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Application of ultrasound microbubble contrast technology in ophthalmic targeted therapy:literature analysis

International Journal of Ophthalmology(English edition) 2011年第5期4卷 537-542页

作者： Jia-Ying Yuan, shuan-Jie Gao Department of Ultrasonography Directly under Hospital of Military Area of Henan Zhengzhou 450003 Henan ProvinceChina The Faculty of Biomedical Engineering of Zhengzhou University Zhengzhou 450001 Henan Province China Department of Ultrasonography Xi'an Electricity Hospital Xi'an 710032 Shaanxi Province China

AIM: To analyze the application of microbubble contrast technology in the treatment of ophthalmic diseases, mainly analyzing its advantages and existing problems. METHODS: A total of 30 representative literatures about the application of ultrasound contrast agent in gene targeted therapy at home and abroad were collected, and focusing on sorting out the literature reporting the treatment of ophthalmic diseases with microbubble contrast technology in recent years, then recalling its advantages and problems, finally making reasonable assessment on existing problems and proposing possible solutions to the problems. RESULTS: Due to its unique safety and efficacy, the treatment of ophthalmic diseases with microbubble contrast technology has increasingly drawn the attention of clinicians, but two relevant issues should be considered: first, the nature of contrast agent and the choice of corresponding ultrasound parameters; second, relative incidence of tissue bleeding, intravascular hemolysis, moderate or severe allergy as well as other side effects. CONCLUSION: Microbubble may become the carrier of targeted therapy, and as a kind of new non-invasive delivery system, the ultrasound contrast agent has broad application prospects, but its application in ophthalmic research is still in its initial stage and the safety of contrast-enhanced ultrasound still needs further study.

关键词： microbubble contrast technology targeted therapy ophthalmic diseases

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Damage evolution model of strain hardening cementitious composites under the uniaxial stress state

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International Journal of Minerals,Metallurgy and Materials 2013年第2期20卷 196-204页

作者： Rui He shuan-fa Chen Pei-liang Cong Shao-hua Ji School of Highway Chang'an University Via Department of Civil and Environmental Engineering Virginia Polytechnic Institute and State UniversityBlacksburg VA 24061USA Engineering Research Center of the Ministry of Education for Transportation Materials Chang'an University

The deformation and damage behaviors of strain hardening cementitious composites （SHCC） under the uniaxial stress state were investigated in this paper. Two ductile failure-based constitutive models were introduced to describe the uniaxial tension and compression properties of SHCC only using a few parameters. The computation method of model parameters was developed to ease the simulation procedures. Damage evolution of the SHCC was simulated by the formulation of continuum damage mechanics subsequently. The results show that the proposed models fit the stress-strain curves reasonably well, and the damage variables show different growth rules under uniaxial tension and compression. It is concluded that the proposed method can not only simply simulate the constitutive behavior of SHCC with the reasonable accuracy but also capture the characteristic of material degradation.

关键词： cementitious composites strain hardening constitutive models ductile fracture continuum damage mechanics

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Influences of Yttrium on Cyclic Oxidation Behavior of Fe-Cr-Al Alloy

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Journal of Rare Earths 2001年第1期19卷 53-56页

作者：辛丽李美栓钱余海李铁藩 Corrosion Sci. Lab. Inst. of Corrosion Chinese Acad. of Sci. Shenyang 110015 China

The 1100 degreesC cyclic oxidation behavior of Fe-23Cr-5Al alloy modified by yttrium was studied. Yttrium was added to this alloy in the form of (1) metallic addition, (2) yttrium oxide dispersion and (3) ion implantation. Cracking and spalling occurred on the convoluted scale formed on Y-free alloy and the substrate was exposed. A flat dense scale without spallation was formed on the yttrium alloying addition or yttrium oxide dispersion alloy. Spallation mainly occurred between two layers of the scale on the 1 x 10(17)Y ions/cm(2)-implanted alloy. The results indicate the main reason that the adhesion of alumina scale was improved by yttrium addition lies in that yttrium is liable to form a stable yttrium sulfide with sulfur in the alloy and prevent sulfur interface segregation. Another reason is that the growth mechanism of alumina scale was changed by yttrium addition.

关键词： rare earths yttrium Fe-Cr-Al alloy cyclic oxidation

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Electro-catalytic degradation of sulfisoxazole by using graphene anode

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Journal of Environmental Sciences 2016年第5期28卷 54-60页

作者： Yanyan Wang shuan Liu Ruiping Li Yingping Huang Chuncheng Chen Collaborative Innovation Center for Geo-Hazards and Eco-Environment in Three Gorges Area Yichang 443002 China Key Laboratory of Marine New Materials and Application Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of Sciences Ningbo 315201 China

Graphite and graphene electrodes were prepared by using pure graphite as precursor. The electrode materials were characterized by a scanning electron microscope（SEM）, X-ray diffraction（XRD） and cyclic voltammetry（CV） measurements. The electro-catalytic activity for degradation of sulfisoxazole（SIZ） was investigated by using prepared graphene or graphite anode. The results showed that the degradation of SIZ was much more rapid on the graphene than that on the graphite electrode. Moreover, the graphene electrode exhibited good stability and recyclability. The analysis on the intermediate products and the measurement of active species during the SIZ degradation demonstrated that indirect oxidation is the dominant mechanism, involving the electro-catalytic generation of OH and O_2^- as the main active oxygen species. This study implies that graphene is a promising potential electrode material for long-term application to electro-catalytic degradation of organic pollutants.

关键词： Graphite Graphene Electro-catalytic Degrade Sulfisoxazole

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Twisting theory for weak Hopf algebras

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Applied Mathematics(A Journal of Chinese Universities) 2008年第1期23卷 91-100页

作者： CHEN Ju-zhen ZHANG Yan WANG shuan-hong Dept. of Math. Southeast Univ. Nanjing 210096 China.

The main aim of this paper is to study the twisting theory of weak Hopf algebras and give an equivalence between the （braided） monoidal categories of weak Hopf bimodules over the original and the twisted weak Hopf a... 详细信息

关键词： weak Hopf algebra weak Hopf bimodule twisting theory.

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具有二次加速功能的三药室发射装置实验研究

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兵工学报 2015年第11期36卷 2045-2052页

作者：伍俊肖玲庄铁栓赵骞总参谋部工程兵科研三所河南洛阳471023

提高初速是身管武器技术永恒的研究主题。提出了一种具有二次加速功能的三药室发射装置工作原理,对其发射进行了实验研究。该装置特点是在身管上离主药室一定长度的水平位置,增加两个辅助药室,弹丸通过辅助药室入口处时,弹后高温、高压... 详细信息

提高初速是身管武器技术永恒的研究主题。提出了一种具有二次加速功能的三药室发射装置工作原理,对其发射进行了实验研究。该装置特点是在身管上离主药室一定长度的水平位置,增加两个辅助药室,弹丸通过辅助药室入口处时,弹后高温、高压火药燃气点燃辅助药室装药,辅助装药燃烧产生的气体可减缓弹后空间压力下降,使弹底维持较高压力,达到弹丸二次增速目的。发射实验结果表明,该装置在不显著增加膛压的情况下,比单药室发射时平均初速提高15%左右,对工程防护终点弹道效应实验研究具有参考价值。

关键词：兵器科学与技术二次加速三药室辅助药室发射装置终点效应

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Synthesis of Mesoporous Silica and Ti-containing Molecular Sieves via A Novel Assembly

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Chinese Chemical Letters 2001年第8期12卷 737-740页

作者： Jing XIN Ji shuan SUO Xiao Ming ZHANG State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000

Thermally stable mesoporous silica and Ti-containing molecular sieves have been synthesized at mild temperature using low-cost and biodegradable --- amphoteric tetradecyl betaine as template. The physicochemical chara... 详细信息

关键词： Synthesis meosoporous silica and Ti-containing molecular sieves amphoteric tetradecyl betaine novel assembly.

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Expression patterns and action analysis of genes associated with drug-induced liver diseases during rat liver regeneration

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World Journal of Gastroenterology 2006年第43期12卷 6966-6972页

作者： Qian-Ji Ning Shao-Wei Qin Cun-shuan Xu College of Life Science HenanNormal University Xinxiang 453007 Henan Province China Key Laboratory for Cell Differentiation Regulation Xinxiang 453007 Henan Province China

AIM: To study the action of the genes associated with drug-induced liver diseases at the gene transcriptional level during liver regeneration (LR) in rats. METHODS: The genes associated with drug-induced liver diseases were obtained by collecting the data from databases and literature, and the gene expression changes in the regenerating liver were checked by the Rat Genome 230 2.0 array. RESULTS: The initial and total expression numbers of genes occurring in phases of 0.5-4 h after partial hepatectomy (PH), 4-6 h after PH (G0/G1 transition), 6-66 h after PH (cell proliferation), 66-168 h after PH (cell differentiation and structure-function reconstruction) were 21, 3, 9, 2 and 21, 9, 19, 18, respectively. It is illustrated that the associated genes were mainly triggered at the initial stage of LR and worked at different phases. According to their expression similarity, these genes were classified into 5 types: only up- regulated (12 genes), predominantly up-regulated (4 genes), only down-regulated (11 genes), predominantly down-regulated (3 genes), and approximately up-/ down-regulated (2 genes). The total times of their up- and down-expression were 130 and 79, respectively, demonstrating that expression of most of the genes was increased during LR, while a few decreased. The cell physiological and biochemical activities during LR were staggered according to the time relevance and were diverse and complicated in gene expression patterns. CONCLUSION: Drug metabolic capacity in regenerating liver was enhanced. Thirty-two genes play important roles during liver regeneration in rats.

关键词： Partial hepatectomy Rat Genome 230 2.0array Drug-induced liver diseases Genes associatedwith liver regeneration

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Improving the Performance of Thermoelectric Materials by Atomic Layer Deposition-based Grain Boundary Engineering

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Chinese Journal of Structural Chemistry 2020年第5期39卷 831-837页

作者： LI shuan-Kui ZHU Wei-Ming XIAO Yin-Guo PAN Feng School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China

Thermoelectric materials can directly achieve the conversion between heat and electricity,providing a clean and reliable way to alleviate energy ***,the wide use of thermoelectric materials is subjected to their low energy conversion *** boundary engineering is considered as an effective strategy to improve thermoelectric performance,particularly for the most polycrystalline thermoelectric materials in bulk ***,the precise controlling over the microstructure and composition of grain boundary at atomic scale has been achieved by atomic layer deposition(ALD)technology,which has been confirmed in various thermoelectric materials,such as Bi2Te2.7Se0.3,Bi0.4Sb1.6Te3,and ***,it is demonstrated that the decoupling between three key thermoelectric parameters,*** coefficient,electrical conductivity and thermal conductivity,can be realized by ALD-based grain boundary ***,these key parameters can be optimized simultaneously toward the desired direction,which is extremely important for improving the thermoelectric *** this review,the relevant progress on the grain boundary engineering by ALD-based strategy is reviewed and some prospects are proposed.

关键词： grain boundary engineering atomic layer deposition thermoelectric materials

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Application of droplet digital PCR in detection of seed-transmitted pathogen Acidovorax citrulli

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Journal of Integrative Agriculture 2020年第2期19卷 561-569页

作者： LU Yu ZHANG Hai-jun zhao Zi-jing WEN Chang-long WU Ping SONG Shun-hua YU shuan-cang Luo Lai-xin XU Xiu-lan Beijing Key Laboratory of Vegetable Germplasms Improvement Beijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry SciencesBeijing 100097P.R.China Supervision Inspection and Test Center of Vegetable Seed Quality of Ministry of Agriculture and Rural AffairsBeijing 100097P.R.China Beijing Key Laboratory of Seed Disease Testing and Control College of Plant PathologyChina Agricultural UniversityBeijing 100093P.R.China

Bacterial fruit blotch caused by Acidovorax citrulli is a serious threat to cucurbit industry *** pathogen is seedtransmitted,so seed detection to prevent distribution of contaminated seed is crucial in disease *** this study,we adapted a quantitative real-time PCR(qPCR)assay to droplet digital PCR(ddPCR)format for *** detection by optimizing reaction *** performance of ddPCR in detecting *** pure culture,DNA,infested watermelon/melon seed and commercial seed samples were compared with multiplex PCR,qPCR,and dilution plating *** lowest concentrations detected(LCD)by ddPCR reached up to 2 fg DNA,and 102 CFU mL–1 bacterial cells,which were ten times more sensitive than those of the *** testing artificially infested watermelon and melon seed,0.1%infestation level was detectable using ddPCR and dilution plating *** 26 positive samples were identified in 201 commercial seed samples through ddPCR,which was the highest positive number among all the *** detection sensitivity achieved by ddPCR demonstrated a promising technique for improving seed-transmitted pathogen detection threshold in the future.

关键词： bacterial fruit blotch Acidovorax citrulli droplet digital PCR seed detection quantitative real-time PCR

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