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Early Outcomes of Primary Total Hip Arthroplasty for Osteonecrosis of the Femoral Head in Patients with Human Immunodeficiency Virus in China

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Chinese Medical Journal 2015年第15期128卷 2059-2064页

作者： Chang-Song zhao xin li Qiang Zhang Sheng Sun Ru-Gang zhao Juan Cai Department of Orthopedics Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background：Studies have reported that patients with human immunodeficiency virus （HIV） have a high incidence of osteonecrosis of the femoral head （ONFH）.Total hip arthroplasty （THA） is an effective management of ***,little data exist regarding the use of THA for the HIV patients with ONFH in *** study reviewed the outcomes of HIV-positive patients who underwent THA for ONFH,compared with HIV-negative ***：The patients who underwent THA for ONFH from September 2012 to September 2014 in Beijing Ditan Hospital,Capital Medical University were retrospectively ***-eight HIV-positive patients and 35 HIV-negative patients underwent 48 THAs and 45 THAs with cementless components,*** records and follow-up data were *** Hip Score （HHS） was applied to evaluate the pain and function of the hips before and after *** such as wound healing,surgical site infection,deep venous thrombosis,pulmonary embolism,sepsis,mortality,and complications from the prosthesis were *** operation time,blood loss,and hospital stay were compared between the two ***：The mean follow-up period was 19.5 ± 5.8 months （ranging from 6 to 30 months）.The mean age of the HIV-positive patients with osteonecrosis at the time of surgery was 35 years old,which was significantly lower than that of the HIV-negative group （42 years old）（P 〈 0.05）.The HIV-positive patients underwent surgery a mean of 2.5 years after their original symptoms,which was significantly shorter than the HIV-negatives＇（mean 4 years）（P 〈 0.05）.Among HIV-positive patients,the prevalence of being male and rate of bilateral procedures were significantly higher than those in the HIV-negative group （P 〈 0.05）.The operation time in HIV-positive patients was significantly longer than that in HIV-negative patients （P 〈 0.05）.There were no significant differences in blood loss or hospital stay between the two groups （P 〉 0.05）.The HHSs of two groups

关键词： Arthroplasty Harris Hip Score Hip Human Immunodeficiency Virus Infections Osteonecrosis of the Femoral Head Outcomes

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Accurate Robotic Grasp Detection with Angular Label Smoothing

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Journal of Computer Science & Technology 2023年第5期38卷 1149-1161页

作者：石敏路昊李兆歆朱登明王兆其 School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

Grasp detection is a visual recognition task where the robot makes use of its sensors to detect graspable objects in its *** the steady progress in robotic grasping,it is still difficult to achieve both real-time and high accuracy grasping *** this paper,we propose a real-time robotic grasp detection method,which can accurately predict potential grasp for parallel-plate robotic grippers using RGB *** work employs an end-to-end convolutional neural network which consists of a feature descriptor and a grasp *** for the first time,we add an attention mechanism to the grasp detection task,which enables the network to focus on grasp regions rather than ***,we present an angular label smoothing strategy in our grasp detection method to enhance the fault tolerance of the *** quantitatively and qualitatively evaluate our grasp detection method from different aspects on the public Cornell dataset and Jacquard *** experiments demonstrate that our grasp detection method achieves superior performance to the state-of-the-art *** particular,our grasp detection method ranked first on both the Cornell dataset and the Jacquard dataset,giving rise to the accuracy of 98.9%and 95.6%,respectively at realtime calculation speed.

关键词： robotic grasp detection attention mechanism angular label smoothing anchor box deep learning

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Medical comorbidities at admission is predictive for 30-day in-hospital mortality in patients with acute myocardial infarction： analysis of 5161 cases

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Journal of Geriatric Cardiology 2011年第1期8卷 31-34页

作者： Xue-Dong Yang Yu-Sheng zhao Yu-Feng li xin-Hong Guo Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Background The present study investigated the prognostic value of medical comorbidities at admission for 30-day in-hospital mortality in patients with acute myocardial infarction （AMI）. Methods A total of 5161 patients with AMI were admitted in Chinese PLA General Hospital between January 1, 1993 and December 31, 2007. Medical comorbidities including hypertension, diabetes mellitus, previous myocardial infarction, valvular heart disease, chronic obstructive pulmonary disease （COPD）, renal insufficiency, previous stroke, atrial fibrillation and anemia, were identified at admission. The patients were divided into 4 groups based on the number of medical comorbidities at admission （0, 1, 2, and ≥3）. Cox regression analysis was used to calculate relative risk （RR） and 95% confidence intervals （CI）, with adjustment for age, sex, heart failure and percutaneous coronary intervention （PCI）. Results The mean age of the studied population was 63.9 ± 13.6 years, and 80.1% of the patients were male. In 74.6% of the patients at least one comorbidity were identified. Hypertension （50.7%）, diabetes mellitus （24.0%） and previous myocardial infarction （12%） were the leading common comorbidities at admission. The 30-day in-hospital mortality in patients with 0, 1, 2, and ≥3 comorbidities at admission （7.2%） was 4.9%, 7.2%, 11.1%, and 20.3%, respectively. The presence of 2 or more comorbidities was associated with higher 30-day in-hospital mortality compared with patients without comorbidity （RR： 1.41, 95% CI： 1.13-1.77, P = 0.003, and RR： 1.95, 95% CI： 1.59-2.39, P = 0.000, respectively）. Conclusions Medical comorbidities were frequently found in patients with AMI. AMI patients with more comorbidities had a higher 30-day in-hospital mortality might be predictive of early poor outcome in patients with AMI.

关键词： acute myocardial infarction comorbidity mortality

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu Tingting li Chengcheng Gai Danqing xin Yijing zhao Yan Song Yahong Cheng Tong li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting liu Wei Huang Jiayi Wen xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian zhao Shihua li Xiaojiang li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou Ke Yajing zhao xin Min Yanghong li Ruiyu Mi Yangai liu Xiaowen Wu Minghao Fang zhaohui Huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan zhao Yidan Zhang xin liu Jian Zhang Ya Gao Shuyue li Cui Chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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基于1∶80缩比实验机的离心熔铸模拟实验研究

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兵工学报 2018年第8期39卷 1601-1606页

作者：徐鑫莉张心明蔡鹏于阳赵立新长春理工大学机电工程学院吉林长春130022 长春工程学院吉林长春130012 中国第一汽车集团有限公司吉林长春130011 中国科学院长春光学精密机械与物理研究所吉林长春130033 吉林省留学回国人员和专家服务中心吉林长春130022

在实验室环境下进行非球面镜离心熔铸实验,研究大口径非球面镜的离心熔铸技术,并验证研究方法的可行性。通过对大口径非球面镜离心熔铸工艺的温度场相似准则和缩比模型参数匹配方法的研究,设计1∶80离心熔铸环境相似缩比实验机,进行物... 详细信息

在实验室环境下进行非球面镜离心熔铸实验,研究大口径非球面镜的离心熔铸技术,并验证研究方法的可行性。通过对大口径非球面镜离心熔铸工艺的温度场相似准则和缩比模型参数匹配方法的研究,设计1∶80离心熔铸环境相似缩比实验机,进行物理模拟实验。测量了缩比实验的温度场、应力场以及最终的镜胚面形偏差。实验结果与仿真结果对比显示,温度场测量结果与仿真结果的相对误差在1.0%~1.4%之间。非球面镜在转变温度附近采取适当保温工艺后,最大压应力降为0.98 MPa.通过轮廓仪检测制得的非球面镜面形偏差为-83.823 3μm,与仿真结果相符。采用仿真联合缩比实验的方法对离心熔铸工艺中的不可观测量进行研究,为离心熔铸工艺提供了理论参考依据和实验指导。

关键词：非球面镜离心熔铸相似性准则缩比模型温度场

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城市农民工市民化问题研究

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人口学刊 2006年第4期28卷 40-45页

作者：赵立新鲁东大学政法学院山东烟台264025

城市农民工市民化是健康城市化的要求,也是建设社会主义和谐社会的要求。社会资本缺失是农民工市民化进程受阻,进而引发许多社会问题的主要原因。因此,要促进农民工市民化进程就必须增加农民工的社会资本存量。主要对策有:转变城乡分割... 详细信息

城市农民工市民化是健康城市化的要求,也是建设社会主义和谐社会的要求。社会资本缺失是农民工市民化进程受阻,进而引发许多社会问题的主要原因。因此,要促进农民工市民化进程就必须增加农民工的社会资本存量。主要对策有:转变城乡分割思想,在全社会确立一种城乡开放、平等、统筹观念;打造促进农民工与城市市民进行互动和交往的文化环境;积极进行制度改革,创建农民工同城市融合的制度平台;建立健全公平、共享的社会保障机制,消除人为差别,增强农民工对城市社会的认同感;加强对农民工就业培训,积极增加农民工的人力资本存量;加强和发挥民间志愿性组织的作用,增强人们的社会参与意识。

关键词：社会资本城市农民工市民化

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东北亚区域合作的深层障碍——中韩日民族主义诉求及其影响

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东北亚论坛 2011年第3期20卷 20-28页

作者：赵立新延边大学人文学院国际政治教研室

冷战结束至今,东北亚区域没有战争爆发,经济的发展使这一地区充满活力,然而政治上的互信和文化上的共享却与此形成鲜明的反差。东亚国家——中韩日之间在很多问题上构成"对抗"姿态,国家间关系风波不断,加之外部力量的影响,东亚和平与安... 详细信息

冷战结束至今,东北亚区域没有战争爆发,经济的发展使这一地区充满活力,然而政治上的互信和文化上的共享却与此形成鲜明的反差。东亚国家——中韩日之间在很多问题上构成"对抗"姿态,国家间关系风波不断,加之外部力量的影响,东亚和平与安全的隐患一直处在集结和酝酿之中。期待中的区域合作进展缓慢,而对抗却衍生出副产品——东亚民族主义思潮重新泛起。围绕突发事件和敏感问题,民族主义对东亚国家间关系的不良影响日益凸现,对此区域安全形势时有冲击,在客观上延缓了东亚国家稳定的政治、经济合作机制的形成,限制或削弱了已有机制的作用,加深了东亚各国民众之间固有的隔阂和猜忌,更成为东北亚区域合作的深层障碍。

关键词：中国韩国日本民族主义区域合作

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