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Synthesis and Biological Activity of Novel 1-Substituted Phenyl（glycosyl）-4-{4-[（4,6-dimethoxy）pyrimidin-2-yl] Piperazin-l-yl}methyl-lH-1,2,3-triazoles

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Chemical Research in Chinese Universities 2013年第5期29卷 900-905页

作者： MAO Ming-zhen LI Yu-xin ZHOU Yun-yun YANG Xiao-ping zhang xiu-lan zhang Xiao LI Zheng-ming State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China School of Pharmacy University of Wyoming Laramie WY 82071 USA

A series of novel 1-substituted phenyl or glycosyl 1,2,3-triazoles was designed and synthesized by azide-alkyne 1,3-dipolar cyeloaddition between 4,6-dimethoxy-2-[（4-prop-2-ynyl）piperazin-l-yl]pyrimidine and each of different azides catalysed by in situ generated Cu（I）. The O-acyl protecting groups on glycosyl 1,2,3-triazoles were removed by triethylamine in wet methanol. Their chemical structures were established on the basis of corresponding tH NMR, 13C NMR, MS and elemental analysis. The fungicidal activities of target compounds were evaluated in vitro against Fusarium omysporum, Physalospora piricola, Alternaria solani, Phytophthora capsici, Cercospora arachi- dicola and Gibberella zeae at 50 μg/mL. The bioassay results indicate that some of the compounds exhibited mode- rate but promising fungicidal activities. In particular, acetylated glucopyranosyl triazole displayed a good fungicidal activity against Physalospora piricola, which is equal to that of the positive control compound chlorothalonil.

关键词： 1 H-1,2,3-Triazole Fungicidal activity Huisgen cycloaddition reaction Pyrimidinylpiperzine

Neuroprotection in glaucoma： present and future

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Chinese Medical Journal 2013年第8期126卷 1567-1577页

作者： CHEN Shi-da WANG Lu zhang xiu-lan Zhongshan Ophthalmic Center State Key Laboratory ofOphthalmology Sun Yat-sen University Guangzhou Guangdong5/oo6o China

Objective To review the updated research on neuroprotection in glaucoma, and summarize the potential agents investigated so far. Data sources The data in this review were collected from PubMed and Google Scholar databases published in English up to September 2012, with keywords including glaucoma, neuroprotection, and retinal ganglion cells, both alone and in combination. Publications from the past ten years were selected, but important older articles were not excluded. Study selection Articles about neuroprotection in glaucoma were selected and reviewed, and those that are cited in articles identified by this search strategy and judged relevant to this review were also included. Results Although lowering the intraocular pressure is the only therapy approved as being effective in the treatment of glaucoma, increasing numbers of studies have discovered various mechanisms of retinal ganglion cells death in the glaucoma and relevant neuroprotective strategies. These strategies target neurotrophic factor deprivation, excitotoxic damage, oxidative stress, mitochondrial dysfunction, inflammation, activation of intrinsic and extrinsic apoptotic signals, ischemia, and protein misfolding. Exploring the mechanism of axonal transport failure, synaptic dysfunction, the glial system in glaucoma, and stem cell used in glaucoma constitute promising research areas of the future. Conclusions Neuroprotective strategies continue to be refined, and future deep investment in researching the pathogenesis of glaucoma may provide novel and practical neuroprotection tactics. Establishing a system to assess the effects of neuroprotection treatments may further facilitate this research.

关键词： glaucoma, neuroprotection retinal ganglion cells

Possibilities for the synthesis of superheavy element Z=121 in fusion reactions

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Nuclear Science and Techniques 2024年第6期35卷 90-100页

作者： Ming-Hao zhang Yu-Hai zhang Ying Zou xiu-xiu Yang Gen zhang Feng-Shou zhang The Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China School of Physical Science and Technology Guangxi UniversityNanning 530004China National Laboratory of Heavy Ion Accelerator of lanzhou Center of Theoretical Nuclear PhysicsLanzhou 730000China

Based on the dinuclear system model,the calculated evaporation residue cross sections matched well with the current experimental *** synthesis of superheavy elements Z=121 was systematically studied through combinations of stable projectiles with Z=21-30 and targets with half-lives exceeding 50 *** influence of mass asymmetry and isotopic dependence on the projectile and target nuclei was investigated in *** reactions^(254)Es(^(46)Ti,3n)^(297)121 and^(252)Es(^(46)Ti,3n)^(295)121 were found to be experimentally feasible for synthesizing superheavy element Z=121,with maximal evaporation residue cross sections of 6.619 and 4.123 fb at 219.9 and 223.9 MeV,respectively.

关键词： Superheavy nuclei Dinuclear system model Fusion reaction Evaporation residue cross section

Gamma-Rays Generated from Plasmas in the Interaction of Solid Targets with Femtosecond Laser Pulses

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Chinese Physics Letters 1998年第11期15卷 816-818页

作者： HE Jing-tang zhang Ping CHEN Duan-bao LI Zu-hao zhang Ying WANG Long FENG Bao-hua zhang xiu-lan WEI Zhi-yi LI Zan-liang TANG Xiao-wei zhang Jie Institute of High Energy Physics Chinese Academy of SciencesBeijing 100039 Laboratory of Optical Physics Institute of PhysicsChinese Academy of SciencesBeijing 100080 Department of Physics University of OxfordOX13PUUK

The γ-rays with energies up to 300keV have been observed from plasmas produced by femtosecond laser pulses at a focused intensity of 5 × 10^(15) ***^(-2).μm^(2) irradiating Ta,Mo,and Cu *** introducing an 8% prepulse of 70ps before the main pulse,the fraction of high energy γ-ray photons(hv>l00keV)was significantly enhanced relative to low energy photons(hv<100 keV).

关键词： Femto femtosecond Solid

Disorder of blood-aqueous barrier following Ahmed Glaucoma Valve implantation

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Chinese Medical Journal 2013年第6期126卷 1119-1124页

作者： ZHOU Min-wen WANG Wei CHEN Shi-da HUANG Wen-bin zhang xiu-lan Department of Glaucoma Sun Yat-sen University Guangzhou Guangdong 520275 China Department of Neuro-ophthalmology Sun Yat-sen University Guangzhou Guangdong 520275 China Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat-sen University Guangzhou Guangdong 520275 China

Background Ahmed Glaucoma Valve implantation （AGVI） is blood-aqueous barrier （BAB） has been noted after some surgica BAB disruption afterAGVl. used to treat refractory glaucoma. Breakdown of the techniques. The current study was designed to assess Methods Anterior chamber protein content was measured by the laser flare cell photometry in 22 eyes of 22 patients with refractory glaucoma before AGVI and at each postoperative visit up to 1 month. Results Before AGVI the mean aqueous flare values in all eyes were （15.17＋9.84） photon counts/ms. After AGVI, the values significantly increased at day 1, day 3, and week I compared to those before AGVI （all P 〈0.05） with a peak at day 3. They returned to pre-operative levels at week 2, and were lower than preoperative level at month 1. Eyes with previous intraocular surgery history had greater aqueous flare values than those without previous intraocular surgery history, but there were no significant differences at all time points postoperatively （all P 〉0.05）. Furthermore, eyes with shallow anterior chambers had greater aqueous flare values at day 3 and week 1 （all P 〈0.05）. When comparing eyes with other refractory glaucoma conditions, neovascular glaucoma combined with intravitreal bevacizumab injection resulted in lower aqueous flare values after AGVI, but no significant differences were observed at all time points, postoperatively （all P 〉0.05）. Conclusions The BAB was impaired and inflammation was present in the anterior chamber in refractory glaucomatous eyes following AGVI. However, such conditions were resolved within 1 month postoperatively. Intravitreal bevacizumab treatment in neovascular glaucoma eyes before AGVI may prevent BAB breakdown.

关键词： aqueous flare blood-aqueous barrier Ahmed Glaucoma Valve implantation

A bifunctional POM-based Cu-viologen complex with mixed octamolybdate clusters for rapid oxidation desulfurization and effective photogeneration of hydrogen

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Rare Metals 2024年第1期43卷 236-246页

作者： Lin Yang Zhong zhang Chao-Nan zhang xiu-Li Wang College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell Bohai UniversityJinzhou 121013China

The design and synthesis of catalysts for the oxidation desulfurization and production of hydrogen are extremely important for solving environmental pollution and energy ***,a novel bifunctional [α-Mo_(8)O_(26)]^(4-)/[β-Mo_(8)O_(26)]^(4-)-based Cu-viologen complex H_(4)[Cu_(2)~ⅠCl_(2)(Hbcbpy)_(4)] [α-Mo_(8)O_(26)] [β-Mo8O_(26)]·H_(2)O(BHU-2,Hbcbpy=1-(4-carboxybenzyl)-4,4'-bipyridinium) was synthesized and characterized by single-crystal X-ray diffraction(XRD),infrared radiation spectra,powder X-ray diffraction(PXRD) and X-ray photoelectron spectroscopy(XPS) *** structural characteristic of BHU-2 is the presence of two types of octamolybdate clusters [α-Mo_(8)O_(26)]^(4-)/[β-Mo_(8)O_(26)]^(4-)and a new binuclear Cu~Ⅰ-Hbcbpy complex linked by Cl-bridges[Cu_(2)ⅠCl_(2)(Hbcbpy)_(4)]^(4+).BHU-2 as a heterogeneous catalyst exhibits excellent activities to the oxidation desulfurization and photocatalytic hydrogen *** room temperature,BHU-2 can catalyze 96% conversion of methyl phenyl sulfide with 98% selectivity,and the process obeys the pseudo-first-order reaction kinetic with the half-life of9.6 *** notorious 2-chloroethyl ethyl sulfide can achieve 99% conversion with 98% selectivity within only1 min at the presence of BHU-2,and the turnover frequency(TOF) is up to 7400 h^(-1).BHU-2 also exhibits high catalytic activity for the oxidation of other aromatic and aliphatic thioethers within short time at room ***,BHU-2 shows a high catalytic activity for visible-light-driven hydrogen evolution with an H_(2) evolution rate of 1677.85 μmol·g^(-1)·h^(-1) within 10 ***,the catalytic activities do not decrease evidently after three cycles,revealing the prominent structural stability and recyclability.

关键词： Polyoxometalate Metal-organic complex Viologen Oxidation desulfurization Photocatalytic hydrogen production

房水引流物植入术能否作为青光眼治疗的首选术式

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中华眼科杂志 2010年第6期46卷 487-490页

作者：张秀兰中山大学中山眼科中心眼科学国家重点实验室广州510060

随着青光眼房水引流物的不断改进和植入技术的逐渐娴熟,房水引流物植入术的应用范围有不断扩大的趋势.至于房水引流物植入术能否成为治疗青光眼的首选术式,目前尚存争议.因此,有必要分析和比较房水引流物植入术与常规小梁切除术的临床疗... 详细信息

随着青光眼房水引流物的不断改进和植入技术的逐渐娴熟,房水引流物植入术的应用范围有不断扩大的趋势.至于房水引流物植入术能否成为治疗青光眼的首选术式,目前尚存争议.因此,有必要分析和比较房水引流物植入术与常规小梁切除术的临床疗效,对引流物植入术的适应证及存在分歧的原因进行探讨.多数研究结果表明房水引流物植入术可以作为难治性青光眼的首选术式,其临床疗效优于小梁切除术,其有效性和安全性亦支持扩大应用于非难治性青光眼,但能否取代常规小梁切除术治疗原发性青光眼,目前尚无充分证据支持,尤其还缺乏我国相关的研究数据,尚待多中心的随机临床对照研究结果证实.

关键词：青光眼青光眼引流植入物小梁切除术滤过外科手术

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新生血管性青光眼是否难治

中华眼科杂志 2012年第6期48卷 488-491页

作者：张秀兰中山大学中山眼科中心、眼科学国家重点实验室广州510060

新生血管性青光眼（NVG）是临床眼科医师感到非常棘手的病征。以往对眼压难以控制、视功能差的患者，多采用睫状体冷凝或眼球摘除术等。随着近年来眼科诊疗技术的飞速发展，NVG这一顽疾的治疗方式也获得突破。如房水引流阀植入术治疗NV... 详细信息

新生血管性青光眼（NVG）是临床眼科医师感到非常棘手的病征。以往对眼压难以控制、视功能差的患者，多采用睫状体冷凝或眼球摘除术等。随着近年来眼科诊疗技术的飞速发展，NVG这一顽疾的治疗方式也获得突破。如房水引流阀植入术治疗NVG已显示出良好的应用前景，可为治疗NVG的原发病带来一段眼压正常的“时间窗”；全视网膜光凝或抗血管内皮生长因子（VEGF）治疗可促使虹膜新生血管消退，为实施青光眼手术创造了条件。目前，以抗VEGF为核心的NVG治疗策略提高了NVG的手术成功率。积极治疗原发病是预防NVG的关键，尽全力保留或挽救患者视功能是治疗NVG的目标。NVG治疗应依据患者的发病病因、疾病进展分期、视功能存留等因素进行综合考虑，以制订科学而合理的个体化治疗方案。

关键词：新生血管化,管理学青光眼视网膜疾病血管内皮生长因子A 临床方案

Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 214-233页

作者： Mao-xiu Yuan Qi-Gui Cai Zhen-Yang zhang Jian-Zhong Zhou Cai-Yun lan Jiang-Bo Lin The Graduate School Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350000Fujian ProvinceChina

BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of *** To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database *** up to December 2022 comparing nCRT and nCT in patients with EC were *** The analysis revealed significant differences between nCRT and nCT in terms of disease-free *** results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than ***,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for ***,nCT exhibited better performance in terms of postoperative complications.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy Meta-analysis