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Science china(Technological Sciences) 2003年第z1期46卷 42-51页

作者： zhang xiaoyan the transportation department of sichuan province, chengdu 610041, china Transportat Dept sichuan Prov Chengdu 610041 Peoples R China

sichuan-Tibet Highway traverses the two principal geomorphic units and their transition belt in western china; it has some hazardous slopes characterized by high altitude and chilliness, high elevation, large scale and complexity. Various hazards usually concur in groups. The integrated hazards of these slopes cannot be reflected by any single hazardl they act on one another and develop at the same time, like many other things experiencing a recurrent evolving course from growth to demise. Based on the mechanisms of the typical dangerous No.1 slope of Erlang Mountain on the sichuan-Tibet Highway, various simulations through geotechnical test, numerical calculation, and in-situ monitoring have been carried out to control and regularize the last phase of evolution of the slope. The text shows that such slopes have developed under geological and engineering conditions that might have enforced the potentiality of hazards; interactions between different hazards are of more menace than any single factor; structures in cooperation with the hazardous bodies may be effective for preventing such calamities.

关键词： hazards of large slope evolution, hazards concurring in group, structure control.

The endoplasmic reticulum membrane protein complex subunit Emc6 is essential for rhodopsin localization and photoreceptor cell survival

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Genes & Diseases 2024年第2期11卷 1035-1049页

作者： Kuanxiang Sun Lu Liu xiaoyan Jiang Heting Wang Lin Wang Yeming Yang Wenjing Liu Lin zhang Xiaohui Zhao Xianjun Zhu Health Management Center Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Key Laboratory of Tibetan Medicine Research Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine ResearchNorthwest Institute of Plateau BiologyXiningQinghai 810008China The sichuan Provincial Key Laboratory for Human Disease Gene Study and department of Laboratory Medicine Center for Medical GeneticsSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026) Sichuan Academy of Medical Sciences and Sichuan Provincial People's HospitalChengduSichuan 610072China department of Ophthalmology The First People's Hospital of ShangqiuShangqiuHenan 476000China

The endoplasmic reticulum(ER)membrane protein complex(EMC)is responsible for monitoring the biogenesis and synthetic quality of membrane proteins with tail-anchored or multiple transmembrane *** EMC subunit EMC6 is one of the core members of EMC and forms an enclosed hydrophilic vestibule in cooperation with *** studies demonstrating that deletion of EMC3 led to rhodopsin mislocalization in rod photoreceptors of mice,the precise mechanism leading to the failure of rhodopsin trafficking remains ***,we generated the first rod photoreceptor-specific knockout of Emc6(RKO)and cone photoreceptor-specific knockout of Emc6(CKO)mouse *** of Emc6 in rod photoreceptors led to progressive shortening of outer segments(OS),impaired visual function,mislocalization and reduced expression of rhodopsin,and increased gliosis in rod *** addition,CKO mice displayed the progressive death of cone photoreceptors and abnormal localization of cone opsin ***,proteomics analysis of the RKO mouse retina illustrated that several cilium-related proteins,particularly anoctamin-2(ANO2)and transmembrane protein 67(TMEM67),were significantly down-regulated prior to OS *** rod photoreceptor cilia and mislocalized membrane disc proteins were evident in RKO *** data revealed that in addition to monitoring the synthesis of rhodopsin-dominated membrane disc proteins,EMC6 also impacted rod photoreceptors'ciliogenesis by regulating the synthesis of membrane proteins associated with cilia,contributing to the mislocalization of membrane disc proteins.

关键词： ANO2 Cilium EMC6 ER membrane protein complex Mislocalization Photoreceptor degeneration TMEM67

Expert consensus on irrigation and intracanal medication in root canal therapy

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International Journal of Oral Science 2024年第1期16卷 26-35页

作者： Xiaoying Zou Xin Zheng Yuhong Liang Chengfei zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Center of Stomatology Peking University HospitalBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West china Hospital of Stomatology Sichuan UniversityChengduChina department of Emergency Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Restorative Dental Sciences EndodonticsFaculty of DentistryThe University of Hong KongPok Fu LamHong Kong SARChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina State Key Laboratory of Oral&Maxillofacial Reconstruction and R

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.

关键词： treatment irrigation Expert

New method to identify optimal discontinuity set number of rock tunnel excavation face orientation based on Fisher mixed evaluation

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Underground Space 2024年第4期17卷 300-319页

作者： Keshen zhang Wei Wu Min zhang Yongsheng Liu Yong Huang Baolin Chen College of Civil Engineering Tongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China Shudao Investment Group Co.Ltd Chengdu 610095China china Railway Tunnel Group Co.Ltd Guangzhou 511466China china Railway First Survey and Design Institute Group Co.Ltd Xi’an 710043China Zhejiang Institute of Communications Co.Ltd Hangzhou 310012China

Discontinuity is critical for strength,deformability,and permeability of rock *** information is one of the essential discontinuity characteristics and is usually accessed by orientation *** methods of identifying optimal discontinuity set numbers are usually achieved by clustering validity indexes,which mainly relies on the aggregation and dispersion of clusters and leads to the inaccuracy and instability of *** paper proposes a new method of Fisher mixed evaluation(FME)to identify optimal group numbers of rock mass discontinuity *** FME,orientation distribution is regarded as the superposition of Fisher mixed *** grouping results are identified by considering the fitting accuracy of Fisher mixed distributions,the probability monopoly and central location significance of independent Fisher centers.A Halley-Expectation-Maximization(EM)algorithm is derived to achieve an automatic fitting of Fisher mixed *** real rock discontinuity models combined with three orientation clustering algorithms are adopted for discontinuity *** clustering validity indexes are used to automatically identify optimal group numbers for *** results show that FME is more accurate and robust than the other clustering validity indexes in optimal discontinuity group number identification for different rock models and orientation clustering algorithms.

关键词： Rock mass discontinuity Orientation grouping Fisher mixed distribution 3D point cloud Stereo photogrammetry

Prediction of high-embankment settlement combining joint denoising technique and enhanced GWO-v-SVR method

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 317-332页

作者： Qi zhang Qian Su Zongyu zhang Zhixing Deng De Chen School of Civil Engineering Southwest Jiaotong UniversityChengduChina MOE Key Laboratory of High Speed Railway Engineering Southwest Jiaotong UniversityChengduChina

Reliable long-term settlement prediction of a high embankment relates to mountain infrastructure *** study developed a novel hybrid model(NHM)that combines a joint denoising technique with an enhanced gray wolf optimizer(EGWO)-n-support vector regression(n-SVR)***-embankment field measurements were preprocessed using the joint denoising technique,which in-cludes complete ensemble empirical mode decomposition,singular value decomposition,and wavelet packet ***,high-embankment settlements were predicted using the EGWO-n-SVR *** this method,the standard gray wolf optimizer(GWO)was improved to obtain the EGWO to better tune the n-SVR model *** proposed NHM was then tested in two case ***,the influences of the data division ratio and kernel function on the EGWO-n-SVR forecasting performance and prediction efficiency were *** results indicate that the NHM suppresses noise and restores details in high-embankment field ***,the NHM out-performs other alternative prediction methods in prediction accuracy and *** demonstrates that the proposed NHM is effective in predicting high-embankment settlements with noisy field ***,the appropriate data division ratio and kernel function for EGWO-n-SVR are 7:3 and radial basis function,respectively.

关键词： High embankment Settlement prediction Joint denoising technique Enhanced gray wolf optimizer Support vector regression

Expert consensus on difficulty assessment of endodontic therapy

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International Journal of Oral Science 2024年第1期16卷 15-25页

作者： Dingming Huang xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei Chen Jiyao Li Ling Ye Lei Cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan zhang Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghuaSchool of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina department of Operative Dentistry&Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina department of Endodontics Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Preventive Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Geriatric dentistry West China Hospital of Stomatology

Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.

关键词： anatomy difficulty treatment

Effect of dynamic loading orientation on fracture properties of surrounding rocks in twin tunnels

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 393-409页

作者： Ze Deng Zheming Zhu Lei Zhou Leijun Ma Jianwei Huang Yao zhang Key Laboratory of Deep Earth and Engineering(Ministry of Education) College of Architecture and EnvironmentSichuan UniversityChengdu610065China Failure Mechanics and Engineering Disaster Prevention Key Laboratory of sichuan province College of Architecture and EnvironmentSichuan UniversityChengdu610065China Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu610065China

For expedited transportation,vehicular tunnels are often designed as two adjacent tunnels,which frequently experience dynamic stress waves from various orientations during blasting *** analyze the impact of dynamic loading orientation on the stability of the twin-tunnel,a split Hopkinson pressure bar(SHPB)apparatus was used to conduct a dynamic test on the twin-tunnel *** two tunnels were rotated around the specimen’s center to consider the effect of dynamic loading ***-DYNA software was used for numerical simulation to reveal the failure properties and stress wave propagation law of the twin-tunnel *** findings indicate that,for a twin-tunnel exposed to a dynamic load from different orientations,the crack initiation position appears most often at the tunnel corner,tunnel spandrel,and tunnel *** the impact direction is created by a certain angle(30°,45°,60°,120°,135°,and 150°),the fractures are produced in the middle of the line between the left tunnel corner and the right tunnel *** the impact loading angle(a)is 90°,the tunnel sustains minimal damage,and only tensile fractures form in the surrounding *** orientation of the impact load could change the stress distribution in the twin-tunnel,and major fractures are more likely to form in areas where the tensile stress is concentrated.

关键词： Twin-tunnel Dynamic load Split Hopkinson pressure bar(SHPB) Fracture mode Stress distribution Displacement field distribution

Improvement of cloud microphysical parameterization and its advantages in simulating precipitation along the sichuan-Xizang Railway

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Science china Earth Sciences 2024年第3期67卷 856-873页

作者： Xiaoqi XU Zhiwei HENG Yueqing LI Shunjiu WANG Jian LI Yuan WANG Jinghua CHEN Peiwen zhang Chunsong LU china Meteorological Administration transportation Meteorology Key Laboratory Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China Heavy Rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of sichuan province Institute of Plateau MeteorologyCMAChengdu 610072China State Key Laboratory of Disaster Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation Center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China china Meteorological Administration Aerosol-Cloud and Precipitation Key Laboratory and Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science and TechnologyNanjing 210044China

The sichuan-Xizang Railway is an important part of the railway network in china, and geological disasters, such as mountain floods and landslides, frequently occur in this region. Precipitation is an important cause of these disasters;therefore,accurate simulation of the precipitation in this region is highly important. In this study, the descriptions for uncertain processes in the cloud microphysics scheme are improved;these processes include cloud droplet activation, cloud-rain autoconversion, rain accretion by cloud droplets, and the entrainment-mixing process. In the default scheme, the cloud water content of different sizes corresponds to the same cloud droplet concentration, which is inconsistent with the actual content;this results in excessive cloud droplet size, unreasonable related conversion rates of microphysical process(such as cloud-rain autoconversion), and an overestimation of precipitation. Our new scheme overcomes the problem of excessive cloud droplet size. The processes of cloudrain autoconversion and rain accretion by cloud droplets are similar to the stochastic collection equation, and the mixing mechanism of cloud droplets is more consistent with that occurred during the actual physical process in the cloud. Based on the new and old schemes, multiple precipitation processes in the flood season of 2021 along the sichuan-Xizang Railway are simulated, and the results are evaluated using ground observations and satellite data. Compared to the default scheme, the new scheme is more suitable for the simulation of cloud physics, reducing the simulation deviation of the liquid water path and droplet radius from 2 times to less than 1 time and significantly alleviating the overestimation of precipitation intensity and range of precipitation center. The average root-mean-square error is reduced by 22%. Our results can provide a scientific reference for improving precipitation forecasting and disaster prevention in this region.

关键词： The sichuan-Xizang Railway Cloud microphysics Precipitation Model improvement

Facile microwave-assisted synthesis of 1H-pyrazino[1,2-a]quinoxaline-1,5(6H)-dione derivatives via a nucleophilic substitution reaction

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Science china Chemistry 2015年第7期58卷 1239-1242页

作者： xiaoyan zhang Guiting Song Hailei Cui Zhigang Xu Jin Zhu Zhongzhu Chen Key Laboratory of the Ministry of Education for Advanced Catalysis Materials department of Chemistry and Life Science Zhejiang Normal University Key Laboratory for Asymmetric Synthesis and Chiral Technology of sichuan province chengdu Institute of Organic Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Drug Discovery Center of Innovation Chongqing University of Arts and Sciences

A series of compounds containing the 1H-pyrazino[1,2-a]quinoxaline-1,5(6H)-dione scaffold have been synthesized using a one-pot procedure under microwave irradiation. This new strategy allowed for the facile synthesis of target compounds in good yields and could be readily applied to the construction of diverse libraries of compounds for high throughput screening in medicinal chemistry.

关键词： nucleophilic substitution reaction microwave Ugi reaction MCRs 1H-pyrazino[1 2-a]quinoxaline-l 5(6H)-dione

重症监护病房患者多重耐药菌感染危险因素的Meta分析

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医药导报 2024年第10期43卷 1562-1571页

作者：黎琪杨柔沈晓妍周小诗李果霖张昌吉杨勇电子科技大学医学院/四川省医学科学院·四川省人民医院药学部成都610072 电子科技大学医学院个体化药物治疗四川省重点实验室成都610072

目的分析重症监护病房(ICU)患者多重耐药菌(MDRO)感染的相关危险因素,探索针对性的防控措施。方法计算机检索Embase、Website of Science、the Cochrane Library、PubMed、中国知网、万方、维普等数据库从建库至2022年10月26日ICU患者M... 详细信息

目的分析重症监护病房(ICU)患者多重耐药菌(MDRO)感染的相关危险因素,探索针对性的防控措施。方法计算机检索Embase、Website of Science、the Cochrane Library、PubMed、中国知网、万方、维普等数据库从建库至2022年10月26日ICU患者MDRO感染危险因素的病例对照研究与队列研究。并且使用RevMan 5.3版软件进行危险因素的Meta分析。结果共纳入文献32篇,研究对象10985例,文献质量为中高等。本研究Meta分析结果显示性别[OR=1.21,95%CI=(1.08,1.36),P=0.002]、ICU住院时间[WMD=5.36,95%CI=(3.99,6.73),P<0.00001]、总住院时间[WMD=8.96,95%CI=(6.51,11.41),P<0.00001]、高血压[OR=1.33,95%CI=(1.10,1.60),P=0.003]、肾功能异常[OR=1.69,95%CI=(1.33,2.16),P<0.00001]、低蛋白血症[OR=1.87,95%CI=(1.51,2.32),P<0.00001]、机械通气[OR=2.26,95%CI=(1.18,4.33),P=0.01]、机械通气时间[WMD=8.83,95%CI=(2.52,15.14),P=0.006]、动静脉置管[OR=1.46,95%CI=(1.23,1.72),P<0.0001]、安置尿管[OR=1.71,95%CI=(1.25,2.36),P<0.00001]、消化道置管[OR=0.10,95%CI=(0.03,0.18),P=0.008]、抗菌药物种类≥3种[OR=4.27,95%CI=(2.06,8.85),P<0.00001]、使用碳青霉烯类抗生素[OR=4.09,95%CI=(3.00,5.58),P<0.00001]、使用第3代头孢菌素[OR=1.63,95%CI=(1.15,2.33),P=0.007]、使用喹诺酮类抗菌药物[OR=1.86,95%CI=(1.42,2.44),P<0.00001]、使用氨基苷类抗生素[OR=1.99,95%CI=(1.49,2.67),P<0.00001]、使用哌拉西林-他唑巴坦[OR=2.94,95%CI=(1.56,5.54),P=0.0009]、使用糖肽类抗生素[OR=3.78,95%CI=(2.48,5.78),P<0.00001]、使用镇静剂[OR=3.25,95%CI=(2.06,5.14),P<0.00001]、使用抑酸药[OR=1.51,95%CI=(1.06,2.16),P=0.02]是ICU患者MDRO感染的危险因素。结论ICU患者MDRO感染与性别、ICU住院时间、慢性肺部疾病、总住院时间、高血压、肾功能异常、低蛋白血症、机械通气、机械通气时间、动静脉置管、安置尿管、消化道置管、抗菌药物种类≥3种、使用碳青霉烯类抗生素、使用第3代头孢菌素、使用喹诺酮类抗菌药物、使用氨基苷类抗生素、使用哌拉西林-他唑巴坦、使用糖肽类抗生素、使用镇静剂、使用抑酸药等多种因素相关。针对性地对基本情况、合并症、侵入性操作、抗菌药物与其他治疗性药物的使用等多方面因素进行控制,对ICU患者采取合理措施,能够降低ICU患者MDRO的感染风险。

关键词：重症监护病房多重耐药菌危险因素抗菌药物 Meta分析