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负面信息如何影响农户对保险公司的信任

保险研究 2024年第3期 19-30页

作者：张跃华阎文溯 Calum G.Turvey 浙江大学公共管理学院浙江大学长三角智慧绿洲创新中心康奈尔大学Dyson应用经济与管理学院

保险需求“不足”是阻碍保险高质量发展的重要问题。缺乏信任可能是导致参保不足的重要原因之一,而信息是信任成立的关键因素。本文基于负面信息(行政约谈)冲击下保险信任的重复博弈模型,构建农户信任形成的分析框架,利用2017、2018年... 详细信息

保险需求“不足”是阻碍保险高质量发展的重要问题。缺乏信任可能是导致参保不足的重要原因之一,而信息是信任成立的关键因素。本文基于负面信息(行政约谈)冲击下保险信任的重复博弈模型,构建农户信任形成的分析框架,利用2017、2018年河南省A市养猪业的随机抽样数据和认可实验,引入背叛厌恶研究负面信息对农户信任的削弱影响及机制。研究发现,负面信息会显著降低农户对保险公司的信任,农户对保险公司的信任具有背叛厌恶的性质,为保险公司自我约束展业行为、提高农业保险保障水平提供了学理依据。

关键词：农业保险负面信息投保人信任背叛厌恶认可实验

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基于自然教育理念重塑学前儿童科学教育

黑龙江教师发展学院学报 2024年第9期43卷 146-151页

作者：肖乾燕张悦桦西华师范大学教育学院四川南充637009

自然教育理念源于西方,在当前的教育实践中逐渐被重视,其根本目标是为了突出儿童在学习中的主体地位和加强人与自然间的联结。基于当前我国学前儿童科学教育中的一系列问题,以自然教育理念重构学前儿童科学教育的目标取向、内容取向、... 详细信息

自然教育理念源于西方,在当前的教育实践中逐渐被重视,其根本目标是为了突出儿童在学习中的主体地位和加强人与自然间的联结。基于当前我国学前儿童科学教育中的一系列问题,以自然教育理念重构学前儿童科学教育的目标取向、内容取向、过程取向、文化取向和能力取向,在此基础上审视学前儿童科学教育的组织与实施。

关键词：自然教育学前儿童科学教育价值取向组织与实施

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柚子皮活性碳制备及吸附性能探究

广州城市职业学院学报 2024年第3期18卷 90-95页

作者：张卫丽张越华广州城市职业学院食品健康学院广东广州510000

利用柚子皮制备出IR-750、IR-850和IR-950三种吸附碳,并对吸附碳进行红外吸收光谱表征,探究了样品在不同的pH、吸附时间、吸附剂量单因素条件下对Cu^(2+)、Cr^(6+)、Ag^(+)和Zn^(2+)四种离子的吸附性能。通过单因素实验探究后选取了对C... 详细信息

利用柚子皮制备出IR-750、IR-850和IR-950三种吸附碳,并对吸附碳进行红外吸收光谱表征,探究了样品在不同的pH、吸附时间、吸附剂量单因素条件下对Cu^(2+)、Cr^(6+)、Ag^(+)和Zn^(2+)四种离子的吸附性能。通过单因素实验探究后选取了对Cu2+离子综合吸附性能正交试验进行研究。结果表明三种吸附碳中都有-C=O、-OH、-C-O特征官能团,在吸附性试验中,得出了不同因素对吸附性能的影响效果。根据单因素结果选择了样品IR-850进行正交试验探究,结果表明吸附时间对IR-850样品吸附性能影响最大,其最优化吸附条件为吸附反应时间240分钟,pH为5,加入吸附剂100mg,此时测得对400mg/L的Cu^(2+)溶液吸附率最高,达88.73%。本研究发现柚子皮碳化制备生物碳样品对环境中金属离子有一定的吸附效果,是一种可开发的吸附碳材料。

关键词：柚子皮生物碳吸附性

肩关节腔注射富血小板血浆联合新Bobath技术治疗脑卒中后肩痛疗效及对疼痛相关因子的影响

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罕少疾病杂志 2024年第8期31卷 114-117页

作者：熊玉鑫张跃华程艳秋河南三门峡市中心医院康复医学科河南三门峡472000

目的评价肩关节腔注射富血小板血浆(PRP)联合新Bobath技术治疗脑卒中后肩痛疗效及对疼痛相关因子的影响。方法取2017年6月至2020年2月于河南三门峡市中心医院康复医学科就诊的脑卒中后肩痛患者88例,按随机数字表法将其分为研究组(45例)... 详细信息

目的评价肩关节腔注射富血小板血浆(PRP)联合新Bobath技术治疗脑卒中后肩痛疗效及对疼痛相关因子的影响。方法取2017年6月至2020年2月于河南三门峡市中心医院康复医学科就诊的脑卒中后肩痛患者88例,按随机数字表法将其分为研究组(45例)及对照组(43例)。入院后所有受试者均予以常规治疗措施,在此基础上,研究组予超声引导下肩关节腔内注射PRP联合新Bobath技术治疗,而对照组仅予新Bobath技术治疗,均连续治疗4周。于治疗前及治疗后2、4周,采用Fugl-Meyer运动功能量表上肢部分(FMA-UE)、视觉模拟评分法(VAS)、通用量角器检测所有受试者肩关节被动活动范围,同时采用酶联免疫吸附法测定血清中白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)及基质金属蛋白酶-3(MMP-3)水平。结果两组患者治疗后的VAS评分、FMA-U评分、肩关节前屈、外展及外旋被动ROM以及MMP-3水平、TNF-α水平、IL-1β水平随着时间的推移,改善程度是不相等的,但以研究组的改善程度最大(F时间=15.692,F时间=12.082,F时间=8.640,F时间=9.033,F时间=16.025,F时间=7.695,F时间=8.359,F时间=7.448,P时间<0.01)。结论与新Bobath技术干预比较,辅以超声引导下肩关节腔内注射PRP治疗更能够缓解脑卒中后肩痛,改善肩关节功能,同时可以显著降低血清疼痛相关因子水平。

关键词：肩关节腔. 富血小板血浆新Bobath技术脑卒中后肩痛

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan Yang hua yue Shuang Wang Xiao zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

High-temperature oxidation resistance of Si-coated C/SiC composites

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Rare Metals 2024年第9期43卷 4566-4572页

作者： Jie Xiao hua-yue zhang Sheng-Kai Gong Hui-Bin Xu Hong-Bo Guo School of Materials Science and Engineering Beihang UniversityBeijing 100191China Key Laboratory of High-Temperature Structure Materials and Protective Coatings(Ministry of Industry and Information Technology) Beihang UniversityBeijing 100191China

In this paper,Si coatings were sprayed onto C/SiC composite substrates by atmospheric plasma spraying(APS).The high-temperature oxidation behavior of the substrate and coating at temperatures of 1100 and 1300℃was also *** C/SiC ceramic matrix composite will be damaged seriously and even failed due to the oxidation of carbon fibers in *** Si coating effectively improved the oxidation resistance of the C/SiC substrate in the high-temperature oxidation *** effect of the thickness of the Si coatings on the oxidation resistance was *** 150-μm coating is proved to enable the substrate to have the lowest oxidation weight loss and the best oxidation resistance after static oxidation for 5 h.

关键词： Ceramic matrix composites(CMCs) Carbon fiber Si coating Oxidation Plasma spray

Design and Synthesis of 3-Substituedmethylenethiochroman-4-ones as Anticancer Agents

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Chemical Research in Chinese Universities 2011年第5期27卷 787-791页

作者： MA Zheng-yue zhang Xing-hua LI Chun-na ZHENG Ya-jun YANG Geng-liang WANG Shi-kui HE Yang Key Laboratory for Pharmaceutical Quality Control of Hebei Province College of Pharmaceutical Sciences Hebei University Baoding 071002 P R. China

A series of 3-substituedmethylenethiochroman-4-ones was designed and synthesized, and their structures were confirmed by 1H NMR, 13C NMR, MS, IR, UV and elemental analysis. The results of their anticancer activity studies show that almost all 3-chloromethylenethiochroman-4-ones exhibit high anticancer activities and their activities are all better than reference cisplatin. Their IC50 against cancer cells is in a range of 0.80―9.17 μg/mL. Thus they could be promising candidates for anticancer drugs. However, compound 5 has no activity against cancer cells, thus chloromethylene at the 3 position of thiochroman-4-ones seems to play an important role in observed anticancer activities.

关键词： Anticancer activity 3-Chloromethylene Thiochromanone

Elite Dung Beetle Optimization Algorithm for Multi-UAV Cooperative Search in Mountainous Environments

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Journal of Bionic Engineering 2024年第4期21卷 1677-1694页

作者： Xiaoyong zhang Wei yue The College of Marine Electrical Engineering Dalian Maritime UniversityDalian116026China

This paper aims to address the problem of multi-UAV cooperative search for multiple targets in a mountainous environment,considering the constraints of UAV dynamics and prior environmental ***,using the target probability distribution map,two strategies of information fusion and information diffusion are employed to solve the problem of environmental information inconsistency caused by different UAVs searching different areas,thereby improving the coordination of UAV ***,the task region is decomposed into several high-value sub-regions by using data clustering *** on this,a hierarchical search strategy is proposed,which allows precise or rough search in different probability areas by adjusting the altitude of the aircraft,thereby improving the search ***,the Elite Dung Beetle Optimization Algorithm(EDBOA)is proposed based on bionics by accurately simulating the social behavior of dung beetles to plan paths that satisfy the UAV dynamics constraints and adapt to the mountainous terrain,where the mountain is considered as an obstacle to be ***,the objective function for path optimization is formulated by considering factors such as coverage within the task region,smoothness of the search path,and path *** effectiveness and superiority of the proposed schemes are verified by the simulation.

关键词： Mountainous environment Multi-UAV cooperative search Environment information consistency Elite dung beetle optimization algorithm(EDBOA) Path planning

PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes

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World Journal of Pediatrics 2024年第1期20卷 82-91页

作者： Han zhang Kai Gao Shuang Wang yue-hua zhang Zhi-Xian Yang Ye Wu Yu-Wu Jiang Department of Pediatrics Peking University First Hospital.No.1 Xi'an Men StreetWest DistrictBeijing 100034China Bejing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases BeijingChina Children Epilepsy Center Peking University First HospitalBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijingChina

Background The PACS gene family has been demonstrated to be related to intracellular vesicular *** phenotypic manifestations caused by the pathogenic variants of PACS include epilepsy,intellectual disability/developmental delay,and malformations,such as facial *** We identified seven new cases with pathogenic or likely pathogenic PACS variants using next-generation *** information obtained from these patients was analyzed along with that obtained from previously reported *** With the inclusion of the newly diagnosed cases in this study,103 cases with PACS gene family-related neurological diseases were reported,of which 43 were PACS2-related cases and the remaining were PACSI-related *** patients had seizures,which have been reported to be effectively controlled by several types of anti-seizure medications(ASMs).The most efficacious and frequently prescribed ASMs included sodium valproate(43.3%,13/30),oxcarbazepine/carbamazepine(26.7%,8/30),and levetiracetam(20%,6/30).Almost all patients had intellectual disability/developmental *** most common pathogenic missense variants were PACSI ***203Trp and PACS2 *** addition,we report a patient carrying a likely pathogenic copy number variation(CNV)(de novo heterozygous deletion of chr14:105821380-106107443,286 kilobase,destroyed part of the furin-binding region domain and the protein structure after it)with more severe and refractory late-onset *** The clinical phenotypes of the different PACS heterozygous missense variants were *** pathogenic variant sites of PACSI and PACS2 were quite limited but located in different regions.A CNV destroying part of the PACS2 gene might also be *** findings may provide an important clue for further functional studies on the pathogenic mechanism of neurological disorders related to the PACS gene family.

关键词： Developmental delay Epilepsy Intellectual disability PACSI PACS2