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Encoding and display technologies for combinatorial libraries in drug discovery:The coming of age from biology to therapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3362-3384页

作者： Yu Fan Ruibing feng Xinya zhang Zhen-Liang Wang feng Xiong Shuihua zhang zhang-feng zhong Hua Yu Qing-Wen zhang zhang zhang Yitao Wang Guodong Li Macao Centre for Research and Development in Chinese Medicine State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development Ministry of Education(MoE)of People’s Republic of ChinaCollege of PharmacyJinan UniversityGuangzhou 510632China Zhuhai UM Science and Technology Research Institute Zhuhai 519031China Department of Pharmacy Guangzhou Red Cross HospitalFaculty of Medical ScienceJinan UniversityGuangzhou 510632China Geriatric Medicine First People’s Hospital of XinXiang and the Fifth Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453100China Shenzhen Innovation Center for Small Molecule Drug Discovery Co. Ltd.Shenzhen 518000China

Drug discovery is a sophisticated process that incorporates scientific innovations and cuttingedge *** to traditional bioactivity-based screening methods,encoding and display technologies for combinatorial libraries have recently advanced from proof-of-principle experiments to promising tools for pharmaceutical hit discovery due to their high screening efficiency,throughput,and resource *** review systematically summarizes the development history,typology,and prospective applications of encoding and displayed technologies,including phage display,ribosomal display,mRNA display,yeast cell display,one-bead one-compound,DNA-encoded,peptide nucleic acidencoded,and new peptide-encoded technologies,and examples of preclinical and clinical *** discuss the progress of novel targeted therapeutic agents,covering a spectrum from small-molecule inhibitors and nonpeptidic macrocycles to linear,monocyclic,and bicyclic peptides,in addition to *** also address the pending challenges and future prospects of drug discovery,including the size of screening libraries,advantages and disadvantages of the technology,clinical translational potential,and market *** review is intended to establish a comprehensive high-throughput drug discovery strategy for scientific researchers and clinical drug developers.

关键词： Drug screening Phage display DNA-encoded chemical libraries Peptide-encoded chemical libraries Clinical drugs

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Adaptive optical design in surface plasma resonance sensor

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Optoelectronics Letters 2006年第1期2卷 31-33页

作者： zhang feng zhong Jin-gang Institute of Optoelectronic Engineering Jinan University Guangzhou 510632 China

A double-prism adaptive optical design in surface plasma resonance （SPR） sensor is proposed,which consists of two identical isosceles right-triangular prisms. One prism is used as a component of Kretschmann configuration, and the other is for regulation of the optical path. When double-prism structure is angle-scanned by an immovable incident ray, the output ray will be always parallel with the incident ray and just has a small displacement with the shift of output point. The output ray can be focused on a fixed photodetector by a convex lens. Thus it can be avoided that a prism and a photodetector rotate by 8 and 28 respectively in conventional angular scanning SPR sensor. This new design reduces the number of the movable components, makes the structure simple and compact, and makes the manipulation convenient.

关键词：谐振传感器光学设计表面等离子体光传播途径

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： zhong-Liang Gong Hong-Jie zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui feng Qiong zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

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Effects of Grain Protein Content Selection on Protein Content and Key Enzyme Activity Involved in Nitrogen Metabolism in Progenies Derived from a Rice Cross

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Rice science 2010年第2期17卷 156-160页

作者： HUANG Xing JIN Zheng-xun LI Xiao-guang LIU Hong-liang Xu Mei-lan zhang feng-zhuan zhang zhong-chen Agricultural College Northeast Agricultural University Harbin 150030 China

Two japonica rice parents （Tong 769 and Xixuan 1） and their progenies, significantly different in protein content of grains, were investigated to reveal the activities of proteinase in leaves and glutamine synthetase in grains, as well as the dynamic changes of soluble protein content in grains during rice grain filling. The results showed that the parents were very similar in protein content, however, advanced lines with different protein contents in grains and varied activities of proteinase and glutamine synthetase were acquired by consecutively directional selection of the grain protein content in their progenies. Moreover, the enzyme activity and the protein content in grains exceeded their parents during grain filling. The protein content in grains was positively related with the proteinase activity, and the soluble protein content was negatively related with the glutamine synthetase activity in grains to some extent.

关键词： rice hybrid progeny protein content nitrogen metabolism enzyme activity

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论丑在西方文学发展中的演变

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山东大学学报（哲学社会科学版） 2011年第3期 30-36页

作者：张中锋山东大学文学与新闻传播学院济南大学文学院

丑被当作独立的美学范畴虽在美学界早已得到公认,但学者们大多是从哲学理论和艺术实践方面来论证它的,其实还可以从西方文学的发展中来了解丑,了解丑从发生、发展到独立的演变过程。这种演变过程大致上经历了三个发展阶段,即在古代文学... 详细信息

丑被当作独立的美学范畴虽在美学界早已得到公认,但学者们大多是从哲学理论和艺术实践方面来论证它的,其实还可以从西方文学的发展中来了解丑,了解丑从发生、发展到独立的演变过程。这种演变过程大致上经历了三个发展阶段,即在古代文学中,丑虽已经存在,但力量还比较弱小,还不得不以壮美的形式表现出来;到了近现代文学中丑得以迅速发展,但还不足够壮大,只能以崇高的形式表现出来;而到了20世纪现代主义文学中丑才真正壮大起来,并作为独立的美学范畴表现出来。当然,在论证丑如何独立的过程中,也同时深化了对西方文学的理解。

关键词：丑西方文学演变

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论和谐派美学中的丑学理论研究

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山东大学学报（哲学社会科学版） 2010年第1期 151-156页

作者：张中锋济南大学文学院

与其他实践派美学流派不同,和谐派比较重视对丑学理论的研究与运用,如代表人物周来祥、邹华、牛宏宝等在他们的一些著述里,对于丑的产生、价值、地位、审美特性、本质、特点等均有所论述,并逐渐使丑学理论走向体系化。和谐派美学流派中... 详细信息

与其他实践派美学流派不同,和谐派比较重视对丑学理论的研究与运用,如代表人物周来祥、邹华、牛宏宝等在他们的一些著述里,对于丑的产生、价值、地位、审美特性、本质、特点等均有所论述,并逐渐使丑学理论走向体系化。和谐派美学流派中的部分同仁之所以如此看重丑,这一方面与丑学在美学中的地位日隆有关;另一方面也与和谐派美学体系的建构需要否定因素有关。尽管如此,但在客观上却促进了对丑学理论研究的深入,特别是其中对于丑本质的挖掘、审丑可能性的论述、丑特性的概括,以及把丑放在一个动态状况中来考察的做法,还是应该引起"丑学界"关注的。

关键词：和谐派丑学崇高体系化

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Anti-proliferative Effects of Evodiamine in Resistant and Non-resistant Human Ovarian Cancer

Anti-proliferative Effects of Evodiamine in Resistant and No...

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第十四届全国中药和天然药物学术研讨会

作者： zhang-feng zhong Chung-Hang Leung Yi-Tao Wang University of Macau

Aim Accumulating evidence has indicated that evodiamine displays broad-spectrum and potent anticancer activity in vitro and in *** aim of this study was to investigate the anticancer activities of evodiarnine in resistant and non-resistant human ovarian cancer *** Resistant and non-resistant human ovarian cancer cells were treated with different concentrations of evodiarnine,and cell viability,cell proliferation,cell apoptosis and P-gp function were *** and Conclusion Evodiarnine showed strong anti-proliferative effects in resistant and non-resistant human ovarian cancer ***,evodiarnine exhibited no cytotoxic effects in ovarian cancer cells as determined using the LDH assay.A CFSR assay also indicated that evodiarnine shows anti-proliferative effects against ovarian cancer cells,but not cytotoxic *** cycle analysis suggested that the anti-proliferative effects of evodiamine on ovarian cancer cells may be attributed to its ability to induce G2/M phase cell cycle ***,evodiamine increased oxidative stress in ovarian cancer cells induced by different oxidative stress agents,as revealed by an increase in calcium level and mitochondrial function in evodiamine-treated ***,evodiamine induced disruption of mitochondrial transmembrane potential in ovarian cancer *** enhanced caspase3/7 activity in ovarian cancer cells,and treatment of cells with a caspase inhibitor reversed the effect of *** addition,evodiamine is not a specific substrate of P-gp in resistant ovarian cancer *** results indicate that evodiamine suppresses cell proliferation and enhances apoptosis in ovarian cancer cells,and suggesting its potential to be developed as an effective anticancer agent against resistant and non-resistant ovarian cancer.

关键词： evodiamine cell proliferation cell apoptosis multidrug resistance ovarian cancer

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浅议建立有利于内部知识共享的图书馆文化

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图书馆论坛 2007年第2期27卷 32-34页

作者：张忠凤河北经贸大学图书馆河北石家庄050061

剖析图书馆内部知识共享障碍因素,阐述图书馆构建知识共享文化的具体措施。

关键词：知识共享共享文化图书馆

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微流控芯片分析系统中硅胶整体柱和膜滤复合预处理单元的构建

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高等学校化学学报 2008年第5期29卷 892-896页

作者：徐溢张剑张文品张钟锋温志渝重庆大学化学化工学院重庆大学微系统研究中心

以改性C18反相硅胶整体柱为微流控芯片分析系统中固相萃取介质材料,构建不同功能单元的样品预处理微分析系统,实现了血清样品中痕量盐酸多巴酚丁胺的富集.初步构建了单一改性硅胶微柱固相萃取预处理单元,测试得到了改性硅胶整体柱对血... 详细信息

以改性C18反相硅胶整体柱为微流控芯片分析系统中固相萃取介质材料,构建不同功能单元的样品预处理微分析系统,实现了血清样品中痕量盐酸多巴酚丁胺的富集.初步构建了单一改性硅胶微柱固相萃取预处理单元,测试得到了改性硅胶整体柱对血清中痕量盐酸多巴酚丁胺的平均富集倍数为77.2,RSD为12.35%.为了提高测试的精密度,进而设计含膜复合式预处理芯片,探讨了不同预处理单元对血清样品中痕量盐酸多巴酚丁胺富集效率的影响,优化设计了外接式硅胶整体柱-亲和膜微芯片固相萃取预处理单元,复合式的反相硅胶整体柱对血清中微量盐酸多巴酚丁胺的平均富集倍数提高到89.4,RSD为4.37%.结果显示了该预处理单元在血清中痕量药物富集的可行性和有效性.

关键词：微流控芯片分析系统固相萃取预处理单元硅胶整体柱亲和膜

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FTS理念的护理干预对进展期胃癌患者腹腔镜辅助D2根治术后康复及护理满意度的影响

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世界华人消化杂志 2018年第5期26卷 325-331页

作者：张先凤钟伟诸暨市中医医院手术室浙江省诸暨市311821 诸暨市中医医院消化外科浙江省诸暨市311821

目的探讨快速康复外科(fast track surgery,FTS)理念的护理干预对进展期胃癌患者腹腔镜辅助D2根治术后康复及护理满意度的影响.方法选取2013-01/2017-09诸暨市中医医院收治的70例行腹腔镜辅助D2根治术治疗的进展期胃癌患者,按照入院顺... 详细信息

目的探讨快速康复外科(fast track surgery,FTS)理念的护理干预对进展期胃癌患者腹腔镜辅助D2根治术后康复及护理满意度的影响.方法选取2013-01/2017-09诸暨市中医医院收治的70例行腹腔镜辅助D2根治术治疗的进展期胃癌患者,按照入院顺序分为观察组(n=35)与对照组(n=35).对照组给予常规围手术期护理干预,观察组实施以FTS为指导的围手术期护理干预.对比两组手术及术后恢复情况(手术用时、术中出血量、淋巴结清扫数目及术后排气时间、术后进食时间、住院时间)、围手术期应激反应[手术前及术后1 d血清C反应蛋白(C-reactive protein,CRP)、白介素-6(interleukin 6,IL-6)水平]、免疫功能[手术前及术后1 d外周血T淋巴细胞亚群(CD3^+、CD4^+、CD4^+/CD8^+)]、术后并发症发生率及护理满意度.结果两组手术时间、淋巴结清扫数目比较无显著差异(P>0.05),与对照组比较,观察组术中失血量少、术后排气时间、进食时间及住院时间短(P0.05),术后1 d两组血清C R P、I L-6水平较手术前升高(P0.05),术后1 d两组CD3^+、CD4^+、CD4^+/CD8^+较手术前降低(P0.05);观察组护理满意度高于对照组(91.43%vs 71.43%,P<0.05).结论给予行腹腔镜辅助D2根治术的进展期胃癌患者基于FTS理念的护理干预,可减轻手术所致应激反应及免疫功能损害、降低并发症发生率,有利于促进患者术后早期康复,且护理满意度高.

关键词：进展期胃癌腹腔镜辅助D2根治术术后康复护理满意度

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