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昆明市居民慢性病患病情况及影响因素分析

预防医学论坛 2015年第2期21卷 90-92,136页

作者：颜芳张茂镕李云涛李志坤沈岚刘怡昆明市疾病预防控制中心云南昆明650028

目的了解昆明市居民2013年慢性病患病情况,探讨其影响因素,找出其重点干预人群,为预防与控制慢性病提供依据。方法采用多阶段分层抽样的方法,共收集了6 461份有效调查资料,通过问卷调查和体格检查获取相关资料,应用描述性分析、χ2检验... 详细信息

目的了解昆明市居民2013年慢性病患病情况,探讨其影响因素,找出其重点干预人群,为预防与控制慢性病提供依据。方法采用多阶段分层抽样的方法,共收集了6 461份有效调查资料,通过问卷调查和体格检查获取相关资料,应用描述性分析、χ2检验和非条件Logistic回归分析。结果 2013年昆明市居民慢性病患病率为42.58%(标化率为40.41%),其中高血压、糖尿病、冠心病、脑卒中患病率分别为24.07%、8.17%、0.85%、0.87%;几类慢性病的影响因素存在差异,其中仅年龄为其共同的危险因素。结论慢性病严重威胁着居民的健康状况,健康生活方式是降低慢性病发生的重要措施,全社会应积极参与。

关键词：慢性病患病,影响因素

The IOCAS intermediate coupled model(IOCAS ICM) and its real-time predictions of the 2015–2016 El Nio event

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Science Bulletin 2016年第13期61卷 1061-1070页

作者： rong-Hua zhang Key Laboratory of Ocean Circulation and Waves Institute of Oceanology Chinese Academy of SciencesQingdao 266071 China Laboratory for Ocean and Climate Dynamics Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237 China University of Chinese Academy of Sciences Beijing 100049 China

The tropical Pacific is currently experiencing an El Nifio event. Various coupled models with different degrees of complexity have been used to make real-time E1 Nifio predictions, but large uncertainties exist in the inten- sity forecast and are strongly model dependent. An intermediate coupled model （ICM） is used at the Institute of Oceanology, Chinese Academy of Sciences （IOCAS）, named the IOCAS ICM, to predict the sea surface temper- ature （SST） evolution in the tropical Pacific during the 2015-2016 E! Nifio event. One unique feature of the IOCAS ICM is the way in which the temperature of subsurface water entrained in the mixed layer （Te） is parameterized. Observed SST anomalies are only field that is utilized to initialize the coupled prediction using the IOCAS ICM. Examples are given of the model＇s ability to predict the SST conditions in a real-time manner. As is commonly evident in E1 Nifio- Southern Oscillation predictions using coupled models, large discrepancies occur between the observed and pre- dicted SST anomalies in spring 2015. Starting from early summer 2015, the model can realistically predict warming conditions. Thereafter, good predictions can be made through the summer and fall seasons of 2015. A transition to normal and cold conditions is predictecl to occur in rote spring 2016. Comparisons with other model predictions are made and factors influencing the prediction performance of the IOCAS ICM are also discussed.

关键词： The 2015 E1 Nifio event IOCAS ICM Real-time prediction Model performance and improvement Air-sea interactions

Soliton Solutions of Coupled KdV System from Hirota's Bilinear Direct Method

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Communications in Theoretical Physics 2008年第1期49卷 22-26页

作者： YANG Jian-rong mao Jie-Jian Department of Physics Shangrao Normal College Shangrao 334001 China Department of Physics Ningbo University Ningbo 315211 China

With Hirota＇s bilinear direct method, we study the special coupled KdV system to obtain its new soliton solutions. Then we further discuss soliton evolution, corresponding structures, and interesting interactive phenomena in detail with plot. As a result, we find that after the interaction, the solitons make elastic collision and there are no exchanges of their physical quantities including energy, velocity and shape except the phase shift.

关键词： coupled KdV system Hirota's bilinear method soliton solutions interactive property

Retention Mechanism of Phenolic Compounds in Subcritical Water Chromatography

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Chemical Research in Chinese Universities 2015年第1期31卷 103-106页

作者： WUYichao DENG Xiuqing mao Yinchun zhang Yan LIU Jiaqin rong Li XU Zhihong School of Physics and Chemistry Xihua University Chengdu 610039 P. R. China

The transfer enthalpies and entropies of hydroxyl and nitryl in different mobile phase systems were compared by van＇t Hoff curve. Results suggest that the presence of acetonitrile and methanol in the mobile phase may decrease the interaction of solute and stationary phase with respect to subcritical water, thereby reducing the contribution of enthalpy to the retention. Retention mechanisms of phenolic compound appear to be more similar in subcritical water and water/methanol systems on the PRP-1 column. Hydrogen bond in subcritical water system plays a very important role in the retention of the phenols.

关键词： Subcritical water chromatography Phenols Retention mechanism Hydrogen bond

Painlevé Property and Complexiton Solutions of a Special Coupled KdV Equation

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Communications in Theoretical Physics 2008年第10期50卷 809-813页

作者： YANG Jian-rong mao Jie-Jian Department of Physics Jiangxi Shangrao Normal College Shangrao 334001 China Department of Physics Ningbo University Ningbo 315211 China

A special coupled KdV equation is proved to be the Painleve property by the Kruskal＇s simplification of WTC method. In order to search new exact solutions of the coupled KdV equation, Hirota＇s bilinear direct method and the conjugate complex number method of exponential functions are applied to this system. As a result, new analytical eomplexiton and soliton solutions are obtained synchronously in a physical field. Then their structures, time evolution and interaction properties are further discussed graphically.

关键词： special coupled KdV equation Painleve integrability bilinear method complexiton solution

Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 8-24页

作者： Qin FU Chen HE Zheng-rong mao Department of Pathology and Pathophysiology School of Medicine Zhejiang University Hangzhou 310058 China

Epstein-Barr virus(EBV),a human gammaherpesvirus carried by more than 90% of the world's population,is associated with malignant tumors such as Burkitt's lymphoma(BL),Hodgkin lymphoma,post-transplant lymphoma,extra-nodal natural killer/T cell lymphoma,and nasopharyngeal and gastric carcinomas in immune-compromised *** the process of infection,EBV faces challenges:the host cell environment is harsh,and the survival and apoptosis of host cells are precisely *** when host cells receive sufficient survival signals may they *** establish efficiently a lytic or long-term latent infection,EBV must escape the host cell immunologic mechanism and resist host cell apoptosis by interfering with multiple signaling *** review details the apoptotic pathway disrupted by EBV in EBV-infected cells and describes the interactions of EBV gene products with host cellular factors as well as the function of these factors,which decide the fate of the host *** relationships between other EBV-encoded genes and proteins of the B-cell leukemia/lymphoma(Bcl) family are ***,EBV seems to contribute to establishing its own latency and the formation of tumors by modifying events that impact cell survival and proliferation as well as the immune response of the infected *** discuss potential therapeutic drugs to provide a foundation for further studies of tumor pathogenesis aimed at exploiting novel therapeutic strategies for EBV-associated diseases.

关键词： Epstein-Barr virus Bcl family members Apoptosis Drugs therapy

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Keap1翻译后修饰调控氧化应激相关疾病

基础医学与临床 2025年第1期45卷 107-111页

作者：瞿瑛毛彩云钟晴张蓉宋运佳黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学基础医学院药理教研组黑龙江哈尔滨150040

Keap1-Nrf2信号通路的激活是细胞对抗氧化应激的重要机制。氧化应激条件下,Keap1受到谷胱甘肽化、烷基化以及S-巯基化等翻译后修饰(PTM)的影响,与Nrf2的结合被减弱,导致Nrf2积累、核易位以及下游解毒和抗氧化防御蛋白质的表达和转录。Ke... 详细信息

Keap1-Nrf2信号通路的激活是细胞对抗氧化应激的重要机制。氧化应激条件下,Keap1受到谷胱甘肽化、烷基化以及S-巯基化等翻译后修饰(PTM)的影响,与Nrf2的结合被减弱,导致Nrf2积累、核易位以及下游解毒和抗氧化防御蛋白质的表达和转录。Keap1的PTM参与调控癌、帕金森病和动脉粥样硬化等多种氧化应激相关疾病,例如烷基化抑制腹主动脉瘤形成、甲基化促进乳腺癌固有抵抗以及S-巯基化改善动脉粥样硬化,为寻找新的药物靶点和生物标志物提供理论基础。

关键词： Keap1 氧化应激翻译后修饰作用机制

Peptide-based nanomaterials:Self-assembly,properties and applications

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Bioactive Materials 2022年第5期7卷 268-282页

作者： Tong Li Xian-mao Lu Ming-rong zhang Kuan Hu Zhou Li College of Chemistry and Chemical Engineering Center of Nanoenergy ResearchGuangxi UniversityNanning530004China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing101400China Department of Advanced Nuclear Medicine Sciences The National Institute of Radiological SciencesThe National Institutes for Quantum and Radiological Science and TechnologyChiba263-8555Japan School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing101400China

Peptide-based materials that have diverse structures and functionalities are an important type of *** former times,peptide-based nanomaterials with excellent stability were constructed through *** with individual peptides,peptide-based self-assembly nanomaterials that form well-ordered superstructures possess many advantages such as good thermo-and mechanical stability,semiconductivity,piezoelectricity and optical ***,due to their excellent biocompatibility and biological activity,peptide-based self-assembly nanomaterials have been vastly used in different *** this review,we provide the advances of peptide-based self-assembly nanostructures,focusing on the driving forces that dominate peptide self-assembly and assembly mechanisms of *** that,we outline the synthesis and properties of peptide-based nanomaterials,followed by the applications of functional peptide ***,we provide perspectives on the challenges and future of peptide-based nanomaterials.

关键词： Self-assembly Peptide-based nanomaterials Supercapacitor Biosensing Drug delivery

On Reproducing Kernel Banach Spaces:Generic Definitions and Unified Framework of Constructions

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Acta Mathematica Sinica,English Series 2022年第8期38卷 1459-1483页

作者： rong rong LIN Hai zhang zhang Jun zhang School of Mathematics and Statistics Guangdong University of TechnologyGuangzhou 510520P.R.China School of Mathematics(Zhuhai) and Guangdong Province Key Laboratory of Computational ScienceSun Yat-sen UniversityZhuhai 519082P.R.China Department of Psychology and Department of Statistics University of MichiganAnn ArborMI48109USA

Recently,there has been emerging interest in constructing reproducing kernel Banach spaces(RKBS)for applied and theoretical purposes such as machine learning,sampling reconstruction,sparse approximation and functional *** constructions include the reflexive RKBS via a bilinear form,the semi-inner-product RKBS,the RKBS with?~1 norm,the p-norm RKBS via generalized Mercer kernels,*** definitions of RKBS and the associated reproducing kernel in those references are dependent on the ***,relations among those constructions are *** explore a generic definition of RKBS and the reproducing kernel for RKBS that is independent of ***,we propose a framework of constructing RKBSs that leads to new RKBSs based on Orlicz spaces and unifies existing constructions mentioned above via a continuous bilinear form and a pair of feature ***,we develop representer theorems for machine learning in RKBSs constructed in our framework,which also unifies representer theorems in existing RKBSs.

关键词： Reproducing kernel Banach spaces feature maps reproducing kernels machine learning the representer theorem

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