效果高达80.0%和83.9%;0.1%茚虫威饵剂有较好的持效性,药后30 d仍均有100%的防治效果。综上,0.1%茚虫威饵剂是较为理想的红火蚁田间防治药剂,0.6%高效氯氰菊酯粉剂可用于红火蚁的应急防治。

关键词：灵川县红火蚁防治效果

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基于多智能体近端策略优化的多信道动态频谱接入

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电子学报 2024年第6期52卷 1824-1831页

作者：陈平平张旭谢肇鹏丘毓萍方毅福州大学先进制造学院福建晋江362251 福州大学物理与信息工程学院福建福州350108 广东工业大学信息工程学院广东广州510006

为了在多用户多信道通信场景中应用动态频谱接入(Dynamic Spectrum Access,DSA)技术提高通信效率,保证用户公平,本文基于多智能体近端策略优化(Multi-Agent Proximal Policy Optimization,MAPPO)提出了MAPPO-DSA算法.该算法首先针对单... 详细信息

为了在多用户多信道通信场景中应用动态频谱接入(Dynamic Spectrum Access,DSA)技术提高通信效率,保证用户公平,本文基于多智能体近端策略优化(Multi-Agent Proximal Policy Optimization,MAPPO)提出了MAPPO-DSA算法.该算法首先针对单信道接入在多个信道同时空闲时存在的频谱浪费问题,使用多信道接入作为解决方案.同时,多信道接入导致状态空间与动作空间指数增长,计算成本高,学习难度大.为此本文引入MAPPO深度强化学习(Deep Reinforcement Learning,DRL)算法,在复杂环境中高效学习和优化接入策略.通过设计优化MAPPO中观测及奖励等强化学习要素和共享网络参数来保证用户公平.最后,在不同场景下的实验结果表明,所提出的MAPPO-DSA能够学习到近似最优的接入策略,部分场景中的网络吞吐量逼近理论上限,显著优于现有算法,且有效保证用户公平.

关键词：动态频谱接入深度强化学习多智能体近端优化多信道接入

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Two-dimensional linear connected-k system with trinary states and its reliability

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Journal of Systems Engineering and Electronics 2011年第5期22卷 866-870页

作者： Xian zhao Wei zhao Weijuan xie School of Management and Economics Beijing Institute of Technology Beijing 100081 P. R. China

Existing studies about two-dimensional consecutivek-out-of-n： F system is dealt with two states （either component or system）： working or failure. A new model for two-dimensional linear consecutive-k-out-of-n： F system is proposed, in which the components and systems can be at any of the three states： full working, derating working, and failure. Furthermore, two engineer- ing concrete instances of the new system are given. By using the finite Markov chain imbedding approach, the system reliability is presented in a unified formula with the product of matrices for the case of independent and identically distributed component states which can be extended to the independent but non-identical case easily. Finally, an example is given to illustrate the effectiveness of the above approach and tractability of various problems.

关键词： reliability two-dimensional systems trinary states

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