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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia deng Nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

A Cross-Multi-Domain Trust Assessment Authority Delegation Method Based on Automotive Industry Chain

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Computers, Materials & Continua 2025年第1期82卷 407-426页

作者： Binyong Li Liangming deng Jie zhang Xianhui deng School of Cybersecurity(Xin Gu Industrial College) Chengdu University of Information TechnologyChengdu610225China Advanced Cryptography and System Security Key Laboratory of Sichuan Province Chengdu610225China SUGON Industrial Control and Security Center Chengdu610225China

To solve the challenges of connecting and coordinating multiple platforms in the automotive industry and to enhance collaboration among different participants,this research focuses on addressing the complex supply relationships in the automotive market,improving data sharing and interactions across various platforms,and achieving more detailed integration of data and *** propose a trust evaluation permission delegation method based on the automotive industry *** proposed method combines smart contracts with trust evaluation mechanisms,dynamically calculating the trust value of users based on the historical behavior of the delegated entity,network environment,and other factors to avoid malicious node attacks during the permission delegation *** also introduce strict control over the cross-domain permission granting and revocation mechanisms to manage the delegation path,prevent information leakage caused by malicious node interception,and effectively protect data integrity and *** analysis shows that this method meets the realtime requirements of collaborative interaction in the automotive industry chain and provides a feasible solution to permission delegation issues in the automotive industry chain,offering dynamic flexibility in authorization and scalability compared to most existing solutions.

关键词： Automotive industry chain cross-domain access block chain delegate authority trust assessment

Isobaric enzymatic assays reveal depth-dependent variation in microbial ectoenzyme activities in the deepest ocean on Earth

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Science China Earth Sciences 2025年第1期68卷 185-194页

作者： Junwei CAO Jiahua WANG Hongge zhang Junhao deng Binbin PAN Jiawang CHEN Li zhang Jiasong FANG College of Oceanography and Ecological Science Shanghai Ocean UniversityShanghai201306China Ocean College Zhejiang UniversityZhoushan316000China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266237China

Microbial ectoenzymes play essential roles in the transformation and mineralization of organic matter in the ***,conventional methods for measuring microbial ectoenzyme activities(MEAs)in the deep ocean under atmospheric conditions can misrepresent the metabolic activities of indigenous microbial *** overcome this limitation,we measured the activities of three microbial ectoenzymes(aminopeptidase,α-glucosidase,andβ-glucosidase)under both atmospheric and in situ pressure conditions in seawater collected using pressure-retaining and non-pressure-retaining samplers in the Challenger Deep,Mariana *** the case of aminopeptidase andα-glucosidase,the highest isobaric MEAs were observed in the surface layer(50 m),followed by those at abyssopelagic depths(4,000–6,000 m)for aminopeptidase,hadal realm(10,903 m)forα-glucosidase,whileβ-glucosidase activity exhibited the highest value at 10,903 ***,the isobaric MEAs in hadal waters were commonly found to be higher than the decompressed counterparts,highlighting the importance of pressure-retaining sampling and isobaric enzymatic *** half-saturation constant(K_(m))showed a general decreasing trend with depth,suggesting that the deep ocean microbes might have adapted to the high-pressure and oligotrophic environment by increasing their ectoenzyme's affinity to ***,particle-free MEAs contribute more to the total MEAs in the deep ocean than particle-associated MEAs,suggesting the significance of cell-associated and dissolved ectoenzymes in ocean *** study provides a foundation for future investigations of MEAs in the ocean and has important implications for understanding the dynamics of microbially mediated biogeochemical cycling in marine ecosystems.

关键词： Pressure-retaining sampling Microbial ectoenzyme activity Deep-sea microbes High pressure Mariana Trench

Propagating subduction initiation of the Caroline Plate at the Mussau Trench

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Science China Earth Sciences 2025年第1期68卷 253-269页

作者： Chun-Feng LI Yongkang deng Tao WU Dongdong DONG Guoliang zhang Jiazheng zhang Yutao LIU Yaqing LI Fugui TANG Lulu zhang Department of Marine Sciences Zhejiang UniversityZhoushan316021China Laboratory of Marine Mineral Resources Laoshan LaboratoryQingdao266237China Key Lab of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao266071China Key Lab of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China Science&Technology on Integrated Information System Lab Institute of SoftwareChinese Academy of SciencesBeijing100190China

New seismic imaging from the Mussau Trench confirms that,under horizontal compression on an oceanic plate boundary,it is within the young and weak oceanic plate that a trench will develop,and it is the young plate,not so long after its birth,that starts to subduct toward the old *** Mesozoic Pacific Plate cannot easily bend,under the joint horizontal compression and vertical gravity pull,even with a pre-existing weak zone in place and with a large age offset across the plate *** bending of the Caroline Plate near the northern end of the Mussau Trench started only after a long-time span of trench migration,and/or after a prolonged transition from initial compression to trench *** contrasting trench deformation and sedimentary accretion between two parallel seismic sections support an evident migration of underthrusting or significant longitudinal heterogeneity along the *** swift transition from underthrusting to non-thrusting can be explained by a counter-clockwise rotation of the Caroline *** miniature accretionary wedges develop even before the subduction initiates imply strong compression and uplifting before the underthrusting can *** of the Caroline Plate have been halted as the Mussau Trench is seismically rather quiet and the Lyra Trough to the east shows relaxational extension.

关键词： Mussau Trench Subduction initiation Seismic reflection Caroline Plate

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COMPrompter: reconceptualized segment anything model with multiprompt network for camouflaged object detection

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Science China(Information Sciences) 2025年第1期68卷 189-203页

作者： Xiaoqin zhang Zhenni YU Li ZHAO deng-Ping FAN Guobao XIAO Zhejiang Province Key Laboratory of Intelligent Informatics for Safety and Emergency Wenzhou University Nankai International Advanced Research Institute (SHENZHEN FUTIAN) College of Computer Science Nankai University School of Computer Science and Technology Tongji University

We rethink the segment anything model(SAM) and propose a novel multiprompt network called COMPrompter for camouflaged object detection(COD). SAM has zero-shot generalization ability beyond other models and can provide an ideal framework for COD. Our network aims to enhance the single prompt strategy in SAM to a multiprompt strategy. To achieve this, we propose an edge gradient extraction module, which generates a mask containing gradient information regarding the boundaries of camouflaged objects. This gradient mask is then used as a novel boundary prompt, enhancing the segmentation process. Thereafter, we design a box-boundary mutual guidance module, which fosters more precise and comprehensive feature extraction via mutual guidance between a boundary prompt and a box prompt. This collaboration enhances the model's ability to accurately detect camouflaged objects. Moreover, we employ the discrete wavelet transform to extract high-frequency features from image embeddings. The high-frequency features serve as a supplementary component to the multiprompt ***, our COMPrompter guides the network to achieve enhanced segmentation results, thereby advancing the development of SAM in terms of COD. Experimental results across COD benchmarks demonstrate that COMPrompter achieves a cutting-edge performance, surpassing the current leading model by an average positive metric of 2.2% in COD10K. In the specific application of COD, the experimental results in polyp segmentation show that our model is superior to top-tier methods as well. The code will be made available at https://***/guobaoxiao/COMPrompter.

关键词： segment anything model camouflaged object detection boundary prompt

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Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao LIURui ZHENG Liang deng Jiahui zhang Wenzheng HUO Jinlu HUANG Li Shanghai Marine Diesel Engine Research Institute Shanghai 201108China National Key Laboratory of Marine Engine Science and Technology Shanghai 201108China Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm)and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC)with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT)imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： dual-orifice nozzle nozzle structure atomization spray flame asymmetry

Impact of human activities on the long-term change and seasonal variability of Ebinur Lake,Northwest China

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Science China Earth Sciences 2025年第2期68卷 473-486页

作者： Haoxin deng qiuhong TANG Zhidong zhang Xingcai LIU Gang ZHAO Shibo CUI Zhiping zhang Shuai SHAO Jianbao LIU Fahu CHEN Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Hydroscience and Engineering Department of Hydraulic EngineeringTsinghua UniversityBeijing 100084China School of Geography Nanjing Normal UniversityNanjing 210023China Group of Alpine Paleoecology and Human Adaptation(ALPHA) State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Inland lakes in arid Central Asia are particularly susceptible to the impact of climate change and human *** Lake,the largest salt inland lake in Xinjiang,Northwest China,has experienced rapid shrinkage,with human activities identified as the primary influencing ***,it remains unclear how human water use in different sectors,such as irrigation,husbandry,and industry,is responsible for the long-term change and seasonal variability of the lake area under changing *** study aims to address this knowledge gap by developing an integrated hydrological-socioeconomic-lake model that simulates the changes in the Ebinur Lake area during the period of 1950–*** simulated lake area changes under different model experiments were then compared with separate the impacts of climate change and human water use of different *** results indicate that climate change,irrigation,husbandry,and industry water uses have contributed+5%,-79%,-25%,and-1%of the long-term change in the lake area,*** climate change alone increasing the lake area,the increase in human water use has resulted in the persistent decline of Ebinur ***,husbandry water use emerges as a significant contributor to lake shrinkage,accounting for approximately one-third of the impact of ***,irrigation water use has contributed to the enhanced seasonal variability,as indicated by the difference between the maximum and minimum monthly lake area in a *** difference has increased from 120 km2in the 1950s to 183 km2in the 2010s.

关键词： Ebinur Lake Climate change Irrigation Seasonal variability Hydrological-socioeconomic-lake model

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Efficient gene disruption in polyploid genome by Cas9–Trex2 fusion protein

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Journal of Integrative Plant Biology 2025年第1期67卷 7-10页

作者： Wenbo Pan Chunlei Gao De Niu Jinghua Cheng Jiao zhang Xiying Yan qiang Long Yao Yao Zhu Wenjing Sun qi Xie Yuehui He Xing Wang deng Huawei zhang Jian Li State Key Laboratory of Wheat Improvement Shandong Laboratory of Advanced Agricultural Sciences in WeifangPeking University Institute of Advanced Agricultural SciencesWeifang 261325China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development Ministry of Education&Guangdong Provincial Key Laboratory of Laser Life ScienceSchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Shenzhen Tidy field System Biotechnology Co. LtdShenzhen 518107China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China

Despite significant advancements in the efficiency of the CRISPR/Cas9 genome editing system over the past decade,performing gene disruption in polyploid crops such as common wheat(Triticum aestivum L.)remains challeng... 详细信息

关键词： CRISPR/Cas9 crops trait

Modeling of Spring Phenology of Boreal Forest by Coupling Machine Learning and Diurnal Temperature Indicators

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Chinese Geographical Science 2025年第1期35卷 38-54页

作者： deng Guorong zhang Hongyan HONG Ying GUO Xiaoyi YI Zhihua EHSAN BINIYAZ School of Hydraulic Engineering Nanchang Institute of TechnologyNanchang 330099China Key Laboratory of Geographical Processes and Ecological Security in Changbai Mountains Ministry of EducationSchool of Geographical SciencesNortheast Normal UniversityChangchun 130024China Urban Remote Sensing Application Innovation Center School of Geographical SciencesNortheast Normal UniversityChangchun 130024China School of Geographical Sciences Inner Mongolia Normal UniversityHohhot 010022China Landscape Ecology and Geoinformation Science Department of GeographyKiel UniversityKiel 24118Germany

The roles of diurnal temperature in providing heat accumulation and chilling requirements for vegetation spring phenology *** previous studies have established a stronger correlation between leaf onset and diurnal temperature than between leaf onset and average temperature,current research on modeling spring phenology based on diurnal temperature indicators remains *** this study,we confirmed the start of the growing season(SOS)sensitivity to diurnal temperature and average temperature in boreal *** estimation of SOS was carried out by employing K-Nearest Neighbor Regression(KNR-TDN)model,Random Forest Regres-sion(RFR-TDN)model,eXtreme Gradient Boosting(XGB-TDN)model and Light Gradient Boosting Machine model(LightGBM-TDN)driven by diurnal temperature indicators during 1982-2015,and the SOS was projected from 2015 to 2100 based on the Coupled Model Intercomparison Project Phase 6(CMIP6)climate scenario *** sensitivity of boreal forest SOS to daytime temperature is greater than that to average temperature and nighttime *** LightGBM-TDN model perform best across all vegetation types,exhibiting the lowest RMSE and bias compared to the KNR-TDN model,RFR-TDN model and XGB-TDN *** incorporating diurn-al temperature indicators instead of relying only on average temperature indicators to simulate spring phenology,an improvement in the accuracy of the model is ***,the preseason accumulated daytime temperature,daytime temperature and snow cover end date emerged as significant drivers of the SOS simulation in the study *** simulation results based on LightGBM-TDN model exhibit a trend of advancing SOS followed by stabilization under future climate *** study underscores the potential of diurn-al temperature indicators as a viable alternative to average temperature indicators in driving spring phenology models,offering a prom-ising new method for simulating spring phenology.

关键词： spring phenology diurnal temperature machine learning future climate scenarios boreal forest