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Two New Flavonol Glycosides from Bridelia tomentosa

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Chinese Chemical Letters 2006年第10期17卷 1339-1342页

作者： Shi Hui SHU Jin Lan zhang ying Hong WANG hai Lin QIN Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Beijing 100050

Two new flavonol glycosides, tamarixetin 3-O-β-D-xylopyranosyl-（1-2）-α-L-ribopyranoside （1） and tamarixetin 3-O-α-L-ribopyranoside （2） were isolated from the leaves of Bridelia tomentosa. Their structures wer... 详细信息

关键词： Bridelia tomentosa flavonol glycosides tamarixetin 3-O-β-D-xylopyranosyl-(1-2)-α-L-ribopyranoside tamarixetin 3-O-α-L-ribopyranoside.

A channel estimation algorithm for optical orthogonal frequency division multiplexing systems

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Optoelectronics Letters 2013年第3期9卷 217-220页

作者： WANG Dong YOU Nian-yu WANG Wei-dong zhang ying-hai Laboratory of Information and Electronics Technology Beijing University of Posts and Telecommunications Bei-jing 100876 China Research Institute of Photonics Dalian Polytechnic University Dalian 116034 China

A simple channel estimation (CE) scheme, which is pilot-aided with just a little number of pilots inserted in the first half part of the subcarriers, is proposed and simulated for resisting the fiber dispersion in optical orthogonal frequency division multiplexing (OFDM) systems. The simulation results verify that the receiver sensitivity is improved by 2-3 dBm for bit error rate (BER) of 10~(-3) with the proposed CE algorithm than that with other kinds of CE algorithms based on linear square principle. The good constellation performance for a 40 Gbit/s transmission system can be also obtained by the proposed scheme.

关键词：正交频分复用系统信道估计算法接收灵敏度 OFDM 仿真结果传输系统子载波飞行员

Synthesis of substituted polyaryls via sterically hindered double Suzuki cross-couplings

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Chinese Chemical Letters 2009年第8期20卷 927-930页

作者： Zhan zhang hai ying Ji Xian Lei Fu Yu Yang Yun Rong Xue Guo Hua Gao Shanghai Key Laboratory of Green Chemistry and Chemical Process Department of ChemistryEast China Normal University Shanghai 200062 China

Substituted polyaryls were synthesized successfully via sterically hindered double Suzuki cross-couplings of arylboronic acids with aryl dibromides in the presence of Pd（PPh3）4 and KOtBu within a very short time. ？... 详细信息

关键词： Double Suzuki coupling Sterically Polyaryls

CB1 receptor activation on VgluT2-expressing glutamatergic neurons underlies Δ9-tetrahydrocannabinol(Δ9-THC)-induced aversive effects in mice

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中国药理学与毒理学杂志 2018年第9期32卷 715-716页

作者： HAN Xiao HE Yi BI Guo-hua zhang hai-ying SONG Rui LI Jin XI Zheng-xiong Beijing Institute of Pharmacology and Toxicology Beijing 100850 China Molecular Targets and Medications Discovery Branch Intramural Research Program National Institute on Drug Abuse Baltimore MD 21224 USA

OBJECTIVE Cannabis can be rewarding or *** reward is believed to be mediated by activation of cannabinoid CB1 receptors(CB1 Rs) on GABAergic neurons that disinhibit dopaminergic neurons in the ventral tegmental area(VTA).However,little is known about the mechanisms underlying cannabis aversion in *** study aimed at dig the mechanisms underlying cannabis *** We first created CB1-floxed mice and then generated conditional CB1-knockout mice(VgluT2-CB1-/-) in glutamatergic neurons that express vesicular glutamate transporter 2(VgluT2).We then used immunohistochemistry and RNAscope in situ hybridization assays to examine whether CB1 Rs are expressed in VTA GABAergic neurons and glutamatergic *** also used Cre-dependent viral vector to express light-sensitive channelrhodopsin-2 into VTA glutamatergic ***,conditioned place preference and intracranial self-stimulation(ICSS) maintained by optical activation of VTA glutamatergic neurons were employed to evaluate the effects of Δ9-THC on brain reward *** CB1 Rs are found not only on VTA GABAergic neurons,but also on VTA glutamatergic neurons that express vesicular glutamate transporter 2(VgluT2).Photoactivation of VTA glutamatergic neurons produced robust intracranial self-stimulation(ICSS) behavior,which was dose-dependently blocked by DA receptor antagonists,but enhanced by *** contrast,Δ9-tetrahydrocannabinol(Δ9-THC),the major psychoactive component of cannabis,produced dose-dependent conditioned place aversion and a reduction in the above optical ICSS in VgluT2-cre control mice,but not in VgluT2-CB1-/-*** Activation of CB1 Rs in VgluT2-expressing glutamate neurons produces aversive effects that might explain why cannabinoid is not rewarding in rodents and might also account for individual differences in the hedonic effects of cannabis in humans.

关键词： cannabis cannabinoid receptor type 1 RNAscope conditioned knock-out intracrnialself-stimulation

Validation And Reliability of Distress Thermometer in Chinese Cancer Patients

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Chinese Journal of Cancer Research 2011年第1期23卷 54-58页

作者： Li-li Tang Ye-ning zhang ying Pang hai-wei zhang Li-li Song Key laboratory of Corcinogenesis and Translational Research (Ministry of Education) Department of Psycho-OntologyPeking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective：To examine the validation and reliability of the distress thermometer（DT） recommended by National Comprehensive Cancer Network（NCCN） in Chinese cancer ***：A total of 574 Chinese cancer patients from Beijing Cancer Hospital completed the detection of DT,the Hospital Anxiety and Depression Scale（HADS） and Symptom Checklist 90（SCL-90）,Receiver Operating Characteristic（ROC） curve and Area Under the Curve（AUC） were used to analyze the validation relative to HADS and *** patients with DT≥4 and whose distress caused by emotional problems were interviewed with the MiNi International Neuro-psychiatric Interview（MINI）（Chinese Version 5.0）.This version was used to analyze cancer patients＇ psychological and Psychiatric symptoms during the cancer process;*** 106 cancer patients in rehabilitation stage and stable condition were asked to fill in DT two times,at the base time and after 7-10 ***：Data of ROC indicates that a DT cutoff score of 4 yielded AUC of 0.80 with a optimal sensitivity（0.80） and specificity（0.70） relative to HADS,and AUC of 0.83 with the greatest sensitivity（0.87） and specificity（0.72） against *** DT also has acceptable test-retest reliability（r=0.800,P=0.000）;According to the interview results,the most common psychiatric problems cancer patients have adjustment disorder,depression,and ***：The data suggest that DT has acceptable overall accuracy and reliability as a screening tool for testing distress severity and specific problems causing distress in Chinese cancer *** is worth being used in oncology clinic,the rapid screening and interview could help caregivers to identify psychological and psychiatric problems of cancer patients and provide useful information for further treatment.

关键词： Validation Reliability Cancer patients Distress thermometer

Ikaros在急性B淋巴细胞白血病中的作用

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中国实验血液学杂志 2015年第4期23卷 1194-1198页

作者：张海英白海兰州军区兰州总医院血液科全军血液病中心甘肃兰州730050

Ikaros是一类DNA结合锌指蛋白,作为染色质重塑和基因转录的调控元件,在调节免疫系统的发育和功能以及调控造血系统的分化方面起着重要的作用。IKZF1基因编码Ikaros蛋白,其功能丧失突变在急性B淋巴细胞白血病(B-ALL)中频率很高并且与预... 详细信息

Ikaros是一类DNA结合锌指蛋白,作为染色质重塑和基因转录的调控元件,在调节免疫系统的发育和功能以及调控造血系统的分化方面起着重要的作用。IKZF1基因编码Ikaros蛋白,其功能丧失突变在急性B淋巴细胞白血病(B-ALL)中频率很高并且与预后不良密切相关。本文简要综述Ikaros的结构和功能,作为肿瘤抑制因子Ikaros在B-ALL中的作用及调控机制。

关键词： Ikaros IKZF1 淋巴细胞白血病

Development of rheometer for semi-solid high-melting point alloys

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China Foundry 2005年第4期2卷 268-274页

作者： LIU Wen XING Shu-min zhang Lin zhang Mi-lian zhang hai-ying Beijing Jiaotong University Beijing 100044 P. R. China Zhengzhou Vocation Technical College Zhengzhou 450121 Henan P.R. China

A rheometer for semi-solid high-melting point alloys was developed based on the principle of a double-bucket rheometer, with which the solidifying of semi-solid high-melting point alloy melt could be effectively controlled by the control of temperature and the outer force-field; and different microstructures have also been obtained. This rheometer can be used to investigate the rheological behavior under different conditions by changing the Theological parameters. By way of full-duplex communication between the computer and each sensor, automatic control of the test equipment and real- time measurement of rheological parameters were realized. Finally, the influencing factors on torque are also quantitatively analyzed .

关键词： rheometer rheological behavior high-melting alloys semi-solid

一种新的用于点目标检测与跟踪的闭环pipeline算法

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计算机学报 2005年第3期28卷 377-385页

作者：张海英张田文哈尔滨工业大学计算机科学与技术学院哈尔滨理工大学计算机与控制学院哈尔滨150008

提出了一种由滤波管道、检测管道构成的闭环管道算法用于检测与跟踪复杂云天背景下的点目标.引入了基于单帧局部对比度门限的预处理算法进行杂波抑制,设计了基于三帧图像相关性分析的连续滤波器进行噪声剔除.实验分析表明,该算法不仅能... 详细信息

提出了一种由滤波管道、检测管道构成的闭环管道算法用于检测与跟踪复杂云天背景下的点目标.引入了基于单帧局部对比度门限的预处理算法进行杂波抑制,设计了基于三帧图像相关性分析的连续滤波器进行噪声剔除.实验分析表明,该算法不仅能够检测出作任意轨迹运动的点目标,而且能够有效地预测跟踪窗.它在搜索空间的缩小、计算复杂性的降低以及杂波剔除方面优于传统的管道算法.

关键词：过零点局部对比度高阶相关闭环管道目标检测

基于多阶段轨迹融合的交叉多目标检测与跟踪算法

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电子学报 2005年第6期33卷 1109-1112页

作者：张海英张田文哈尔滨工业大学计算机科学与技术学院

构建了一种多阶段轨迹融合算法,预处理阶段利用局部对比度自适应门限抑制杂波,同时结合高阶相关滤波器剔除噪声和杂波边缘.在轨迹互联阶段,多阶段的双向搜索算法辅佐以目标航迹的能量累积,能够尽早锁定目标.实验分析表明,该方法能够准... 详细信息

构建了一种多阶段轨迹融合算法,预处理阶段利用局部对比度自适应门限抑制杂波,同时结合高阶相关滤波器剔除噪声和杂波边缘.在轨迹互联阶段,多阶段的双向搜索算法辅佐以目标航迹的能量累积,能够尽早锁定目标.实验分析表明,该方法能够准确的检测和跟踪作任意轨迹运动的多个点目标,在搜索空间和时间复杂度上明显优于传统的相关性算法.

关键词：与管道局部对比度双向相关滤波器点目标检测