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中国肿瘤临床 2007年第1期34卷 56-59页

作者：赵晓东张毅北京医院妇产科北京市100730

子宫内膜癌是发病率最高的妇科恶性肿瘤,急需治疗规范化。但是,治疗上有很多争议。比如,手术范围、术后辅助治疗方式方法等。近几年这些方面的临床试验和探索很多。本文综述这些治疗进展,希望对该病的标准化治疗提供帮助。

关键词：子宫内膜癌治疗手术放疗化疗内分泌治疗

毒蛇咬伤致皮肤坏死性感染的危险因素及预测模型研究

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临床急诊杂志 2024年第3期25卷 110-114页

作者：郝嘉宁王宇宏王文博戴秋婷朱明月李伦超赵晓东刘双庆解放军总医院第四医学中心急诊医学科北京100037 联勤保障部队天津康复疗养中心内分泌科三峡大学第二临床附属医院心内科

目的:分析毒蛇咬伤致皮肤坏死性感染的危险因素,并构建预测模型。方法:回顾性分析99例毒蛇咬伤患者的临床资料,确定是否发生皮肤坏死性感染为结局,采用单因素及多因素logistics回归分析构建预测模型并予以验证。结果:蛇伤严重度评分、... 详细信息

目的:分析毒蛇咬伤致皮肤坏死性感染的危险因素,并构建预测模型。方法:回顾性分析99例毒蛇咬伤患者的临床资料,确定是否发生皮肤坏死性感染为结局,采用单因素及多因素logistics回归分析构建预测模型并予以验证。结果:蛇伤严重度评分、血糖及D-二聚体水平为毒蛇咬伤致皮肤坏死性感染的危险因素(均P<0.05)。利用上述危险因素构建列线图预测模型,预测发生皮肤坏死性感染的曲线下面积分别为0.92;预测模型的校准曲线在两组中均表现出较好的一致性。结论:蛇伤严重度评分、血糖及D-二聚体水平是毒蛇咬伤后发生皮肤坏死性感染的危险因素,该模型可为临床决策提供参考。

关键词：毒蛇咬伤坏死性感染危险因素预测模型

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一种低功耗K频段低噪声放大器

电讯技术 2021年第5期61卷 634-639页

作者：赵晓冬中国西南电子技术研究所成都610036

基于0.13μm锗硅(SiGe)双极型互补金属氧化物(Bipolar Complementary Metal Oxide Semiconductor,BiCMOS)工艺,设计制作了一种高增益低功耗K频段低噪声放大器(Low Noise Amplifier,LNA),通过优化晶体管尺寸及利用硅通孔设计高品质因数... 详细信息

基于0.13μm锗硅(SiGe)双极型互补金属氧化物(Bipolar Complementary Metal Oxide Semiconductor,BiCMOS)工艺,设计制作了一种高增益低功耗K频段低噪声放大器(Low Noise Amplifier,LNA),通过优化晶体管尺寸及利用硅通孔设计高品质因数射极退化电感,降低了LNA噪声。实测结果表明,在1.6 V偏置条件下,该LNA在20 GHz的噪声系数等于1.94 dB,输入1 dB压缩点等于-29.6 dBm;18~21.3 GHz频率范围内,LNA增益大于23.3 dB,S 11和S 22均小于-10 dB。包含偏置电路功耗在内,芯片功耗仅21 mW,优于其他同等噪声系数的K频段SiGe BiCMOS LNA。该LNA可应用于卫星通信等K频段低功耗接收机系统。

关键词：卫星通信 K频段低噪声放大器低功耗高品质因数硅通孔电感

miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK

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Oncology Research 2024年第5期32卷 933-941页

作者： XIAOXI WANG YANFEI JIA QIANG LI QIANG YANG YINGFENG LIU BEIFENG WEI XIANG NIU YINJIE ZHANG xiaodong LUO ZIYU zhao PENG WANG Department of Neurosurgery Tianshui First People’s HospitalTianshuiChina Department of Neurosurgery The Second Affiliated Hospital of Lanzhou UniversityLanzhouChina

MicroRNA(miR)-200b-3p has been associated with many tumors,but its involvement in pituitary adenoma is *** study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for *** was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and *** well,the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene *** expression of miR-200b-3p in clinical samples was analyzed by in situ *** of the miR-200b-3p inhibitor and small interfering-RECK(si-RECK)was verified by ***3 cell viability and proliferation were detected using CCK8 and EdU *** was detected by flow cytometry and western *** healing and Transwell assays were used to detect cell migration and *** effects of miR-200b-3p and RECK on GH3 cells were verified using salvage ***-200b-3p was highly expressed in pituitary tumor *** of miR-200b-3p inhibited cell proliferation promoted cell apoptosis,inhibited invasion and migration,and inhibited the expression of matrix ***,miR-200b-3p negatively regulated *** expression of RECK in pituitary adenoma tissues was lower than that in neighboring ***-RECK rescued the function of miR-200b-3p inhibitors in the above cellular behaviors,and miR-200b-3p accelerated the development of pituitary adenoma by negatively regulating RECK *** summary,this study investigated the molecular mechanism by which miR-200b-3p regulates the progression of pituitary adenoma through the negative regulation of *** findings provide a new target for the treatment of pituitary adenoma.

关键词： Pituitary adenomas miR-200b-3p RECK Matrix metalloproteinase

A probe into the acid deposition mitigation path in China over the last four decades and beyond

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National Science Review 2024年第4期11卷 84-92页

作者： Qian Yu xiaodong Ge Haotian Zheng Jia Xing Lei Duan Dongwei Lv Dian Ding zhaoxin Dong Yisheng Sun Posch Maximilian Danni Xie Yu zhao Bin zhao Shuxiao Wang Jan Mulder Thorj?rn Larssen Jiming Hao State Key Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua University State Key Laboratory of Pollution Control &Resource Reuse and School of the Environment Nanjing University State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex School of EnvironmentTsinghua University International Institute for Applied System Analysis(IIASA) School of Land Engineering Chang'an University Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life Sciences Norwegian Institute for Water Research

China currently has the highest acid deposition globally, yet research on its status, impacts, causes and controls is lacking. Here, we compiled data and calculated critical loads regarding acid deposition. The results showed that the abatement measures in China have achieved a sharp decline in the emissions of acidifying pollutants and a continuous recovery of precipitation p H, despite the drastic growth in the economy and energy consumption. However, the risk of ecological acidification and eutrophication showed no significant decrease. With similar emission reductions, the decline in areas at risk of acidification in China(7.0%) lags behind those in Europe(20%) or the USA(15%). This was because, unlike Europe and the USA, China's abatement strategies primarily target air quality improvement rather than mitigating ecological impacts. Given that the area with the risk of eutrophication induced by nitrogen deposition remained at 13%of the country even under the scenario of achieving the dual targets of air quality and carbon dioxide mitigation in 2035, we explored an enhanced ammonia abatement pathway. With a further 27% reduction in ammonia by 2035, China could largely eliminate the impacts of acid deposition. This research serves as a valuable reference for China's future acid deposition control and for other nations facing similar challenges.

关键词： acid deposition critical loads acidification eutrophication ammonia abatement

Intrauterine Adhesions (IUAs) or Asherman’s Syndrome (AS) and the Stem Cells Treatment: A Systemic Review and Meta-Analysis

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Journal of Biosciences and Medicines 2021年第1期9卷 105-118页

作者： Sichen Zhang Ying Mao xiaodong zhao Huiwen Zhang Min Ma Xingbo Long Shaowei Wang Department of Gynecology and Obstetrics Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China Peking Union Medical College Chinese Academy of Medical Sciences Santiao Beijing China National Cancer Center/Cancer Hospital Beijing China

Background: Intrauterine Adhesions (IUAs) or Asherman’s Syndrome (AS) usually contains symptoms such as decreased menstrual flow or even amenorrhea, chronic pelvic pain, recurrent abortion and infertility. The current treatment of IUAs includes hysteroscopic adhesiolysis, oral hormone and biological barriers, but each of them has limitation. Stem cell therapy may be an expanding field seeking for therapy in IUAs. Objective: We will discuss current advances in stem cell therapy as a treatment for endometrial pathophysiology. Materials and Methods: We search on PubMed, Embase and Cochrane library and select several keywords on researches, then review the cell biology theories and animal experiments, finally do meta-analysis in human clinical trials. Results: 77 articles on PubMed, 71 articles on Embase and 17 articles on Cochrane Library, as a result, 37 articles are included under the criteria, which are intrauterine adhesions (IUAs), Asherman’s Syndrome (AS), cell therapy, stem cells, bone marrow stem cells, clinical trials, recent 10 years and human or animal experiments. The included criteria: original articles, cohort study, case control study, animal experiments, human clinical trials, high quality, 10 years recent. The excluded articles are case reports, meeting reports, low quality or more than 10 years ago. Conclusion: Stem cell may be a new therapeutic schedule for IUAs in the future clinical treatment, but it is necessary to compare it with traditional therapy such as oral hormone, also the development of random clinical tests should proceed. For clinical treatment on IUAs, stem cells could be a new choice.

关键词： Intrauterine Adhesions IUA Asherman’s Syndrome Stem Cells Therapy Infertility Meta-Analysis

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大型汽轮发电机匝间短路保护必要性探讨

电力系统自动化 1999年第11期23卷 39-41页

作者：赵晓东段乃娴北京大唐发电股份有限公司陡河发电厂

介绍了陡河发电厂４例发电机定子绕组短路故障情况，认为发电机定子绕组的同槽同相、发电机制造工艺的缺陷及绝缘材料的老化均可能造成匝间短路，因此有必要装设匝间保护。

关键词：匝间短路保护汽轮发电机大型发电机

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TNT分子印迹聚合物微球的合成与性能研究

高分子学报 2010年第3期20卷 360-365页

作者：杜自卫刘学涌赵小东中国工程物理研究院化工材料研究所绵阳621900

以三硝基甲苯(TNT)为模板分子,EDMA为交联剂,采用沉淀聚合法制备了TNT分子印迹微球.讨论了溶剂用量、模板分子用量、功能单体种类等对分子印迹微球的形貌及吸附性能的影响;利用紫外吸收光谱和BET表征了印迹聚合物微球的结合位点相互作... 详细信息

以三硝基甲苯(TNT)为模板分子,EDMA为交联剂,采用沉淀聚合法制备了TNT分子印迹微球.讨论了溶剂用量、模板分子用量、功能单体种类等对分子印迹微球的形貌及吸附性能的影响;利用紫外吸收光谱和BET表征了印迹聚合物微球的结合位点相互作用与印迹孔穴结构;通过平衡吸附和选择性吸附实验,研究了印迹聚合物微球的吸附性能和选择性识别性能.结果表明,以丙烯酰胺为功能单体制备的分子印迹聚合物为规则的球形,内部含有分子印迹孔穴,微球的粒径为1～2μm.印迹聚合物微球可在30 min内达到吸附平衡,在1 mmol/L的TNT乙醇溶液中,印迹聚合物微球的平衡吸附量为32.5 mmol/kg,对TNT分离系数为25.19,具有较好的特异性吸附能力,并可选择性识别TNT分子.

关键词：分子印迹聚合物微球 TNT 分子识别沉淀聚合

TCR diversity is selectively skewed in T-cell populations of Wiskott-Aldrich syndrome patients

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TCR diversity is selectively skewed in T-cell populations of...

Study of static recrystallization microstructure evolution of 304 stainless steel

第九届全国免疫学学术大会

作者： Junfeng Wu Dawei Liu Wenwei Tu Wenxia Song xiaodong zhao Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical University Department of Paediatrics & Adolescent Medicine LKS Faculty of Medicinethe University of Hong Kong Department of Cell Biology & Molecular Genetics University of MarylandCollege ParkMD 20742U.S.A

Background:Wiskott-Aldrich syndrome(WAS)is a severe disorder characterized by thrombocytopenia,eczema,immunodeficiency,and increased risk of autoimmune disease and lymphoid *** immunodeficiency caused by lack of WAS protein(WASP)expression has been mainly attributed to defective T-cell *** WAS mutations differentially influence the T cell receptor(TCR)diversity of different T-cell subsets is ***:We aimed to identify the degree and the pattern of skewing in the variable region of theβ-chain(Vβ)TCR repertoire in different T-cell subsets from patients with ***:The TCR repertoire diversity in total peripheral T cells,sorted CD4+and CD8+T cells,CD45RA+(CD45RA+CD45RO-)and CD45RO+(CD45RA-CD45RO+)CD4+and CD8+T cells from patients with WAS and age-matched healthy controls were analyzed and compared,using spectratyping,of complementarity-determining region3(CDR3);and the CDR3 region of TCRβtranscripts in CD45RA+CD4+and CD8+T cells,CD45RO+CD4+T cells,CD8+terminally differentiated effctor memory T cells(Temra)and naive CD8+T(CD8+CD45RO-CCR7+)cells from patients and controls were analyzed and compared by high-throughput sequencing(HTS).Results:The TCR repertoire diversity in CD45RO+CD4+T cells and CD8+Temra of WAS patients was significantly skewed,compared to that in age-matched ***:Our results indicate that WAS gene mutations selectively influence the repertoire development or expansion of CD45RO+(memory)CD4+T cells.

关键词： Wiskott-Aldrich syndrome TCR diversity CDR3 spectratyping high-throughput sequencing

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Study of static recrystallization microstructure evolution o...