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基于孟德尔随机化探讨肠道菌群与失眠的因果关联研究

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中国全科医学 2025年第8期28卷 954-961页

作者：郭玉梦崔杨霖张宪忠山东中医药大学山东省日照市中医医院中医经典科

背景随着失眠的发病率逐渐升高，其严重影响患者的精神及工作状态。肠道菌群被认为是失眠的一个危险因素，但目前存在相关证据较为缺乏的问题，难以准确认识二者之间的关系。目的使用两样本孟德尔随机化作为研究方法，探索肠道菌群与... 详细信息

背景随着失眠的发病率逐渐升高，其严重影响患者的精神及工作状态。肠道菌群被认为是失眠的一个危险因素，但目前存在相关证据较为缺乏的问题，难以准确认识二者之间的关系。目的使用两样本孟德尔随机化作为研究方法，探索肠道菌群与失眠之间的因果关系。方法使用MiBioGen联盟进行的最大可用全基因组关联研究荟萃分析（n=18 340）中肠道菌群的汇总统计数据，根据预设的阈值提取与196种肠道微生物相对丰度显著相关的单核苷酸多态性（SNPs）作为工具变量（IVs）。失眠的汇总统计数据来自英国生物样本库（UK Biobank）(n=462 341)。采用逆方差加权法（IVW）、MR-Egger回归、加权中位数法（WME）、加权众数法（WM）等检测肠道菌群与失眠之间的因果关系，其中以IVW法为主，根据效应指标优势比（OR）和95%置信区间（CI）评估结果。结合敏感性分析、异质性检验、基因多效性检验和异常值检验（MR-PRESSO）等方法来验证结果的稳定性和可靠性。并对发现与失眠有因果关系的菌群进行反向孟德尔随机化分析。结果 IVW结果显示蔷薇菌属(OR=0.787,95%CI=0.671～0.923,PFDR=0.016)、丹毒杆菌属(OR=0.880,95%CI=0.794～0.976,PFDR=0.077)、副普雷沃菌属(OR=0.891,95%CI=0.801～0.991,PFDR=0.083)、瘤胃球菌属UCG014组(OR=0.818,95%CI=0.697～0.961,PFDR=0.072)、巴斯德菌科(OR=0.897,95%CI=0.814～0.988,PFDR=0.081)、巴斯德菌目(OR=0.897,95%CI=0.814～0.988,PFDR=0.094)和失眠有关，未发现IVs存在基因多效性或显著异质性。根据反向孟德尔随机化分析结果，失眠对肠道菌群无显著的因果影响。结论蔷薇菌属、丹毒杆菌属、副普雷沃菌属、瘤胃球菌属UCG014组、巴斯德菌科、巴斯德菌目6种肠道菌群丰度与失眠的发病风险呈负相关，即丰度降低会增加失眠的发病风险，为失眠的保护因素。

关键词：肠道菌群失眠孟德尔随机化因果关联

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Synthesis of several MPP derivatives for ^(99m)Tc-labelling and evaluated as potential 5-HT_(1A) receptor imaging agents

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Science China Chemistry 2011年第7期54卷 1148-1154页

作者： YANG WenJiang LIN Yan zhang xianzhong zhang JunBo WANG XueBin Key Laboratory of Radiopharmaceuticals(Beijing Normal University) Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China

The(2-methoxyphenyl) piperazine(MPP) was selected as the functional group and conjugated to dithiocarbamate through different spacers.A series of new MPP derivatives(MPPnDTC,n = 2-6) were synthesized and radiolabelled with 99mTc-nitrido core or 99mTc-tricarboxyl core as potential 5-HT1A receptor imaging *** the six 99mTc-labelled complexes were lipophilic and *** results showed that those radiotracers had moderate initial brain and hippocampus *** have no significant relation was observed between the biological properties of these tracers with the length of its carbon *** radioactivity concentrations of hippocampus of 99mTcN-MPP2DTC,99mTcN-MPP3DTC,99mTcN-MPP4DTC,99mTcN-MPP5DTC,99mTcN-MPP6DTC and 99mTc(CO)3-MPP3DTC at 2 min post-injection time(p.i.) were 0.43,1.15,0.99,1.04,1.13 and 0.83 %ID/g,respectively.

关键词： MPP 99mTc-nitrido core 99mTc-tricarboxyl core 5-HT_(1A) receptor

SPNS1 ablation drives skeletal muscle atrophy by disrupting mitophagy,mitochondrial function,and apoptosis in mice

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Genes & Diseases 2024年第5期11卷 25-28页

作者： xianzhong zhang Fengmin zhang Haofan Wu Zhen Yu Chengle Zhuang Department of Gastrointestinal Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai200092China Colorectal Cancer Center Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China

Sarcopenia is characterized by a dramatic decline in muscle mass and function during aging,which of ten leads to reduced mobility,diminished quality of life,and shortened *** recent advances in sarcopenia,the mechanisms that mediate skeletal muscle dysfunction remain unclear.1 Lysosomal plays a vital role in digesting and recycling macromolecules,and several studies have shown that lysosomal acidification and autophagy decrease with age,which may impair the clearance of damaged mitochondria.

关键词： skeletal function spite

Synthesis and biological evaluation of ^(99m)Tc-HEDTA/HYNIC-MPP4 complex for 5-HT_(1A) receptor imaging

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Science China Chemistry 2009年第5期52卷 590-598页

作者： FAN WeiWei LIN Yan zhang xianzhong PANG Yan MA Cong TANG ZhiGang zhang JunBo WANG XueBin Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China

5-HT_(1A)receptor is associated with a variety of pathophysiology of neuropsychiatric ***,we have synthesized a new 5-HT_(1A) receptor ligand(HYNIC-MPP4)and labeled it with^(99m)Tc using N-(2-hydroxyethyl)ethylenediaminetriacetic acid(HEDTA)as coligand.^(99m)Tc-HEDTA/HYNIC-MPP4 was prepared under pH 6 at room *** of^(99m)Tc-HEDTA/HYNIC-MPP4 in normal mice showed that this complex had moderate brain uptake(0.60%ID·g^(-1)at 2 min p.i.)and good *** hippocampus had the highest radioactivity uptake at 2 min p.i.(1.84%ID·g^(-1)).The ratio of Hipp/CB was 3.1 at 2 min *** increased to 4.4 at 60 min *** blocking with 8-hydroxy-2-(dipropylamino)tetralin,the uptake of hippocampus was decreased significantly from 1.84%ID·g^(-1) to 0.53%ID·g^(-1) at 2 min p.i.,while the cerebellum had no significant ***^(99m)Tc complex could be a potent agent for 5-HT_(1A) receptor imaging.

关键词： 5-HT_(1A)receptor ^(99m)Tc N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-(6-hydrazinyl)pyridyl carboxamide(HYNIC-MPP4) biodistribution

Colorful World Of Potteries

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China's Tibet 2003年第5期14卷 43-46页

作者： zhang xianzhong

Pottery making in Tibet has ancient *** unearthed from the Karub Ruins in Qamdo,a New Stone Age site, include more than 20,000 pottery shards,

关键词：陶器历史文化新石器时代历史考古制造技术

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主动担当奋力作为不负韶华

长江蔬菜 2020年第12期 10-11页

作者：张献忠洪湖市蔬菜生产领导小组办公室

生命重于泰山,疫情就是命令,防控就是责任。作为一名党员和荆州市党代表,张献忠同志说:“做好疫情防控和蔬菜保供工作是我义不容辞的责任。”新冠肺炎疫情发生以来,作为洪湖市蔬菜生产领导小组办公室主任,他主动担当、勇于奉献、冲锋在... 详细信息

生命重于泰山,疫情就是命令,防控就是责任。作为一名党员和荆州市党代表,张献忠同志说:“做好疫情防控和蔬菜保供工作是我义不容辞的责任。”新冠肺炎疫情发生以来,作为洪湖市蔬菜生产领导小组办公室主任,他主动担当、勇于奉献、冲锋在前、深入一线进行联防联控的同时,结合自己的专业特点,主动帮助群众化解蔬菜积压问题,为稳产保供、赶本赶超建言献策,处处彰显“荆州最美退役军人”的风采。

关键词：退役军人疫情防控联防联控党代表建言献策保供洪湖市荆州市

Molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes

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Nano Research 2020年第1期13卷 173-182页

作者： Zhide Guo Liu Yang Mei Chen Xuejun Wen Huanhuan Liu Jingchao Li Duo Xu Yuanyuan An Changrong Shi Jindian Li Xinhui Su Zijing Li Ting Liu Rongqiang Zhuang Nanfeng Zheng Haibo Zhu xianzhong zhang State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen361102China State Key Laboratory for Bioactive Substances and Functions of Natural Medicines Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China College of Materials Science and Engineering Hunan UniversityChangsha410082China The State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryXiamen UniversityXiamen361005China Zhongshan Hospital Affiliated to Xiamen University Xiamen361004China

Vulnerable atherosclerotic plaques are responsible for most cardiovascular diseases(CVDs).Folate receptor(FR)positive activated macrophages were thought to be a prominent component in the development of vulnerable *** objective of this study is to develop folate conjugated two-dimensional(2D)Pd@Au nanomaterials(Pd@Au-PEG-FA)for targeted multimodal imaging of the FRs in advanced atherosclerotic *** and imaging studies(single photon emission computed tomography(SPECT),computed tomography(CT)and photoacoustic(PA)imaging)were performed to confirm the prolonged blood half-life and enrichment of radioactivity in atherosclerotic *** signals were detected in vivo with SPECT,CT and PA imaging in heavy atherosclerotic plaques,which were significantly higher than those of the normal aortas after injection of Pd@*** studies with preinjection of excess FA could effectively reduce the targeting ability of Pd@Au-PEG-FA in atherosclerotic plaques,further demonstrating the specific binding of Pd@Au-PEG-FA for plaque *** characterization revealed that the signal of probe was in accordance with the high-risk *** summary,the Pd@Au-PEG-FA has favorable pharmacokinetic properties and provides a valuable approach for detecting high-risk plaques in the presence of FRs in atherosclerotic plaques.

关键词： 2D material folate receptor multifunctional imaging activated macrophages atherosclerosis

Research on chasing algorithm based on motion control of cutting machine

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Research on chasing algorithm based on motion control of cut...

阳明心学、佛学对明中后期科举考试的影响——以袁黄所纂举业用书为中心的考察

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作者： xianzhong zhang Shixu Xu Shizong zhang Chang’an Bian School of Automation Qingdao University

In order to improve the cutting requirement of high speed and high precision on the production line, a cutting algorithm based on the motion control of the cutting machine was designed. In this paper, we take the mechanical structure and process flow of the cutting machine as the research object, the process flow of the cutting machine is abstracted, the mathematical model is established, and the motion control chase and shear algorithm of the cutting machine is designed and the relevant parameters are obtained. The three-axis coordinated motion problem of the feed axis, the tracking axis and the cutting axis is solved. A five-order polynomial optimization is used for the cam curve to solve the rigid impact problem of the catton and jitter of the equipment. At present, the system has been put into use in the production line of the enterprise, which solves many production problems and greatly improves the production efficiency of the enterprise.

关键词： Cutting machine Chasing algorithm Electronic cam curve

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四川大学学报（哲学社会科学版） 2012年第1期 55-62页

作者：张献忠天津人民出版社天津250100

明代中后期,随着思想文化的日趋多元化,程朱理学的统治地位受到动摇,科举考试的指导思想也因此发生了变化,阳明心学、佛学和老庄以及其他各种思想开始向科举渗透,其中对科举考试影响最大者当属阳明心学和佛学,这一趋向从袁黄所纂举业用... 详细信息

明代中后期,随着思想文化的日趋多元化,程朱理学的统治地位受到动摇,科举考试的指导思想也因此发生了变化,阳明心学、佛学和老庄以及其他各种思想开始向科举渗透,其中对科举考试影响最大者当属阳明心学和佛学,这一趋向从袁黄所纂举业用书中可以得到印证。

关键词：阳明心学佛学科举考试袁黄