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国际医学放射学杂志 2014年第6期 600-601页

作者： S.h.zhao j.W.Qiang G.F.zhang F.h.Ma S.Q.Cai h.M.Li 成杰 Department of Radiology Jinshan HospitalFudan University

摘要目的探讨MR扩散加权成像(DWI)鉴别卵巢交界性与恶性上皮性肿瘤。方法回顾性研究共纳入48例病人共60个交界性上皮性卵巢肿瘤(BEOT),54例病人共65个

关键词：恶性上皮性肿瘤交界性卵巢性腺扩散加权 MRI

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

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Nano Research 2020年第8期13卷 2197-2202页

作者： hongxia Liang zhenhua Li zhigang Ren Qiaodi jia Linna Guo Shasha Li hongyu zhang Shiqi hu Dashuai zhu Deliang Shen zujiang Yu Ke Cheng Department of Infectious Disease and hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State UniversityRaleighNC27607USA joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State UniversityRaleighNC27695USA Department of Cardiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China The Key Lab of Chemical Biology and Organic Chemistry of henan Province Zhengzhou UniversityZhengzhou450001China

Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic stellate cells (hSC) is considered an essential pathological hallmark in liver fibrosis. Although nitric oxide (NO) can effectively induce hSC apoptosis, the systemic administration of NO is ineffective and may cause severe complications such as hypotension. To overcome this limitation, nanoparticles were designed to target hSCs and release NO locally under the exposure of near infrared light (NIR). To achieve this, upconversion nanoparticle (UCNP) cores were enveloped in mesoporous silica shells (UCNP@mSiO2), which were modified with hyaluronic acid (hA-UCNP@mSiO2) and Roussin’s black salt (RBS). hA molecules recognize and bind to CD44 proteins, which are overexpressed on activated hSCs. Under exposure to a 980-nm NIR laser, the UCNP cores convert the 980-nm wavelength into ultraviolet (UV) light, which then energizes the RBS (NO donors), resulting in an efficient release of NO inside of the hSCs. Once released, NO triggers hSC apoptosis and reverses the liver fibrosis. This targeted and controlled release method provides the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis.

关键词： liver fibrosis nitric oxide(NO) hepatic stellate cells(hSC) nanoparticles near infrared light(NIR)-controlled release

不同浓度能量和粗蛋白质饲粮中屎肠球菌对断奶仔猪的影响

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饲料博览 2014年第12期24卷 16-16页

作者： zhang z F Lee j M Kim I h

摘要：试验旨在研究不同能量和蛋白质浓度的饲粮中添加屎肠球菌DSM7134对断奶仔猪生长性能、养分消化率、血液指标、粪中微生物以及粪中有害气体含量的影响。将平均体重为6．1±0．35蝇的断奶仔猪140只随机分为4组，有两个屎肠球菌浓度... 详细信息

摘要：试验旨在研究不同能量和蛋白质浓度的饲粮中添加屎肠球菌DSM7134对断奶仔猪生长性能、养分消化率、血液指标、粪中微生物以及粪中有害气体含量的影响。将平均体重为6．1±0．35蝇的断奶仔猪140只随机分为4组，有两个屎肠球菌浓度（O或1×10^9efu·kg^-1饲粮）和两个能量和蛋白水平。试验共进行28d。每个处理有7个重复，每个重复5头猪。高浓度能量、蛋白质和屎肠球菌饲粮组的15。28d和整体的平均日增重和肉料比显著增加（P〈0．05）。

关键词：蛋白质浓度断奶仔猪屎肠球菌粗蛋白质饲粮能量养分消化率平均日增重

A delayed SEIRS epidemic model with impulsive vaccination and nonlinear incidence rate

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International journal of Biomathematics 2014年第3期7卷 149-162页

作者： jiancheng zhang and jitao Sun Department of Mathernatics Tongji University Shanghai 200092 P. R. China

In this paper, a delayed SEIRS epidemic model with nonlinear incidence rate and impul- sive vaccination is investigated. In vaccination strategy, we perform impulsive vaccina- tion of newborn infants. Using the discrete dynamic system determined by stroboscopic map, we obtain an infection-free periodic solution and establish conditions, on which the solution is globally attractive. We also conclude that the disease is permanent if the parameters of the model satisfy appropriate conditions. Finally, we illustrate the effec- tiveness of our theorems with numerical simulation. The results obtained in this paper are a good extension of the results obtained in [j. hou and z. Teng, Continuous and impulsive vaccination of SEIR epidemic models with saturation incidence rate, Math. Comput, Simulat. 79 （2009） 3038 3054] to the corresponding delayed SEIRS epidemic model with nonlinear incidence rate and impulsive vaccination.

关键词： SEIRS impulsive vaccination delay globally attractive permanence.

Probing star formation and feedback using CCOSMA and archival data in the CFG028.68–0.28 quasi-sinusoidal filament

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Research in Astronomy and Astrophysics 2019年第12期19卷 305-317页

作者： jin-Long Xu jirgen Stutzki Yuefang Wu Xin Guan jun-jie Wang M.Miller Yang Chen Sheng-Li Qin jun-zhi Wang Chang-Chun Ning Danzengluobu Tian-Lu Chen Nai-Ping Yu Chuan-Peng zhang Xiao-Lan Liu jian-Bin L Karl jacobs Urs UGraf Gang Xu Nan Li Guo-Yin zhang and Qi Wu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China I.Physikalisches Institut Universitat zu KolnZilpicher Str.7750937 KolnGermany Department of Astronomy Peking UniversityBeijing 100871China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan ProvinceKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Tibet University LhasaTibet 850000China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China NAOC-TU joint Center for Astrophysics Lhasa 850000China

We have performed a multi-wavelength study toward a quasi-sinusoidal filament(CFG028.68–0.28). A new large-scale ^12CO j = 3-2 map was obtained from the China-Cologne Observation for Sub Millimeter Astronomy(CCOSMA) 3m radio telescope. Based on the ATLASGAL catalog, we have identified 27 dust clumps in the filament. Through the relationship between the mass and radius of these clumps, 67% of these clumps are dense and massive enough to potentially form massive stars. The obtained CFE is ~11% in the filament. The filament has a linear mass density of ~305 M⊙pc^-1, which is smaller than its critical mass to length ratio. This suggests that the external pressure from the neighboring h Ⅱ regions may help prevent the filament from dispersing under the effects of turbulence. Comparing the energy injection from outflows and h Ⅱ regions in the filament, the ionization feedback from the h Ⅱ regions can help maintain the observed turbulence.

关键词： stars:formation stars:early-type ISM:hⅡregions ISM:individual(CFG028.68-0.28,IRDC G28.53-0.25,and N49)

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia

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Signal Transduction and Targeted Therapy 2021年第3期6卷 864-874页

作者： Dan Wang huan Yang Yun zhang Rong hu Dongjie hu Qunxian Wang Yannan Liu Mingjing Liu zijun Meng Weihui zhou Weihong Song Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and Disorders(Chongqing)Department of NeurologyChildren's Hospital of Chongqing Medical University400014 ChongqingChina Townsend Family Laboratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada

Increased endogenous hydrogen sulfide(h_(2)S)level by cystathionine β-synthase(CBS)has been shown to closely relate tumorigenesis.h_(2)S promotes angiogenesis,stimulates bioenergy metabolism and inhibits selective ***,the role of CBS and h_(2)S in chronic myeloid leukemia(CML)remains *** this study,we found that CBS and h_(2)S levels were increased in the bone marrow mononuclear cells of pediatric CML patients,as well as in the CML-derived K562 cells and CBS expression levels were correlated with different disease *** of CBS reduced the proliferation of the CML primary bone marrow mononuclear cells and induced growth inhibition,apoptosis,cell cycle arrest,and migration suppression in K562 cells and tumor *** knockdown of CBS expression by shRNA and inhibiting CBS activity by AOAA decreased the endogenous h_(2)S levels,promoted mitochondrial-related apoptosis and inhibited the NF-xB-mediated gene *** study suggests that inhibition of CBS induces cell apoptosis,as well as limits cell proliferation and migration,a potential target for the treatment of chronic myeloid leukemia.

关键词： endogenous myeloid metabolism

high Efficiency Dye-Sensitized Solar Cells Based on Solid-state Composite Electrolyte

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High Efficiency Dye-Sensitized Solar Cells Based on Solid-st...

highly in-plane anisotropy of thermal transport in suspended ternary chalcogenide Ta_(2)NiS_(5)

2004全国太阳能光化学与光催化学术会议

作者： h.X.Wang, B. F. Xue, z.X.Wang, h.Li, Q.B. Meng. X. j.huang, L.Q.Chen (Beijing National Laboratory for Condensed Matter Physics Institute of Physics, Chinese Academy of Sciences, Beijing 100080. China)

＜正＞ A novel solid-state electrolyte composed of LiI and hPN and ceramic oxide for dye-sensitized solarcells（DSSC）has been prepared and *** ionic conductivity of the electrolyte reaches to 10-3S/cm at room temperature determined by impedance spectroscopy and the conductivity behavior obeys theArrihenius law（Figure 1）.Single crystal structure of the compound formed by LiI/hPN indicates thatiodide spreads orderly in *** these results suggest that the electrolyte is probably a good

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Nano Research 2022年第7期15卷 6601-6606页

作者： Yue Su Chuyun Deng jinxin Liu Xiaoming zheng Yuehua Wei Yangbo Chen Wei Yu Xiao Guo Weiwei Cai Gang Peng han huang Xueao zhang College of Physical Science and Technology Xiamen UniversityXiamen 361005China College of Arts and Sciences National University of Defense TechnologyChangsha 410073China College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China jiujiang Research Institute of Xiamen University Jiujiang 332105China hunan Key Laboratory of Super-microstructure and Ultrafast Process School of Physics and ElectronicsCentral South UniversityChangsha 410083China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China

Energy dissipation has always been an attention-getting issue in modern electronics and the emerging low-symmetry two-dimensional(2D)materials are considered to have broad prospects in solving the energy dissipation *** the thermal transport of a typical 2D ternary chalcogenide Ta_(2)NiS_(5) is *** the first time we have observed strongly anisotropic in-plane thermal conductivity towards armchair and zigzag axes of suspended few-layer Ta_(2)NiS_(5) flakes through Raman *** 7-nm-thick Ta_(2)NiS_(5) flakes,theκz i g z a g is 4.76 W·m^(−1)·K^(−1) andκa r m c h a i r is 7.79 W·m^(−1)·K^(−1),with a large anisotropic ratio(κa r m c h a i r/κz i g z a g)of 1.64 mainly ascribed to different phonon mean-free-paths along armchair and zigzag ***,the thickness dependence of thermal anisotropy is also *** the flake thickness increases,theκa r m c h a i r/κz i g z a g reduces sharply from 1.64 to *** could be attributed to the diversity in phonon boundary scattering,which decreases faster in zigzag direction than in armchair *** anisotropic property enables heat flow manipulation in Ta_(2)NiS_(5) based devices to improve thermal management and device *** work helps reveal the anisotropy physics of ternary transition metal chalcogenides,along with significant guidance to develop energy-efficient next generation nanodevices.

关键词： anisotropic thermal conductivity ternary transition metal chalcogenide Ta_(2)NiS_(5) energy dissipation phonon mode

近红外低能量激光调节血小板活性氧水平对防止冷藏损伤的研究

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临床输血与检验 2024年第5期26卷 617-623页

作者：谢如锋张景怡杨懿铭高跞蒋雪玉孙娟杨洁上海市血液中心输血研究所血液工程学科上海200051

目的探究近红外低能量激光(Low Level Laser,LLL)照射处理对冷藏血小板保存期间活性氧的调节作用,进而对减少被巨噬细胞和肝细胞识别吞噬的影响。方法将白膜来源的浓缩血小板分为室温保存组(RTP)、冷藏保存组(CSP)和LLL照射组(CSP-L)。... 详细信息

目的探究近红外低能量激光(Low Level Laser,LLL)照射处理对冷藏血小板保存期间活性氧的调节作用,进而对减少被巨噬细胞和肝细胞识别吞噬的影响。方法将白膜来源的浓缩血小板分为室温保存组(RTP)、冷藏保存组(CSP)和LLL照射组(CSP-L)。LLL照射组为血小板冷藏12 h后,采用1 j、5 j、10 j不同辐照强度的LLL单次照射并继续冷藏保存。各组保存5 d后,流式细胞仪检测血小板ROS生成、活化指标表达、糖基蛋白及其残基的暴露情况并进行比较。佛波酯诱导的ThP-1细胞和hepG2肝细胞用于检测对各组血小板的吞噬作用。结果保存5 d后,CSP组血小板胞内ROS(cyto-ROS)水平较RTP组显著升高(RTP ***,3960±259.6 vs.5846±757.4,Pj)照射后,CSP-L1组血小板较CSP组显著降低了cyto-ROS水平(5846±757.4 vs.3945±459.4,PhP-1和hepG2对CSP-L1组血小板的吞噬率也显著低于CSP组(Ph值和MPV均无明显影响。结论低强度LLL照射处理可显著降低冷藏血小板胞内ROS水平并维持线粒体ROS的低水平生成,并能有效的抑制血小板活化和GPⅠb/ɑ去唾液酸化,减轻冷藏损伤,进而减少冷藏血小板被巨噬细胞和肝细胞识别吞噬。

关键词：近红外低能量激光冷藏血小板冷藏损伤活性氧

一种改善冷喷涂铝合金组织和摩擦学性能的有效途径

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表面工程与再制造 2023年第5期23卷 63-63页

作者： jiang T. Tariq N.U.h. Qiu X. zhang Q. Li L. Du j. Department of Petroleum Engineering China University of Petroleum (East China) Qingdao 266580 China Department of Metallurgy and Materials Engineering Pakistan Institute of Engineering and Applied Sciences Islamabad Nilore Pakistan Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Navy Submarine Academy Qingdao 260199 China CAS Key Laboratory of Marine Environment of Corrosion and Bio-fouling Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Yantai University Yantai 264005 China

冷喷涂被认为是一种在各种金属材料表面制备耐磨金属基复合涂层的新兴技术。在本项工作中,一种可行的"冷喷涂+热轧后处理"策略被成功应用于在商用6061铝板上制备耐磨B4C/6061Al复合涂层。结果表明,热轧后处理通过有效愈合喷涂态沉积层... 详细信息

冷喷涂被认为是一种在各种金属材料表面制备耐磨金属基复合涂层的新兴技术。在本项工作中,一种可行的"冷喷涂+热轧后处理"策略被成功应用于在商用6061铝板上制备耐磨B4C/6061Al复合涂层。结果表明,热轧后处理通过有效愈合喷涂态沉积层中的缺陷和层片边界,使合金基体中B4C颗粒分布均匀,层片间结合良好,且层片内具有足够的塑性。与喷涂态样品相比,热轧态样品中的膜层-基体结合强度增加了两倍。

关键词：冷喷涂基体结合强度金属材料表面制备合金基体热轧态复合涂层铝板