检索结果-南通市图书馆

Copper homeostasis and neurodegenerative diseases

Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang feng zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Depression mechanism of sulfite ions on sphalerite and Pb2+ activated sphalerite in the flotation separation of galena from sphalerite

引用

International Journal of Minerals,Metallurgy and Materials 2025年第02期 335-345页

作者： feng zhang Chenyang zhang Linlin Wu Wei Sun Hongliang zhang Jianhua Chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Join Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South University State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&Metallurgy Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South University School of Resources Environment and MaterialsGuangxi University Department of Chemistry Xiangtan University China Railway Resource Group Co.Ltd

The depression mechanism of sulfite ions on sphalerite and Pb2+activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb2+activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory（DFT） *** X-ray photoelectric spectroscopy （XPS） results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO3in *** hydrophilic PbSO3was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb2+activated sphalerite.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

引用

World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei zhang Xiao Guo Hua Guo Shou-feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-feng zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

构建聚己内酯/纳米金刚石-磷脂复合材料及性能评价

引用

中国组织工程研究 2025年第16期29卷 3380-3387页

作者：田家宇李多华张锋冯虎孙伟徐州医科大学江苏省徐州市221000 徐州医科大学附属医院骨科江苏省徐州市221000

背景:聚己内酯因具有良好的加工和降解性能在骨组织工程中得到广泛应用,但其较差的亲水性及机械强度并不能为成骨细胞提供良好的生长环境。目的:制备聚己内酯/纳米金刚石-磷脂复合材料,评估其生物相容性和体外促成骨分化能力。方法:使... 详细信息

背景:聚己内酯因具有良好的加工和降解性能在骨组织工程中得到广泛应用,但其较差的亲水性及机械强度并不能为成骨细胞提供良好的生长环境。目的:制备聚己内酯/纳米金刚石-磷脂复合材料,评估其生物相容性和体外促成骨分化能力。方法:使用磷脂对纳米金刚石进行改性,以聚己内酯为原材料,采用溶液浇铸法制备含不同质量比例(0%,2.5%,7.5%,10%)纳米金刚石-磷脂的聚己内酯/纳米金刚石-磷脂复合膜,使用聚己内酯/纳米金刚石膜进行对比,通过对各组材料表面形貌、元素组成、力学性能及水接触角的观察,选取理化性能较佳的复合膜。将MC3T3-E1细胞分别接种于纯聚己内酯膜、聚己内酯/7.5%纳米金刚石-磷脂膜及聚己内酯/7.5%纳米金刚石膜,检测细胞增殖、黏附及成骨分化能力。结果与结论:①通过扫描电镜及表面元素组成证实聚己内酯/纳米金刚石-磷脂复合膜制备成功,与纯聚己内酯膜相比,聚己内酯/7.5%纳米金刚石-磷脂膜的拉伸强度提高了86.06%,弹性模量提高了54.76%,水接触角降低至70.0°,显示出良好的理化性能;②CCK-8检测结果显示,相较于纯聚己内酯膜、聚己内酯/7.5%纳米金刚石膜,聚己内酯/7.5%纳米金刚石-磷脂膜可促进MC3T3-E1细胞的增殖;鬼笔环肽染色显示,相较于聚己内酯/7.5%纳米金刚石膜,纯聚己内酯膜、聚己内酯/7.5%纳米金刚石-磷脂膜上的MC3T3-E1细胞多为菱形或纺锤形纤维状,细胞连接更紧密;碱性磷酸酶染色显示,相较于纯聚己内酯膜、聚己内酯/7.5%纳米金刚石膜,聚己内酯/7.5%纳米金刚石-磷脂膜上的MC3T3-E1细胞展现了更强的成骨分化能力;③结果表明,聚己内酯/纳米金刚石-磷脂复合材料具有良好的力学性能、亲水性、生物相容性及体外促成骨分化能力。

关键词：纳米金刚石聚己内酯磷脂溶液浇铸法 MC3T3-E1细胞成骨分化骨组织工程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

STOCHASTIC MAXIMUM PRINCIPLE FOR MIXED REGULAR-SINGULAR CONTROL PROBLEMS OF FORWARD-BACKWARD SYSTEMS

引用

Journal of Systems Science & Complexity 2013年第6期26卷 886-901页

作者： zhang feng School of Mathematics and Quantitative Economics Shandong University of Finance and Economics

This paper considers a stochastic optimal control problem of a forward-backward system with regular-singular controls where the set of regular controls is not necessarily convex and the regular control enters the diffusion *** control problem is difficult to solve with the classical method of spike *** authors use the approach of relaxed controls to establish maximum principle for this stochastic optimal control *** optimality conditions are also investigated.

关键词： Forward-backward system maximum principle relaxed control singular control.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Challenges and opportunities facing game theory and control: an interview with Tamer Ba?ar

引用

National Science Review 2020年第7期7卷 1142-1146页

作者： Ji-feng zhang the Academy of Mathematics and Systems Science of the Chinese Academy of Sciences

The Control community has recently witnessed an almost exponentially growing interest in the application of game-theoretic concepts and tools in research on control, multi-agent systems, and networks. In an interview with NSR, Professor Tamer Ba?ar, a member of the US National Academy of Engineering, Swanlund Endowed Chair and CAS Professor of Electrical and Computer Engineering, and Director of the Center for Advanced Study at the University of Illinois at Urbana-Champaign in the USA, former president of both the IEEE Control

关键词： Game theory

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Stochastic maximum principle for optimal control problems involving delayed systems

引用

Science China(Information Sciences) 2021年第1期64卷 269-271页

作者： feng zhang School of Mathematics and Quantitative Economics Shandong University of Finance and Economics

Dear editor,The main objective of this study is to investigate one type of stochastic optimal control problem for a delayed system using the maximum principle *** existing research can be categorized into two *** the first category,the adjoint equation comprises two backward stochastic differential equations (BSDEs) and one backward ordinary differential equation (BODE),which is assumed to have a zero solution;see e.g.,[1-3].However,there is still scope for improvement in this research ***,a special setting is considered for the system parameters;see e.g.,(3.9)and (3.12) in *** BODE is assumed to result in a zero solution when the necessary maximum principle is strictly applied;see e.g.,Theorem 5.1 in *** the second category,a typee of anticipated/time-advanced BSDE is introduced as the adjoint equation;see e.g.,[1,4-7].

关键词： Information Systems and Communication Service

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Coupled Dynamics and Integrated Control for Position and Attitude Motions of Spacecraft:A Survey

引用

IEEE/CAA Journal of Automatica Sinica 2023年第12期10卷 2187-2208页

作者： feng zhang Guangren Duan the Research and Development Center China Academy of Launch Vehicle TechnologyBeijing 100076China IEEE the Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055 the Center for Control Theory and Guidance Technology Harbin Institute of TechnologyHarbin 150001China

Inspired by the integrated guidance and control design for endo-atmospheric aircraft,the integrated position and attitude control of spacecraft has attracted increasing attention and gradually induced a wide variety of study results in last over two decades,fully incorporating control requirements and actuator characteristics of space *** paper presents a novel and comprehensive survey to the coupled position and attitude motions of spacecraft from the perspective of dynamics and *** this end,a systematic analysis is firstly conducted in details to show the position and attitude mutual couplings of ***,in terms of the time discrepancy between spacecraft position and attitude motions,space missions can be categorized into two types:space proximity operation and space orbital *** on this classification,the studies on the coupled dynamic modeling and the integrated control design for position and attitude motions of spacecraft are sequentially summarized and *** the one hand,various coupled position and dynamic formulations of spacecraft based on various mathematical tools are reviewed and compared from five aspects,including mission applicability,modeling simplicity,physical clearance,information matching and *** the other hand,the development of the integrated position and attitude control of spacecraft is analyzed for two space missions,and especially,five distinctive development trends are captured for space operation ***,insightful prospects on future development of the integrated position and attitude control technology of spacecraft are proposed,pointing out current primary technical issues and possible feasible solutions.

关键词： Coupled position and attitude dynamic modeling integrated position and attitude control position and attitude coupling analysis spacecraft space missions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Existence of Optical Vortex Solitons in Pair Plasmas

引用

Acta Mathematicae Applicatae Sinica 2023年第3期39卷 571-582页

作者： Rui-feng zhang School of Mathematics and Statistics Henan UniversityKaifeng 475004China

Optical vortices arise as phase dislocations of light fields and they are of importance in modern optical *** this study,we employ the calculus of variations method to develop an existence theory for the steady state vortex solutions of a nonlinear Schr?dinger type equation to model light waves that propagate in a medium with a new focusing-defocusing ***,we demonstrate the existence of positive radially symmetric solutions by constrained minimization,where we give some interesting explicit estimates related to vortex winding numbers and the wave propagation ***,we establish the existence of saddle-point solutions through a mountain-pass argument.

关键词： Calculus of variations mountain-pass theorem pair plasmas nonlinear Schr?dinger type equation optical vortices

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solving Low-Density Multiple Subset Sum Problems with SVP Oracle

引用

Journal of Systems Science & Complexity 2016年第1期29卷 228-242页

作者： PAN Yanbin zhang feng Key Laboratory of Mathematics Mechanization NCMISAcademy of Mathematics and Systems ScienceChinese Academy of Sciences

It is well known that almost all subset sum problems with density less than 0.9408… can be solved in polynomial time with an SVP oracle that can find a shortest vector in a special *** this paper,the authors show that a similar result holds for the k-multiple subset sum problem which has k subset sum problems with exactly the same ***,for the single subset sum problem(k=1),a modified lattice is introduced to make the proposed analysis much simpler and the bound for the success probability tighter than ***,some extended versions of the multiple subset sum problem are also considered.

关键词： Lattice low-density multiple modular subset sum problem multiple subset sum problem

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：