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Role of necroptosis in spinal cord injury and its therapeutic implications

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BIOCELL 2023年第4期47卷 739-749页

作者： JIAWEI FU CHUNSHUAI WU GUANHUA XU jinlong zhang YIQIU LI CHUNYAN JI ZHIMING CUI The Affiliated Hospital 2 of Nantong University Nantong UniversityThe First People’s Hospital of NantongNantong226001China Key Laboratory for Restoration Mechanism and Clinical Translation of Spinal Cord Injury Nantong226001China Research Institute for Spine and Spinal Cord Disease of Nantong University Nantong226001China

Spinal cord injury(SCI),a complex neurological disorder,triggers a series of devastating neuropathological events such as ischemia,oxidative stress,inflammatory events,neuronal apoptosis,and motor ***,the classical necrosome,which consists of receptor-interacting protein(RIP)1,RIP3,and mixed-lineage kinase domain-like protein,is believed to control a novel type of programmed cell death called necroptosis,through tumour necrosis factor-alpha/tumour necrosis factor receptor-1 signalling or other *** studies reported that necroptosis plays an important role in neural cell damage,release of intracellular pro-inflammatory factors,lysosomal dysfunction and endoplasmic reticulum *** research indicates that necroptosis is crucial to the pathophysiology of a number of neurological disorders and *** our review,we summarize the potential role of programmed cell death regulated by necroptosis in SCI based on its molecular and pathophysiological *** also summarize the targets of several necroptosis pathways,which provide a more reliable reference for the treatment of SCI.

关键词： Necroptosis Spinal cord injury Pathological mechanisms Therapeutics

Angular Dependence of Critical Current in Ag-Seathed Bi(2223)-Superconductor Tape

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Chinese Physics Letters 1993年第9期10卷 566-568页

作者： GUO Shuquan QIN Xiaonnei zhang jinlong WU Zu'an YE Bin ZENG Roung ZHOU Yiru ZHOU Min Natioual Laboratory on Superconductivity Institute of PhysicsAcadenia Sinica.Beijing 100080 General Research Institute for Non-ferrous Metal Beijing 100088

The critical current Ic(B.T.)of Ag-slcatled Bi(223)tape was uuceasured at 4.2 and 77K in magnetic field up to CT as a function of the tield *** maximn Ie is observed when the fnx line are along the CuO:*** effect is due to an in trinsic pinning between CuO_(2) *** H>0.5 T at 4.2K.I_(c) decreascs very slowly with the mlaguetic *** resnlts nre colusistent with our early-proposed scaling luws for flux pining in Ag-sheathed tape.

关键词： field. direction. Superconductor

Emission characteristics of surface second-order metal grating distributed feedback semiconductor lasers

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Chinese Science Bulletin 2012年第17期57卷 2083-2086页

作者： SHI JunXiu QIN Li LIU Yun zhang Nan zhang Jian zhang LiSen JIA Peng NING YongQiang ZENG YuGang zhang jinlong WANG LiJun Key Laboratory of Excited State Processes Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

To obtain high-power semiconductor lasers with stable operation in a single longitudinal mode and improve the characteristics of the output beam,an end-emitting surface second-order metal grating distributed feedback(DFB) laser emitting at around 940 nm is *** characteristics of the uncoated devices with and without gratings are tested under room temperature continuous-wave conditions without any temperature-control device and *** devices with gratings achieve high powers of up to 385 mW/facet and a small lateral far-field angle of 2.7° at 1.5 A,have only 4.13 nm/A wavelength-shift,and 0.09 nm spectral linewidth at 600 mA,and operate in a stable longitudinal *** without gratings operate in multimode,with a larger lateral far-field angle(7.3°) and spectral linewidth(1.3 nm),although with higher output *** of the integration of second-order metal gratings and their very high coupling capability,the output beam quality is improved greatly,the lasing wavelength is stable and varies slowly with changes in injection current,while the spectrum is narrowed dramatically,and the far-field angles are greatly *** opens the way for the realization of watt-scale power broad-stripe(>100 μm) surface second-order metal grating end and surface-emitting DFB lasers and arrays with single frequency,single mode operation and high output beam quality.

关键词：高功率半导体激光器金属光栅分布反馈二阶表面排放特性 DFB激光器稳定运行

Whole-genome methylation analysis reveals epigenetic variation between wild-type and nontransgenic cloned,ASMT transgenic cloned dairy goats generated by the somatic cell nuclear transfer

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Journal of Animal Science and Biotechnology 2023年第1期14卷 98-113页

作者： Hao Wu Wendi Zhou Haijun Liu Xudai Cui Wenkui Ma Haixin Wu Guangdong Li Likai Wang jinlong zhang Xiaosheng zhang Pengyun Ji Zhengxing Lian Guoshi Liu National Engineering Laboratory for Animal Breeding Key Laboratory of Animal Genetics and Breeding of the Ministry of AgriculturalBeijing Key Laboratory for Animal Genetic ImprovementCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China. Sany Institute of China Agricultural University Sanya 572025China. Institute of Animal Husbandry and Veterinary Academy of Agricultural Sciences of TianjinTianjin 300192China. Qingdao Senmiao Industrial Co. Ltd.Qingdao 266101China.

Background:SCNT(somatic cell nuclear transfer)is of great significance to biological research and also to the livestock ***,the survival rate of the SCNT cloned animals is relatively low compared to other transgenic *** indicates the potential epigenetic variations between *** methylation is a key marker of mammalian epigenetics and its alterations will lead to phenotypic *** this study,ASMT(acetylserotonin-Omethyltransferase)ovarian overexpression transgenic goat was produced by using *** investigate whether there are epigenetic differences between cloned and WT(wild type)goats,WGBS(whole-genome bisulfite sequencing)was used to measure the whole-genome methylation of these ***:It is observed that the different m Cp G sites are mainly present in the intergenic and intronic regions between cloned and WT animals,and their CG-type methylation sites are strongly ***(differentially methylated region)lengths are located around 1000 bp,mainly distributed in the exonic,intergenic and intronic functional domains.A total of 56 and 36 DMGs(differentially methylated genes)were identified by GO and KEGG databases,*** annotation showed that DMGs were enriched in biological-process,cellularcomponent,molecular-function and other signaling pathways.A total of 10 identical genes related to growth and development were identified in GO and KEGG ***:The differences in methylation genes among the tested animals have been identified.A total of 10 DMGs associated with growth and development were identified between cloned and WT *** results indicate that the differential patterns of DNA methylation between the cloned and WT goats are probably caused by the *** novel observations will help us to further identify the unveiled mechanisms of somatic cell cloning technology,particularly in goats.

关键词： Acetylserotonin-O-methyltransferase Dairy goat DNA methylation Gene editing Somatic cell nuclear transfer

Z-scheme CdS/WO_(3)on a carbon cloth enabling effective hydrogen evolution

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Frontiers in Energy 2021年第3期15卷 678-686页

作者： Zehong XU Qiaohong ZHU Xinguo XI Mingyang XING jinlong zhang Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China School of Chemistry and Chemical Engineering Yancheng Institute of TechnologyYancheng 224051China

Photocatalytic water splitting for hydrogen(H2)generation is a potential strategy to solve the problem of energy crisis and environmental ***,powder-like photocatalysts are difficult to recycle,and the agglomeration of particles would affect the photocatalytic ***,a direct Z-scheme CdS/WO_(3)composite photocatalyst was fabricated based on carbon cloth through a two-step *** the support of carbon cloth,photocatalysts tend to grow uniformly for further *** experimental results showed that the H2 yield of adding one piece of CdS/WO_(3)composite material was 17.28μmol/h,which was 5.5 times as compared to that of pure CdS-loaded carbon cloth material.A cycle experiment was conducted to verify the stability of the asprepared material and the result demonstrated that the H2 generation performance of CdS/WO_(3)decreased slightly after 3 *** work provides new ideas for the development of recyclable photocatalysts and has a positive significance for practical applications.

关键词： photocatalysis CdS/WO_(3) carbon cloth Z-scheme hydrogen evolution

Effects of the TLR4 transgene on reproductive traits and DNA methylation pattern of oocytes in ewes

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Frontiers of Agricultural Science and Engineering 2014年第4期1卷 314-320页

作者： Yi FANG Xiangwei FU Junjie LI Ming DU Baoyu JIA jinlong zhang Xiaosheng zhang Shien ZHU National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of AgricultureCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology Agricultural University of HebeiBaoding 071000China Animal Husbandry and Veterinary Research Institute of Tianjin Tianjin 300412China

This study was conducted to systematically assess the reproductive performance of transgenic TLR4 *** the TLR4 transgenic founders(F_(0))and their positive offspring(F_(1)),hematological and reproductive parameters and the global DNA methylation level in oocytes at various stages were *** values of the physiological and biochemical parameters determined from the blood samples did not differ significantly between the transgenic and wild-type ***,the transgenic ewes showed reproductive traits similar to the wildtype *** traits included characteristics of puberty,the estrus cycle,estrus duration,gestation,the pregnancy rate and the superovulation ***,no significant differences were found between transgenic and wild-type ewes in the DNA methylation level of the oocytes at various *** summary,the preliminary evidence presented in this paper demonstrates that the presence of the TLR4 transgene did not affect the reproductive performance in sheep.

关键词： TLR4 transgenic ewe safety assessment reproductive trait oocyte DNA methylation

Observation on Cardiac Opening of the Inferior Vena Cava in Goat Fetuses

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Agricultural Biotechnology 2019年第6期8卷 138-139页

作者： Jie zhang jinlong zhang Department of Cardiology Eastern Theater General HospitalNanjing 210002China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses/College of Veterinary Medicine Yangzhou UniversityYangzhou 225009China

[Objectives] This study was conducted to better understand the characteristics of the fetal blood circulation. [Methods] The cardiac opening of the inferior vena cava was observed in goat fetuses. There are two cardiac openings of the inferior vena cava, namely, the foramen ovale with the valves and the right atrium opening of the inferior vena cava. The blood from the inferior vena cava moves easily into the right atrium via the right atrium opening because the right atrium opening without the valves is located in the lower right of the foramen ovale, and is bigger than the interatrial foramen. [Results] The blood may flow into the left atrium through the foramen ovale when the blood volume into the right atrium exceeds the limit of the right atrium. The fetal inferior vena cava compared with after birth receives oxygenated blood in the umbilical vein from the placenta besides the normal blood. Accordingly the blood volume into the right atrium exceeds the limit of the right atrium. Extra oxygenated blood is diverted directly into the left atrium through the foramen ovale. [Conclusions] This study provides a reference for studying the blood circulation of fetuses and even adults.

关键词： Fetal circulation Inferior vena cava Foramen ovale Interatrial foramen

Non-orthogonal joint diagonalization with diagonal constraints

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Progress in Natural Science:Materials International 2008年第6期18卷 735-739页

作者： Guoxu Zhou*,Zuyuan Yang,Zongze Wu,jinlong zhang School of Electrics and Information Engineering,South China University of Technology,Guangzhou 510641,China School of Electrics and Information Engineering South China University of Technology Guangzhou 510641 China

Joint diagonalization has attracted much attention and many algorithms have been presented so ***,some ambiguities still exist in the objective functions for joint *** this paper,some criterions are proposed to eliminate the above ambiguities at first,and then a new objective function which satisfies these criterions is *** new objective function introduces diagonal con-straints for joint diagonalization,thus the trivial and unbalance solutions are excluded *** jointly diagonalizable theorem is built to interpret the reasonableness of the new objective function and the conjugate gradient method is used to provide fast and reliable ***,non-orthogonal joint diagonalization algorithm with diagonal constraints(DDiag)is *** show that DDiag is ecient and robust.

关键词： Joint diagonalization Blind source separation Conjugate gradient method

New method for signal encryption using blind source separation based on subband decomposition

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Progress in Natural Science:Materials International 2008年第6期18卷 751-755页

作者： Zuyuan Yang*,Guoxu Zhou,Zongze Wu,jinlong zhang School of Electrics and Information Engineering,South China University of Technology,Guangzhou 510641,China School of Electrics and Information Engineering South China University of Technology Guangzhou 510641 China

A novel cryptosystem based on subband decomposition independent component analysis(SDICA)is proposed in this work,where no assumption of independence for the ciphers and the plaintexts is *** the proposed cryptosystem,the encryption is asynchronous,*** plaintexts are mixed mutually firstly and then mixed with the *** addition,the decryption is asynchronous,such that the decryption accuracy of the plaintexts can be *** special information about the original mixing matrix is used for solving the indeterminacy of the permutation and scale of columns of the recovered mixing matrix in SDICA,instead of the characteristics of the *** are given to illustrate security and availability of our cryptosystem.

关键词： SDICA Signal encryption BSS