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Effects of Long-term Right Ventricular Apical Pacing on Left Ventricular Remodeling and Cardiac Function

Chinese Journal of Biomedical Engineering(English Edition) 2009年第4期18卷 139-143,161页

作者： REN Xiao-qing zhang shu PU Jie-lin WANG Fang-zheng Center of Arrhythmia Diagnosis and Treatment Fuwai Hospital and Cardiovascular Institute Peking Union Medical College and Chinese Academy of Medical Sciences Bering 100037 China

Objective: To investigate the impacts of long-term right ventricular apical pacing on the ventricular remodeling and cardiac functions of patients with high-grade and third-degree atrioventricular blockage with normal heart structures and cardiac functions. In addition, we provide many evidences for choosing an optimal electrode implantation ***: Study participants included patients who were admitted for pacemaker replacements and revisited for examinations of implanted pacemakers at outpatient. Pacemakers were implanted to treat high-grade and third-degree atrioventricular blockage. At the time of pacemaker implantation, patients had normal cardiac functions and showed no serious heart diseases or cardiac dilatation. The durations from the implantation to follow-up were more than 5 years. The pacing rate was higher than 80%. Patients with a left ventricular ejection fraction (LVEF) 55 mm were excluded. Ventricular remodeling was defined as follows:increase of LVEDD by 10% and a reduction of LVEF by 25% for five years after implantation. Cardiac functions were evaluated according to New York Heart Association (NYHA) ***:A total of 82 patients with a mean age of (66.97±13.19) years (range, 12 to 91 years old),among which 39 male and 43 female were enrolled in this study. The average duration between two assessments was 8.7 years (104.4 months). Before pacemaker implantation, the average left atrial diameter (LA), LVEDD and LVEF were 37.0 mm, 50.23 mm and 64.87%, respectively. After the implantation, these values were 39.39 mm (P=0.000163), 50.82 mm (P=0.177842) and 60.50% (P=0.000104), respectively. Four patients (4.87%) had ventricular remodeling with deteriorations of cardiac function, three of which had anterior wall myocardial infarction after implantation and one had type II diabetes. Clinical symptoms of heart failure were not found among the patients who did not exhibit v

关键词： ventricular remodeling cardiac function cardiac pacemaker atrioventricular blockage

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Comprehensive identification and potential application of genetic alteration-driven enhancer RNAs for eRNA-targeted therapy in breast cancer

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Genes & Diseases 2024年第5期11卷 59-62页

作者： Hongying Zhao Caiyu zhang lin Bo Lixia Wang Wangyang Liu Yaopeng shu Kailai Liu Ying Liu Meiting Fei Li Wang College of Bioinformatics Science and Technology Harbin Medical UniversityHarbinHeilongjiang 150081China Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200125China Shanghai Institute of Precision Medicine Shanghai 200125China

Enhancer RNAs(eRNAs)are a class of non-coding RNA,which play a critical role in tumor progression.1 Previous studies have indicated abundant CpG methylation,somatic mutation,and copy number variation in eRNA regions in cancers.2,3 We constructed a landscape of genetic alteration-driven eRNAs and provided an integrative pipeline to identify drug candidates that affect eRNA ***,we explored the prognostic value of genetic alteration-driven eRNAs.

关键词： alteration breast targeted

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论名胜古迹名称的法律保护——从“兵马俑”被抢注为坐便器商标谈起

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内蒙古大学学报（哲学社会科学版） 2005年第2期37卷 25-28页

作者：张术麟中央民族大学经济学院北京100081

名胜古迹名称与普通名称相比具有很大商业价值,是宝贵的无形财产;名胜古迹名称应当归名胜古迹单位所有。抢注名胜古迹名称行为是一种侵权行为。名胜古迹单位应利用商标法等法律法规,通过异议程序撤销被抢注商标或通过协商实现收购、共... 详细信息

名胜古迹名称与普通名称相比具有很大商业价值,是宝贵的无形财产;名胜古迹名称应当归名胜古迹单位所有。抢注名胜古迹名称行为是一种侵权行为。名胜古迹单位应利用商标法等法律法规,通过异议程序撤销被抢注商标或通过协商实现收购、共有或许可使用;未被抢注的应尽快通过注册商标、认定驰名商标等手段,加强对名胜古迹名称无形财产权的法律保护。解决问题的根本途径还是从限制商标注册范围、认定所有名胜古迹名称为驰名商标等方面修订、完善现行商标法律制度。

关键词：抢注驰名商标法律保护认定商标法律制度无形财产权异议程序名胜古迹行商收购

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Hydrothermal carbonization pretreatment makes a remarkable difference in activation of rice and lettuce in food waste

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Green Chemical Engineering 2024年第3期5卷 348-363页

作者： Lijun zhang Yifan Sun Chao Li shu zhang Mortaza Gholizadeh Xun Hu School of Material Science and Engineering University of JinanJinan250022China Joint International Research Laboratory of Biomass Energy and Materials College of Materials Science and EngineeringNanjing Forestry UniversityNanjing210037China Faculty of Chemical and Petroleum Engineering University of TabrizTabrizIran

Cooked rice and the vegetables like lettuce are common kitchen waste,which are carbonaceous materials and have the potential as feedstock for the production of activated *** is similar to hydrothermal treatment(HTC),which might impact the subsequent activation of kitchen *** this study,the HTC of lettuce,rice,or their mixture and the activation of the resulting hydrochars were *** results indicated that cross-polymerization between the N-containing organics from lettuce and the sugar derivatives from rice took place in their co-HTC,which significantly increased the hydrochar *** of the hydrochar from the coHTC generated the AC with a yield of 2 times that from direct activation of mixed lettuce/***,the coHTC facilitated aromatization,reducing reactivity with K2C2O4in activation and producing the AC with main micropores and low specific surface *** of the hydrochar from HTC of rice followed the above trend,while that from lettuce was the *** organics in lettuce were thermally unstable and could not undergo sufficient *** activation of hydrochar from HTC of lettuce thus generated the AC with the lowest yield,but the highest specific surface area(1684.9 m2/g),abundant mesopores,and superior capability for adsorption of ***,the environmental impacts and energy consumption for the production of AC from the hydrochar of lettuce were higher than that from hydrochar of co-HTC.

关键词： Food waste Hydrothermal pretreatment Hydrochar Chemical activation Products properties

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Laser-rewritable room temperature phosphorescence based on in-situ polymerized tartaric acid

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Science China Chemistry 2024年第9期67卷 3029-3038页

作者： Tuo-Yu Zhou Tai-Wen Li Hai-Fu zhang Rui-lin Chai Qian Zhao Penglin zhang Guang-Yue Li Qian-Wen Wang Chang Li Yu shu Zhi Fan Sheng-Hua Li College of Chemical Engineering and Materials Science College of SciencesTianjin University of Science&TechnologyTianjin 300457China College of Chemical Engineering North China University of Science and TechnologyTangshan 063210China Tianjin Key Laboratory of Multiplexed Identification for Port Hazardous Chemicals Tianjin University of Science&TechnologyTianjin 300457China

Organic room temperature phosphorescence(RTP)materials have potential applications in information technology and ***,the precise control of the afterglow in reversible manners remains challenging for organic ***,we report a kind of organic RTP material fabricated by simple heating mixtures of tartaric acid(TA)and aromatic acids,which can switch their phosphorescence by *** mixtures show tunable phosphorescence from indigo to orange with phosphorescence efficiency of up to 53.99% due to locking different organic luminogens by the TA-formed matrix through the noncovalent *** afterglow of those materials lasts a few seconds and disappears by water fumigation,which can be repeated in response to wet/heat *** drop-casting those materials on glass slides,a laser-repatternable phosphorescence is achieved by facile laser direct writing and quenched by water *** results open the opportunity for the design of smart stimuli-responsive phosphorescence materials from sustainable natural products.

关键词： room temperature phosphorescence tunable afterglows tartaric acid laser direct writing stimuli-response

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Incentive Feedback Stackelberg Strategy in Mean-Field Type Stochastic Difference Games

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Journal of Systems Science & Complexity 2024年第4期37卷 1425-1445页

作者： GAO Wenhui lin Yaning zhang Weihai School of Mathematics and Statistics Shandong University of TechnologyZibo 255000China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

This paper designs an incentive Stackelberg strategy for the discrete-time stochastic systems with mean-field *** conditions for the existence of such a design are ***,the incentive strategy is obtained as a feedback form including the deviation of the state and its mathematical ***,the stability analysis is *** is found that the stability can be guaranteed by the *** addition,the specific algorithm is proposed and its effectiveness is checked by two examples.

关键词： Discrete-time mean-field stochastic systems incentive strategy Stackelberg game teamoptimal solution

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Accumulated-state-error-based event-triggered sampling scheme and its application to H∞ control of sampled-data systems

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Science China(Information Sciences) 2024年第6期67卷 328-341页

作者： Xian-Ming zhang Qing-Long HAN Bao-lin zhang Xiaohua GE Dawei zhang School of Science Computingand Engineering TechnologiesSwinburne University of Technology College of Automation and Electronic Engineering Qingdao University of Science & Technology School of Mathematics Shandong University

This paper is concerned with event-triggered H∞control of sampled-data systems. Its novelties lie in three aspects:（i） A novel accumulated-state-error-based event-triggered scheme is introduced by comparing the integral of the state error from tk to t with the system state sampled at tk. This condition works well due to the fact that the so-called Zeno behaviour does not occur.（ii） A novel Lyapunov functional is constructed to establish a criterion to ensure some certain H∞performance of the closed-loop system. This Lyapunov functional is dependent on the integral of the state error involved in the event-triggered scheme.（iii） Under the event-triggered sampling scheme, suitable state-feedback controllers can be designed rather than be given a priori. Moreover, a self-triggered implementation of the proposed event-triggered sampling scheme is presented as well. Finally, a batch reactor model and an inverted pendulum system are given to demonstrate the effectiveness of the proposed method.

关键词： event-triggered sampling self-triggered implementation $H_\infty$ control looped-functional

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Transverse momentum balance of dijets in Xe+Xe collisions at the LHC

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Nuclear Science and Techniques 2024年第7期35卷 137-146页

作者： Yao Li shu-Wan Shen Sa Wang Ben-Wei zhang Key Laboratory of Quark&Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan430079China College of Science China Three Gorges UniversityYichang443002China Center for Astronomy and Space Sciences and Institute of Modern Physics China Three Gorges UniversityYichang443002China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou510006China

We present a theoretical study of the medium modifications of the p_(T)balance (x_(J)) of dijets in Xe+Xe collisions at■.The initial production of dijets was carried out using the POWHEG+PYTHIA8 prescription,which matches the next-toleading-order (NLO) QCD matrix elements with the parton shower (PS) *** SHELL model described the in-medium evolution of nucleus–nucleus collisions using a transport *** theoretical results of the dijet xJin the Xe+Xe collisions exhibit more imbalanced distributions than those in the p+p collisions,consistent with recently reported ATLAS *** utilizing the Interleaved Flavor Neutralisation,an infrared-and-collinear-safe jet flavor algorithm,to identify the flavor of the reconstructed jets,we classify dijets processes into three categories:gluon–gluon (gg),quark–gluon (qg),and quark–quark (qq),and investigated the respective medium modification patterns and fraction changes of the gg,qg,and qq components of the dijet sample in Xe+Xe *** is shown that the increased fraction of qg component at a small x_(J)contributes to the imbalance of the dijet;in particular,the q_(1)g_(2)(quark-jet-leading) dijets experience more significant asymmetric energy loss than the g_(1)q_(2)(gluon-jet-leading) dijets traversing the *** comparing the■of inclusive,■ dijets in Xe+Xe collisions,we observe■.Moreover,ρ_(Xe),P_(b),the ratios of the nuclear modification factors of dijets in Xe+Xe to those in Pb+Pb,were calculated,which indicates that the yield suppression of dijets in Pb+Pb is more pronounced than that in Xe+Xe owing to the larger radius of the lead nucleus.

关键词： Heavy-ion collisions Quark-gluon plasma Jet quenching Transverse momentum balance

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The key role of myostatin b in somatic growth in fishes derived from distant hybridization

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Science China(Life Sciences) 2024年第7期67卷 1441-1454页

作者： Qingfeng Liu Lujiao Duan Bei Li Xuanyi zhang Fanglei Liu Jianming Yu Yuqin shu Fangzhou Hu Jingjing lin Xiaoxia Xiong Shaojun Liu State Key Laboratory of Developmental Biology of Freshwater Fish Hunan Normal UniversityChangsha 410081China College of Life Sciences Hunan Normal UniversityChangsha 410081China

The basic mechanism of heterosis has not been systematically and completely *** previous studies,we obtained three economically important fishes that exhibit rapid growth,WR(WCC♀×RCC♂),WR-Ⅱ(WR♀×WCC♂),and WR-Ⅲ(WR-Ⅱ♀×4nAU♂),through distant ***,the mechanism underlying this rapid growth remains *** this study,we found that WR,WR-Ⅱ,and WR-Ⅲshowed muscle hypertrophy and higher muscle protein and fat contents compared with their parent species(RCC and WCC).Candidate genes responsible for this rapid growth were then obtained through an analysis of 12 muscle ***,the mRNA level of mstnb(myostatin b),which is a negative regulator of myogenesis,was significantly reduced in WR,WR-Ⅱ,and WR-Ⅲcompared with the parent *** verify the function of mstnb,a mstnb-deficient mutant RCC line was generated using the CRISPR-Cas9 *** average body weight of mstnb-deficient RCC at 12 months of age was significantly increased by 29.57%compared with that in wild-type ***,the area and number of muscle fibers were significantly increased in mstnb-deficient RCC,indicating hypertrophy and ***,the muscle protein and fat contents were significantly increased in mstnb-deficient *** molecular regulatory mechanism of mstnb was then revealed by transcription profiling,which showed that genes related to myogenesis(myod,myog,and myf5),protein synthesis(PI3K-AKT-mTOR),and lipogenesis(pparγand fabp3)were highly activated in hybrid fishes and mstnb-deficient *** study revealed that low expression or deficiency of mstnb regulates somatic growth by promoting myogenesis,protein synthesis,and lipogenesis in hybrid fishes and mstnb-deficient RCC,which provides evidence for the molecular mechanism of heterosis via distant hybridization.

关键词： distant hybridization heterosis somatic growth myostatin b genome editing

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Europium-bearing organic framework with excellent X-ray scintillating luminescence

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Journal of Rare Earths 2024年第2期42卷 251-255,I0001页

作者： Yugang zhang Lanhua Chen Xia Wang Wei Liu shu'ao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123China School of Environmental and Materials Engineering Yantai UniversityYantai264005China

Two europium-bearing organic frameworks,termed as EuTPO-1 and EuTPO-2(H_(3)TPO=tris(4-carboxylphenyI)-phosphineoxide),are reported in this work.A series of characterizations of EuTPO-1and EuTPO-2,such as X-ray crystallography and photoluminescence spectroscopy,was performed to expatiate their structure and physicochemical *** of them are constructed by dimers of the europium-oxygen subunit of [Eu_(2)O_(16)] and TPO *** from high X-ray stopping attenuation and excellent luminescence efficiency,they emit sufficient luminescence when irradiated with ***,they possess stable light outputs when exposed to high humidities and strong radiation dose,outperforming the commercial scintillator CsI:*** result paves the way for developing new scintillator and enriches the compound of europium-bearing organic framework with X-ray scintillating luminescence.

关键词： Metal-organic frameworks Scintillating material Luminescence efficiency Rare earths

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