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Development and validation of a score predicting mortality for older patients with mitral regurgitation

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Journal of Geriatric Cardiology 2023年第8期20卷 577-585页

作者： De-Jing FENG Yun-qing YE zhe LI bin zhang qing-Rong liu Wei-Wei WANG zhen-yan zhao zheng ZHOU qing-Hao zhao Zi-Kai YU Hai-Tong zhang zhen-ya DUAN bin-Cheng WANG Jun-Xing LV Shuai GUO Run-Lin GAO Hai-yan XU Yong-Jian WU on behalf of the China-DVD and China-VHD study investigators Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

OBJECTIVE To develop and validate a user-friendly risk score for older mitral regurgitation(MR)patients,referred to as the Elder-MR *** The China Senile Valvular Heart Disease(China-DVD)Cohort Study functioned as the development cohort,while the China Valvular Heart Disease(China-VHD)Study was employed for external *** included patients aged 60 years and above receiving medical treatment for moderate or severe MR(2274 patients in the development cohort and 1929 patients in the validation cohort).Candidate predictors were chosen using Cox’s proportional hazards model and stepwise selection with Akaike’s information *** Eight predictors were identified:age≥75 years,body mass index<20 kg/m^(2),NYHA class Ⅲ/Ⅳ,secondary MR,anemia,estimated glomerular filtration rate<60 mL/min per 1.73 m^(2),albumin<35 g/L,and left ventricular ejection fraction<60%.The model displayed satisfactory performance in predicting one-year mortality in both the development cohort(C-statistic=0.73,95%CI:0.69-0.77,Brier score=0.06)and the validation cohort(C-statistic=0.73,95%CI:0.68-0.78,Brier score=0.06).The Elder-MR score ranges from 0 to 15 *** a one-year follow-up,each point increase in the Elder-MR score represents a 1.27-fold risk of death(HR=1.27,95%CI:1.21-1.34,P<0.001)in the development cohort and a 1.24-fold risk of death(HR=1.24,95%CI:1.17-1.30,P<0.001)in the validation *** to EuroSCORE II,the Elder-MR score demonstrated superior predictive accuracy for one-year mortality in the validation cohort(C-statistic=0.71 vs.0.70,net reclassification improvement=0.320,P<0.01;integrated discrimination improvement=0.029,P<0.01).CONCLUSIONS The Elder-MR score may serve as an effective risk stratification tool to assist clinical decision-making in older MR patients.

关键词： patients mitral score

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玉米专用高分子缓释肥的制备及肥效研究

中北大学学报（自然科学版） 2007年第2期28卷 138-142页

作者：赵贵哲刘亚青薛怀清张斌中北大学材料科学与工程学院山西太原030051 山西农业大学林学院山西太谷030801

以自制的脲甲醛低聚物和磷酸二氢钾-磷酸混合液反应合成了一种多营养元素高分子缓释化肥.通过控制投料比使其N∶P2O5∶K2O=10∶7.6∶1.5,符合玉米生长对N,P,K的需要.大田试验结果表明,单独施用高分子化肥的增产率为16.56%,高分子化肥与... 详细信息

以自制的脲甲醛低聚物和磷酸二氢钾-磷酸混合液反应合成了一种多营养元素高分子缓释化肥.通过控制投料比使其N∶P2O5∶K2O=10∶7.6∶1.5,符合玉米生长对N,P,K的需要.大田试验结果表明,单独施用高分子化肥的增产率为16.56%,高分子化肥与农家肥混合施用的增产率为56.51%,明显高于常规施肥的SV玉米专用肥和农家肥混用时的增产率49.11%.

关键词：多营养元素高分子缓释化肥玉米大田试验

Who can benefit more from its twelve-week treatment:A prospective cohort study of blonanserin for patients with schizophrenia

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World Journal of Psychiatry 2024年第11期14卷 1735-1745页

作者： Bao-yan Xu Kun Jin Hai-Shan Wu Xue-Jun liu Xi-Jin Wang Hong Sang Ke-qing Li Mei-Juan Sun Hua-qing Meng Huai-Li Deng Zhi-Yuan Xun Xiao-Dong yang Lin zhang Guan-Jun Li Rui-Ling zhang Duan-Fang Cai Jia-Hong liu gui-Jun zhao Long-Fa liu Gang Wang Chang-Lie zhao bin Guo Sheng-Chun Jin Ling-Yun Huang Fu-De yang Jian-Min zheng gui-Lai Zhan Mao-Sheng Fang Xiang-Jun Meng Guang-ya zhang Hai-Min Li Xiang-Lai liu Ju-Hong Li bin Wu Hai-Yun Li Jin-Dong Chen Department of Psychiatry National Clinical Research Center for Mental DisordersNational Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Psychiatry Hebei Provincial Mental Health CenterHebei Key Laboratory of Major Mental and Behavioral DisordersThe Sixth Clinical Medical College of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceChangsha 410000Hunan ProvinceChina Department of Psychiatry The First Psychiatric Hospital of HarbinHarbin 150000Heilongjiang ProvinceChina Mental Health Center Changchun Sixth HospitalChangchun 130000Jilin ProvinceChina Department of Pharmacy Daqing Third HospitalDaqing 163000Heilongjiang ProvinceChina Department of Physical and Psychological Rehabilitation Guangda Rehabilitation HospitalChongqing 400000China Department of Psychology Shanxi Provincial Mental Health CenterTaiyuan 030000Shanxi ProvinceChina Department of Psychiatry Tianjin Anding HospitalTianjin 300000China Department of Psychiatry Shandong Mental Health CenterJinan 250000Shandong ProvinceChina Department of Psychiatry Fuzhou Shenkang HospitalFuzhou 350000Fujian ProvinceChina Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200000China Department of Psychiatry The Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Psychiatry The Fifth People’s Hospital of ZigongZigong 643000Sichuan ProvinceChina Department of Psychiatry The Affiliated Kangning Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Psychiatry Guangyuan Mental Health CenterGuangyuan 628000Sichuan ProvinceChina Department of Psychiatry Jilin Sixth People’s HospitalJilin 132000Jilin ProvinceChina The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital

BACKGROUND Blonanserin(BNS)is a well-tolerated and effective drug for treating *** To investigate which types of patients would obtain the most benefit from BNS *** A total of 3306 participants were evaluated in a 12-week,prospective,multicenter,open-label post-marketing surveillance study of *** psychiatric rating scale(BPRS)scores were calculated to evaluate the effectiveness of BNS,and its safety was assessed with the incidence of adverse drug *** regression was used to screen the influencing factors for the reduction of BPRS total score,and logistic regression was used to identify patients with a better response to *** The baseline BPRS total score(48.8±15.03)decreased to 27.7±10.08 at 12 weeks(P<0.001).Extrapyramidal symptoms(14.6%)were found to be the most frequent adverse drug *** acute phase,baseline BPRS total score,current episode duration,number of previous episodes,dose of concomitant antipsychotics,and number of types of sedative-hypnotic agents were found to be independent factors affecting the reduction of BPRS total score after treatment ***,patients in the acute phase with baseline BPRS total score≥45,current episode duration<3 months,and≤3 previous episodes derived greater benefit from 12-week treatment with *** Patients in the acute phase with more severe symptoms,shorter current episode duration,fewer previous episodes,and a lower psychotropic drug load derived the greatest benefit from treatment with BNS.

关键词： Schizophrenia Blonanserin Effectiveness Psychosocial functioning Prospective cohort study

超临界二氧化碳在聚合物挤出成型中的应用进展

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中北大学学报（自然科学版） 2008年第1期29卷 57-61页

作者：刘亚青赵贵哲张燕君中北大学山西省高分子复合材料工程技术研究中心山西太原030051

详述了国内外在超临界二氧化碳降低挤出成型过程中聚合物的熔体粘度和作为发泡剂制备微孔塑料制品两方面的研究进展,指出了目前国内外在超临界二氧化碳(SC-CO2)应用于聚合物挤出成型方面存在的问题.为了解超解超临界二氧化碳在聚合物科... 详细信息

详述了国内外在超临界二氧化碳降低挤出成型过程中聚合物的熔体粘度和作为发泡剂制备微孔塑料制品两方面的研究进展,指出了目前国内外在超临界二氧化碳(SC-CO2)应用于聚合物挤出成型方面存在的问题.为了解超解超临界二氧化碳在聚合物科学中的应用潜能提供了参考.

关键词：超临界二氧化碳聚合物挤出成型

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1845-1855页

作者： Huijie Bian zhao-Hui zheng Ding Wei Aidong Wen zheng zhang Jian-Qi Lian Wen-zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di zhang Mingru zhang Xiu-Xuan Sun Likun Ding Kui zhang Junfeng Jia Jin Ding Zhiqin Li yanyan Jia Lin-Na liu zhe zhang zhao-Wei Gao Hong Du Na yao qing Wang Ke Wang Jie-Jie Geng bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui yao Ying Shi Xiang-Min yang Jian-Sheng Zhou Yi-Nan Ma ya-Tao Wang Xue Liang Fei Huo zhe Wang yang zhang Xu yang Ye zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang liu qing-Yi Wang Zhi-Nan Chen Ping Zhu National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anChina Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi'anChina Center for Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'anChina department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXKanChina College of Military Preventive Medicine Fourth Military Medical UniversityXi'anChina Department of Pharmaceutics Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Pathology Fourth Military Medical UniversityXi'anChina Jiangsu Pacific Meinuoke Biopharmaceutical Co.Ltd ChangzhouChina Department of Foreign Languages Fourth Military Medical UniversityXi'anChina

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 *** is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)***,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 *** phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was *** serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic *** obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each *** biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to *** the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent *** meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control *** results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

关键词： patients dosage phase

Development and calibration of the Moon-based EUV camera for Chang'e-3

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Research in Astronomy and Astrophysics 2014年第12期14卷 1654-1663页

作者： Bo Chen Ke-Fei Song zhao-Hui Li qing-Wen Wu Qi-Liang Ni Xiao-Dong Wang Jin-Jiang Xie Shi-Jie liu Ling-Ping He Fei He Xiao-Guang Wang bin Chen Hong-Ji zhang Xiao-Dong Wang Hai-Feng Wang Xin zheng Shu-Lin E Yong-Cheng Wang Tao Yu Liang Sun Jin-Ling Wang Zhi Wang Liang yang qing-Long Hu Ke Qiao Zhong-Su Wang Xian-Wei yang Hai-Ming Bao Wen-Guang liu zhe Li ya Chen yang Gao Hui Sun Wen-Chang Chen Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences

The process of development and calibration for the first Moon-based ex- treme ultraviolet （EUV） camera to observe Earth＇s plasmasphere is introduced and the design, test and calibration results are presented. The EUV camera is composed of a multilayer film mirror, a thin film filter, a photon-counting imaging detector, a mech- anism that can adjust the direction in two dimensions, a protective cover, an electronic unit and a thermal control unit. The center wavelength of the EUV camera is 30.2 nm with a bandwidth of 4.6nm. The field of view is 14.7° with an angular resolution of 0.08°, and the sensitivity of the camera is 0.11 count s-1 Rayleigh-1. The geomet- ric calibration, the absolute photometric calibration and the relative photometric cal- ibration are carried out under different temperatures before launch to obtain a matrix that can correct geometric distortion and a matrix for relative photometric correction, which are used for in-orbit correction of the images to ensure their accuracy.

关键词： Chang'e-3 -- EUV camera: development: calibration -- Earth's plas-masphere -- lunar exploration

Solar X-ray and EUV imager on board the FY-3E satellite

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Light(Science & Applications) 2022年第12期11卷 2939-2951页

作者： Bo Chen Xiao-Xin zhang Ling-Ping He Ke-Fei Song Shi-Jie liu Guang-Xing Ding Jin-Ping Dun Jia-Wei Li zhao-Hui Li Quan-Feng Guo Hai-Feng Wang Xiao-Dong Wang Yun-Qi Wang Hong-Ji zhang Guang zhang zhen-Wei Han Shuang Dai Pei-Jie zhang Liang Sun yang liu software engineer Peng Wang Kun Wu Chen Tao Shi-Lei Mao gui Mei Liang yang Li-Heng Chen Chun-yang Han bin Huang yang liu mechanical engineer Shuai Ren Peng Zhou Ze-XiWei Xiao-Xue zhang Yue zhang Xin zheng yang Wang ya Chen Jing-Jiang Xie Fei He Qiao Song Wei-Guo Zong Xiu-qing Hu Peng zhang Jing-Song Wang Zhong-Dong yang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key Laboratory of Applied Optics Chinese Academy of SciencesChangchunChina National Satellite Meteorological Center China Meteorological AdministrationBeijingChina Key Laboratory of Space Weather National Center for Space WeatherChina Meteorological AdministrationBeijingChina Innovation Center for Fengyun Meteorological Satellite(FYSIC) BeijingChina Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijingChina

The solar X-ray and Extreme Ultraviolet Imager(X-EUVI),developed by the Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences(CIOMP),is the first space-based solar X-ray and Extreme ultraviolet(EUV)imager of China loaded on the Fengyun-3E(FY-3E)satellite supported by the China Meteorological Administration(CMA)for solar *** started work on July 11,2021,X-EUVI has obtained many solar *** instrument employs an innovative dual-band design to monitor a much larger temperature range on the Sun,which covers 0.6-8.0 nm in the X-ray region with six channels and 19.5 nm in the EUV region.X-EUVI has a field of view of 42′,an angular resolution of 2.5″per pixel in the EUV band and an angular resolution of 4.1″per pixel in the X-ray *** instrument also includes an X-ray and EUV irradiance sensor(X-EUVS)with the same bands as its imaging optics,which measures the solar irradiance and regularly calibrates the solar *** radiometric calibration of X-EUVS on the ground has been completed,with a calibration accuracy of 12%.X-EUVI is loaded on the FY-3E satellite and rotates relative to the Sun at a uniform ***-field calibration is conducted by utilizing successive rotation solar *** agreement between preliminarily processed X-EUVI images and SDO/AIA and Hinode/XRT images indicates that X-EUVI and the data processing algorithm operate properly and that the data from X-EUVI can be applied to the space weather forecast system of CMA and scientific investigations on solar activity.

关键词： image instrument Solar

Study on ZnO Nanowire Prepared by Nuclear Track Technique

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Study on ZnO Nanowire Prepared by Nuclear Track Technique

Study on Anti-infrared Reflectivity of CR-39 With Nuclear Track Technique

作者： liu Chao liu Cun-xiong GAO Si-ze NI Bang-fa TIAN Wei-zhi XIAO Cai-jin NIE Peng zhao Chang-jun WANG Ping-sheng QIN ya-li CHEN zhe zhang gui-ying HUANG Dong-hui SUN Hong-chao zhang Hai-qing College of Physics Science and Engineering Technology Guangxi University

As aⅡ-Ⅵcompound semiconductor with a wide and direct band gap of 3.37 eV,bound excition binding energy of 60 MeV,zinc oxide(ZnO) has been shown to be a candidate for electronic and

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Study on Anti-infrared Reflectivity of CR-39 With Nuclear Tr...