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Inter-layer interference for multi-layered tight gas reservoir in the absence and presence of movable water

Petroleum Science 2024年第3期21卷 1751-1764页

作者： Tao Zhang Bin-Rui Wang Yu-long zhao Lie-Hui Zhang Xiang-Yang Qiao Lei Zhang Jing-Jing Guo Hung Vo Thanh National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu60500SichuanChina Shaanxi Yanchang Petroleum(Group)Corp.Ltd. Xian710075ShaanxiChina Waseda Research Institute for Science and Engineering Waseda UniversityTokyoJapan

Due to the dissimilarity among different producing layers,the influences of inter-layer interference on the production performance of a multi-layer gas reservoir are ***,systematic studies of inter-layer interference for tight gas reservoirs are really limited,especially for those reservoirs in the presence of *** this work,five types of possible inter-layer interferences,including both absence and presence of water,are identified for commingled production of tight gas ***,a series of reservoir-scale and pore-scale numerical simulations are conducted to quantify the degree of influence of each type of *** field evidence from the Yan'an tight gas reservoir(Ordos Basin,China)is found to support the simulation ***,suggestions are proposed to mitigate the potential inter-layer *** results indicate that,in the absence of water,commingled production is favorable in two situations:when there is a difference in physical properties and when there is a difference in the pressure system of each *** reservoirs with a multi-pressure system,the backflow phenomenon,which significantly influences the production performance,only occurs under extreme conditions(such as very low production rates or well shut-in periods).When water is introduced into the multi-layer system,inter-layer interference becomes nearly *** both the gas-rich layer and water-rich layer for commingled production is not desirable,as it can trigger water invasion from the water-rich layer into the gas-rich *** gas-rich layer might also be interfered with by water from the neighboring unperforated water-rich layer,where the water might break the barrier(eg weak joint surface,cement in fractures)between the two layers and migrate into the gas-rich ***,the gas-rich layer could possibly be interfered with by water that accumulates at the bottom of the wellbore due to gravitational diff

关键词： Tight gas Comingled production Interference Two-phase flow Water blocking

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Distal margin distance in radical resection of locally advanced rectal cancer after neoadjuvant therapy

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Chinese Journal of Cancer Research 2024年第2期36卷 226-232页

作者： Jun Luo Mingxuan Zhu long zhao Meiwen He Bei Li Yifan Liu Yuhan Sun Guoqing Lyu Zhanlong Shen Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036China Department of Gastroenterological Surgery Laboratory of Surgical OncologyBeijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment ResearchPeking University People's HospitalBeijing 100044China School of Medicine the Chinese University of Hong KongShenzhen 518172China

Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more *** tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal ***, there is currently no consensus on the specific distance of distal resection margin.

关键词： Colorectal cancer distal resection margin neoadjuvant therapy

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Petrogenesis and tectonic implications of the Silurian adakitic granitoids in the eastern segment of the Qilian Orogenic Belt,Northwest China

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Acta Geochimica 2024年第1期43卷 72-86页

作者： Jiao-long zhao Xiao-Jun Huang Pei-Qing Hu Zhen-Xi Yang Ying Fan Er-Teng Wang Fu-Bo Yang Jing-Yu Zhang School of Earth Sciences Key Laboratory of Mineral Resources in Western China(Gansu Province)Lanzhou UniversityLanzhou 730000China Nuclear Industry 247 Brigade Tianjin North China Geological Survey BureauTianjin 301800China Fourth Institute of Geological and Mineral Exploration of Gansu Provincial Bureau of Geology and Mineral Resources Jiuquan 735000China

Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age, and systematic whole-rock geochemical data for the Haoquangou and Liujiaxia granitoids within the North Qilian orogenic belt and the Qilian Block, respectively, to constrain their petrogenesis, and the Silurian tectonic evolution of the Qilian orogenic belt. Zircon U–Pb ages indicate that the Haoquangou and Liujiaxia intrusions were emplaced at423 ± 3 Ma and 432 ± 4 Ma, respectively. The Haoquangou granodiorites are calc-alkaline, while the Liujiaxia granites belong to the high-K calc-alkaline *** are peraluminous in composition and have relatively depleted Nd isotopic [ε_(Nd)(t) =(-3.9 – + 0.6)] characteristics compared with regional basement rocks, implying their derivation from a juvenile lower crust. They show adakitic geochemical characteristics and were generated by partial melting of thickened lower continental crust. Postcollisional extensional regime related to lithospheric delamination was the most likely geodynamic mechanism for the generation of the Haoquangou granodiorite, while the Liujiaxia granites were generated in a compressive setting during continental collision between the Qaidam and Qilian blocks.

关键词： Silurian adakitic granitoids Petrogenesis Tectonic setting Qilian Orogenic Belt

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Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU Ai-ling CHEN Ken HUANG Yun-ke zhao Qiu-long HUANG Wen-ya HUANG Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

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RpL 38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis

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Science China Life Sciences 2024年

作者： Yang Fang Fengchao Zhang Fangzhen zhao Jiajia Wang Xinkai Cheng Fei Ye Jiayu He long zhao Ying Su Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China College of Marine Life Sciences Ocean University of China Fisheries College Ocean University of China

Switching from mitotic spermatogonia to meiotic spermatocytes is critical to producing haploid sperms during male germ cell differentiation. However, the underlying mechanisms of this switch remain largely unexplored. In Drosophila melanogaster, the gene RpL38encodes the ribosomal protein L38, one component of the 60S subunit of ribosomes. We found that its depletion in spermatogonia severely diminished the production of mature sperms and thus led to the infertility of male flies. By examining the germ cell differentiation in testes,we found that RpL38-knockdown blocked the transition from spermatogonia to spermatocytes and accumulated spermatogonia in the testis. To understand the intrinsic reason for this blockage, we conducted proteomic analysis for these spermatogonia populations. Differing from the control spermatogonia, the accumulated spermatogonia in RpL38-knockdown testes already expressed many spermatocyte markers but lacked many meiosis-related proteins, suggesting that spermatogonia need to prepare some important proteins for meiosis to complete their switch into spermatocytes. Mechanistically, we found that the expression of bag of marbles (bam), a crucial determinant in the transition from spermatogonia to spermatocytes, was inhibited at both the mRNA and protein levels upon RpL38 depletion. We also confirmed that the bam loss phenocopied RpL38 RNAi in the testis phenotype and transcriptomic profiling. Strikingly, overexpressing bam was able to fully rescue the testis abnormality and infertility of RpL38-knockdown flies, indicating that bam is the key effector downstream of RpL38 to regulate spermatogonia differentiation. Overall, our data suggested that germ cells start to prepare meiosis-related proteins as early as the spermatogonial stage, and RpL38 in spermatogonia is required to regulate their transition toward spermatocytes in a bamdependent manner, providing new knowledge for our understanding of the transition process from spermatogonia to spe

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基于客观理性的算法法益构造及刑法保护

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学习与实践 2024年第2期 32-40页

作者：赵龙烟台大学法学院山东烟台264005

算法的客观理性属于算法的技术特征,指向的是算法计算的客观性。在算法犯罪场景下,算法理性围绕算法法益及其规范保护展开。算法法益的构造以算法安全、算法公正为核心,具有双重法益形态。逻辑上,算法安全法益的理性构造与算法公正法益... 详细信息

算法的客观理性属于算法的技术特征,指向的是算法计算的客观性。在算法犯罪场景下,算法理性围绕算法法益及其规范保护展开。算法法益的构造以算法安全、算法公正为核心,具有双重法益形态。逻辑上,算法安全法益的理性构造与算法公正法益的逻辑创新,符合算法理性的认识论要求,亦反映了理性算法的价值论评价。基于理性主义立场,通过对财产犯罪典型范式的规范性解释,类型化界定行为论上形式可罚性与结果论上实质可罚性的基本标准,可彰显算法法益理论的可解释性、可实践性以及犯罪论上行为的可责难性,以回应人工智能时代推进刑法现代化的基本要求。

关键词：技术理性算法犯罪算法法益算法安全算法公正

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自动化行政的技术性正当程序规制研究

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法律科学（西北政法大学学报） 2024年第3期42卷 94-104页

作者：赵龙山西大学法学院山西太原030006

技术跃迁诱发行政机关对数字技术的拓深应用,行政许可、行政处罚等公共行政迎来了自动化行政时代。自动化行政具有的算法特征导致法律赋予相对人的陈述、申辩、说明理由、听证等程序性权利被悬置。技术性正当程序是正当程序的数字化延... 详细信息

技术跃迁诱发行政机关对数字技术的拓深应用,行政许可、行政处罚等公共行政迎来了自动化行政时代。自动化行政具有的算法特征导致法律赋予相对人的陈述、申辩、说明理由、听证等程序性权利被悬置。技术性正当程序是正当程序的数字化延伸。应通过对自动化行政构成要素的提取、要素关系的梳理及要素价值的论证,构建解决自动化行政正当程序问题的“四维度八要素”规制框架,丰富技术性正当程序理论的时代内涵。在将该规制框架转化为法律制度的过程中,应立足于我国自动化行政的规范实践,从理念革新与制度构建两方面形成自动化行政的技术性正当程序规制进路。

关键词：自动化行政正当程序技术性正当程序程序规制

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车载GNSS/SINS/里程计分布式弹性融合导航方法

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测绘学报 2024年第3期53卷 425-434页

作者：穆梦雪赵龙北京航空航天大学自动化科学与电气工程学院北京100191 北京航空航天大学数字导航中心北京100191 北京航空航天大学飞行器控制科学与技术实验室北京100191

为提升复杂环境下低成本车载导航系统的容错性能,本文研究了基于次优增益融合(SGF)算法的GNSS/SINS/里程计分布式弹性融合方法。该方法首先根据阿克曼转向几何建立了四轮里程计测速补偿模型,提升了惯性测量单元(IMU)安装中心处的前向和... 详细信息

为提升复杂环境下低成本车载导航系统的容错性能,本文研究了基于次优增益融合(SGF)算法的GNSS/SINS/里程计分布式弹性融合方法。该方法首先根据阿克曼转向几何建立了四轮里程计测速补偿模型,提升了惯性测量单元(IMU)安装中心处的前向和侧向测速精度;然后设计了基于卡方检验统计量的故障检测与分类准则,充分利用了可获取的观测信息;最后构建了随机模型和信息分配因子(ISF)弹性优化模型,分别从传感器层和决策层减少了异常观测的影响,实现了车载多源信息的弹性融合。通过实际跑车数据对GNSS/SINS/里程计分布式弹性融合方法进行测试验证。试验结果表明,本文方法能有效减少子系统故障对全局状态估计的影响,提升复杂环境下系统的容错性能。此外,与经典的联邦卡尔曼滤波(FKF)算法相比,SGF算法全局融合精度损失有限,计算效率却显著提升,有利于多源信息弹性融合的实际工程应用。

关键词：多源信息弹性融合 GNSS/SINS/里程计融合里程计测速补偿模型次优增益融合分布式滤波

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Analysis of the causes of primary revision after unicompartmental knee arthroplasty: A case series

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World Journal of Clinical Cases 2024年第9期12卷 1560-1568页

作者： Jin-long zhao Xiao Jin He-Tao Huang Wei-Yi Yang Jia-Hui Li Ming-Hui Luo Jun Liu Jian-Ke Pan The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Chinese Medicine The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina The Second School of Clinical Medical Sciences Guangzhou University of Chinese MedicineGuangdong Academy of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Affiliated Hospital Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120Guangdong ProvinceChina The Affiliated TCM Hospital Guangzhou Medical UniversityGuangzhou 510405Guangdong ProvinceChina The Research Team on Bone and Joint Degeneration and Injury Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Unicompartmental knee arthroplasty(UKA)has great advantages in the treatment of unicompartmental knee osteoarthritis,but its revision rate is higher than that of total knee *** To summarize and analyse the causes of revision after *** This is a retrospective case series study in which the reasons for the first revision after UKA are *** analysed the clinical symptoms,medical histories,laboratory test results,imaging examination results and treatment processes of the patients who underwent revision and summarized the reasons for primary revision after *** A total of 13 patients,including 3 males and 10 females,underwent revision surgery after *** average age of the included patients was 67.62 *** prosthesis was used for 3 d to 72 *** main reasons for revision after UKA were improper suturing of the surgical opening(1 patient),osteophytes(2 patients),intra-articular loose bodies(2 patients),tibial prosthesis loosening(2 patients),rheumatoid arthritis(1 patient),gasket dislocation(3 patients),anterior cruciate ligament injury(1 patient),and medial collateral ligament injury with residual bone cement(1 patient).CONCLUSION The causes of primary revision after UKA were gasket dislocation,osteophytes,intra-articular loose bodies and tibial prosthesis *** of these factors may greatly reduce the rate of revision after UKA,improve patient satisfaction and reduce medical burden.

关键词： Unicompartmental knee arthroplasty Total knee arthroplasty Causes Revision Case series

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量子多体系统中的拓扑序与分数化激发

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物理学报 2024年第7期73卷 1-7页

作者：顾昭龙李建新南京大学物理学院固体微结构物理国家重点实验室南京210093 南京大学人工微结构科学与技术协同创新中心南京210093

朗道费米液体理论和金兹堡-朗道相变理论是传统凝聚态物理两座重要的基石,在处理BCS超导体和液氦超流体的形成机制等重要物理问题中取得了巨大成功.然而,以20世纪80年代量子霍尔效应和高温超导的发现为开端,人们逐渐认识到,对于一大类... 详细信息

朗道费米液体理论和金兹堡-朗道相变理论是传统凝聚态物理两座重要的基石,在处理BCS超导体和液氦超流体的形成机制等重要物理问题中取得了巨大成功.然而,以20世纪80年代量子霍尔效应和高温超导的发现为开端,人们逐渐认识到,对于一大类新的量子态,比如分数量子霍尔态和量子自旋液体,其性质超越了朗道费米液体理论和金兹堡-朗道相变理论.拓扑序及其所具有的长程多体量子纠缠和分数化激发成为我们理解这些奇异量子态的关键概念.在量子材料和量子模拟系统中设计并寻找具有拓扑序的物态、探测并操控其分数化激发是当代凝聚态物理重要的研究方向.近期,在里德伯原子体系、超导量子处理器和二维摩尔超晶格等具有高度可调控性的量子实验平台中,拓扑序的量子模拟和操控得到了快速发展并取得了重要成果.本文将简要论述拓扑序在传统凝聚态材料体系和量子模拟体系中最近的研究进展和挑战,并对该领域未来可能的发展方向做出展望.

关键词：拓扑序长程多体量子纠缠分数化激发

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