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A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t（8;14）（q24;q32） translocation

Frontiers of Medicine 2018年第3期12卷 324-329页

作者： Xiaofeng Shi Rong Ba Haiyan You Qian Jiang Jiansong Huang Jianhua Mao Lanxiu Han Shuo zhang Qin zhuang Xianqiu Yu Lixia Wang Yun Wang Dongya Li Wei zhu Yong zhang Yan zhu Xiaodong Xi Department of Hematology Affiliated Hospital of Jiangsu University Zhenjiang 212001 China The Center of Thrombosis Affiliated Hospital of Jiangsu University Zhenjiang 212001 China State Key Laboratory of Medical Genomics Shanghai Institute of Hematology Collaborative Innovation Center of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Institute of Hematology The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China School of Medicine Jiangsu University Zhenjiang 212013 China Blood Cell Development and Function Program Fox Chase Cancer Center 333 Cottman Avenue Room 364 Philadelphia PA 19111-2497 USA

Splenic lymphoma with villous lymphocytes （SLVL） or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t（8;14）（q24;q32） translocation has been reported. In this study, we report a case of B- lymphoproliferative disorder with villous lymphocytes harboring t（8;14）（q24;q32） chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis （lymphocytes 〉 200 × 10^9/L）. The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19^＋, CD20^＋, HLA- DR^＋, CD22^＋, CD5^＋, Kappa^＋, CD25^dim, CD71^dim, Lambda, CD7, CD10-, CD23 , CD34, CD33, CD13 , CD14, CDll7, CD64, CD103, and CD11c-. The karyotype showed complex abnormality： 46XX,＋ 3,-10, t（8;14）（q24; q32）lll]/46XX[9]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t（8,14） chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t（8;14）（q24;q32） translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.

关键词： splenic lymphoma with villous lymphocytes splenic marginal zone lymphoma transformation chromosometranslocation

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Formation and growth of nanophase iron particles on the surface of Mercury revealed by experimental study

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Acta Geochimica 2024年第4期43卷 774-784页

作者： Ronghua Pang Yang Li Chen Li Pengfei zhang zhuang Guo Sizhe Zhao Han Yu Li Wang Chenxi zhu Shuangyu Wang Kairui Tai Qinwei zhang Yuanyun Wen Rui Li Center for Lunar and Planetary Sciences Institute of GeochemistryChinese Academy of SciencesGuiyangChina University of Chinese Academy of Sciences BeijingChina Center for Excellence in Comparative Planetology Chinese Academy of SciencesHefeiChina Institute of Remote Sensing and Geographical Information System School of Earth and Space SciencesPeking UniversityBeijingChina State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacaoChina Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunmingChina State Key Laboratory of High Performance Ceramics and Superfi ne Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Laboratory for Space Environment and Physical Sciences Harbin Institute of TechnologyHarbinChina Research Center for Planetary Science College of Earth ScienceChengdu University of TechnologyChengduChina Key Laboratory of Planetary Sciences Purple Mountain ObservatoryChinese Academy of SciencesNanjingChina

Space weathering is a primary factor in altering the composition and spectral characteristics of surface materials on airless ***,current research on space weathering focuses mainly on the Moon and certain types of *** particular,the impacts of meteoroids and micrometeoroids,radiation from solar wind/solar flares/cosmic rays,and thermal fatigue due to temperature variations are being *** weathering produces various transformation products such as melted glass,amorphous layers,iron particles,vesicles,and solar wind *** in turn lead to soil maturation,changes in visible and near-infrared reflectance spectra(weakening of characteristic absorption peaks,decreased reflectance,increased near-infrared slope),and alterations in magnetism(related to small iron particles),collectively termed the“lunar model”of space weathering *** to the Moon and asteroids,Mercury has unique spatial environmental characteristics,including more intense meteoroid impacts and solar thermal radiation,as well as a weaker particle radiation environment due to the global distribution of its magnetic ***,the lunar model of space weathering may not apply to *** studies have extensively explored the eff ects of micrometeoroid ***,this work focuses on the eff ects of solar-wind particle radiation in global magnetic-field distribution and on the weathering transformation of surface materials on Mercury under prolonged intense solar *** the utilization of highvalence state,heavy ion implantation,and vacuum heating simulation experiments,this paper primarily investigates the weathering transformation characteristics of the major mineral components such as anorthite,pyroxene,and olivine on Mercury’s surface and compares them to the weathering transformation model of the *** experimental results indicate that ion implantation at room temperature is insufficient to generate np-Fe^(0)directly but

关键词： Mercury Space weathering Np-Fe^(0) Solar thermal radiation Solar wind

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Hydrogen-assisted scalable preparation of ultrathin Pt shells onto surfactant-free and uniform Pd nanoparticles for highly efficient oxygen reduction reaction in practical fuel cells

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Nano Research 2022年第3期15卷 1892-1900页

作者： Liuxuan Luo Cehuang Fu Aiming Wu Zechao zhuang Fengjuan zhu Fangling Jiang Shuiyun Shen Xiyang Cai Qi Kang Zhifeng Zheng Chenyi Hu Jiewei Yin Guofeng Xia Junliang zhang Institute of Fuel Cells Key Laboratory for Power Machinery and Engineering of MOESchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Tsinghua UniversityBeijing 100084China The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Department of Polymer Science and Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240China

Concentrating active Pt atoms in the outer layers of electrocatalysts is a very effective approach to greatly reduce the Pt loading without compromising the electrocatalytic performance and the total electrochemically active surface area(ECSA)for the oxygen reduction reaction(ORR)in hydrogen-based proton-exchange membrane fuel ***,a facile,low-cost,and hydrogen-assisted two-step method is developed in this work,to massively prepare carbon-supported uniform,small-sized,and surfactant-free Pd nanoparticles(NPs)with ultrathin~3-atomic-layer Pt shells(Pd@Pt_(3L) NPs/C).Comprehensive physicochemical characterizations,electrochemical analyses,fuel cell tests,and density functional theory calculations reveal that,benefiting from the ultrathin Pt-shell nanostructure as well as the resulting ligand and geometric effects,Pd@Pt_(3L) NPs/C exhibits not only significantly enhanced ECSA,electrocatalytic activity,and noble-metal(NM)utilization compared to commercial Pt/C,showing 81.24 m^(2)/gPt,0.710 mA/cm^(2),and 352/577 mA/mgNM/Pt in ECSA,area-,and NM-/Pt-mass-specific activity,respectively;but also a much better electrochemical stability during the 10,000-cycle accelerated degradation *** importantly,the corresponding 25-cm^(2) H2-air/O_(2) fuel cell with the low cathodic Pt loading of~0.152 mgPt/cm^(2)geo achieves the high power density of 0.962/1.261 W/cm^(2)geo at the current density of only 1,600 mA/cm^(2)geo,which is much higher than that for the commercial Pt/*** work not only develops a high-performance and practical Pt-based ORR electrocatalyst,but also provides a scalable preparation method for fabricating the ultrathin Pt-shell nanostructure,which can be further expanded to other metal shells for other energy-conversion applications.

关键词： palladium platinum oxygen reduction reaction core@shell nanostructure scalable preparation proton-exchange membrane fuel cell

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A novel small-animal locomotor activity recording device for biological clock research

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Animal Models and Experimental Medicine 2024年第1期7卷 71-76页

作者： Yi-Long Wu Ming Zhong Jun Yin Wei-Jie Ou Yu-Bin zhuang Nan-Wen zhang Su Lin Yue-Yong zhu Endoscopy Center The First Affiliated HospitalFujian Medical UniversityFuzhouChina Department of Endocrinology The First Affiliated HospitalFujian Medical UniversityFuzhouChina Chuangke Workshop Technology Co. LtdShenzhenChina Department of Digestive Nutrition Fujian Children's HospitalFuzhouChina Experimental Animal Center Fujian Medical UniversityFuzhouChina Department of Pharmacology Fujian Medical UniversityFuzhouChina Department of Hepatology Hepatology Research InstituteClinical Research Center for Liver and Intestinal Diseases of Fujian ProvinceThe First Affiliated HospitalFujian Medical UniversityFuzhouChina

The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian *** study demonstrated how to construct a simple and intelligent running-wheel recording *** running wheel was attached to the cage's base,whereas the Hall sensor was attached to the cage's ***,the RJ25 adaptor relayed the running signal to the main control ***,the main control board was connected to the USB port of the computer with the USB *** were collected using the online-accessible,self-created software *** Magturning,generated data were saved and exported in real ***,the device was validated by collecting data on the locomotor activities of mice under dif-ferent light *** conclusion,this new device can record circadian activity of *** device is appropriate for interdisciplinary investigations related to biological clock research.

关键词： biological clock circadian rhythm intelligent equipment locomotor activity running wheel

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Ultrafine ordered L1_(2)-Pt-Co-Mn ternary intermetallic nanoparticles as high-performance oxygen-reduction electrocatalysts for practical fuel cells

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Journal of Energy Chemistry 2024年第6期93卷 157-165,I0005页

作者： Enping Wang Liuxuan Luo Yong Feng Aiming Wu Huiyuan Li Xiashuang Luo Yangge Guo Zehao Tan Fengjuan zhu Xiaohui Yan Qi Kang Zechao zhuang Daihui Yang Shuiyun Shen Junliang zhang China-UK Low Carbon College Shanghai Jiao Tong UniversityShanghai 201306China Institute of Fuel Cells Key Laboratory for Power Machinery and Engineering of MOESchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Tangfeng Energy Technology Co.Ltd. Shanghai 201306China State Key Laboratory of Advanced Chemical Power Sources Guizhou Meiling Power Sources Co.Ltd.Zunyi 563003GuizhouChina School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China Institute of New Energy for Vehicles School of Materials Science and EngineeringTongji UniversityShanghai 201804China Department of Chemical Engineering Columbia UniversityNY 10027USA

The long-range periodically ordered atomic structures in intermetallic nanoparticles(INPs)can significantly enhance both the electrocatalytic activity and electrochemical stability toward the oxygen reduction reaction(ORR)compared to the disordered atomic structures in ordinary solid-solution alloy ***,through a facile and scalable synthetic method,a series of carbon-supported ultrafine Pt_3Co_(x)Mn_(1-x)ternary INPs are prepared in this work,which possess the"skin-like"ultrathin Pt shells,the ordered L1_(2) atomic structure,and the high-even dispersion on supports(L1_(2)-Pt_3Co_(x)Mn_(1-x)/~SPt INPs/C).Electrochemical results present that the composition-optimized L1_(2)-Pt_3Co_(0.7)Mn_(0.3)/~SPt INPs/C exhibits the highest electrocata lytic activity among the series,which are also much better than those of the pristine ultrafine Pt/***,it also has a greatly enhanced electrochemical *** addition,the effects of annealing temperature and time are further *** importantly,such superior ORR electrocatalytic performance of L1_(2)-Pt_3Co_(0.7)Mn_(0.3)/~SPt INPs/C are also well demonstrated in practical fuel *** characterization analyses further reveal the major origins of the greatly enhanced ORR electrocata lytic performance:the Pt-Co-Mn alloy-induced geometric and ligand effects as well as the extremely high L1_(2) atomic-ordering *** work not only successfully develops a highly active and stable ordered ternary intermetallic ORR electrocatalyst,but also elucidates the corresponding"structure-function"relationship,which can be further applied in designing other intermetallic(electro)catalysts.

关键词： Platinum Cobalt Manganese Oxygen reduction reaction Ordered intermetallic L1_(2)atomic structure Proton-exchange membrane fuel cell

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Exciton luminescence and many-body effect of monolayer WS2 at room temperature

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Chinese Physics B 2022年第5期31卷 670-676页

作者： Jian-Min Wu Li-Hui Li Wei-Hao Zheng Bi-Yuan Zheng Zhe-Yuan Xu Xue-Hong zhang Chen-Guang zhu Kun Wu Chi zhang Ying Jiang Xiao-Li zhu Xiu-Juan zhuang Key Laboratory for Micro-Nano Physics and Technology of Hunan Province School of Physics and ElectronicsHunan UniversityChangsha 410082China College of Materials Science and Engineering Hunan UniversityChangsha 410082China

Monolayer transition metal dichalcogenides favor the formation of a variety of excitonic quasiparticles,and can serve as an ideal material for exploring room-temperature many-body effects in two-dimensional ***,using mechanically exfoliated monolayer WS;and photoluminescence(PL)spectroscopy,exciton emission peaks are confirmed through temperature-dependent and electric-field-tuned PL *** dependence of exciton concentration on the excitation power density at room temperature is quantitatively *** concentrations covering four orders of magnitude are divided into three *** the low carrier concentration stage,the system is dominated by excitons,with a small fraction of trions and localized *** the high carrier concentration stage,the localized exciton emission from defects coincides with the emission peak position of trions,resulting in broad spectral characteristics at room temperature.

关键词： transition metal dichalcogenides photoluminescence localized exciton exciton density

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Conversion of effector CD4^(+)T cells to a CD8^(+)MHC Ⅱ-recognizing lineage

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Cellular & Molecular Immunology 2021年第1期18卷 150-161页

作者： Elizabeth Robins Ming Zheng Qingshan Ni Siqi Liu Chen Liang Baojun zhang Jian Guo Yuan zhuang You-Wen He Ping zhu Ying Wan Qi-Jing Li Department of Immunology Duke University Medical CenterDurhamNC 27710USA Department of Cell Biology National Translational Science Center for Molecular MedicineFourth Military Medical UniversityXi'anChina Biomedical Analysis Center Third Military Medical UniversityChongqingChina Immuno-Oncology Comprehensive Cancer CenterOhio State University Wexner Medical CenterColumbusOH 43210USA

CD4^(+)and CD8^(+)T cells are dichotomous lineages in adaptive *** conventionally viewed as distinct fates that are fixed after thymic development,accumulating evidence indicates that these two populations can exhibit significant lineage plasticity,particularly upon TCR-mediated *** define a novel CD4^(-)CD8αβ^(+)MHC Ⅱ-recognizing population generated by lineage conversion from effector CD4^(+)T ***4-CD8αβ^(+)effector T cells downregulated the expression of T helper cell-associated costimulatory molecules and inaeased the expression of cytotoxic T lymphocyte-associated cytotoxic *** shift in functional potential corresponded with a CD8^(+)-lineage skewed transcriptional ***β repertoire sequencing and in vivo genetic lineage tracing in acutely infected wild-type mice demonstrated that CD4^(-)CD8αβ^(+)effector T cells arise from fundamental lineage reprogramming of bona fide effector CD4^(+)T *** autophagy via functional deletion of the initiating kinase Vps34 or the downstream enzyme Atg7 enhanced the generation of this cell *** findings suggest that effector CD4^(+)T cells can exhibit a previously unreported degree of skewing towards the CD8^(+)T cell lineage,which may point towards a novel direction for HIV vaccine design.

关键词： CD4^(+)T cell CD8^(+)T cell ThPOK Runx3 autophagy

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The role of corneal endothelium in macular corneal dystrophy development and recurrence

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Science China(Life Sciences) 2024年第2期67卷 332-344页

作者： Bi-Ning zhang Benxiang Qi Chunxiao Dong Bin zhang Jun Cheng Xin Wang Suxia Li Xiaoyun zhuang Shijiu Chen Haoyun Duan Dewei Li Sujie zhu Guoyun Li Yihai Cao Qingjun Zhou Lixin Xie Eye Institute of Shandong First Medical University Qingdao Eye Hospital of Shandong First Medical UniversityQingdao 266071China State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyQingdao 266071China School of Ophthalmology Shandong First Medical UniversityQingdao 250021China Department of Medicine Qingdao UniversityQingdao 266071China Eye Institute of Shandong First Medical University Eye Hospital of Shandong First Medical University(Shandong Eye Hospital)Jinan 250021China Department of Ophthalmology School of Clinical MedicineWeifang Medical UniversityWeifang 261072China Institute of Translational Medicine College of MedicineQingdao UniversityQingdao 266071China Key Laboratory of Marine Drugs of Ministry of Education Shandong Provincial Key Laboratory of Glycoscience and GlycotechnologySchool of Medicine and PharmacyOcean University of ChinaQingdao 266071China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China Department of Microbiology Tumor and Cell BiologyBiomedicumKarolinska InstitutetStockholm 17177Sweden

Macular corneal dystrophy(MCD)is a progressive,bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6(CHST6).Corneal transplantation is the ultimate therapeutic solution for MCD ***,postoperative recurrence remains a significant *** conducted a retrospective review of a clinical cohort comprising 102 MCD patients with 124 eyes that underwent either penetrating keratoplasty(PKP)or deep anterior lamellar keratoplasty(DALK).Our results revealed that the recurrence rate was nearly three times higher in the DALK group(39.13%,9/23 eyes)compared with the PKP group(10.89%,11/101 eyes),suggesting that surgical replacement of the corneal endothelium for treating MCD is advisable to prevent postoperative *** experimental data confirmed the robust m RNA and protein expression of CHST6 in human corneal endothelium and the rodent homolog CHST5 in mouse *** knockdown of wild-type Chst5 in mouse corneal endothelium(AC^(siChst5)),but not in the corneal stroma,induced experimental MCD with similar extracellular matrix synthesis impairments and corneal thinning as observed in MCD *** carrying Chst5 point mutation also recapitulated clinical phenotypes of MCD,along with corneal endothelial *** injection of wild-type Chst5 rescued the corneal impairments in AC^(siChst5)mice and retarded the disease progression in Chst5 mutant ***,our study provides new mechanistic insights and therapeutic approaches for MCD treatment by highlighting the role of corneal endothelium in MCD development.

关键词： macular corneal dystrophy recurrence corneal endothelium keratan sulfate penetrating keratoplasty

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PdAg bimetallic electrocatalyst for highly selective reduction of CO2 with low COOH^* formation energy and facile CO desorption

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Nano Research 2019年第11期12卷 2866-2871页

作者： Rui Lin Xuelu Ma Weng-Chon Cheong Chao zhang Wei zhu Jiajing Pei Kaiyue zhang Bin Wang Shiyou Liang Yuxi Liu Zhongbin zhuang Rong Yu Hai Xiao Jun Li Dingsheng Wang Qing Peng Chen Chen Yadong Li Department of Chemistry Tsinghua UniversityBeijing100084China School of Chemical&Environment Engineering China University of Mining&TechnologyBeijing100083China College of Chemical Engineering Beijing University of Chemical TechnologyBeijing100029China College of Environmental and Energy Engineering Beijing University of TechnologyBeijing100124China Sinopec Beijing Research Institute of Chemical Industry Beijing100013China School of Materials Science and Engineering National Center for Electron Microscopy in BeijingTsinghua UniversityBeijing100084China

For electrocatalytic reduction of CO2 to CO,the stabilization of intermediate COOH^* and the desorption of CO^* are two key *** can easily stabilize COOH^*,whereas the strong CO^* binding to Pd surface results in severe poisoning,thus lowering catalytic activity and stability for CO2 *** Ag surface,CO^* desorbs readily,while COOH^* requires a relatively high formation energy,leading to a high *** light of the above issues,we successfully designed the PdAg bimetallic catalyst to circumvent the drawbacks of sole Pd and *** PdAg catalyst with Ag-terminated surface not only shows a much lower overpotential(-0.55 V with CO current density of 1 mA/cm^2)than Ag(−0.76 V),but also delivers a CO/H2 ratio 18 times as high as that for Pd at the potential of-0.75 V *** issue of CO poisoning is significantly alleviated on Ag-terminated PdAg surface,with the stability well retained after 4h electrolysis at-0.75 V *** functional theory(DFT)calculations reveal that the Ag-terminated PdAg surface features a lowered formation energy for COOH^* and weakened adsorption for CO^*,which both contribute to the enhanced performance for CO2 reduction.

关键词： CO2 reduction bimetallic low overpotential CO desorption

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饱和粉质黏土动弹性模量影响因素分析及骨干曲线模型研究

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中南大学学报（自然科学版） 2019年第2期50卷 445-451页

作者：庄妍朱伟张飞河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 河海大学岩土工程科学研究所江苏南京210098

为了研究交通动荷载作用下地基土动弹模量的变化规律,利用室内动三轴试验系统对东南沿海地区饱和粉质黏土进行动三轴试验,研究围压、超固结比、孔隙比和应变幅值对动弹性模量变化规律的影响;采用经典Hardin-Drmevich等效线性模型,提出... 详细信息

为了研究交通动荷载作用下地基土动弹模量的变化规律,利用室内动三轴试验系统对东南沿海地区饱和粉质黏土进行动三轴试验,研究围压、超固结比、孔隙比和应变幅值对动弹性模量变化规律的影响;采用经典Hardin-Drmevich等效线性模型,提出考虑超固结比、孔隙比影响的饱和粉质黏土动弹性模量修正公式。研究结果表明:在相同应变水平下,动弹性模量随着围压和超固结比增大而增大,随着孔隙比增大而减小;与经典Hardin-Drmevich公式相比,本文提出的动弹性模量修正公式对试验结果的拟合效果更好。

关键词：饱和粉质黏土动弹性模量动三轴试验修正Hardin-Drmevich模型

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