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Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin

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Chinese Chemical Letters 2024年第3期35卷 384-388页

作者： Yi-Jing Li Lingze zhang Ming-Hao Pang Pei-Pei Yang Lu-Ming Guo Kuo zhang Da-Yong Hou Lei Wang Hao Wang Hui Cao State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Peptide drugs are known for their high biological ***,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in ***,inspired by the long circulation of albumin in blood,we screened albumin binding peptides(ABPs)from a one-bead one-compound(OBOC)peptide library to increase the half-life of peptide *** displaying random peptides were screened using fluorescent labeled human serum *** beads with specific binding to albumin were isolated for *** selected ABPs can effectively bind to albumin,thus possessing the long circulation of *** dissociation constant(K_(D))of ABPs to albumin is up to 1×10^(-8)mol/*** one of ABPs(ABP2)was coupled to triptorelin,the circulation half-life of triptorelin in mice was significantly prolonged to 263.50 h much longer than that of triptorelin alone(179.07 h).In addition,the combination therapy using ABP-conjugated triptorelin and doxorubicin(DOX)can effectively inhibit the proliferation of tumor cells in *** OBOC screening strategy and resulting ABPs showed great potential for enhancing the delivery efficiency of peptide drugs.

关键词： One-bead one-compound Combinatorial library Albumin binding Drug delivery Triptorelin

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锆基金属有机框架复合膜在水处理中的应用

高校化学工程学报 2024年第1期38卷 14-23页

作者：史丽秀许亚晴史亚慧张植翔陈宏长沙理工大学水利与环境工程学院湖南长沙410114 洞庭湖水环境治理与生态修复湖南省重点实验室湖南长沙410114 河南工业大学环境工程学院河南郑州450001

锆基金属有机框架(Zr-MOFs)复合膜具有良好的渗透性和抗污染性,被广泛应用于水处理领域。了解Zr-MOFs复合膜在水处理应用中的研究现状,对拓展Zr-MOFs膜的实际应用具有重要意义。鉴此,总结了Zr-MOFs的类型,复合膜的成膜方法、表面特性和... 详细信息

锆基金属有机框架(Zr-MOFs)复合膜具有良好的渗透性和抗污染性,被广泛应用于水处理领域。了解Zr-MOFs复合膜在水处理应用中的研究现状,对拓展Zr-MOFs膜的实际应用具有重要意义。鉴此,总结了Zr-MOFs的类型,复合膜的成膜方法、表面特性和过滤性能及其对水中污染物的去除效能方面的最新研究进展,重点讨论了Zr-MOFs复合膜制备方法存在的问题和优化策略以及污染物的去除机制。最后,提出优化Zr-MOFs复合膜制备方法、提升选择分离性及推进水处理中的实际应用等重要研究方向。

关键词：锆基金属有机框架膜分离水处理

Parameterization, sensitivity, and uncertainty of 1-D thermodynamic thin-ice thickness retrieval

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Acta Oceanologica Sinica 2024年第7期43卷 93-111页

作者： Tianyu zhang Mohammed Shokr Zhida zhang Fengming Hui Xiao Cheng Zhilun zhang Jiechen Zhao Chunlei Mi School of Geospatial Engineering and Science Sun Yat-Sen University/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-Sen University) Ministry of EducationZhuhai 519082China State Key Laboratory of Remote Sensing Science College of Global Change and Earth System ScienceBeijing Normal UniversityBeijing 100875China Science and Technology Branch Environment and Climate Change CanadaToronto M3H5T4Canada Qingdao Innovation and Development Base(Centre) Harbin Engineering UniversityQingdao 266500China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Retrieval of Thin-Ice Thickness(TIT)using thermodynamic modeling is sensitive to the parameterization of the independent variables(coded in the model)and the uncertainty of the measured input *** article examines the deviation of the classical model’s TIT output when using different parameterization schemes and the sensitivity of the output to the ice ***,it estimates the uncertainty of the output in response to the uncertainties of the input *** parameterized independent variables include atmospheric longwave emissivity,air density,specific heat of air,latent heat of ice,conductivity of ice,snow depth,and snow *** input parameters include air temperature,ice surface temperature,and wind *** the independent variables,the results show that the highest deviation is caused by adjusting the parameterization of snow conductivity and depth,followed ice *** sensitivity of the output TIT to ice thickness is highest when using parameterization of ice conductivity,atmospheric emissivity,and snow conductivity and *** retrieved TIT obtained using each parameterization scheme is validated using in situ measurements and satellite-retrieved *** in situ measurements,the uncertainties of the measured air temperature and surface temperature are found to be *** resulting uncertainties of TIT are evaluated using perturbations of the input data selected based on the probability distribution of the measurement *** results show that the overall uncertainty of TIT to air temperature,surface temperature,and wind speed uncertainty is around 0.09 m,0.049 m,and−0.005 m,respectively.

关键词： Arctic sea ice 1-D thermodynamic ice model thin-ice thickness sea ice parameterization

Food-Borne Poisoning Accident from Amanitin Toxin in Wild Mushrooms—Xingtai City,Hebei Province,China,2023

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China CDC weekly 2024年第3期6卷 56-59页

作者： Baopu Lv Liang Liu Hao Xiao Qingbing Meng Rui zhang Yaqing An Yingli Jin Yu Ma Hengbo Gao Yongkai Li Qian He Yutao zhang Changqing Liu Xiaoyan Luo Xiaomin Xu Fenshuang Zheng Yingping Tian hongshun zhang Dongqi Yao Emergency Department The Second Hospital of Hebei Medical UniversityShijiazhuang CityHebei ProvinceChina National Institute of Occupational Health and Poison Control Chinese Centre for Disease Control and PreventionBeijingChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Emergency Department The Affiliated Hospital of Yunnan UniversityKunming CityYunnan ProvinceChina

What is already known about this topic?Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of *** toxins primarily induce gastrointestinal symptoms initially,which are then followed by potentially life-threatening acute liver *** is added by this report?This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai *** individuals reported consuming wild mushrooms from the same origin,and laboratory tests confirmed the presence ofα-amanitin in their blood *** are the implications for public health practice?This underscores the risk associated with the collection and consumption of amanita toxin-containing mushrooms in *** is important to note that the identification of toxic and non-toxic mushrooms should not solely rely on personal experience or appearance.

关键词： Hebei consuming initially

Dynamic analysis of beta oscillations in Parkinsonian neural networks with the pedunculopontine nucleus under optogenetic control

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Acta Mechanica Sinica 2024年第6期40卷 125-140页

作者： Yuzhi Zhao honghui zhang Ying Yu Lin Du Zichen Deng School of Mathematics and Statistics Northwestern Polytechnical UniversityXi’an710072China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China

Clinical experiments have proven that the pedunculopontine nucleus(PPN)plays a crucial role in the modulation of beta oscillations in Parkinson’s disease(PD).Here,we propose a new computational framework by introducing the PPN and related synaptic connections to the classic basal ganglia-thalamo-cortical ***,the improved model can not only simulate the basic saturated and beta activities mentioned in previous studies but also produce the normal alpha rhythm that is much closer to physiological ***,the results show that Parkinsonian oscillation activities can be controlled and modulated by the connection strength between the PPN and the globus pallidus internal nucleus(GPi)and the subthalamic nucleus(STN),supporting the fact that PPN is overinhibited in ***,the internal mechanism underlying these state transitions is further explained from the perspective of ***,both deep brain stimulation(DBS)and optogenetic technology are considered effective in terms of abnormal *** when a low-frequency DBS is added to the PPN,beta oscillations can be suppressed,but it is excited again as the DBS’s frequency gradually increases to a larger *** results coincide with the experimental results that low-frequency stimulation of the PPN is effective,and verify the rationality of the ***,we show that optogenetic stimulation of the globus pallidus external(GPe)expressing excitatory channelrhodopsin(ChR2)can effectively inhibit beta oscillations,whereas exciting the STN and PPN has a limited *** results are consistent with experimental reports suggesting that the symptoms of PD’s movement disorder can be alleviated under the GPe-ChR2,but not STN-ChR2,*** the functional role of the PPN and the feasibility of optogenetic stimulation remain to be clinically explored,the results obtained help us understand the mechanisms of beta oscillations in PD.

关键词： Pedunculopontine nucleus Beta oscillations Optogenetic Deep brain stimulation Parkinson’s disease

内体分选转运复合体:确保有丝分裂正确进行的分子机器

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中国医学科学院学报 2024年第2期46卷 287-292页

作者：高吴陆怡杨玉张鹏霞商宇佳木斯大学基础医学院微生态-免疫调节网络与相关疾病重点实验室黑龙江佳木斯154007

有丝分裂是真核细胞增殖的重要环节。内体分选转运复合体是与膜剪切过程密切相关的多蛋白复合体,其功能涉及内体成熟、病毒出芽、自噬等过程,其结构和功能异常与癌症等疾病发生发展密切相关。本文总结了内体分选转运复合体在细胞有丝分... 详细信息

有丝分裂是真核细胞增殖的重要环节。内体分选转运复合体是与膜剪切过程密切相关的多蛋白复合体,其功能涉及内体成熟、病毒出芽、自噬等过程,其结构和功能异常与癌症等疾病发生发展密切相关。本文总结了内体分选转运复合体在细胞有丝分裂不同阶段所发挥的作用,以及内体分选转运复合体调控有丝分裂作用在疾病方面的研究进展。

关键词：有丝分裂内体分选转运复合体纺锤体检查点癌症

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Total laparoscopic liver resection in 78 patients

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World Journal of Gastroenterology 2009年第45期15卷 5727-5731页

作者： Lei zhang Ya-Jin Chen Chang-Zhen shang hong-Wei zhang Ze-Jian Huang Department of Hepatobiliary Surgery Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou 510120 Guangdong Province China

AIM： To summarize the clinical experience of laparoscopic hepatectomy at a single center. METHODS： Between November 2003 and March 2009, 78 patients with hepatocellular carcinoma （n = 39）, metastatic liver carcinoma （n = 10）, and benign liver neoplasms （n = 29） underwent laparoscopic hepatectomy in our unit. A retrospective analysis was done on the clinical outcomes of the 78 patients. RESULTS： The lesions were located in segments Ⅰ （n = 3）, Ⅱ （n = 16）, Ⅲ （n = 24）, Ⅳ （n = 11）, Ⅴ （n = ii）, Ⅵ （n = 9）, and Ⅷ （n = 4）. The lesion sizes ranged from 0.8 to 15 cm. The number of lesions was three （n = 4）, two （n = 8） and one （n = 66） in the study cohort. The surgical procedures included left hemi-hepatectomy （n = 7）, left lateral lobectomy （n = 14）, segmentectomy （n = 11）, local resection （n = 39）, and resection of metastatic liver lesions during laparoscopic surgery for rectal cancer （n = 7）. Laparoscopic liver resection was successful in all patients, with no conversion to open procedures. Only four patients received blood transfusion （400-800 mL）. There were no perioperative complications, such as bleeding and biliary leakage. The liver function of all patients recovered within 1 wk, and no liver failure occurred. CONCLUSION： Laparoscopic hepatectomy is a safe and feasible operation with minimal surgical trauma. It should be performed by a surgeon with sufficient experience in open hepatic resection and who is proficient in laparoscopy.

关键词： Hepatectomy Laparoscopy Liver neoplasms

A transformer-based coupled ocean-atmosphere model for ENSO studies

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Science Bulletin 2024年第15期69卷 2323-2327页

作者： Rong-Hua zhang Lu Zhou Chuan Gao Lingjiang Tao School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Ocean Observation and Forecasting and Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 101408China Laoshan Laboratory Qingdao 266237China

The El Nino-Southern Oscillation (ENSO) is the strongest interannual anomalies affecting weather and climate worldwide. As has been well recognized, ENSO originates from the coupling between the ocean and atmosphere in the tropical Pacific, characterized by a coherent evolution of subsurface temperature anomalies that profoundly impact sea surface temperature (SST) and surface wind fields.

关键词： ocean atmosphere interannual

基于频域阻抗网络建模分析的交直流微电网振荡问题研究

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电工技术学报 2024年第8期39卷 2294-2310页

作者：吴翔宇张晓红尚子轩赵一钢吴潇雨北京交通大学电气工程学院北京100044 北京市轨道交通电气工程技术研究中心北京100044 国网山西省电力公司忻州供电公司忻州034001 国网能源研究院有限公司北京102209

交直流微电网在不同类型电力电子变流器的不同带宽控制环节作用下,容易引发系统发生宽频振荡问题。现有的微电网振荡分析主要基于阻抗分析法和特征分析法,然而这两种方法存在一定的局限性。为此,该文研究了基于频域阻抗网络模型的交直... 详细信息

交直流微电网在不同类型电力电子变流器的不同带宽控制环节作用下,容易引发系统发生宽频振荡问题。现有的微电网振荡分析主要基于阻抗分析法和特征分析法,然而这两种方法存在一定的局限性。为此,该文研究了基于频域阻抗网络模型的交直流微电网振荡问题建模与分析方法。首先,建立了交直流微电网在频域下的等效阻抗网络模型,并计算节点频域导纳矩阵及回路频域阻抗矩阵。其次,基于频域模式分析法,建立了交直流微电网的节点/回路振荡参与程度指标以及设备和控制参数的灵敏度指标,给出了振荡的交直流传播特性分析方法,便于明晰系统振荡机理与关键影响因素。最后,通过Matlab/Simulink时域仿真及算例分析验证了上述频域阻抗网络建模和振荡稳定性分析方法的有效性。

关键词：交直流微电网频域阻抗网络建模振荡稳定性频域模式分析