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ERK信号通路在七氟醚抑制大鼠氧糖剥夺-复糖复氧皮质神经元凋亡中的作用：与mPTP的关系

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中华麻醉学杂志 2016年第4期36卷 452-455页

作者：吴春玲张立民张冬雪孙文波李睿罗星燎沧州市中心医院麻醉科 061000 沧州市中心医院老年内科 061000 华北石油管理局总医院麻醉科任丘市062552

目的评价细胞外调节蛋白激酶（ERK）信号通路在七氟醚抑制大鼠氧糖剥夺复糖复氧皮质神经元凋亡中的作用及其与线粒体通透性转换孔（mPTP）的关系。方法体外培养大鼠皮质神经元并接种于6孔板或12孔板培养皿，采用随机数字表法分为4组（n... 详细信息

目的评价细胞外调节蛋白激酶（ERK）信号通路在七氟醚抑制大鼠氧糖剥夺复糖复氧皮质神经元凋亡中的作用及其与线粒体通透性转换孔（mPTP）的关系。方法体外培养大鼠皮质神经元并接种于6孔板或12孔板培养皿，采用随机数字表法分为4组（n=18）：对照组（C组）、氧糖剥夺-复糖复氧组（O组）、七氟醚组（OS组）和七氟醚＋ERK1／2抑制剂组（OSP组）。O组神经元氧糖剥夺90rain，复糖复氧24h；OS组氧糖剥夺-复糖复氧后2％七氟醚孵育神经元2h；OSP组培养皿中加入ERK1／2抑制剂PD98059 30μmol／L后1h时行氧糖剥夺-复糖复氧，七氟醚处理同OS组。于复糖复氧24h时采用Western blot法测定磷酸化ERK1／2（p-ERKl／2）表达，采用AnnexinV—FITC／PI双染色-流式细胞法测定神经元凋亡率，采用酶标仪测定mPTP开放程度。结果与c组比较，O组神经元p-ERK1／2表达上调，神经元凋亡率和mPTP开放程度增加（P〈0．05）；与O组比较，OS组神经元p-ERKI／2表达上调，神经元凋亡率和mPTP开放程度降低（P〈0．05）；与OS组比较，OSP组神经元p-ERK1／2表达下调，神经元凋亡率和mPTP开放程度增加（Jp〈0．05）。结论七氟醚抑制氧糖剥夺．复糖复氧大鼠皮质神经元凋亡的机制与激活ERK信号通路后抑制mPTP开放有关。

关键词：细胞外信号调节MAP激酶类线粒体膜转运蛋白类麻醉药,吸入神经元细胞凋亡

Spinosin protects Neuro-2a/APP695 cells from oxidative stress damage by inactivating p38

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中医杂志:英文版 2023年第5期43卷 868-875页

作者： zhang Xiaoying WANG Ruixuan WANG Yiqing XU Fanxing YAN Tingxu WU Bo zhang Ming JIA Ying School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China Gynecology Department Shenyang Women's and Children's HospitalShenyang 110011China

OBJECTIVE:To explore the protective mechanism of spinosin(SPI)on Alzheimer's disease(AD)model cells,Neuro-2a/APP695(N2a/APP695),against H_(2)O_(2)-induced oxidative stress damage,to reflect the influence of oxidative stress on the development of AD,and to provide a valuable basis for the research and development of therapeutic drug for ***:N2a/APP695 cells were exposed to H2O2 and then treated with ***,the secretion level of amyloidβ(Aβ)1-42 and the production of malondialdehyde(MDA)and lactate dehydrogenase(LDH)were detected by enzyme linked immunosorbent assay ***,the oligomerization degree of Aβ1-42 was performed by Thioflavin T ***,the expression levels of p-Tau(Ser199/202/396),synaptophysin(SYP),postsynaptic density protein 95(PSD95),and mitogen-activated protein kinase(MAPK)family-related proteins were detected by Western blot *** addition,FITC-labeled phalloidin was used in cytoskeleton staining to reflect synaptic ***:This study showed that H2O2 stimulated N2a/APP695 cells to produce excessive MDA and LDH and secrete a large amount of Aβ,promoted the aggregation of Aβ,induced Tau protein hyperphosphorylation,and led to synaptic *** reversed these changes caused by H2O2 by inactivating p38,which was verified by treatment with the p38 inhibitor ***:Spinosin protects N2a/APP695 cells from oxidative stress damage caused by H2O2 through inactivating p38.

关键词： Alzheimer disease spinosin oxidative stress p38 mitogen-activated protein kinases

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钢筋混凝土中防腐添加剂的研究进展

硅酸盐通报 2023年第1期42卷 1-21页

作者：徐宁杨恒熊传胜张栋蒋鹏刘璨刘欣昕程星燎南京水利科学研究院南京210029 水文水资源与水利工程科学国家重点实验室南京210029 青岛理工大学土木工程学院青岛266033

在钢筋混凝土结构服役过程中,由环境侵蚀因素导致的耐久性问题是制约结构长效服役的重要原因,其中,氯离子侵蚀导致的钢筋锈蚀是引起钢筋混凝土耐久性劣化的主要因素之一。在混凝土内掺加防腐添加剂,可从促进钢筋表面成膜和改善混凝土自... 详细信息

在钢筋混凝土结构服役过程中,由环境侵蚀因素导致的耐久性问题是制约结构长效服役的重要原因,其中,氯离子侵蚀导致的钢筋锈蚀是引起钢筋混凝土耐久性劣化的主要因素之一。在混凝土内掺加防腐添加剂,可从促进钢筋表面成膜和改善混凝土自身性能(孔隙结构、水化过程、Friedel’s盐生成)等方面提升阻锈能力,近年来逐渐成为研究热点。本文将防腐添加剂分为传统阻锈剂、绿色植物提取物阻锈剂、纳米材料以及矿物掺合料等四类,从材料开发、作用机制、阻锈影响因素等方面对防腐添加剂的研究进行了综述。最后,探讨了防腐添加剂研究中存在的问题,并对未来的研究提出了建议,以期为防腐添加剂能够更好地防治混凝土中的钢筋锈蚀问题提供参考。

关键词：钢筋混凝土防腐添加剂钢筋锈蚀阻锈剂纳米材料矿物掺合料氯离子侵蚀

Gas release characteristics during carbonization of iron coke hot briquette and influence of heating rate

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Journal of Iron and Steel Research International 2023年第11期30卷 2163-2172页

作者： Zi-yu Wang Dong Han Zheng-gen Liu Man-sheng Chu Yong-jie zhang Li-feng zhang Ji-wei Bao Ming-yu Wang School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang110819LiaoningChina Liaoning Province Engineering Research Center for Technologies of Low-Carbon Steelmaking Shenyang110819LiaoningChina

The release characteristics of CH_(4),H_(2),CO and CO_(2) from iron coke hot briquette(ICHB)during carbonization were *** results show that compared with briquette without iron ore,Fe_(3)O_(4) can inhibit the release rate of H2 and promote the production of CO and CO_(2).In addition,when the heating rate increases from 3 to 7℃/min,the release rates of CH4 and H2 increase,while the release rates of CO and CO_(2) first increase and then *** carbonization process of ICHB was segmented,and corresponding kinetic analysis was carried *** results show that the activation energy of StageⅡand StageⅣis higher in the carbonization process of ICHB,and the active pyrolysis of coal and the reduction of iron ore occur in these two *** addition,the effect of heating rate on the kinetic parameters of ICHB carbonization process was *** was found that when the heating rate increased,the reaction activation energy of StageⅣdecreased first and then increased,which was consistent with the release law of CO and CO_(2).The analysis showed that the increase in heating rate leads to more reactions at higher temperatures,resulting in an increase in the release rate of some *** addition,thermal hysteresis can also cause some processes to fail to fully react at the end of *** is also found that the apparent activation energy and preexponential factor have kinetic compensation effect during the car-bonization of ICHB.

关键词： Iron coke hot briquette Carbonization Gas release characteristic Heating rate Kinetics

Evolution characteristics of precursor information of coal and gas outburst in deep rock cross‑cut coal uncovering

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International Journal of Coal Science & Technology 2022年第1期9卷 138-150页

作者： Jupeng Tang Xin zhang Shengjie Sun Yishan Pan Liping Li School of Mechanics and Engineering Collage of Mechanics EngineeringLiaoning Technical UniversityNo.47Zhonghua RoadXihe DistrictFuxin City 123000Liaoning ProvinceChina School of Physics Liaoning UniversityShenyang 110036LiaoningChina

As mines become deeper,the potential for coal and gas outbursts in deep rock cross-cut coal uncovering is *** outburst precursors are unclear,which restricts the effectiveness and reliability of warning *** reveal the evolution characteristics of coal and gas outburst precursor information in deep rock cross-cut coal uncovering,briquette specimens are constructed and experiments are conducted using a self-developed true triaxial outburst test *** acoustic emission monitoring technology,the dynamic failure of coal is monitored,and variations in the root mean square(RMS)of the acoustic emissions allow the effective cracking time and effective cracking gas pressure to be *** characteristics are obviously different in deep and shallow *** characteristic parameters of gas outburst exhibit stepwise variations at different *** RMS and cumulative RMS have stepped failure characteristics with respect to changes in gas *** characteristic parameters of coal failure are negatively correlated with the average in-situ stress and effective stress,but positively correlated with the lateral pressure coefficient of in-situ stress and the critical gas *** transition characteristics are highly sensitive in all *** critical depth between deep and shallow coal and gas outbursts is 1700 *** expansion multiple of acoustic emission intensity from the microfracture stage to the sharp-fracture stage of coal is defined as the outburst risk index,*** depths of 1100–1700 m,N1≥7 denotes a higher risk of outburst,whereas at depths of 1700–2500 m,N1≥3 indicates enhanced risk.

关键词： Deep coal and gas outburst Rock cross-cut coal uncovering Acoustic emission Critical gas pressure Risk index

颈动脉内膜剥脱术患者术后短期认知障碍的危险因素

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中华麻醉学杂志 2019年第6期39卷 676-679页

作者：张立民彭艳超李睿王明丽马亚利罗星燎沧州市中心医院麻醉科 061001 沧州市人民医院麻醉科 061001 华北石油管理局总医院麻醉科任丘062552

目的筛选颈动脉内膜剥脱术患者术后短期认知障碍的危险因素.方法选择2014年1月1日至2017年5月30日行颈动脉内膜剥脱术的颈动脉狭窄患者158例,年龄≥18岁,术前无认知功能障碍.收集患者年龄、性别、身高、体重、受教育程度、术前并存疾病... 详细信息

目的筛选颈动脉内膜剥脱术患者术后短期认知障碍的危险因素.方法选择2014年1月1日至2017年5月30日行颈动脉内膜剥脱术的颈动脉狭窄患者158例,年龄≥18岁,术前无认知功能障碍.收集患者年龄、性别、身高、体重、受教育程度、术前并存疾病(高血压、Ⅱ型糖尿病、心肌梗死、脑梗死)、颈内动脉狭窄程度、术前基础MAP、右美托咪定用量、手术时间、颈动脉阻断时间、阻断期MAP、术中输液量(晶体液、胶体液)、尿量、出血量、EEG显著改变和术后24 h时VAS评分.术后24 h时采用MMSE评分评估认知功能,根据患者是否发生术后短期认知障碍分为STCD组和非STCD组.将组间比较差异有统计学意义的因素进行二元逻辑回归分析,筛选术后短期认知障碍的危险因素.结果有49例患者发生术后短期认知障碍,发生率为31.0%.术中胶体液用量<5 ml/kg、阻断期MAP较基础值升高<20%和阻断期EEG显著改变是颈动脉内膜剥脱术患者术后短期认知障碍的独立危险因素(P<0.05).结论术中胶体液用量<5 ml/kg、阻断期MAP较基础值升高<20%和阻断期EEG显著改变是颈动脉内膜剥脱术患者术后短期认知障碍的独立危险因素.

关键词：认知障碍危险因素颈动脉内膜切除术

Influence of stress wave-induced disturbance on ultra-low friction in broken blocks

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International Journal of Coal Science & Technology 2022年第2期9卷 107-123页

作者： Liping Li Haitao zhang Yishan Pan Xiangyu Ju Lei Tang Minghui Li School of Mechanics and Engineering Liaoning Technical UniversityNo.47Zhonghua RoadXihe DistrictFuxin City 123000Liaoning ProvinceChina School of Physics Liaoning UniversityShenyang 110036China

Deep rock mass tends to be broken into blocks when mining for materials deep below the *** rock layer of the roof of the mine can be regarded as a system of blocks of fractured rock *** subjected to high ground stress and mining-induced disturbance,the efect of the ultra-low friction of the block system easily becomes apparent,and can induce rock burst and other *** taking the block of rock mass as research object,this study developed a test system for ultra-low friction to experimentally examine its efects on the broken blocks under stress wave-induced *** used the horizontal displacement of the working block as the characteristic parameter refecting the efect of ultra-low friction,and examine its characteristic laws of horizontal displacement,acceleration,and energy when subjected to the efects of ultra-low friction by changing the frequency and amplitude of the stress wave-induced *** results show that the frequency of stress wave-induced disturbance is related to the generation of ultra-low friction in the broken *** frequency of disturbance of the stress wave is within 1–3 Hz,and signifcantly increases the maximum acceleration and horizontal displacement of the broken *** greater the intensity of the stress wave-induced disturbance is,the higher is the degree of block fragmentation,and the more likely are efects of ultra-low friction to occur between the *** greater the intensity of the horizontal impact load is,the higher is the degree of fragmentation of the rock mass,and the easier it is for the efects of ultra-low friction to *** wave-induced disturbance and horizontal impact are the main causes of sliding instability of the broken *** the dominant frequency of the kinetic energy of the broken block is within 20 Hz,the efects of ultra-low friction are more likely.

关键词： Rock burst Block rock mass Ultra-low friction efect Stress wave-induced disturbance Horizontal displacement

Effect of Initial Microstructure Prior to Extrusion on the Microstructure and Mechanical Properties of Extruded AZ80 Alloy with a Low Temperature and a Low Ratio

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Chinese Journal of Mechanical Engineering 2023年第3期36卷 339-349页

作者： Hang zhang Haipeng Li Rongguang Li Boshu Liu Ruizhi Wu Dongyue Zhao Shanshan Li School of Mechanical and Power Engineering Shenyang University of Chemical TechnologyShenyang 110142China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China

Magnesium(Mg)alloys are the lightest metal structural material for engineering applications and therefore have a wide market of ***,compared to steel and aluminum alloys,Mg alloys have lower mechanical properties,which greatly limits their *** is one of the most important processing methods for Mg and its ***,the effect of such a heterogeneous microstructure achieved at low temperatures on the mechanical properties is lacking *** this work,commercial AZ80 alloys with different initial microstructures(as-cast and as-homogenized)were selected and extruded at a low extrusion temperature of 220℃and a low extrusion ratio of *** microstructure and mechanical properties of the two extruded AZ80 alloys were *** results show that homogenized-extruded(HE)sample exhibits higher strength than the cast-extruded(CE)sample,which is mainly attributed to the high number density of fine dynamic precipitates and the high fraction of recrystallized ultrafine *** to the coarse compounds existing in CE sample,the fine dynamical precipitates of Mg17(Al,Zn)12form in the HE sample can effectively promote the dynamical recrystallization during extrusion,while they exhibit a similar effect on the size and orientation of the recrystallized *** results can facilitate the designing of high-strength wrought magnesium alloys by rational microstructure construction.

关键词： Magnesium alloy Low temperature and low ratio extrusion Bimodal grain structure Dynamic precipitate Dynamic recrystallization

Electrochemically exfoliated WS_(2)in molten salt for sodium-ion battery anode

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Rare Metals 2023年第4期42卷 1227-1237页

作者： Bei-Lei zhang Xiang Chen Hai-Jia Zhao Hong-Wei Xie Hua-Yi Yin Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education School of MetallurgyNortheastern UniversityShenyang110819China School of Resource and Environmental Science Wuhan UniversityWuhan430072China

The poor crystallinity and unstable crystal structure of tungsten disulfide(WS2)limit its application in *** this paper,a molten salt electrolysis method is proposed to intercalate metal ions into the interlayers of layered WS2 to obtain few-layer sheetlike *** effect of the molten salt system,applied constant current and electrolysis duration on the exfoliation degree of WS2 bulk has been *** results show that the products electrolyzed in molten LiCl-NaCl-KCl and NaClKCl salts under 25 mA were more transparent and thinner flakes sheets due to the uniform intercalation of Li^+and Na^+with smaller *** exfoliated WS_(2)was used as an anode material for sodium-ion batteries with a potential of 0.01-2.50 *** comparison,the WS_(2)-NaCl-25 mA electrode displays a high reversible capacity of 373 mAh·g^(-1)at0.1 A·g^(-1)after cycling for 100 cycles at the same time showing great rate and cycle *** also presents a high capacitive ratio of 90.65%at 1.0 mV·s^(-1).The molten salt electrolysis provides a new perspective on the exfoliation of layered material,while demonstrating the great potential of WS2 as an anode material for sodium-ion battery.

关键词： Tungsten disulfide Molten salt electrolysis Exfoliation Sodium-ion battery(SIB)anode