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Prediction of the short-term efficacy of anti-VEGF therapy for neovascular age-related macular degeneration using optical coherence tomography angiography

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Eye and Vision 2024年第3期10卷 21-30页

作者： Huixun Jia Bing Lu Zhi zhao Yang Yu Fenghua Wang Minwen Zhou xiaodong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of Medicine100 Hai Ning RoadShanghai200080People’s Republic of China Shanghai Key Laboratory of Ocular Fundus Diseases ShanghaiChina National Clinical Research Center for Eye Diseases ShanghaiChina Shanghai Engineering Center for Visual Science and Photomedicine ShanghaiChina Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases ShanghaiChina Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina

Background To evaluate whether the specific choroidal neovascularization(CNV)characteristics measured using optical coherence tomography angiography(OCTA)can predict the 6-month prognosis of neovascular age-related macular degeneration(nAMD)after anti-vascular endothelial growth factor(anti-VEGF)*** Patients with type 1,type 2,or mixed-type neovascularization(NV)were prospectively *** underwent an initial loading phase of three consecutive monthly intravitreal injections of Conbercept(0.5 mg)and were switched to a pro re nata(PRN)treatment *** images were evaluated for eyes that underwent follow-up assessments for more than 6 *** lesions were manually segmented,and the CNV area,vessel area,greatest vascular caliber(GVC),and greatest linear dimension(GLD)were compared between responders and *** masked graders independently measured the above-mentioned parameters using OCTA,and consistency was assessed using the intraclass correlation coefficient(ICC)*** logistic regression analysis was performed to evaluate the effect of a 3-month change in the CNV area,GLD,and GVC on the 6-month response to anti-VEGF *** Among the 60 eyes of 60 patients with nAMD,39 were responders and 21 were *** proportion of CNV types was significantly different between responders and non-responders(P=0.009).Patients with type 2 or mixed NV seemed more likely to respond to the treatment(28.2%vs.0.0%,and 30.8%vs.23.8%,respectively).The change in GVC showed a significant difference between responders(−4.98±17.17μm)and non-responders(11.01±14.10μm)after three monthly intravitreal anti-VEGF *** logistic regression analysis showed that only the change in GVC remained significant after controlling for baseline GVC,injection number,and CNV type(adjusted OR=1.083;P=0.008).Conclusions Type 2 and mixed-type NV were significantly associated with a better response to anti-VEGF *** i

关键词： Age-related macular degeneration Choroidal neovascularization Optical coherence tomography angiography Anti-VEGF

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Late-stage modification of bioactive compounds:Improving druggability through efficient molecular editing

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1030-1076页

作者： Tongyu Huo Xinyi zhao Zengrui Cheng Jialiang Wei Minghui Zhu xiaodong Dou Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Changping Laboratory Beijing 102206China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Synthetic chemistry plays an indispensable role in drug discovery,contributing to hit compounds identification,lead compounds optimization,candidate drugs preparation,and so *** Nobel Prize laureate James Black emphasized,“the most fruitful basis for the discovery of a new drug is to start with an old drug”***-stage modification or functionalization of drugs,natural products and bioactive compounds have garnered significant interest due to its ability to introduce diverse elements into bioactive compounds *** modifications alter the chemical space and physiochemical properties of these compounds,ultimately influencing their potency and *** enrich a toolbox of chemical modification methods for drug discovery,this review focuses on the incorporation of halogen,oxygen,and nitrogen—the ubiquitous elements in pharmacophore components of the marketed drugs—through late-stage modification in recent two decades,and discusses the state and challenges faced in these *** also emphasize that increasing cooperation between chemists and pharmacists may be conducive to the rapid discovery of new activities of the functionalized ***,we hope this review would serve as a valuable resource,facilitating the application of late-stage modification in the construction of novel molecules and inspiring innovative concepts for designing and building new drugs.

关键词： Late-stage modification Drug space Halogenation Oxygenation Nitrogenation Synthetic chemistry

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Abatacept is effective in Chinese patients with LRBA and CTLA4 deficiency

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Genes & Diseases 2021年第5期8卷 662-668页

作者： Lu Yang Xiuhong Xue Xuemei Chen Junfeng Wu Xi Yang Li Xu Xuemei Tang Mo Wang Huawei Mao xiaodong zhao Chongqing Key Laboratory of Child Infection and Immunity Children’s Hospital of Chongqing Medical UniversityChongqing400015PR China Department of Rheumatology and Immunology Children’s Hospital of Chongqing Medical UniversityChongqing400015PR China Department of Internal Nephrology Children’s Hospital of Chongqing Medical UniversityChongqing400015PR China Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders(Chongqing)China International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing400015PR China

CTLA4 deficiency and LRBA deficiency are a group disorders of immune dysregula-tion that affect CTLA4 *** patients mainly present with autoimmunity,antibody defi-ciency and recurrent *** we reported three Chinese patients with LRBA and CTLA4 *** all presented with chronic diarrhea,hypokalemia,organomegaly,recurrent in-fections,and *** Treg cells and increased percentage of circu-lating follicular helper T(cTfh)cells were revealed in these *** steroid and immunoglobulin therapy were given,the enteropathy was ***,abatacept treatment was provided to these *** showed a marked improvement of enteropathy and gastrointestinal endoscopy showed alleviated inflammatory lesion and follicular ***,the frequency of cTfh cells was reduced after abatacept *** together,targeted therapy with abatacept is a promising treatment modality for patients with LRBA and CTLA4 *** findings also suggest that the frequency of cTfh cells could serve as a marker for tracking disease activity and the response to abatacept therapy.

关键词： LRBA deficiency CTLA4 deficiency Target therapy Abatacept Efficacy

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Obliteration of empty sella for therapy of empty sella syndrome by transsphenoidal and tranfrontal approach

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吉林大学学报(医学版) 1997年第1期 42-45页

作者： zhao xiaodong,Zhu Jianguo,Yang Zhanquan (Department of Otorhinolaryngology,Head and Neck Surgery)

作者报道７例空蝶鞍综合征，其中原发性２例，继发性５例。经蝶窦进路充填法手术治疗５例，经额进路治疗２例。除１例因有原发性脑积水未愈外，余６例治愈。本病与鞍隔缺损、良性颅内高压、长期服用嗅隐亭、垂体手术或放疗后有关。临床... 详细信息

作者报道７例空蝶鞍综合征，其中原发性２例，继发性５例。经蝶窦进路充填法手术治疗５例，经额进路治疗２例。除１例因有原发性脑积水未愈外，余６例治愈。本病与鞍隔缺损、良性颅内高压、长期服用嗅隐亭、垂体手术或放疗后有关。临床以头痛、视力视野损害和垂体功能低下为主要特点。经蝶窦充填法治疗是简单有效的方法。

关键词： Empty sella syndrome Surgery Operation

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基于CiteSpace的中医药治疗围绝经期失眠研究文献可视化分析

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中国中医药图书情报杂志 2024年第5期48卷 171-176页

作者：卞旭东赵晓东陈正光郭浩林于苗杨秀元北京中医药大学东直门医院北京中医药大学

目的分析近20年来中医药治疗围绝经期失眠的发展脉络、研究热点及前沿趋势。方法检索中国知识资源总库（CNKI）2003年1月1日-2023年4月30日中医药治疗围绝经期失眠相关文献，运用Citespace6.2.R3软件绘制知识图谱，并对作者、机构、... 详细信息

目的分析近20年来中医药治疗围绝经期失眠的发展脉络、研究热点及前沿趋势。方法检索中国知识资源总库（CNKI）2003年1月1日-2023年4月30日中医药治疗围绝经期失眠相关文献，运用Citespace6.2.R3软件绘制知识图谱，并对作者、机构、关键词等进行可视化分析。结果共纳入文献1 027篇，年度发文量总体呈上升趋势。该领域形成以李红、王丽等为代表的核心作者，以黑龙江中医药大学、广州中医药大学、成都中医药大学等为代表的核心机构，机构间合作不紧密，仅存在少数跨机构、跨地区之间的合作。关键词知识图谱显示，睡眠质量、针刺、数据挖掘是当前该领域的研究热点。结论当前国内中医药治疗围绝经期失眠研究热点集中在中医证型证素、临床经验、疗效观察、中医特色疗法等方面，睡眠质量、针刺、Meta分析、数据挖掘等成为今后研究前沿趋势。该领域具有良好的发展前景，但基础研究有待深入，作者、机构间的交流合作有待加强。

关键词：中医药围绝经期失眠 CiteSpace 可视化分析

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Outbreaks of Acute Respiratory Disease Associated with Human Adenovirus Infection in Closed Camps,China,December 2011–March 2014

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China CDC weekly 2021年第38期3卷 793-798,I0001-I0006页

作者： Juan Du xiaodong zhao Fang Tang Doudou Huang Guangqian Pei Xiaoai Zhang Baogui Jiang Qingbin Lu Wei Liu Yigang Tong Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijingChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina Center for Diseases Control and Prevention of Chinese People’s Armed Police Forces BeijingChina The Affiliated Drum Tower Hospital of Nanjing University Medical School NanjingJiangsuChina College of Life Science and Technology Beijing University of Chemical TechnologyBeijingChina.

Summary What is already known on this topic?Human adenovirus(HAdV)was frequently associated with acute respiratory disease(ARD)outbreaks in military *** is added by this report?HAdV-B7,HAdV-B14,and HAdV-B55 were determined to be responsible for 3,2,and 4 ARD outbreaks in military camps,China,respectively,with a total attack rate of 28.0%during 2011 to 2014.

关键词： acute respiratory Acute

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miR⁃146a通过TGF⁃β1/SMAD通路调控脊柱结核进展的分子机制

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骨科 2024年第1期15卷 55-62页

作者：李小鹏厉锋董阳张扬赵晓栋张骁孙泉王军陈高扬潍坊市人民医院(潍坊医学院第一附属医院)脊柱外科山东潍坊261200 潍坊市人民医院(潍坊医学院第一附属医院)放射科山东潍坊261200 潍坊市第二人民医院骨科山东潍坊261200 深圳市人民医院(南方科技大学第一附属医院暨南大学第二临床医学院)手足显微血管外科深圳市骨科研究所深圳市运动系统组织与功能重建重点实验室(ZDSYS***)广东深圳518020

目的探讨miR⁃146a/转化生长因子-β(transforming growth factor⁃β1,TGF⁃β1)/母亲抗肢瘫(small mother against decapentaplegic,SMAD)通路在脊柱结核进展中的调控机制。方法收集脊柱结核病人和正常病人髓核组织,验证miR⁃146a/TGF⁃β1/SMAD通路在结核髓核组织中的表达量;分离培养髓核细胞,敲低/过表达miR⁃146a,分别应用qPCR、Western blot、CCK⁃8、划痕实验验证miR⁃146a对TGF⁃β1/SMAD通路表达及髓核细胞增殖、迁移能力的影响。结果与正常病人比较,脊柱结核病人髓核细胞增殖及迁移能力显著减低,miR⁃146a在脊柱结核病人髓核组织中表达量显著减低,而脊柱结核病人髓核组织中SMAD同系物2(SMAD2)、SMAD同系物3(SMAD3)、SMAD同系物4(SMAD4)、TGF⁃β1基因表达增高,SMAD同系物7(SMAD7)表达减低,提示miR⁃146a与TGF⁃β1/SMAD通路活性显著负相关。过表达miR⁃146a可抑制SMAD2、SMAD3、SMAD4、TGF⁃β1和促进SMAD7表达,而敲低miR⁃146a可促进SMAD2、SMAD3、SMAD4、TGF⁃β1 mRNA和抑制SMAD7表达水平。细胞实验进一步证实过表达miR⁃146a可促进脊柱结核病人髓核细胞增殖和迁移能力,而敲低miR⁃146a可显著抑制其增殖和迁移能力。结论miR⁃146a是脊柱结核进展的关键调控因子,其可通过抑制TGF⁃β1/SMAD通路活性进而调控髓核细胞增殖及迁移活性。

关键词：脊柱结核 miR⁃146a TGF⁃β1/SMAD通路髓核细胞

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Insights from TARGET-seq:Inflammation drives TP53-mediated clonal evolution

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The Innovation 2024年第2期5卷 7-8页

作者： Yeqian zhao Wenxuan Huo Yue Liang xiaodong Mo Shanshan Pei Yanmin zhao Bone Marrow Transplantation Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China Institute of Hematology Zhejiang UniversityHangzhou 311121China Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing 100044China

Approximately 10%–20%myeloproliferative neoplasms(MPNs)can progress into blast-phase MPNs,also termed secondary acute myeloid leukemias(sAMLs),presenting dismal *** exhibits a distinctive clinical and pathological profile compared to de novo AML,marked by a higher incidence of erythroid leukemias and reduced responsive to conventional chemotherapies,resulting in a median survival of approximately 6 ***53 alterations are prevalent adverse events in leukemic transformation(LT),occurring in around one-third of sAML subjects.

关键词： TP53 neoplasms alterations

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Analysis of Transmission Loss in Droop Control of a Multi-Terminal HVDC System

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Journal of Power and Energy Engineering 2014年第4期2卷 564-572页

作者： xiaodong zhao Kang Li Min Zheng School of Electronics Electrical Engineering and Computer Science Queen’s University Belfast UK School of Mechatronic Engineering and Automation Shanghai University Shanghai China

High Voltage Direct Current (HVDC) electric power transmission is a promising technology for integrating offshore wind farms and interconnecting power grids in different regions. In order to maintain the DC voltage, droop control has been widely used. Transmission line loss constitutes an import part of the total power loss in a multi-terminal HVDC scheme. In this paper, the relation between droop controller design and transmission loss has been investigated. Different MTDC layout configurations are compared to examine the effect of droop controller design on the transmission loss.

关键词： MTDC HVDC VSC Transmission Loss Droop Control

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Effect of miR-375 on non-small cell lung carcinoma invasion,migration,and proliferation through the CIP2A pathway

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Oncology and Translational Medicine 2020年第3期6卷 103-108页

作者： Junyu Wu Weijun Yuan Yuhuan Wang xiaodong zhao Department of Emergency The Fourth Medical Center of General Hospital of Chinese People's Liberation ArmyBeijing 100037China Department of Special Medicine School of Basic Medical CollegeQingdao UniversityQingdao 266021China

Lung cancer is one of the malignant tumors with the fastest increase in morbidity and mortality and the greatest threat to people’s health and ***,lung cancer is the leading cause of cancer death in men and the second leading cause of cancer deaths in women[1].Lung cancer is divided into two major groups,small cell lung cancer(SCLC)and non-small cell lung cancer(NSCLC)[2].SCLC accounts for approximately 20%of lung *** has a high degree of malignancy and early metastasis,and is sensitive to chemotherapy and *** initial remission rate is high,but it is prone to secondary drug resistance and *** is the *** includes three major histological subtypes,lung squamous cell carcinoma(SCC),lung adenocarcinoma(ADC),and large cell lung cancer(LCLC),accounting for approximately 80%of lung *** division is slower,and the diffusion shift is relatively late[3].Nevertheless,while current research on the biological characteristics of different histological subtypes of NSCLC is expanding,its basic molecular mechanism is not yet *** example,smoking is more risky for SCC than ADC[4].Micro-RNA is an endogenous small RNA with a length of approximately 19–25 *** a short non-coding RNA,its main function is to regulate the expression level of *** can be used as proto-oncogenes or tumor suppressors,and participate in various processes including proliferation,apoptosis,metabolism,and differentiation of cells through targeted binding to different transcripts[5].miRNAs are expressed in specific tissue and developmental stages under normal physiological conditions,but abnormal expression of miRNAs can lead to a series of pathological states,such as tumorigenesis and metastasis[6–7].miRNA regulates the function of tumor cells by regulating the expression of functional *** example,miR-206 promotes breast cancer proliferation by inhibiting estrogen receptor alpha(ERα)while miR-34a downregulates E2 fac

关键词： miR-375 invasion migration non-small cell lung cancer(NSCLC) CIP2A

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