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Chromosomal level assembly and population sequencing of the Chinese tree shrew genome

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Zoological Research 2019年第6期40卷 506-521页

作者： Yu Fan Mao-Sen ye Jin-Yan zhang Ling Xu Dan-Dan Yu Tian-Le Gu Yu-Lin Yao Jia-Qi Chen Long-Bao Lv Ping Zheng Dong-Dong Wu Guo-Jie zhang Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China KIZ–CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Yunnan Key Laboratory of Animal Reproduction Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China

Chinese tree shrews (Tupaia belangeri chinensis) have become an increasingly important experimental animal in biomedical research due to their close relationship to primates. An accurately sequenced and assembled genome is essential for understanding the genetic features and biology of this animal. In this study, we used long-read single-molecule sequencing and high-throughput chromosome conformation capture (Hi-C) technology to obtain a high-qualitychromosome-scale scaffolding of the Chinese tree shrew genome. The new reference genome (KIZ version 2: TS_2.0) resolved problems in presently available tree shrew genomes and enabled accurate identification of large and complex repeat regions, gene structures, and species-specific genomic structural variants. In addition, by sequencing the genomes of six Chinese tree shrew individuals, we produced a comprehensive map of 12.8 M single nucleotide polymorphisms and confirmed that the major histocompatibility complex (MHC) loci and immunoglobulin gene family exhibited high nucleotide diversity in the tree shrew genome. We updated the tree shrew genome database (TreeshrewDB v2.0: http://***) to include the genome annotation information and genetic variations. The new high-quality reference genome of the Chinese tree shrew and the updated TreeshrewDB will facilitate the use of this animal in many different fields of research.

关键词： Tupaia belangeri Chromosomal level assembly genome Population sequencing Database

Polyaniline-supported iron catalyst for selective synthesis of lower olefins from syngas

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Journal of Energy Chemistry 2017年第4期26卷 608-615页

作者： Bang Gu Shun He Wei Zhou Jincan Kang Kang Cheng Qinghong zhang ye Wang State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsNational Engineering Laboratory for Green Chemical Productions of AlcoholsEthers and EstersCollege of Chemistry and Chemical EngineeringXiamen University

Uniform iron nanoparticles dispersed on polyaniline have been used as catalysts for the direct conversion of synthesis gas into lower olefins. As compared to active carbon and N-doped active carbon, polyaniline as a support of Fe catalysts showed higher selectivity of lower olefins(C2–4=). The C2–4=selectivity reached50% at a CO conversion of 79% over a 10 wt% Fe/polyaniline catalyst without any *** XRD, H2-TPR, TEM and HRTEM studies revealed that the presence of nitrogen-containing groups in polyaniline structure could promote the dispersion and reduction of iron oxides, forming higher fraction of iron carbides with smaller mean sizes and narrower size distributions. The propylene-TPD result indicates that the use of polyaniline support facilitates the desorption of lower olefins, thus suppressing the consecutive hydrogenation to form undesirable lower paraffins.

关键词： Polyaniline Iron catalyst Lower olefins Fischer–Tropsch Electron effect

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基于数据融合的MIMO雷达抗欺骗干扰算法

信号处理 2011年第2期27卷 314-319页

作者：李伟张辉张群空军工程大学电讯工程学院西安710077 空军工程大学科研部西安710038

多输入多输出雷达与传统相控阵雷达不同,可发射多个相关或相互正交信号,因此可获得更优性能。欺骗干扰的功率需求低、干扰效果逼真,需研究针对其的抗干扰技术。MIMO雷达在面临非组网欺骗干扰时,使用多正交信号可导致欺骗式目标散焦,但... 详细信息

多输入多输出雷达与传统相控阵雷达不同,可发射多个相关或相互正交信号,因此可获得更优性能。欺骗干扰的功率需求低、干扰效果逼真,需研究针对其的抗干扰技术。MIMO雷达在面临非组网欺骗干扰时,使用多正交信号可导致欺骗式目标散焦,但在高干信比条件下,仍会存在虚警目标。提出了一种基于不同信号对间交叉模糊函数起伏不同的虚警目标消除算法。该算法基于遗传算法产生相互正交的二相编码信号作为发射信号,对不同编码信号的回波图像实施恒虚警检测,通过数据融合,对各图像中检测到的目标作相关处理并完成真假鉴别,彻底消除了雷达受到的欺骗干扰。分析了MIMO雷达面临欺骗干扰时的抗干扰效能。仿真结果证明该算法可有效抑制非组网欺骗干扰,对提高雷达抗干扰效能有重要意义。

关键词：多输入多输出雷达欺骗干扰数据融合

PINK1-mediated Drp1^(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1719-1734页

作者： Qingtao Gao Runyi Tian Hailong Han Jesse Slone Caifang Wang Xiao Ke Tongmei zhang Xiangyu Li Yuhong He Panlin Liao Fang Wang ye Chen Shiqing Fu Kexuan zhang Fangfang Zeng Yingxuan Yang Zhuo Li Jieqiong Tan Jiada Li Youming Lu Taosheng Huang Zhonghua Hu Zhuohua zhang Institute of Molecular Precision Medicine Xiangya HospitalKey Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical GeneticsHunan Key Laboratory of Medical GeneticsCentral South UniversityChangshaHunan 410008China Department of Pediatrics Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNew York 14203USA Department of Physiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China The Institute for Brain Research Collaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhanHubei 430030China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Critical Care Medicine Hunan Provincial Clinical Research Center for Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China

Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation and synaptic ***,the underlying mechanism remains *** show here that Pink1 knockout(KO)mice display defective dendritic spine maturation,reduced axonal synaptic vesicles,abnormal synaptic connection,and attenuated long-term synaptic potentiation(LTP).Drp1 activation via ^(S616) phosphorylation rescues deficits of spine maturation in Pink1 KO neurons.

关键词： plasticity activation synaptic

Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014

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Science China(Life Sciences) 2014年第12期57卷 1149-1155页

作者： ZHAO Hui ZHAO Ling Zhai JIANG Tao LI Xiao Feng FAN Hang HONG Wen Xin zhang Yu ZHU Qin ye Qing TONG Yi Gang CAO Wu Chun zhang Fu Chun QIN Cheng Feng State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Guangzhou 8th People's Hospital Guangzhou Medical University

Dengue has been well recognized as a global public health threat,but only sporadic epidemics and imported cases were reported in recent decades in *** July 2014,an unexpected large dengue outbreak has occurred in Guangdong province,China,resulting in more than 40000 patients including six *** clarify and characterize the causative agent of this outbreak,the acute phase serum from a patient diagnosed with severe dengue was subjected to virus isolation and high-throughput sequencing(HTS).Traditional real-time RT-PCR and HTS with Ion Torrent PGM detected the presence of dengue virus serotype 2(DENV-2).A clinical DENV-2 isolate GZ05/2014 was obtained by culturing the patient serum in mosquito C6/36 *** complete genome of GZ05/2014 was determined and deposited in Gen Bank under the access number *** analysis based on the complete envelope gene showed that the newly DENV-2 isolate belonged to Cosmopolitan genotype and clustered closely with other Guangdong strains isolated in the past *** amino acid mutations that are obviously known to increase virulence or replication were identified throughout the genome of GZ05/*** high homology of Guangdong DENV-2 strains indicated the possibility of establishment of local DENV-2 circulation in Guangdong,*** results help clarify the origin of this epidemic and predict the future status of dengue in China.

关键词： dengue virus serotype 2 virus isolation phylogenetic analysis envelope gene

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基于神经网络的振荡模式分析及其应用

生理学报 2015年第2期67卷 143-154页

作者：李群程宁张涛南开大学生命科学学院天津300071 南开大学数学学院天津300071 喀什师范学学院数学系喀什844008

振荡现象以动态形式普遍存在于神经系统中,并且与大脑的信息处理、传递和整合、巩固记忆等高级认知活动密切相关。神经振荡的特定活动模式往往关联认知功能及其变化,因此如何量化分析神经振荡活动模式成为了计算神经生物学的研究热点之... 详细信息

振荡现象以动态形式普遍存在于神经系统中,并且与大脑的信息处理、传递和整合、巩固记忆等高级认知活动密切相关。神经振荡的特定活动模式往往关联认知功能及其变化,因此如何量化分析神经振荡活动模式成为了计算神经生物学的研究热点之一。结合作者实验室近年来的研究工作,本文对在神经生物学和认知科学研究中常用的多种分析算法进行了详细而全面的综述,并试图按照度量指标及耦合或同步方式的差异进行归类。通过算法比较,给出计算特点及算法适用情形。最后对将来有潜在应用价值的几种多维算法进行了深入的探讨。

关键词：神经网络振荡分析算法信息流振荡同步

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荀子游乐观探论

旅游学刊 2011年第11期26卷 89-92页

作者：张野南开大学历史学院天津300071

荀子在广泛的游历实践中实现了他的游乐观与儒家游文化的统一。荀子的游乐观渗透着儒家重仁、重孝、重义等文化内涵和重入世而轻出世的游乐思想,这充分体现在荀子对游乐与山水、孝道、交际、享乐、政治之间关系的论述当中。荀子的游乐... 详细信息

荀子在广泛的游历实践中实现了他的游乐观与儒家游文化的统一。荀子的游乐观渗透着儒家重仁、重孝、重义等文化内涵和重入世而轻出世的游乐思想,这充分体现在荀子对游乐与山水、孝道、交际、享乐、政治之间关系的论述当中。荀子的游乐观与儒家的游乐思想一脉相承,并对韩非子有一定的影响,这对儒家游文化的赓续起到了重要作用。

关键词：荀子游乐观儒家游文化

Interface Width Effect on the Weakly Nonlinear Rayleigh–Taylor Instability in Spherical Geometry

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Chinese Physics Letters 2020年第7期37卷 43-46页

作者： Yun-Peng Yang Jing zhang Zhi-Yuan Li Li-Feng Wang Jun-Feng Wu Wun-Hua ye Xian-Tu He School of Physics Peking UniversityBeijing 100871China Center for Applied Physics and Technology HEDPSand College of EngineeringPeking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100094China

Interface width effect on the spherical Rayleigh–Taylor instability in the weakly nonlinear regime is studied by numerical *** Legendre perturbation mode Pn with wave number Kn and interface half-width L,the commonly adopted empirical linear growth rate formulaγnem(L)=γn/√1+KnL is found to be sufficient in spherical *** the weakly nonlinear stage,the interface width affects the mode coupling *** development of the mode P2n is substantially influenced by the interface ***,the nonlinear saturation amplitude increases with the interface width.

关键词： interface nonlinear weakly

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半仿生法提取细叶小檗总生物碱及抑菌性研究

北京林业大学学报 2018年第5期40卷 117-123页

作者：符群张海婷东北林业大学林学院黑龙江哈尔滨150040

【目的】本文通过对细叶小檗果实中生物碱的研究,为细叶小檗的有效合理利用提供参考。【方法】本实验以细叶小檗总生物碱提取量和抑菌圈直径为考察指标,用10%、20%、30%、40%、50%、60%、70%的乙醇作为溶剂提取细叶小檗中的总生物碱,得... 详细信息

【目的】本文通过对细叶小檗果实中生物碱的研究,为细叶小檗的有效合理利用提供参考。【方法】本实验以细叶小檗总生物碱提取量和抑菌圈直径为考察指标,用10%、20%、30%、40%、50%、60%、70%的乙醇作为溶剂提取细叶小檗中的总生物碱,得出27%乙醇为较好的提取溶剂。以27%乙醇为提取溶剂,进行液料比、温度和超声时间的单因素试验。在单因素试验基础上,采用Plackett-Burman设计、最速上升试验以及中心复合实验响应面设计建立数学模型。【结果】实验结果表明,最佳提取条件为:乙醇含量27%(V/V)、液料比32 m L/g、温度52℃、超声功率800 W,提取液的pH值为2.2时,对应提取时间为50 min;提取液的pH值为7.6时,对应提取时间为25 min;提取液的pH值为8.5时,对应提取时间为25 min。在此条件下,细叶小檗中总生物碱的提取量为(16.24±0.54)mg/g,比单一超声波辅助法的提取量提高了1.31倍;抑菌圈直径为(91.21±0.37)mm。【结论】采用超声波辅助半仿生法比单一采用超声波法对细叶小檗中总生物碱的提取效果更好,提取量提高了1.31倍;抑菌效果提高了1.07倍。相比较国内目前对于小檗属植物小檗碱的平均提取量(16.6±0.6)mg/g相接近,在抑菌活性上有明显提高。

关键词：细叶小檗生物碱抑菌超声波半仿生