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PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells

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Asian Journal of Andrology 2017年第4期19卷 453-457页

作者： Qing yang Zi-Lian cui Qin Wang Xun-Bo Jin Yong zhao mu-wen Wang Wei Song hua-Wei Qu Wei-Ting Kang Department of Breast and Thyroid Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong PR China Shandong University School of Medicine Jinan Shandong PR China Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong PR China Department of Anesthesiology Qilu Hospital Shandong University Jinan Shandong PR China

To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. LNCaP cells were divided into a control group and an LNCaP-PlncRNA-I-siRNA experimental group. Normal prostate RWPE-1 cells were divided into an RWPE-1 control group and an RWPE-1-PlncRNA-1 experimental group. After PlncRNA-1 silencing and overexpression, changes in Her-2 and cyclinD1 expression levels were detected both in vivo and in vitro. In prostate cancer tissues, Her-2 and PIncRNA-1 were highly expressed and significantly correlated. In LNCaP cells, the expression of Her-2 and cyclinD1 decreased following the downregulation of PlncRNA-1 as assessed by real-time PCR and Western blotting. In RWPE-1 cells, the expression of Her-2 and cyclinD1 increased following PlncRNA-1 overexpression. Flow cytometry revealed that the proportion of LNCaP cells in G2/M phase was significantly increased after PlncRNA-1 silencing and that the proportion of RWPE-1 cells in G2/M phase was significantly decreased after PlncRNA-1 overexpression. Furthermore, animal experiments validated these results. In conclusion, in prostate cancer, PlncRNA-1 regulates the cell cycle and cyclinD1 levels and can also regulate proliferation and apoptosis in prostate cancer cells through the Her-2 pathway.

关键词： apoptosis cell cycle Her-2 LNCaP long noncoding RNA PlncRNA-1 prostate cancer

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定量预测煤厚方法研究、影响因素分析及应用

物探化探计算技术 2006年第4期28卷 315-318页

作者：崔辉霞杨文强赵牧华中国矿业大学徐州221008

煤层厚度预测的传统方法是利用钻孔资料的内插对比获得,精度很低。在实际应用中,人们又研究出了多种方法。这里从薄层理论出发,对这些方法进行了研究归纳,采用钻孔约束频域定量预测法(谱矩法)来编制相应的程序进行煤层厚度定量预测,并... 详细信息

煤层厚度预测的传统方法是利用钻孔资料的内插对比获得,精度很低。在实际应用中,人们又研究出了多种方法。这里从薄层理论出发,对这些方法进行了研究归纳,采用钻孔约束频域定量预测法(谱矩法)来编制相应的程序进行煤层厚度定量预测,并对影响煤厚变化的因素进行分析,得出了有用的结论。通过理论模型和实际资料运用,证明该方法预测精度较高,可取得令人满意的效果。

关键词：薄层频域煤层厚度定量预测影响因素

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用方差体技术识别小断层及裂隙发育带

物探化探计算技术 2006年第3期28卷 216-218页

作者：赵牧华杨文强崔辉霞中国矿业大学资源学院江苏徐州221008

为了提高煤田开采的效率,准确、快速地确定断层和裂隙发育带已迫在眉睫。而三维方差体技术突出了地层横向变化对地震道的影响,能够对三维地震地质信息进行提取,还可用于识别断层、裂隙及地层的不连续变化。这里介绍了三维方差体技术的... 详细信息

为了提高煤田开采的效率,准确、快速地确定断层和裂隙发育带已迫在眉睫。而三维方差体技术突出了地层横向变化对地震道的影响,能够对三维地震地质信息进行提取,还可用于识别断层、裂隙及地层的不连续变化。这里介绍了三维方差体技术的原理及基本算法,并在山东某采区三维地震资料的解释工作中进行了实际应用。结果表明,方差体技术对断层、裂隙发育带等地质异常体具有良好的识别效果。

关键词：方差体技术小断层裂隙发育带顺层切片

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钻孔约束频域定量预测煤厚方法研究与应用

煤炭科学技术 2006年第2期34卷 6-8页

作者：崔辉霞杨文强赵牧华中国矿业大学江苏徐州221008

煤层在地震勘探中属于薄层,其厚度预测的传统方法是利用钻孔资料的内插对比获得,精度很低。实际生产中,人们又研究了多种办法。对这些办法进行了归纳,并采用钻孔约束频域定量预测法(谱矩法)来编制相应的程序进行煤层厚度定量预测。

关键词：薄层钻孔约束频域定量预测煤层厚度

Broadband diffusion of terahertz waves by multi-bit coding metasurfaces

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Light(Science & Applications) 2015年第1期4卷 207-215页

作者： Li-hua Gao qiang Cheng Jing yang Shao-Jie Ma Jie zhao Shuo Liu Hai-Bing Chen Qiong He Wei-xiang Jiang hui-Feng Ma Qi-Ye wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun cui State Key Laboratory of Millimeter Waves Department of Radio EngineeringSoutheast UniversityNanjing 210096China Cooperative Innovation Centre of Terahertz Science No.4Section 2North Jianshe RoadChengdu 610054China Institute of Modern Optics Key Laboratory of Optical Information Science and Technology(Ministry of Education)Nankai UniversityTianjin 300071China State Key Laboratory of Surface Physics Key Laboratory of Micro and Nano Photonic Structures(Ministry of Education)Department of PhysicsFudan UniversityShanghai 200433China State Key Laboratory of Electronic Films and Integrated Devices University of Electronic Science and TechnologyChengdu 610054China Research Institute of Superconductor Electronics(RISE) School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Institute of Lasers and Optoelectronics College of Precision Instrument and Opto-Electronics EngineeringTianjin UniversityTianjin 300072China

The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light *** the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional ***,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding *** propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric *** show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding *** an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and *** presented method opens a new route to reducing the scattering of terahertz waves.

关键词： coding diffusion metasurface terahertz waves

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng huang Wei-Zhu yang Guo-wen Yin Bin-Yan Zhong Jun-hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge wen-Bin Ding wen-hui Li Jin-hua huang Wei mu Shan-Zhi Gu Jia-Ping Li hui zhao Shu-Wei wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming huang Wei zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-hui Xu wen-Hao Hu qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya zhao Zhu-Ting Fang Qi Wang Jin-Wei zhao Ai-Bing Xu Jian Xu Qing-hua Wu huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po yang yang zhao xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

Retraction Note:PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells

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Asian Journal of Andrology 2023年第3期25卷 440-440页

作者： Qing yang Zi-Lian cui Qin Wang Xun-Bo Jin Yong zhao mu-wen Wang Wei Song hua-Wei Qu Wei-Ting Kang Department of Breast and Thyroid Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanChina Shandong University School of Medicine JinanChina Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong UniversityJinanChina Department of Anesthesiology Qilu HospitalShandong UniversityJinanChina

During our recent follow-up study,we found that the previous results could not be *** Figure 2f and 3f,Her-2 and CyclinD1 expression was not repeated by western blotting in RWPE-1 *** are therefore retracting our initial article to maintain the integrity of the scientific *** authors have approved this *** deeply apologize for any confusion it may have caused.

关键词： CyclinD1 Figure maintain

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： wen-Tao Zhang Xue-Qian Wang Feng-Qi Zhang xiao-Ya cui Bing-Bing Fan Jia-Ming Guo Zhi-Min Guo Rui huang wen huang Xu-Bo Li Meng-Ru Li Yan Ma Zhi-hua Shen Yong-Gang Sun De-Zhuang Wang Fei-yang Wang Li-qiang Wang Nan Wang Tian-Li Wang Wei Wang xiao-yang Wang Yi-Han Wang Fu-Jie Yu Yu-Zhen Yin Ling-Kun Zhang Yi Zhang Jian-yang Zhang Qi zhao Yu-Ping zhao Xin-Dong Zhu Yasir Sohail Ya-Nan Chen Tao Feng Qi-Long Gao Hai-Yan He Yong-Jiang huang Zeng-Bao Jiao hua Ji Yao Jiang qiang Li xiao-Ming Li Wei-Bing Liao huai-Jun Lin hui Liu Qi Liu Qing-Feng Liu Wei-Di Liu Xiong-Jun Liu yang Lu Yi-Ping Lu wen Ma Xue-Fei Miao Jie Pan Qing Wang Hong-hui Wu Yuan Wu Tao yang Wei-Ming yang Qian Yu Jin-Yu Zhang Zhi-Gang Chen Liang Mao yang Ren Bao-Long Shen Xun-Li Wang Zhe Jia He Zhu Zhen-Duo Wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi hua Jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo cui Jiang-Bin Chen yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-Lin Mao xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-hua Han Da-Jin Liu Li-Qin Duan Ming-Jun zhao cui-Ying Zhang Hai-Ying Dai Ze-hua Li Ying xiao You-Zhi Hu xiao-Yu huang Kun Xing Xin Jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei huang Li-Ping Dou Lan-Jun Sun Ying-qiang zhao Jie Li Yun xia Jun Liu Fan Liu wen-Jin He Ying Li Jian-Cong Tan yang Lin Ya-Bin Zhou Jian-Fei yang Guo-Qing Ma hui-Jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu xiao-Jia Luo xiao-Hong Bin Ya-Nan Yu Hai-xia Dang Bing Li Fei Teng Wang-Min Qiao xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch