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从案例到规则:以程序公正司法审查标准为视角

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中国应用法学 2024年第2期 134-149页

作者：赵贵龙山东省济宁市中级人民法院

程序公正司法审查标准体系的形成在我国法治进程中具有里程碑意义。以1989年《行政诉讼法》将“违反法定程序”列为司法审查标准为重要标志,程序公正理念破茧为蝶,实现了中国法治化的蝶变。正当程序进入程序公正司法审查标准体系是司法... 详细信息

程序公正司法审查标准体系的形成在我国法治进程中具有里程碑意义。以1989年《行政诉讼法》将“违反法定程序”列为司法审查标准为重要标志,程序公正理念破茧为蝶,实现了中国法治化的蝶变。正当程序进入程序公正司法审查标准体系是司法的杰作,通过案例发现,正当程序标准从隐含适用到明示适用、从“规范空缺适用”到“利益衡量适用”,实现了域外规则的本土化,并让程序正义理念在我国司法领域得以完整体现,使得“重实体、轻程序”的法律传统成为昨日黄花。从法定程序到正当程序,进而涉入“过程性审查”这一程序正义的新路径,中国程序公正司法审查标准体系经历了一个逐步发展完善的过程,催发程序正义之树在中国大地上生根发芽、茁壮成长。

关键词：规则形成法定程序正当程序过程性审查案例制度

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安徽某投产前管道内检测工艺应用及风险控制

化工管理 2024年第7期 132-135页

作者：赵波巫鹏航赵贵龙合肥合燃华润燃气有限公司安徽合肥230075

内检测是燃气管道本体检测的重要检测方法,是保障燃气管道安全运行的重要手段。投产前天然气管道作为无输送介质的管道,内检测极易出现检测器运行速度不稳、卡堵、发球失败等情况,因此研究能应用于投产前管道内检测的检测装置工艺是十... 详细信息

内检测是燃气管道本体检测的重要检测方法,是保障燃气管道安全运行的重要手段。投产前天然气管道作为无输送介质的管道,内检测极易出现检测器运行速度不稳、卡堵、发球失败等情况,因此研究能应用于投产前管道内检测的检测装置工艺是十分有必要的。文章以安徽某燃气公司内检测作业为例,详细分析投产前管道内检测装置工艺的设计依据,对出现的内检测器运行速度控制等内检测工艺的关键控制点进行详细阐述和思考,提出的投产前管道内检测装置工艺在实际工作中应用并得到验证,结果达到了对内检测器运行速度的把控,使得内检测器在天然气管道内的运行速度稳定,采集数据精确,顺利帮助完成该段燃气管道内检测工作。同时对出现的内检测器运行速度控制、卡球、发球失败等内检测工艺的关键控制点和风险点给出了原因分析和解决措施,对投产前燃气管道的内检测工作具有借鉴意义。

关键词：投产前管道内检测内检测装置工艺关键控制点

在线甲烷分析仪在管道内甲烷含量监测中的应用探究

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城市燃气 2024年第7期 9-12页

作者：赵波巫鹏航赵贵龙合肥合燃华润燃气有限公司

在天然气管道日常隐患消缺施工和在新建天然气管道投产前甲烷置换作业过程中,都离不开对天然气管道内甲烷含量的监测,通常燃气公司的监测方式多为员工手持泵吸式甲烷分析仪现场检测并记录,但这种方式存在人为操作误差大、监测数据无法... 详细信息

在天然气管道日常隐患消缺施工和在新建天然气管道投产前甲烷置换作业过程中,都离不开对天然气管道内甲烷含量的监测,通常燃气公司的监测方式多为员工手持泵吸式甲烷分析仪现场检测并记录,但这种方式存在人为操作误差大、监测数据无法很好的实现信息化管理等情况。本文设计了一套在线甲烷分析仪,利用减压阀直连管道实现承压取样气检测分析管道内气体甲烷含量,同时数据可实时通过4G网络上传SCADA系统完成监测数据的存储、展示、预警、报警功能,为城市燃气管道施工作业中甲烷含量实时监测提供更加精准、安全、便捷服务,同时也能帮助提升监测数据信息化管理水平。

关键词：天然气管道在线甲烷分析仪 SCADA系统信息化管理

BCAT1抑制剂BAY-069的合成工艺优化

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合成化学 2024年第8期32卷 696-704页

作者：李勇罗文李燕谢华赵桂龙南方医科大学药学院广东广州510515 中科中山药物创新研究院广东中山528400 中国科学院上海药物研究所上海201203

BAY-069是目前体外活性最强的支链氨基酸转氨酶1(BCAT1)抑制剂,但其报道的合成路线存在原料成本较高、总收率极低和中间体结构表征不充分等缺点。本研究基于已有合成路线,重点对其合成工艺中的Ullmann偶联反应进行了系统优化。以1-硝基... 详细信息

BAY-069是目前体外活性最强的支链氨基酸转氨酶1(BCAT1)抑制剂,但其报道的合成路线存在原料成本较高、总收率极低和中间体结构表征不充分等缺点。本研究基于已有合成路线,重点对其合成工艺中的Ullmann偶联反应进行了系统优化。以1-硝基萘(1)为起始原料,经过7步反应和手性色谱柱手性拆分合成目标化合物BAY-069。所有中间体和目标化合物均经1 H NMR,13 C NMR和HR-MS表征。以Ullmann偶联反应为主要优化步骤的路线,其优化后的总收率为11.0%(3b→(±)-BAY-069),是原总收率1.6%(3a→(±)-BAY-069)的6.9倍。

关键词： BAY-069 支链氨基酸转氨酶1抑制剂工艺优化合成 Ullmann偶联反应 Sandmeyer反应轴手性

A Facile Synthetic Approach to 3-Halo-4-substituted-l,5-dihydro-4H-1,2,4-triazoline-5-thiones Based on Retro-Michael Addition

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Chemical Research in Chinese Universities 2017年第4期33卷 587-593页

作者： TIAN He LIU Yuqiang LI Xingwei XIE Yafei LIU Changying WANG Jianwu zhao guilong School of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China Eanjin Key Laboratory of Molecular Design and Drug Discovery Eanjin Institute of Pharmaceutical Research Tianjin 300193 P. R. China

A facile 3-step synthetic approach to 3-halo-4-substituted-l,5-dihydro-4H-1,2,4-triazolme-5-thiones （la--lk） from corresponding unhalogenated 8a---8i was developed based on the strategy of retro-Michael addition, with the key steps being regioselective S-alkylation of compounds 8a-8i with ethyl 3-iodopropionate（12c） and alkaline cleavage of the propionate protecting group via retro-Michael addition. The synthetic approach was characterized by simplicity of operation and wide substrate scope.

关键词： Synthetic approach Protecting group Triazole Halogenation Regioselectivity Retro-Michael addition

Facile Synthesis of Enantiomerically Pure 1-（5-Bromo-2-chlorophenyl）-1-（4-ethoxyphenyl）ethane

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Chemical Research in Chinese Universities 2014年第2期30卷 250-256页

作者： ZHANG Shuo WANG Wenjin LI Chuan LIU Peng XU Weiren TANG Lida WANG Jianwu zhao guilong School of Chemistry and Chemical Engineering Shandong University Jinan 250100 P.R.China Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical ResearchTianjin 300193 P.R.China

A facile 7-step procedure for the synthesis of enantiomerically pure 1-（5-bromo-2-chlorophenyl）-1-（4-ethoxyphenyl）ethanes[（R）-2 and（S）-2] that started from （5-bromo-2-chlorophenyl）（4-ethoxyphenyl）methanone 3 was *** key step was the resolution of 2-（5-bromo-2-chlorophenyl）-2-（4-ethoxyphenyl）acetic acid 6 by crystallizations of its L-and D-menthyl esters 7 and 8 from petroleum ether to give optically pure enantiomers 9 and 10,*** absolute configurations of the products were unambiguously determined by single-crystal X-ray diffractions of four key intermediates,9,10,13 and *** procedure is characterized by inexpensiveness,scalability and ability to produce two individual enantiomers of a diarylethane with unambiguously determined absolute configurations and high enantiomeric purities.

关键词： Diarylethane Diastereomer Enantiomer Resolution SGLT2 inhibitor

gem-Dimethyl-bearing C-Glucosides as Sodium-glucose Co-transporter 2 （SGLT2） Inhibitors

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Chinese Journal of Chemistry 2011年第6期29卷 1192-1198页

作者： Shi, Yongheng zhao, guilong Lou, Yuanyuan Wang, Yuli Shao, Hua Liu, Wei Xu, Weiren Tang, Lida School of Pharmacy Tianjin Medical University Tianjin 300070 China Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical Research Tianjin 300193 China College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao Shandong 266042 China

Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 （SGLT2） inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a facile 8-step protocol, with the key step being anhydrous aluminum chloride-catalyzed Friedel-Crafts alkylation of tertiary alcohols and phenetol. These three SGLT2 inhibitors were evaluated in vivo with a mice oral glucose tolerance test （OGTT）, and the anti-hyperglycemic activities of all these three compounds were comparable with that of the positive control Dapagliflozin.

关键词： sodium-glucose co-transporter 2 (SGLT2) gem-dimethyl synthesis Friedel-Crafts alkylation oral glucose tolerance test (OGTT)

Robust, breathable, and chemical-resistant polytetrafluoroethylene (PTFE) films achieved by novel in-situ fibrillation strategy for highperformance triboelectric nanogenerators

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Nano Research 2024年第3期17卷 1942-1951页

作者： Jialong Chai guilong Wang Jinchuan zhao Guizhen Wang Chao Wei Aimin Zhang Guoqun zhao Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China Key Laboratory of Chinese Education Ministry for Tropical Biological Resources Hainan UniversityHaikou 570228China

In the era of advanced wearable electronic devices,the triboelectric nanogenerators(TENGs)as energy harvesting and self-powered sensing units hold great *** appropriate triboelectric material is the crucial factor to optimize the performance of TENG,while polytetrafluoroethylene(PTFE)stands out as a highly versatile option among the various *** this study,we present an ultrafine nanofibrous PTFE(NF-PTFE)films prepared by novel in-situ fibrillation strategy as the triboelectric material in TENG *** innovative processing methodology facilely addresses the dilemma between high porosity and fine pore size of traditional porous PTFE films,meanwhile achieves exceptional mechanical strength,hydrophobicity,air permeability,and chemical resistance of the *** the integration of nanofibrous PTFE films into contact-separation mode TENG and droplet-based TENG,these devices realize the peak electrical output of 131 V/10.8μA and 54 V/14μA with great durability,which surpass the performance of TENGs using traditional expanded PTFE ***,a smart glove capable of recognizing hand gestures is proposed,which demonstrates the versatility,flexibility,and practicality of this material for potential use in smart *** reported NF-PTFE film provides insights for the design of high-performance TENG device for advanced wearable electrical applications.

关键词： polytetrafluoroethylene(PTFE) nanofibrous film hydrophobic triboelectric nanogenerator self-powered sensor

Design, Synthesis and Biological Activity of Tetrazole-bearing Uric Acid Transporter 1 Inhibitors

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Chemical Research in Chinese Universities 2017年第1期33卷 49-60页

作者： CAI Wenqing LIU Wei XIE Yafei WU Jingwei LIU Yuqiang LIU Changying XU Weiren TANG Lida WANG Jianwu zhao guilong School of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical Research Tianjin 300193 P. R. China

Systematic structure-activity relationship（SAR） exploration of a moderately active tetrazole-bearmg lesinurad-based hit If led to the discovery of a potent uric acid transporter I（URAT1） inhibitor li, which possessed a novel molecular skeleton and was 11-fold more potent than the parent lesinurad against human URAT1 in-vitro （IC50=0.66 gmol/L for li vs. 7.18 μmol/L for lesinurad）.

关键词： URAT1 inhibitor Structure-activity relationship Drug discovery Lesinurad Tetrazole Bioisostere