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A phase Ⅰ study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 46-54页

作者： Pin zhang Lin Wang Yueying Zhen Zhihong Wang hesheng zhang Richard Jones Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin Hemay Pharmaceutical Co. LTDTianjin 300308China

Objective: Hemay022 is a novel small-molecule and an irreversible tyrosine kinase inhibitor with the target of epidermal growth factor receptor(EGFR)/human epidermal growth factor receptor 2(HER2), which demonstrated anti-tumor activity in preclinical studies. This first-in-human study evaluated the safety, pharmacokinetics,tolerability and preliminary anti-tumor activity of Hemay022 in HER2-positive advanced breast cancer ***: Heavily pretreated patients with HER2-positive advanced breast cancer were assigned to eight dose cohorts in a 3+3 dose-escalation pattern at doses of 50-600 mg QD and 300 mg BID. Eligible patients were given a single dose of Hemay022 on d 1 in week 0, followed by once daily continuous doses for four weeks in 28-day *** samples were obtained on d 1 and d 28. Clinical responses were assessed every eight ***: Twenty-eight patients with advanced breast cancer were treated with Hemay022. The most frequently reported drug-related adverse events were diarrhoea(85.7%), vomiting(28.6%), nausea(25.0%) and decreased appetite(17.9%). No grade 4 drug-related adverse events were reported. At 50-600 mg doses, steady state areas under the concentration-time curve and peak concentrations increased with doses. One patient achieved complete response(CR), and three achieved partial response(PR). The objective response rate(ORR) and disease control rate(DCR) were 14.3% and 46.4% in 28 patients, respectively. The median progression-free survival(PFS) was3.98 ***: Hemay022 at the dose of 500 mg once daily was well tolerated. The pharmacokinetic properties and encouraging anti-tumor activities of Hemay022 in advanced breast cancer patients warranted further evaluation of Hemay022 for treating breast cancer patients in the current phase Ⅲ trial(No. NCT05122494).

关键词： Advanced breast cancer HER2-positive Hemay022 first-in-human trial

Improved Fx-VSSLMS algorithm for active vibration control of smart cantilever beam

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High Technology Letters 2020年第1期26卷 44-52页

作者： Fang Yubin Zhu Xiaojin Li Xiangmin Miao Zhonghua Gao Zhiyuan zhang hesheng School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200072P.R.China

Filtered-x least mean square(Fx-LMS) algorithm is popular in many adaptive processes. As its contradiction between convergence speed and stead-state error, the improvements of Fx-LMS algorithm with variable step size(VSS) have been developed. To strengthen the robustness of variable step size least mean square(VSSLMS) algorithms to noise disturbance in active vibration control(AVC) application, nine VSSLMS algorithms are introduced in detail. Then an improved VSSLMS algorithm is proposed for better performance. At last, the performance of these VSSLMS algorithms are compared in AVC experimental system with different noise level. The experimental results verifies the effectiveness and robustness of the proposed VSSLMS algorithm in AVC application.

关键词： active vibration control(AVC) filtered-x least mean square(Fx-LMS) variable step size least mean square(VSSLMS) robustness flexible beam

Standardization of Fieldbus and Industrial Ethernet

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ZTE Communications 2019年第2期17卷 51-58页

作者： CHEN Jinghe zhang hesheng Beijing Jiaotong University

Fieldbus and industrial Ethernet standards can guide the specification andcoordinate bus optimization. The standards are the basis for the development of field-bus and industrial Ethernet. In this paper, we review complex standard systems allover the world. We discuss 18 fieldbus standards, including the International Electro-technical Commission(IEC) 61158, the IEC 61784 standard matched with IEC 61158,the controller and device interface standard IEC 62026 for low voltage distributionand control devices, and the International Organization for Standardization(ISO)11898 and ISO 11519 standards related to the controller area network(CAN) bus. Wealso introduce the standards of China, Europe, Japan and America. This paper pro-vides a reference to develop fieldbus and industrial Ethernet products for Chinese en-terprises.

关键词： fieldbus industrial Ethernet standard

Hippocampal sclerosis in women with temporal lobe epilepsy:seizure and pregnancy outcomes

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Acta Epileptologica 2024年第3期7卷 228-237页

作者： Yujie Chen Nanya Hao Weixi Xiong hesheng zhang Enhui zhang Zhujing Ou Lei Chen Xintong Wu Dong Zhou Department of Neurology West China Hospital of Sichuan UniversityNo.37 Guoxue AlleyWuhou DistrictChengdu610041SichuanChina

Background Temporal lobe epilepsy with hippocampal sclerosis(TLE-HS)is typically resistant to pharmacological interventions;however,achieving seizure freedom is possible through *** objective was to focus on the pregnancy and seizure outcomes during pregnancy of women with TLE-HS,and aim to identify predictors of seizure *** The West China Registry of Pregnancy of Women with Epilepsy(WCPR_EPi)was a monocentric prospective cohort study of women with epilepsy(WWE).We screened women with TLE-HS in this *** clinical profile,anti-seizure medication(ASM)use,and pregnancy outcomes were extracted from the records of the registry(2010–2023).Results Out of 2320 WWE followed up,47 pregnancies in women with TLE-HS were identified and *** exacerbation occurred in 40.4%of pregnancies,and seizure freedom was present in 34.0%of these during *** associated with seizure exacerbation during pregnancy was ASM non-adherence(odds ratio[OR]=7.00,95%confidence interval[CI]1.43–34.07,P=0.016).The surgery group showed a significantly higher seizure freedom rate(OR=6.87,95%CI 1.02–46.23,P=0.016)and lower rate of induced labor(0.0%vs 26.5%,P=0.047)compared to the medically-treated group *** section was chosen in 77.1%of cases due to seizure concerns,with comparable in epilepsy-related(n=20)and obstetric causes(n=24).No major congenital malformations were *** Surgical treatment before pregnancy appears to offer a higher chance of seizure freedom compared to medication *** of women with TLE-HS can deliver healthy offspring regardless of suboptimal seizure control and unwarranted concerns.

关键词： Temporal lobe epilepsy Hippocampal sclerosis Pregnancy outcomes Seizure management Epilepsy in women,Retrospective studies Anti-seizure medications

Time Sensitive Networking Technology Overview and Performance Analysis

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ZTE Communications 2018年第4期16卷 57-64页

作者： FU Shousai zhang hesheng CHEN Jinghe Beijing Jiaotong University Beijing 100044China

Time sensitive networking(TSN)is a set of standards developed on the basis of audio video bridging(AVB).It has a promising future in the Industrial Internet of Things and vehicle-mounted multimedia,with such advantages as high bandwidth,interoperability and low *** this paper,the TSN protocol stack is described and key technologies of network operation are summarized,including time synchronization,scheduling and flow shaping,flow management and fault tolerant *** TSN network model is then *** performance is illustrated to show how the frame priority works and also show the influence of IEEE802.1Qbv time-aware shaper and IEEE802.1Qbu frame preemption on network and time-sensitive ***,we briefly discuss the challenges faced by TSN and the focus of future research.

关键词： TSN AVB the industrial internet of things(IIoT)

基于模糊综合评价的动车组牵引传动系统改进FMECA

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铁道学报 2022年第9期44卷 33-41页

作者：于涵张和生北京交通大学电气工程学院北京100044 北京市轨道交通电气工程技术研究中心北京100044

针对某动车组牵引传动系统的故障模式、影响和危害性分析中易受个人主观影响、影响因素与实际不符和易取重复值等问题进行改进。通过模糊综合评判对多位专家评价指标予以量化,降低了个人主观意见对评价结果的影响;应用层次分析法对主要... 详细信息

针对某动车组牵引传动系统的故障模式、影响和危害性分析中易受个人主观影响、影响因素与实际不符和易取重复值等问题进行改进。通过模糊综合评判对多位专家评价指标予以量化,降低了个人主观意见对评价结果的影响;应用层次分析法对主要的影响因素进行权值分配,使得到的故障模式严酷度等级更加符合工程需要;采取线性插值的方法,增加同一发生概率等级间不同故障模式的区分度。以牵引传动系统的15种典型的故障模式为例进行分析,结果表明牵引控制单元硬件板卡、牵引变流器功率模块是影响牵引传动系统可靠性的关键器件,同时验证了改进FMECA方法能够区分不同故障模式间的优先级,其较传统方法更加明确,便于在实际工程中应用,也为列车优化设计提供相应的支撑。该方法不仅可以应用在动车组牵引传动系统中,也可以在机车车辆的设备故障分析中使用。

关键词：模糊FMECA 层次分析法高速动车组牵引传动系统线性插值

3D Visual Simulation for Missile System Based on VC and Vega Prime

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3D Visual Simulation for Missile System Based on VC and Vega...

Chip Surface Character Recognition Based on Improved LeNet-5 Convolutional Neural Network

第37届中国控制会议

作者： Zhaoxun zhang hesheng zhang Yubin Fang Xiaojin Zhu School of Mechatronic Engineering and Automation Shanghai University

The 3D visual simulation system for missile was based on VC ++ and Vega Prime softwares. The system is mainly divided into three parts. The first part is to bulid 6 DOF models. The second part is based on the 6 DOF model of missile to simulate the controller of the rolling channel. Flight data is obtained through this simulate. The last part is to complete Co-simulation which based on VC++, 3D scene simulation software called Vega Prime and Matlab/Simulink software. The simulation results indicate that this 3D Visual Simulation for Missile System is helpful in confirmation and improvement of missile dynamics model and control system.

关键词： Missile VC++ Vega Prime software Matlab/Simulink software

来源： cnki会议评论

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Chip Surface Character Recognition Based on Improved LeNet-5...

基于IEEE802.11p高速车路通信环境研究

第三十九届中国控制会议

作者： Yiyun Zhu hesheng zhang Long zhang Xiaojin Zhu School of Mechatronic Engineering and Automation Shanghai University

It is very important to detect the correctness of character information on the surface of IC chip in the process of packaging and testing. In this paper, a character segmentation method based on rectangle contour is proposed and the LeNet-5 network model is optimized. The character segmentation algorithm based on contour can effectively segment the characters in both horizontal and vertical directions. The improved convolutional neural network model is verified on the surface character data set of IC chip and has achieved good results.

关键词： Image Preprocessing Optical Character Recognition Convolutional Neural Network

来源： cnki会议评论

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仪器仪表学报 2013年第5期34卷 1181-1187页

作者：张和生张明洋孙伟北京交通大学电气工程学院北京100044 轨道交通控制与安全国家重点实验室北京100044

针对基于IEEE802.11p构成高速车路通信中安全类消息传输的性能是否满足车路通信需求的问题,采用符合实际道路特点的Nakagami分布描述无线信道衰落,Poisson分布描述移动车辆发送的数据流,对单一路侧设备与连续移动车辆通信性能进行了仿... 详细信息

针对基于IEEE802.11p构成高速车路通信中安全类消息传输的性能是否满足车路通信需求的问题,采用符合实际道路特点的Nakagami分布描述无线信道衰落,Poisson分布描述移动车辆发送的数据流,对单一路侧设备与连续移动车辆通信性能进行了仿真。以车辆消息发送间隔、通信车辆数量、车辆行驶速度为变量,得到4种不同接入类消息的车辆数与吞吐量、发包间隔与丢包率、发布间隔与平均时延、车辆速度与投递字节数的关系。结果表明,不同类型消息在车辆数与吞吐量关系上有一个优化点,可实现车辆数和吞吐量的最大化;丢包率和平均时延都会随着车辆数据发送间隔增大而增大。车速增加时,安全类消息的投递字节数下降且与车速成反比。从仿真结果可以看出,IEEE802.11p协议能够保证高优先级安全类消息传输服务质量。

关键词：车路通信性能分析 NS-2仿真 IEEE802 11p协议专用短程通信