检索结果-南通市图书馆

山西财政税务专科学校学报 2013年第4期15卷 31-33页

作者：赵瑞红山西四建集团有限公司山西太原030012

在日益激烈的竞争环境中,建筑施工企业面临巨大的压力,要想保持并增强竞争优势,必须拥有一个有效的成本系统。作业成本法的实施,为建筑施工企业提供了一个有效地进行成本分析、成本控制的手段,同时为有效经营决策及提供准确的成本信息... 详细信息

在日益激烈的竞争环境中,建筑施工企业面临巨大的压力,要想保持并增强竞争优势,必须拥有一个有效的成本系统。作业成本法的实施,为建筑施工企业提供了一个有效地进行成本分析、成本控制的手段,同时为有效经营决策及提供准确的成本信息形成了保证。

关键词：作业成本法作业成本计算施工企业成本核算应用研究

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图书馆管理新理念——馆员能量管理

科技情报开发与经济 2011年第35期21卷 17-18页

作者：赵瑞宏宁波大学图书馆浙江宁波315211

介绍了能量管理的内涵及由来,分析了信息时代图书馆引入能量管理的重要性,并对图书馆能量管理的内容进行了具体论述。

关键词：图书馆管理馆员能量管理管理内容

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RFID技术引入图书管理存在的问题及对策

科技情报开发与经济 2011年第25期21卷 55-57页

作者：赵瑞宏宁波大学图书馆浙江宁波315211

RFID技术用于图书管理是图书馆的发展方向,但与许多新生事物一样,RFID技术用于图书馆工作还存在一些亟待解决的问题。针对这些问题提出一些解决的方法。

关键词： RFID 图书管理读取率盘点工作价格隐私权

Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding

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Chinese Chemical Letters 2025年第2期36卷 57-68页

作者： Liangliang Jia Ye hong Xinyu He Ying Zhou Liujiao Ren hongjun Du Bin zhao Bin Qin Zhe Yang Di Gao The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Center of Digestive Endoscopy Shaanxi Provincial Cancer Hospital Department of Ophthalmology Xijing Hospital Department of Epidemiology Shaanxi Provincial Cancer Hospital Department of Gastroenterology Second Affiliated Hospital Xi'an Jiaotong University Research Institute of Xi'an Jiaotong University

Innovative anti-cancer therapies that activate the immune system show promise in combating cancers resistant to conventional treatments. Photodynamic therapy (PDT) is one such treatment, which not only directly eliminates tumor cells but also functions as an in situ tumor vaccine by enhancing tumor immunogenicity and triggering anti-tumor immune responses through immunogenic cell death (ICD). However, the effectiveness of PDT in enhancing immune responses is influenced by factors, such as photosensitizers and the tumor microenvironment, particularly hypoxia. Current clinically used PDT heavily relies on oxygen (O2) availability and can be limited by tumor hypoxia. Additionally, the tumor immunosuppressive microenvironment induced by hypoxia affects the anti-tumor immunity of tumor-infiltrating effector T cells. Meanwhile, the immunosuppressive myeloid-lineage cells are recruited to the hypoxic tumor tissue and exhibit higher immunosuppressive capabilities under hypoxia conditions. Consequently,numerous strategies have been developed to modulate tumor hypoxia or to create hypoxia-compatible PDT, aiming to reduce the effects of tumor hypoxia on PDT-driven immunotherapy. This review investigates these strategies, including approaches to alleviate, exploit, and disregard tumor hypoxia within the context of PDT/immunotherapy. It also emphasizes the role of advanced nanomedicine and its benefits in these strategies, while outlining current challenges and future prospects in the field.

关键词： Immunogenic cell death Immunotherapy Nanomedicine Photodynamic therapy Photosensitizers Tumor hypoxia

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柏坪煤矿防突技术研究

能源与节能 2013年第2期 93-95页

作者：赵瑞红华鼎矿业公司内蒙古锡林郭勒盟026000

针对柏坪煤矿防突问题,对柏坪煤矿区域防突措施及局部防突措施及工艺进行了研究与设计,采用瓦斯抽采作为区域防突及局部防突的措施,并采用瓦斯解吸指标(K1)和钻屑量(S)作为煤巷掘进工作面和开切眼突出危险性预测和防突效果检验措施,结... 详细信息

针对柏坪煤矿防突问题,对柏坪煤矿区域防突措施及局部防突措施及工艺进行了研究与设计,采用瓦斯抽采作为区域防突及局部防突的措施,并采用瓦斯解吸指标(K1)和钻屑量(S)作为煤巷掘进工作面和开切眼突出危险性预测和防突效果检验措施,结果表明采取瓦斯抽采措施起到了防突的目的,其研究成果可为类似条件的煤层开采提供重要依据和借鉴。

关键词：柏坪煤矿区域防突局部防突瓦斯抽采安全防护措施

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan Zhou hongdong zhao Ye hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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试论课程评价及其改革

价值工程 2013年第19期32卷 217-218页

作者：赵瑞红宁夏大学教育学院银川750021

课程评价是教育领域一个重要环节,对课程评价的认识和理解是课程教育工作者一个重要课题。文中综述了课程评价的含义、取向,在此基础上重点分析了我国课程评价的现状以及存在的问题,最后对课程评价的改革提出了自己的意见。

关键词：课程课程评价改革

Molecular mechanism of exopolysaccharide biosynthesis regulated by wze and wzd genes on the immunomodulatory effects of probiotic Lacticaseibacillus paracasei S-NB

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Food Science and Human Wellness 2025年第1期14卷 293-306页

作者： Luyao Xiao Qian Yang Changliang Zhang Kai Ma Xiaogan zhao Xin rui Wei Li Sanya Institute of Nanjing Agricultural University College of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China Jiangsu New-Bio Biotechnology Co. Ltd.Jiangyin 214400China Jiangsu Biodep Biotechnology Co. Ltd.Jiangyin 214400China

The surface macromolecules of probiotic bacteria play crucial roles in modulating immune responses in the ***(EPS)from lactic acid bacteria(LAB)have been widely reported to exhibit immunomodulatory *** this study,the EPS biosynthesis gene cluster of Lacticaseibacillus paracasei S-NB was analyzed and a deletion mutant S-NBΔ7576(two genes S-NB_2175/wze and S-NB_2176/wzd were responsible for the chain length determination and export of EPS)was successfully constructed,resulting a 40.02%decrease in the production of *** deletion of wze and wzd had little effect on the monosaccharide composition and major groups of the two EPS fractions(BEPS1 and BEPS2).Both BEPS1 and BEPS2 could inhibit the transcriptional level of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),inducible nitric oxide synthase(i NOS)and cyclooxygenase-2(COX-2)mRNA in RAW 264.7 cells induced by lipopolysaccharide(LPS),and enhance host immune tolerance via suppressing NF-κB and MAPK ***,the S-NBΔ7576 mutant supplied with the BEPS1/BEPS2 exhibited more significant inhibition of cytokines production and the phosphorylation of p65 and c-Jun N-terminal kinase(JNK)in LPS-stimulated cells compared with the S-NBΔ7576 mutant *** study provided the immunomodulatory effect of BEPS1 and BEPS2 from *** S-NB,in which the wze and wzd genes associated with EPS biosynthesis may play an important role.

关键词： Lacticaseibacillus paracasei Exopolysaccharide(EPS) Biosynthesis Immunomodulatory

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基于Web Service的GIS模型服务

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测绘通报 2007年第3期 63-66页

作者：谢吉吉赵红蕊唐中实清华大学土木工程系3S中心北京100084

数据和功能是GIS的主体,在数据共享的基础上,功能的共享成为GIS服务的要求之一。研究将专业模型和GIS集成的方式,提出基于Web Service的GIS模型服务共享框架,并利用环北京市环境评价模型对该框架进行试验性的尝试,开发区域环境评价模型... 详细信息

数据和功能是GIS的主体,在数据共享的基础上,功能的共享成为GIS服务的要求之一。研究将专业模型和GIS集成的方式,提出基于Web Service的GIS模型服务共享框架,并利用环北京市环境评价模型对该框架进行试验性的尝试,开发区域环境评价模型共享平台原型。原型系统利用Web Service为系统的环境评价模型提供访问接口,用户可以利用客户端数据和服务端的功能完成环境评价分析。利用原型系统完成环北京地区生态环境评价,结果和实际相符,其服务方式更便利、实用。原型系统验证了基于Web Service的GIS模型服务共享框架的可行性,但还存在很多有待完善的地方。

关键词： Web Service GIS 模型共享

Significant changes in the physicochemical properties of BC-containing particles during the cold season in Beijing

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Journal of Environmental Sciences 2025年第5期151卷 667-676页

作者： Shuya Hu Linghan Zeng Gang zhao Shiyi Chen Chunsheng zhao Weilun zhao Min Hu State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Research Center for Atmospheric Research(IJRC)College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science and TechnologyNanjing 210044China

The ambient air quality has improved significantly under strict emission controls in Beijing,China over the last *** carbon(BC),as a short-lived climate forcer in ambient aerosols,profoundly impacts the air quality and *** studies have demonstrated a decline in the mass concentration of *** this study,we characterized the chemical compositions and size distributions of BC-containing particles during the cold season of 2022 in Beijing using state-of-the-art instruments capable of exclusively measuring BCcontaining *** optical properties of BC-containing particles were further calculated based on the Mie ***,we compared the properties of BC-containing particles in 2022 with the results of previous *** results showed that the diameters of BC cores became larger while the coating thickness of BC-containing particles became thinner in *** the coating materials,the mass fraction of nitrate increased obviously,and even replaced organic matter as the dominant component during the peak of the pollution *** in chemical compositions and size distributions resulted in lower mass absorption cross-sections(MAC)of BC-containing particles from 10.5±1.1 m^(2)/g in 2016 to 7.3±0.8 m^(2)/g in 2022,reduced by 30.5%.Our results demonstrate the synergistic benefits of air pollution control in improving air quality and mitigating climate ***,the MAC of BC adopted in climate models should vary with the changing air pollution *** study emphasizes that it is imperative to conduct long-term observations of BC-containing particles to better estimate BC’s climate effects.

关键词： Black carbon Chemical composition Size distribution Light absorption ability