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Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of hepatology 2024年第5期16卷 809-821页

作者： yuan-yao zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo wang Xin Zheng Yan Huang Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan zhang Wen-Yi Gu Xiao-Mei xiang Yi zhou Yi-Xin Hou Qun zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi yuan-yuan Chen Na Gao Chun-Yan Liu Wei yuan Xue Mei jing Li Tao Li Rong-Jiong Zheng Xin-Yi zhou Jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

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脊柱畸形截骨矫形术神经损伤的相关因素

中国矫形外科杂志 2024年第13期32卷 1153-1157页

作者：张耀申海涌刘玉增周立金杨晋才苏庆军臧磊孟祥龙首都医科大学附属北京朝阳医院骨科北京100020

[目的]探讨脊柱畸形截骨矫形术中神经损伤的危险因素。[方法]2016年1月—2021年12月截骨矫形手术治疗脊柱畸形312例纳入本研究,观察术中神经电生理监测(intra-operative neurophysiological monitoring,IONM)情况,通过单因素和多因素逻... 详细信息

[目的]探讨脊柱畸形截骨矫形术中神经损伤的危险因素。[方法]2016年1月—2021年12月截骨矫形手术治疗脊柱畸形312例纳入本研究,观察术中神经电生理监测(intra-operative neurophysiological monitoring,IONM)情况,通过单因素和多因素逻辑回归分析筛选发生神经损伤的相关因素。[结果]312例患者术中发生IONM异常26例,占比8.3%。术后发生神经损伤11例,占比3.5%。IONM异常组术前MRI脊髓有无异常比率[有/无,(5/21)vs(7/279),P=0.017]、术前CT椎管有无异常比率[有/无,(8/18)vs(25/261),P=0.029]、Cobb角>110°占比[例(%),19(73.1)vs 31(10.8),P=0.011]、柔韧度0.05)。多因素逻辑回归分析显示,术前柔韧度差(OR=9.824,P<0.001)、术前Cobb角度大(OR=6.751,P=0.004)、术前CT椎管异常(OR=3.343,P=0.017)、术前MRI脊髓异常(OR=3.117,P=0.021)、手术截骨等级大(OR=2.897,P=0.026)和手术时间长(OR=1.043,P=0.031)是脊柱畸形截骨矫形术中发生IONM异常和神经损伤并发症的独立危险因素。[结论]脊柱畸形截骨矫形手术是治疗重度脊柱畸形的有效方法,术中应高度警惕神经损伤的风险,术前核磁和术前CT三维重建检查仔细评估脊髓和椎管状况非常重要,手术中尽量减少截骨等级和手术时间,将有益于避免或减少脊柱畸形截骨矫形术中神经损伤。

关键词：脊柱畸形截骨矫形术神经损伤危险因素

Detecting neutrinos from supernova bursts in PandaX-4T

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Chinese Physics C 2024年第7期48卷 14-21页

作者：庞彬宇阿布都沙拉木·阿布都克力木薄子豪陈葳谌勋程晨成兆侃崔祥仪樊英杰方德清符长波付孟婷耿立升 Karl Giboni 顾琳慧郭绪元韩晨成韩柯何昶达何金荣黄迪黄彦霖黄俊挺黄周侯汝全侯钰季向东巨永林李晨翔李家富李名川李帅杰李涛林箐刘江来陆聪聪芦晓盈罗棱尹罗云阳马文博马余刚冒亚军孟月宁旭阳祁宁春钱志成任祥祥 Nasir Shaheed 尚晓凤邵熙元申国防司琳孙文良谈安迪陶奕王安庆王萌王秋红王少博王思广王为王秀丽王舟魏月环武蒙蒙邬维浩夏经铠肖梦姣肖翔谢鹏伟燕斌斌颜玺雨杨继军杨勇姚玉坤喻纯旭袁影苑哲鑫宁张丹张敏桢张鹏张世博张澍张涛张洋张瀛心张园园赵力郑其斌周济芳周宁周小朋周永周钰博 New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai200240China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237ShandongChina School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 102206China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Nankai UniversityTian

Neutrinos from core-collapse supernovae are essential for understanding neutrino physics and stellar ***-phase xenon dark matter detectors can be used to track explosions of galactic supernovae by detecting neutrinos through coherent elastic neutrino-nucleus *** this study,a variation of progenitor masses and explosion models are assumed to predict neutrino fluxes and spectra,which result in the number of expected neutrino events ranging from 6.6 to 13.7 at a distance of 10 kpc over a 10-s duration with negligible backgrounds at *** specialized triggering alarms for monitoring supernova burst neutrinos are *** efficiency of detecting supernova explosions at various distances in the Milky Way is *** alarms will be implemented in the real-time supernova monitoring system at PandaX-4T in the near future,which will provide supernova early warnings for the astronomical community.

关键词： core-collapse supernovae neutrinos liquid xenon detectors supernova early warnings

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.cheng J.cheng S.cheng T.G.cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.geng L.S.geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.he S.Q.he X.G.he Y.L.he Z.B.he Z.X.heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Exploring the Nanomechanical Properties of a Coordination-bond Based Supramolecular Polymer

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Chinese Journal of Polymer Science 2022年第12期40卷 1613-1622,I0008页

作者： Rui-xiang yao Jun-juan Shi Ke-Huan Li Xin Liu Hou-yu zhang Ming wang Wen-Ke zhang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Institute of Theoretical Chemistry College of ChemistryJilin UniversityChangchun 130012China

Due to their dynamic nature and strength tunability,metallo-supramolecular polymers have been introduced into various *** mechanical strength of the metallo-supramolecular polymers in the system directly influences the mechanical properties(e.g.,the toughness)of the ***,it is necessary to explore the mechanical behavior of the metallo-supramolecular ***,we present a single-molecule method to systematically explore the chain structure and mechanical properties of metallo-supramolecular polymer by using a loop protected ***,we found that the mechanical stability of the individual chain,which is determined by the strength of terpyridine-Fe^(2+) -terpyridine(tpy-Fe^(2+)-tpy)bonds,was about 0.6–1.0 nN,depending on the pulling *** value is around three times higher than those measured using old *** addition,the unique loop protected structure further reduces the interference of non-specific polymer-AFM tip(or polymer-substrate)interactions on the quantification of the actual strength and kinetic parameter of noncovalent interactions in supramolecular ***,the single chain flexibility of the metallo-supramolecular polymer was investigated and found to be comparable to the corresponding covalent *** findings provide a new way to explore the force response of supramolecular polymers composed of metal-ligand interactions and will be useful for the design of metallo-supramolecular polymer-based functional materials with tailored mechanical properties.

关键词： Supramolecular polymer Single-molecule force spectroscopy Coordination chemistry Polymer mechanochemistry

Monoclonal antibody-based serological detection of potato virus M in potato plants and tubers

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Journal of Integrative Agriculture 2020年第5期19卷 1283-1291页

作者： zhang yu GAO Yan-ling he Wan-qin wang Ya-qin QIAN Ya-juan zhou Xue-ping WU Jian-xiang State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058P.R.China Potato Research Institute of heilongjiang Academy of Agricultural Sciences Harbin 150086P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Potato virus M(PVM) is one of the common and economically important potato viruses in potato-growing regions worldwide. To investigate and control this viral disease, efficient and specific detection techniques are needed. In this study, PVM virions were purified from infected potato plants and used as the immunogen to produce hybridomas secreting PVM-specific monoclonal antibodies(MAbs). Four highly specific and sensitive murine MAbs, i.e., 1 E1, 2 A5, 8 A1 and 17 G8 were prepared through a conventional hybridoma technology. Using these four MAbs, we have developed an antigen-coated plate(ACP)-ELISA, a dot-ELISA and a Tissue print-ELISA for detecting PVM infection in potato plants and tubers. PVM could be detected in infected potato plant tissue crude extracts diluted at 1:10 240(w/v, g mL^(–1)) by the dot-ELISA or at 1:163 840(w/v, g mL^(–1)) by the ACP-ELISA. The Tissue print-ELISA is the quickest and easiest assay among the three established serological assays and is more suitable for onsite large-scale sample detection. Detection results of the field-collected samples showed that PVM is currently widespread in the yunnan and the heilongjiang provinces in China. The field sample test results of the developed serological assays were supported by the results from RT-PCR and DNA sequencing. We consider that the newly established ACP-ELISA, dot-ELISA and Tissue print-ELISA can benefit PVM detection in potato plant and tuber samples and field epidemiological studies of PVM. These assays can also facilitate the production of virus-free seed potatoes and breeding for PVM-resistant potato cultivars, leading to the successful prevention of this potato viral disease.

关键词： potato virus M monoclonal antibody serological assay antigen-coated plate(ACP)-ELISA dot-ELISA Tissue print-ELISA

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不同饲料对双叉犀金龟生长发育的影响

山东农业大学学报（自然科学版） 2024年第5期55卷 750-756页

作者：张居宇王婕姝赵鹏武刘志文刘玉升刘业超姚湘周诗玉张燕如内蒙古农业大学林学院内蒙古呼和浩特010019 吉林省蚕业科学研究院吉林吉林132000 山东农业大学植物保护学院环境昆虫研究所山东泰安271000

为了探究发酵木耳菌糠、发酵香菇菌糠和发酵木屑3种饲料对双叉犀金龟幼虫生长发育和营养成分的影响,以及3种饲料作为基质对产卵量与孵化率的影响。采用3种饲料,在27℃、饲料湿度70%条件下饲养双叉犀金龟幼虫,分别测定3龄幼虫的体重、体... 详细信息

为了探究发酵木耳菌糠、发酵香菇菌糠和发酵木屑3种饲料对双叉犀金龟幼虫生长发育和营养成分的影响,以及3种饲料作为基质对产卵量与孵化率的影响。采用3种饲料,在27℃、饲料湿度70%条件下饲养双叉犀金龟幼虫,分别测定3龄幼虫的体重、体长、存活率与幼虫体内基本养分物质含量。羽化后用3种饲料作为基质进行雌虫产卵试验,分析不同基质对双叉犀金龟雌虫产卵量与幼虫孵化率的影响。测定并分析饲料营养成分与幼虫营养间的关系。结果表明,在饲养环境条件一致时,发酵木耳菌糠与发酵木屑更有助于双叉犀金龟幼虫生长发育,但体内养分物质含量与另外一种饲料差异不显著。发酵木耳菌糠作为产卵基质时,双叉犀金龟雌成虫产卵量与孵化率显著大于其它两种饲料。发酵香菇菌糠中的总蛋白含量虽然能够保证双叉犀金龟完成生长发育,但纤维素、半纤维素与木质素含量显著低于其它两种饲料,不能代替发酵木屑进行饲养。

关键词：食用菌菌糠双叉犀金龟生长发育营养指标

相场法模拟弹性场对沉淀相变组织演化及相平衡成分的影响

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物理学报 2006年第5期55卷 2433-2438页

作者：张玉祥王锦程杨根仓周尧和西北工业大学凝固技术国家重点实验室西安710072

采用相场法模拟沉淀组织在不均匀共格本征弹性场及外加约束弹性应变作用下的演化历程,探讨了不均匀共格本征弹性场及外加约束弹性应变对共格沉淀组织演化的影响规律,并分析了弹性场在沉淀相变中对基体与沉淀相的平衡成分的影响.

关键词：相场法沉淀组织弹性场相平衡成分

Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community- dwelling populations

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Stroke & Vascular Neurology 2021年第4期6卷 589-594,I0055-I0059页

作者： Mei-Jun Shu Fei-Fei Zhai Ding-Ding zhang Fei Han Lixin zhou Jun Ni Ming yao Shu-yang zhang Li-Ying Cui Zheng-yu jin Hui-juan Zhu Yi-cheng Zhu Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Medical Research Center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Radiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Endocrinology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

Background and purpose This study aimed to investigate the association of metabolic syndrome(MetS)with both intracranial atherosclerotic stenosis(ICAS)and imaging markers of cerebral small vessel disease(CSVD)in a community-based *** This study included 943 participants(aged 55.6±9.2 years,36.1%male)from the community-based Shunyi cohort *** was defined according to the joint interim criteria and quantified by the MetS severity *** was evaluated by brain magnetic resonance *** MRI markers of CSVD,including white matter hyperintensities(WMHs),lacunes,cerebral microbleeds(CMBs)and enlarged perivascular spaces(EPVS),were *** regression models were used to investigate the association of MetS severity Z-score with ICAS and these CSVD *** We found that risk of ICAS(OR=1.75,95%CI 1.39 to 2.21,pher risks of WMH volume(β=0.11,95%CI 0.01 to 0.20,p=0.02)and lacunes(OR=1.28,95%CI 1.03 to 1.59,p=0.03)but not the presence of CMBs(OR=0.93,95%CI 0.74 to 1.16,p=0.51)and PVS severity(EPVS in basal ganglia:OR=0.96,95%CI 0.84 to 1.09,p=0.51 and EPVS in white matter:OR=1.09,95%CI 0.96 to 1.23,p=0.21).Conclusions Our findings suggest that WMH and lacunes share risk factors with atherosclerosis of the cerebral artery,whereas the impact of glucose and lipid metabolic disorder to CMB or EPVS might be weak.

关键词： cerebral severity stenosis