检索结果-南通市图书馆

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang di zhao Lemei Zhu Zheyu Zhang Min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DSMC: Fast direct simulation Monte Carlo solver for the Boltzmann equation by Multi-Chain Markov Chain and multicore programming

引用

International Journal of Modeling, Simulation, and Scientific Computing 2016年第2期7卷 152-166页

作者： di zhao Haiwu He Computer Network Information Center Chinese Academy of Sciences Beijing 100190 P.R.China

direct Simulation Monte Carlo(DSMC)solves the Boltzmann equation with large Knudsen *** Boltzmann equation generally consists of three terms:the force term,the diffusion term and the collision *** the first two terms of the Boltzmann equation can be discretized by numerical methods such as the finite volume method,the third term can be approximated by DSMC,and DSMC simulates the physical behaviors of gas ***,because of the low sampling efficiency of Monte Carlo Simulation in DSMC,this part usually occupies large portion of computational costs to solve the Boltzmann *** this paper,by Markov Chain Monte Carlo(MCMC)and multicore programming,we develop direct Simulation Multi-Chain Markov Chain Monte Carlo(DSMC3):a fast solver to calculate the numerical solution for the Boltzmann *** results show that DSMC3 is significantly faster than the conventional method DSMC.

关键词： Fast solver direct simulation Multi-Chain Markov Chain Monte Carlo DSMC the Boltzmann equation multicore programming

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances on micro-control for near-critical complex systems

引用

Control Theory and Technology 2022年第2期20卷 287-290页

作者： di zhao Yi Dong Department of Control Science and Engineering&Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghaiChina

In this paper,we review some existing control methodologies for complex systems with particular emphasis on those that are near *** to the shortage of the classical control theory in handling complex systems,the reviewed control methods are mainly associated with machine learning techniques,game-theoretical approaches,and sparse control ***,several interesting and promising directions for future research are also proposed.

关键词： Complex systems Near criticality Micro-control Machine learning Game theory Sparse control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Retrospect and prospect on integration of gain and phase for feedback stability analysis

引用

Control Theory and Technology 2022年第4期20卷 555-558页

作者： di zhao Li Qiu Department of Control Science and Engineering&Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201804China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Guangzhou HKUST Fok Ying Tung Research Insititute Nansha DistrictGuangzhou 511458GuangdongChina

In this paper,we review existing approaches to integrating small gain and small phase analysis for feedback stability of dynamical systems,and give a brief outlook for possible future directions in exploring this *** gain analysis has been very successful and popular in control theory since 1960s,while the small phase analysis for multiple-input-multiple-output systems has not been well understood until recently and is now gradually taking ***,there have been attempts to analyzing feedback stability via the integration of gain and phase information over decades,including the combination of small gain with positive realness as well as that with negative *** combinations can be subsumed into a recently proposed framework for gain-phase integration,which brings in new geometrical methods and also sheds new lights on several future directions.

关键词： Small gain Small phase Passivity Positive real Negative imaginary Davis-Wielandt shell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recrystallization Modelling of Hot Deformed Si-Mn TRIP Steel

引用

Journal of Iron and Steel Research International 2007年第2期14卷 61-65页

作者： WU di zhao Xian-ming State Key Laboratory of Rolling Technology and Automation Northeastern University Shenyang 110004 Liaoning China

By means of hot compression single and double hit experiments, the kinetics of dynamic and static recrystallization in hot-rolled Si-Mn TRIP steel was studied, and the emphasis was put on the influence of high silicon content. The results show that the calculated parameters are consistent with the experimental ones, and addition of silicon retards both dynamic and static recrystallization as well as increases the flow stress of austenite, and the non-recrystallization zone can be enlarged by increasing the silicon contents.

关键词： dynamic recrystallization static recrystallization mathematical model TRIP steel silicon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hybrid Weighted l1-Total Variation Constrained Reconstruction for MR Image

引用

Chinese Journal of Electronics 2014年第4期23卷 747-752页

作者： zhao di DU Huiqian MEI Wenbo School of Information and Electronics Beijing Institute of Technology

Compressed sensing based Magnetic resonance(MR) image reconstruction can be done by minimizing the sum of least square data fitting item, the Total variation(TV) and l1 norm regularizations. In this paper, inspired by the conventional constrained reconstruction model, we propose a hybrid weighted l1-TV minimization method to reconstruct MR image. We introduce the iterative mechanism to update the weights for l1 and TV norms adaptively. The weights vary at each element of the image matrix according to the presented weights selection strategy. Experiments on Shepp-Logan phantom and practical MR images demonstrate the proposed method can preserve image details and obtain improved reconstruction quality compared to the traditional CS-MRI method and other weighted methods.

关键词： Compressed sensing(CS) Magnetic resonance imaging(MRI) Image reconstruction Weighted l 1 norm Weighted Total variation(TV)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

EXTRACTION OF ANTHRAQUINONE DERIVATIVES FROM RHUBARB RHIZOMES AND THEIR ANTIBACTERIAL TESTS

引用

Journal of Innovative Optical Health Sciences 2011年第2期4卷 127-132页

作者： YUAN-CHENG CAO YUAN-di zhao College of Life Science and Technology Huazhong University of Science and Technology Wuhan HuBeiP.R.China430074

Photometry was employed to study the optimum extraction conditions of anthraquinone derivatives from rhizomes of Rheum officinale Baill in this *** influences of extraction solvents(chloroform,benzene,ethanol,methanol,and glycerol),acid,and extraction time on the extraction yield were *** results indicate that,to the Rhubarb rhizomes powder with the average particle size 0.18 mm,the conditions of the extraction solvent composed by chloroform,glycerol,and sulfuric acid(20%)in the ratio of 4:1:1(v:v),the weight of dried Rhubarb to the solvent volume in the ratio of 1:12 ew:vT,extraction time of 110 min,the anthraquinone derivatives extraction could achieve the best *** the antibacterial tests showed the raw extraction products had the MIC(minimal inhibitory concentration)of 20μg=mL and 30μg=mL to Staphylococcus aureus and Escherichia coli,respectively.

关键词： Anthraquinone derivatives photometry optimum extraction conditions Rheum officinale Baill antibacterial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances in phenazine-linked porous catalysts toward photo/electrocatalytic applications and mechanism

引用

Green Energy & Environment 2024年第10期9卷 1518-1549页

作者： Yang Liu Yu Zhang zhao-di Yang Liqiang Jing Heilongjiang Provincial Key Laboratory of CO_(2) Resource Utilization and Energy Catalytic Materials School of Material Science and Chemical EngineeringHarbin University of Science and TechnologyHarbinHeilongjiang150080China Institute of Process Engineering Chinese Academy of Sciences100080BeijingChina Key Laboratory of Functional Inorganic Materials Chemistry(Ministry of Education) School of Chemistry and Materials ScienceInternational Joint Research Center for Catalytic TechnologyHeilongjiang UniversityHarbin150080China

In recent years,porous organic catalysts have been developed and become research hotspots in photo/electrocatalysis due to their inherent pores,high specific surface area,chemical and thermal stability,and diverse functional building ***-linked organic catalysts,exhibited excellent conjugation,electrical conductivity,chemical,and thermal stability,could bring in N atoms with specific numbers and positions to regulate electron levels,anchor metals,and absorb near-infrared light,which expands solar energy *** advantages of the phenazine-linked catalysts attracted our group and numerous researchers to conduct experimental and computational work on photo/electrocatalytic applications and *** review summarizes the recent significant research progress,synthesis methods,photo/electrocatalytic performance,and applications of relative phenazine-linked ***,the photo/electrocatalytic mechanism was systematized and summarized by combining experiments and density functional theory calculations simultaneously.

关键词： Phenazine-linked porous catalysts Photo/electrocatalytic applications Catalytic mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of carbon in modifying solidification and microstructure of a Ni?based superalloy with high Al and Ti contents

引用

Journal of Iron and Steel Research International 2021年第1期28卷 98-110页

作者： Guang‑di zhao Xi‑min Zang Wen‑ru Sun School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina

The effect of carbon ranging from 0.014 to 0.071 wt.%on the solidification and microstructure of a Ni-based superalloy with high Al and Ti contents was *** results show that the increase in carbon addition significantly increases the size and volume fraction of MC carbides and promotes the change of their morphology from blocky to elongated ***,the carbon addition obviously decreases the size and volume fraction of eutectic(γ+γ′)and reducesηphase and borides *** change in carbide characteristics is mainly because of the increasing carbide-forming element and carbides precipitation temperature with the increase in carbon which favors the growth of them along the interdendritic liquid *** carbides are formed at an earlier solidification stage than the eutectic(γ+γ′).The increased carbide formation consumes more Ti,which delays and reduces the eutectic(γ+γ′)*** delay of eutectic(γ+γ′)precipitation leads to a deeper undercooling,which significantly decreases the critical Ti concentration for its ***,in turn,lowers Ti/Al ratio in residual liquids ahead of the eutectic(γ+γ′)and hence reducesηformation subsequently.B and Zr are slightly enriched in the carbides,which are considered during discussing how carbon influences the eutectic(γ+γ′)precipitation.

关键词： Carbon Ni-based superalloy Solidification Segregation Eutectic(γ+γ′) MC carbide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparative studies on molecular induced aggregation of hepta-imidazoliumyl-β-cyclodextrin towards anionic surfactants

引用

Chinese Chemical Letters 2015年第7期26卷 829-833页

作者： di zhao Yong Chen Yu Liu Department of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

A β cyclodextrin derivative bearing seven cationic arms and its singly charged analogue, i.e., per-6- deoxy-f-（1-methylimidazol-3-ium-3-yl）-β-cyclodextrin （3） and mono-fi-deoxy-6-（1-methylimidazol- 3-ium-3-yl）-β-cyclodextrin （4） were synthesized and fully characterized. Their induced aggregation behaviours towards two anionic surfactant, that is, sodium dodecyl sulfonate （SDS） and dioctyl sodium sulfosuccinate （Aerosol OT, AOT）, were investigated by UV-vis, NMR, Zeta-potential, dynamic light scattering （DLS）, and transmission electron microscopy. The results revealed that host 3 can induce the molecular aggregation of anionic surfactant at concentration far lower than its original CAC, leading to the larger diameter, the narrower size distribution and the higher thermal stability of the induced aggregate towards the anionic surfactant possessing more hydrophobic tails.

关键词： Cyclodextrin Surfactant Molecular assembly Induced aggregation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：