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术中相干光断层成像术在眼科手术的应用进展

中华眼科杂志 2015年第8期51卷 629-635页

作者：张正威武志峰无锡市第二人民医院眼科南京医科大学附属无锡第二医院眼科 214002

相干光断层成像术（OCT）已成为眼科领域不可或缺的检查技术之一,对各类眼部疾病的正确诊断、病情评估及手术预后等均产生了深远的影响.如今,OCT的应用范围正在进一步扩大,已逐步应用到各类眼科手术当中,即术中OCT（iOCT）.该技术不仅... 详细信息

相干光断层成像术（OCT）已成为眼科领域不可或缺的检查技术之一,对各类眼部疾病的正确诊断、病情评估及手术预后等均产生了深远的影响.如今,OCT的应用范围正在进一步扩大,已逐步应用到各类眼科手术当中,即术中OCT（iOCT）.该技术不仅从新的视角加深了我们对眼科疾病的理解和认识,同时也影响到术者对手术方案的制定和选择,从而大大提高了眼科手术的安全性和成功率.本文对iOCT技术的发展历程及其在眼科手术中的应用进行综述,以期为提高我国临床医师的关注、扩大其临床使用范围提供帮助.

关键词：体层摄影术,光学相干眼外科手术眼前半段

Ultra-compact wavelength multiplexer/demultiplexer based on subwavelength grating-assisted multimode interference coupler by inverse design

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Optoelectronics Letters 2024年

作者： WEN Jin PAN Yu WU zhengwei zhang Ying School of Science， Xi'an Shiyou University Shaanxi Engineering Research Center of Oil and Gas Resource Optical Fiber Detection Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Inverse design of on-chip wavelength multiplexer/demultiplexer has attracted significant attention to improve equipment performance and miniaturization. We proposed and demonstrated the ultra-compact 1310/1550 nm wavelength multiplexer/demultiplexer assisted by subwavelength grating （SWG） using particle swarm optimization （PSO） algorithm in silicon-on-insulator （SOI） platform. Through the self-imaging effect of multimode interference （MMI） coupler， the demultiplexing function for 1310 nm and 1550 nm wavelengths is implemented. After that， three parallel SWG-based slots are inserted into the MMI section so that the effective refractive index of the modes can be engineered and thus the beat length can be adjusted. Importantly， these three SWG slots significantly reduce the length of the device， which is much shorter than the length of traditional MMI-based wavelength demultiplexers. Ultimately， by using the PSO algorithm， the equivalent refractive index and width of the SWG in a certain range are optimized to achieve the best performance of the wavelength demultiplexer. It has been verified that the device footprint is only 2×30.68 μm2， and 1dB bandwidths of larger than 120 nm are acquired at 1310 nm and 1550 nm wavelengths. Meanwhile， the transmitted spectrum shows that the insertion loss （IL） values are below 0.47 dB at both wavelengths when the extinction ratios （ER） values are above 12.65 dB. This inverse design approach has been proved to be efficient in increasing bandwidth and reducing device length.

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Memristive feature and mechanism induced by laser-doping in defect-free 2D semiconductor materials

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Journal of Semiconductors 2024年第7期45卷 85-91页

作者： Xiaoshan Du Shu Wang Qiaoxuan zhang Shengyao Chen Fengyou Yang Zhenzhou Liu zhengwei Fan Lijun Ma Lei Wang Lena Du Zhongchang Wang Cong Wang Bing Chen Qian Liu College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao 266590China National Center for Nanoscience and Technology&University of Chinese Academy of Sciences Beijing 100190China Hebei University of Water Resources and Electric Engineering Electrical Automation Department Cangzhou 061001China The MOE Key Laboratory of Weak-Light Nonlinear Photonics and International Sino-Slovenian Join Re-search Center on Liquid Crystal Pho-tonics TEDA Institute of Applied Physics and School of PhysicsNankai UniversityTianjin 300457China College of Mathematics and Physics Shandong Advanced Optoelectronic Materials and Technologies Engineering LaboratoryQingdao Uni-versity of Science and TechnologyQingdao 266061China Department of Physics Capital Normal UniversityBeijing 100048China Department of Advanced Materials and Computing International Iberian Nanotechnology Laboratory(INL)4715-330 BragaPortugal College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China

Memristors as non-volatile memory devices have gained numerous attentions owing to their advantages in storage,in-memory computing, synaptic applications, etc. In recent years, two-dimensional(2D) materials with moderate defects have been discovered to exist memristive feature. However, it is very difficult to obtain moderate defect degree in 2D materials, and studied on modulation means and mechanism becomes urgent and essential. In this work, we realized memristive feature with a bipolar switching and a configurable on/off ratio in a two-terminal MoS_(2) device(on/off ratio ~100), for the first time, from absent to present using laser-modulation to few-layer defect-free MoS_(2)(about 10 layers), and its retention time in both high resistance state and low resistance state can reach 2×10^(4) s. The mechanism of the laser-induced memristive feature has been cleared by dynamic Monte Carlo simulations and first-principles calculations. Furthermore, we verified the universality of the laser-modulation by investigating other 2D materials of TMDs. Our work will open a route to modulate and optimize the performance of 2D semiconductor memristive devices.

关键词： 2D-material memristor laser doping laser direct writing memristive mechanism

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： zhengwei Hu Jing Yang Shuo zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

高层建筑水平悬挑遮阳板风荷载的风洞试验研究

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建筑结构学报 2022年第3期43卷 92-97页

作者：全涌邱宏浩张正维顾明同济大学土木工程防灾国家重点实验室上海200092 奥雅纳工程顾问(上海)有限公司上海200031 江苏工程职业技术学院江苏南通226007

高层建筑悬挑遮阳板等小尺寸构件直接承受风荷载作用,在强风作用下的安全性备受关注。相对于建筑的整体尺寸,悬挑遮阳板很小,难以在缩尺模型上直接模拟,因此在实际工程的风洞试验研究中常常被简化或者忽略。研究中利用3D打印技术制作了... 详细信息

高层建筑悬挑遮阳板等小尺寸构件直接承受风荷载作用,在强风作用下的安全性备受关注。相对于建筑的整体尺寸,悬挑遮阳板很小,难以在缩尺模型上直接模拟,因此在实际工程的风洞试验研究中常常被简化或者忽略。研究中利用3D打印技术制作了精细化的有悬挑遮阳板的高层建筑风洞试验模型,并在打印遮阳板模型时直接预留测压管道,分析了水平悬挑遮阳板的风压分布规律及遮阳板对建筑立面风压的影响,并对基于建筑立面风压的悬挑遮阳板风压估计方法的估算误差进行了评估。研究结果表明:高层建筑水平悬挑遮阳板的最不利净风压的最大值出现在顶层遮阳板处;水平悬挑遮阳板的存在能较大程度地削弱建筑立面上的最不利负风压;悬挑遮阳板最不利风压可利用其上下两侧附近建筑立面测点的风压差近似估计,但对于建筑立面边缘附近的悬挑遮阳板端部以及建筑底部附近的最底层悬挑遮阳板上的最不利风压,这种方法的估算误差较大。

关键词：高层建筑水平遮阳板建筑立面风洞试验风压系数

Features of inclusions in the Funiushan gold deposits of Central China and its implications for prospecting

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Chinese Science Bulletin 1999年第S2期44卷 15-16页

作者： zhang zhengwei~1, ZHU Bingquan~1 and DENG Jun~2 1. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 2. China University of Geoscience, Beijing 100083, China Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China China University of Geoscience Beijing 100083 China

GOLD mineralization popularly occurs in Funiushan area. Based on the studies on more than 40 gold deposits or ore spots, it is shown that most of them are small in scale except the Pengou gold deposit, whichcan be developed into a medium one. The Pengou is a gold deposit of medium-low temperature hydrothermal type. 1 Geological setting The Funiushan gold mineralization zone lying in the contiguous region of Nanzhao, Fangcheng andLushan Counties, Henan Province, is stituated on the tectonic and geochemical boundary between theNorth China block and Qinling Orogenic belt, and transverses the two first-grade tectonic units. Thehost rocks are mainly the strata of Xionger group （Pt2 ） and the Funiushan granitic batholith. The Penggougold deposit is just located on the large-scale fault of Xiatang-Guihe. A series of metamorphic rocks ofXionger Group outcroped in the north of the deposit. 2 The features of deposit The ore bodies mostly appear in thick plate with sag-and-swell variation. The gold-bearing alterationzone from upper to lower layers can be divided as granite→ pyritization and phyllic alteration→ alteredgranitic porphyry→quartz vein→pyritization and phyllic alteration→cataclastic granite with phyllic alteration, i. e. the upper and lower gold-bearing layers can be separated by the altered granite. The ore

关键词： gold deposit inclusion geochemistry Funiushan.

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紫杉二烯生物合成模块与不同底盘的适配

高等学校化学学报 2014年第1期35卷 75-79页

作者：张正伟丁明珠元英进系统生物工程教育部重点实验室天津大学化工学院制药工程系天津300072

以酿酒酵母BY4742及其单敲菌株作为底盘细胞,优化底盘细胞甲羟戊酸途径,上调并融合表达牻牛儿基牻牛儿基焦磷酸(GGPP)合成的相关基因,引入人工合成的外源GGPP合成酶基因与紫杉二烯合成酶基因,构建了多载体紫杉二烯生物合成模块;还利用... 详细信息

以酿酒酵母BY4742及其单敲菌株作为底盘细胞,优化底盘细胞甲羟戊酸途径,上调并融合表达牻牛儿基牻牛儿基焦磷酸(GGPP)合成的相关基因,引入人工合成的外源GGPP合成酶基因与紫杉二烯合成酶基因,构建了多载体紫杉二烯生物合成模块;还利用酵母组装技术,通过对紫杉二烯合成路径相关基因进行模块化设计组装,构建了依托单一着丝粒(CEN)质粒的紫杉二烯生物合成模块.将构建的2个模块与不同底盘细胞进行适配,使紫杉二烯产量获得了数倍提升,最高产量可达74.84 mg/L.

关键词：紫杉二烯合成生物学人工细胞适配

白云岩风化剖面元素地球化学特征:对黔中九架炉组“三稀金属”富集机制的启示

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岩石学报 2019年第11期35卷 3385-3397页

作者：凌坤跃温汉捷张正伟朱笑青汤好书中国科学院地球化学研究所矿床地球化学国家重点实验室

黔中早石炭世九架炉组铝土矿含矿岩系富集Ti、Li、Sc、V、Ga、Nb、Ta、Zr、Hf、Th和稀土(REEs)等"三稀金属",具有成为独立矿床或伴生资源的潜力。这些元素大部分与九架炉组共有同一母岩,且富集程度受母岩的成分和风化作用控制。本研究... 详细信息

黔中早石炭世九架炉组铝土矿含矿岩系富集Ti、Li、Sc、V、Ga、Nb、Ta、Zr、Hf、Th和稀土(REEs)等"三稀金属",具有成为独立矿床或伴生资源的潜力。这些元素大部分与九架炉组共有同一母岩,且富集程度受母岩的成分和风化作用控制。本研究选取九架炉组母岩乌当娄山关群白云岩和纳雍牛蹄塘组泥质白云岩的现代风化剖面为研究对象,研究元素在风化作用过程中的迁移特征及分布规律,进而为九架炉组微量元素的富集机制提供启示。研究获得以下认识:1)依据剖面结构、ZrHf、Nb-Ta、Y-Ho二元图特征及REE配分曲线和Eu/Eu*值的相似性表明研究区土层主要来源于基底或母岩的风化;2)白云岩风化成土过程中Si、Fe、Cr、As、Sb、Ti、Nb、Ta、Zr、Hf、Th、REEs等元素化学性质相对稳定,富集程度较高,而Ca、Mg、Na、K、Sr、P、Mo、Cd等元素化学性质活泼,容易淋失亏损;3)纳雍剖面REEs3+和Ca2+半径差与REEs富集系数相关性良好,表明碳酸盐岩风化过程中,含钙矿物磷灰石是稀土元素分配的重要控制因素;4)九架炉组的母岩也是Ti、Li、Sc、V、Ga、Nb、Ta、Zr、Hf、Th等微量元素的主要物质来源,母岩风化过程中,这些微量元素首先在副矿物、黏土矿物、铝矿物及磷灰石等矿物相中初步富集,之后随风化碎屑物一起沉积形成微量元素超常富集地层;5)纳雍剖面地表和地下水提供了部分P、Be、Zn、Sb、Pb、Y及REEs来源,指示水体迁入作用也是九架炉组REEs富集的重要原因。研究表明黔中九架炉组微量元素的来源较复杂,风化-沉积过程中,化学性质稳定的元素残留在风化碎屑物中并被搬运-沉积在负地形中,而化学性质活泼的元素首先被带入水体,在沉积-成岩过程中特定条件下发生二次富集作用(例如次生矿物的形成及吸附)形成微量元素富集的地层。

关键词：九架炉组风化剖面 “三稀金属” 富集机制

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竖直埋管换热器热响应半径简化计算方法

太阳能学报 2016年第9期37卷 2338-2343页

作者：张正威赵石娆李晓星浙江农林大学风景园林与建筑学院杭州311300 南京工业大学土木学院南京210009

基于半无限空间均匀介质线热源传热模型,在大量数值计算分析基础上,提出竖直埋管换热器热响应半径的简化计算方法。计算方法考虑了土壤热物性、系统运行时间和钻孔布置方式等因素。计算结果表明,对于钻孔单排、双排和多排布置情况下,本... 详细信息

基于半无限空间均匀介质线热源传热模型,在大量数值计算分析基础上,提出竖直埋管换热器热响应半径的简化计算方法。计算方法考虑了土壤热物性、系统运行时间和钻孔布置方式等因素。计算结果表明,对于钻孔单排、双排和多排布置情况下,本文方法的计算结果与理论解之间最大相对误差分别为3.51%、2.96%和2.76%,满足工程要求。针对实际地源热泵系统运行时常根据需要采用昼夜和季节间歇运行工况的情况,给出系统运行时间的计算方法。为便于工程应用,分别计算单排、双排和多排(三排以上)钻孔布置方式下不同岩土介质竖直埋管换热器热响应半径随时间的变化曲线,绘制出计算图表,为工程应用提供理论依据和方法。

关键词：竖直埋管换热器计算模型传热性能热响应半径简化计算方法