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智能可穿戴设备BPMpathway在全膝关节置换术后患者居家康复中的应用效果

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上海交通大学学报（医学版） 2024年第3期44卷 342-349页

作者：洪洋王洁张霞芬赵丹程敏苏州大学附属第四医院(苏州市独墅湖医院)护理部苏州215125 苏州大学附属第四医院(苏州市独墅湖医院)骨科苏州215125 苏州大学附属第一医院骨科苏州215006

目的·评价基于智能可穿戴设备BPMpathway的居家康复方案在全膝关节置换(total knee arthroplasty,TKA)术后患者中的应用效果。方法·采用方便抽样法,选取苏州大学附属第四医院(苏州市独墅湖医院)和苏州大学附属第一医院骨科2021年4月—... 详细信息

目的·评价基于智能可穿戴设备BPMpathway的居家康复方案在全膝关节置换(total knee arthroplasty,TKA)术后患者中的应用效果。方法·采用方便抽样法,选取苏州大学附属第四医院(苏州市独墅湖医院)和苏州大学附属第一医院骨科2021年4月—2022年12月收治的膝关节骨关节炎并接受TKA术的患者作为研究对象。按照患者入院顺序,将住院号尾数为奇数的患者纳入对照组,住院号尾数为偶数的患者纳入干预组。对照组患者给予常规居家康复训练方案,干预组在对照组的基础上实施基于BPMpathway的远程居家康复训练方案。分别于基线及术后1、3、6个月采用骨科患者功能锻炼依从性量表、美国特种外科医院膝关节评分表(Hospital for Special Surgery Scale,HSS)和36项简明健康状况调查表(36-item Short Form Health Survey,SF-36)对2组患者进行测评,同时测量患者的膝关节活动度。结果·最终纳入110例患者,其中对照组56例,干预组54例。2组患者的一般资料差异无统计学意义。2组患者基线时的膝关节活动度、HSS评分、SF-36评分差异均无统计学意义。重复测量方差分析结果显示:2组患者膝关节活动度、功能锻炼依从性评分、HSS评分及SF-36评分的组间效应、时间效应及交互效应均具有统计学意义(均P1、3、6个月干预组的膝关节活动度、功能锻炼依从性评分、HSS评分及SF-36评分均高于对照组(均P<0.05)。结论·医护人员基于智能可穿戴设备BPMpathway开展的远程康复训练方案,有助于提高TKA术后患者居家康复期间功能锻炼的依从性,改善膝关节活动度,促使膝关节功能恢复,提高其生存质量,对患者预后具有积极的作用。

关键词：膝关节置换术骨关节炎可穿戴设备 BPMpathway 远程康复

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软土地区注浆成型螺纹桩抗拔承载力的计算

岩土力学 2015年第S1期36卷 334-340页

作者：赵赟张陈蓉凌巧龙黄茂松胡玉银同济大学地下建筑与工程系上海200092 同济大学岩土及地下工程教育部重点实验室上海200092 上海建工集团股份有限公司上海200080

注浆成型螺纹桩采用后注浆技术形成桩侧螺纹,有利于在软土地区施工,目前已开始应用。基于螺纹桩上拔过程中螺牙附近土体的应力条件改变,采用摩尔应力圆分析螺牙附近破坏滑裂面的开展,得到了螺牙间距与螺牙突出尺寸的比值与滑裂面展开角... 详细信息

注浆成型螺纹桩采用后注浆技术形成桩侧螺纹,有利于在软土地区施工,目前已开始应用。基于螺纹桩上拔过程中螺牙附近土体的应力条件改变,采用摩尔应力圆分析螺牙附近破坏滑裂面的开展,得到了螺牙间距与螺牙突出尺寸的比值与滑裂面展开角之间的关系,给出了螺牙间土体从圆柱形滑裂面破坏向圆台形滑裂面破坏的判别条件。根据滑裂面的开展,将螺纹桩的抗拔承载力计算分为3种情况,采用极限平衡法得到了相应的螺纹桩抗拔承载力计算公式。最后,通过与有限元数值模拟以及实际工程算例对比,验证了文中方法的合理性。

关键词：螺纹桩抗拔承载力摩尔应力圆滑裂面

黄河下游平面二维非恒定输沙数学模型：Ⅱ—模型验证

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水动力学研究与进展（A辑） 2003年第5期18卷 647-651页

作者：黄远东张红武赵连军江恩惠上海理工大学城建学院上海200093 清华大学水利系北京100084 黄河水利委员会黄河水利科学研究院河南郑州450003

采用黄河下游1982年洪水资料，选取花园口至夹河滩河段为计算区域，对所建模型进行了验证计算，结果表明本模型计算的洪峰传播过程，水位变化过程及含沙量变化过程等均与实测结果接近，流速场、主流线等也较符合实际。从而证明了所建立... 详细信息

采用黄河下游1982年洪水资料，选取花园口至夹河滩河段为计算区域，对所建模型进行了验证计算，结果表明本模型计算的洪峰传播过程，水位变化过程及含沙量变化过程等均与实测结果接近，流速场、主流线等也较符合实际。从而证明了所建立起的平面二维非恒定输沙数学模型与相应的数值计算方法能够模拟黄河下游河道水沙演进过程及河床冲淤变形规律。

关键词：黄河下游平面二维非恒定输沙数学模型模型验证洪水河流挟沙

柴油在超声波/Cu^(2+)/H_2O_2中的氧化脱硫

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燃料化学学报 2007年第2期35卷 188-191页

作者：戴咏川亓玉台赵德智张会成哈尔滨工业大学黑龙江哈尔滨115001 辽宁石油化工大学辽宁抚顺113001 华东理工大学上海200237

为了实现生产低硫柴油和超低硫柴油的目标,以超声波为外加能源,构筑超声波/类Fenton试剂的柴油氧化脱硫反应体系,考察了水相pH值和超声功率这两个参数对柴油氧化脱硫效果的影响。实验结果表明,当类Fenton试剂的水相pH值为2.00左右时,其... 详细信息

为了实现生产低硫柴油和超低硫柴油的目标,以超声波为外加能源,构筑超声波/类Fenton试剂的柴油氧化脱硫反应体系,考察了水相pH值和超声功率这两个参数对柴油氧化脱硫效果的影响。实验结果表明,当类Fenton试剂的水相pH值为2.00左右时,其脱硫效果较好;无超声波下H2O2、类Fenton试剂、超声波/H2O2及超声波/类Fenton试剂的柴油氧化脱硫反应符合表观一级反应动力学规律。超声波功率的提高对氧化脱硫有明显的促进作用,这主要是由于功率的增加,有助于加速空穴的形成与内爆,从而促进反应的进行。

关键词：超声波柴油氧化脱硫类Fenton试剂

Comparative Fasting Bioavailability of Two Letrozole 2.5-mg Tablets in Healthy Chinese Postmenopausal Women:An Open-Label,Randomized-Sequence,Single-Dose,Two-Way Crossover study

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Comparative Fasting Bioavailability of Two Letrozole 2.5-mg ...

Pressure Distinguishes the Dual Emissions in Pseudohalide 2D Ruddlesden-Popper Perovskite Cs_(2)Pb(SCN)_(2)Br_(2)

第十三次全国临床药理学学术大会

作者： Yi Liu,MS~1 Yifan zhang,PhD~2 Qian wang,MS~1 Wei Yang,MS~1 Xiaoyan Chen,PhD~2 Shan Jing,MD~1 Libo zhao,PhD~1 Lihui Wei,MD~3 Xiaoping Li,MD~3 Wanyu Feng,PhD~1 Dafang Zhong,PhD~2 and Yi Fang,PhD~1 1 department of Pharmacy,Peking university People’s Hospital,Beijing,100044,People’s Republic of china 2 shanghai Institute of Materia Medica,Chinese Academy of Sciences,shanghai,201203,People’s Republic of china 3 department of Gynecology,Peking university People’s Hospital,Beijing,100044,People’s Republic of china

Background:Letrozole is an orally active aromatase inhibitor indicated for the treatment of postmenopausal women with breast *** the bioavailability and pharmacokinetic(PK) properties of letrozole have been examined in western populations and healthy Chinese men,a literature search did not identify any reports concerning the bioavailability and PK properties of letrozole in a population of healthy Chinese postmenopausal women. Objective:The study was designed to assess and compare the PK properties and bioequivalence of two 2.5-mg tablets of letrozole:the newly developed generic formulation(test) and a branded formulation(reference) in healthy Chinese postmenopausal women. Methods:A single-dose,randomized,open-label,two-way crossover study was conducted in healthy Chinese postmenopausal women under fasting *** participants were randomly assigned to receive 1 tablet(2.5 mg each) of the test or reference formulation,followed by a 21-day washout period and administration of the alternate *** samples were collected before dosing and at 0.25,0.50,0.75, 1.00,1.25,1.50,2.00,2.50,3.00,3.50,4.00,6.00,8.00,12.00,24.00,48.00,72.00,96.00,144.00,192.00 and 240.00 hours after *** concentrations of letrozole were analyzed with a LC-MS/MS *** safety profile was evaluated by recording adverse events(AEs),assessed using physical examination,vital signs, spontaneous reporting,and clinical laboratory *** two formulations were considered bioequivalent if the 90%CIs for the In-transformed rations of C and AUC values were within the predetermined equivalence range (80%-125%). Results:A total of 30 healthy Chinese postmenopausal women were enrolled in this study;however,only the data from 29 subjects were included(mean[SD]age,54.9[4.7]years;weight,56.4[4.6]kg;height,158.7[4.8] cm;BMI,22.4[1.4]kg/m) in the PK and bioequivalence assessments due to serious adverse events(SAEs) occurred in one *** 90%CIs for the In-tra

关键词： Letrozole bioequivalence pharmacokinetics LC-MS/MS Chinese postmenopausal women

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CCS Chemistry 2024年第7期6卷 1748-1756页

作者： Songhao Guo Yuhong Mao Congcong Chen Yao zhang Guoxiang zhao Kejun Bu Qingyang Hu Haiming Zhu Guifu Zou Wenge Yang Lingling Mao Xujie Lü Center for High Pressure Science and Technology Advanced Research(HPSTAR) Shanghai department of Chemistry Southern University of Science and TechnologyShenzhen department of Chemistry Zhejiang UniversityHangzhou College of Energy Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou

Two-dimensional(2D)Ruddlesden-Popper(RP)halide perovskites with diverse structures and properties have drawn increasing attention due to their promising optoelectronic ***,a new all-inorganic Cs_(2)Pb(SCN)_(2)Br_(2) has been reported that opens up new potential for the development of 2D RP ***,recent reports of unusual dual emissions and two-edge absorption in Cs_(2)Pb(SCN)_(2)Br_(2) have generated intense debate about its origin and remains ***,by combining continuous pressure tuning with in situ diagnostics,we have unambiguously revealed the underlying mechanisms that the 2D Cs_(2)Pb(SCN)_(2)Br_(2) exhibits an intrinsic blue emission at 2.66 eV and an absorption edge close to the emission *** the gradually formed CsPbBr_(3) is responsible for the green emission at 2.33 eV with the absorption shoulder at 2.41 ***,by fitting the temperature-dependent intensity of the intrinsic blue emission,we have determined the corrected value of exciton binding energy for 2D Cs_(2)Pb(SCN)_(2)Br_(2) to be 90 ***,an emission enhancement of 2.5 times is achieved in Cs_(2)Pb(SCN)_(2)Br_(2) under a mild pressure within 0.8 GPa,caused by the pressuresuppressed exciton-phonon *** work not only elucidates the origin of the dual emissions and two-edge absorption in Cs_(2)Pb(SCN)_(2)Br_(2),but it also provides a potential means to regulate and optimize the optoelectronic properties of 2D perovskites.

关键词： two-dimensional perovskite dual emissions two-edge absorption high pressure in situ characterization enhanced photoluminescence

Long non-coding RNA high expressed in hepatocellular carcinoma(IncRNA-HEIH) facilitates tumor growth through enhancer of zeste homolog 2

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Long non-coding RNA high expressed in hepatocellular carcino...

遗传学进步促进粮食安全与人口健康高峰论坛

作者： Fu Yang1,Ling zhang1,Xi-song Huo1,Ji-hang Yuan1,Dan Xu1,Sheng-xian Yuan2,Nan Zhu3,Wei-ping Zhou2,Guang-shun Yang3,Yu-zhao wang1,Jing-li Shang1,Chun-fang Gao4,Feng-rui zhang5,Fang wang1,Shu-han Sun1 department of Medical Genetics,Second Military Medical university,shanghai,china 2 The Third department of Hepatic Surgery,Eastern Hepatobiliary Hospital,Second Military Medical university,shanghai,china 3 The Second department of Hepatic Surgery,Eastern Hepatobiliary Hospital,Second Military Medical university, shanghai,china 4 department of Laboratory Medicine,Eastern Hepatobiliary Hospital,Second Military Medical university,shanghai,china 5 department of Hepatobiliary Surgery,Hebei Cancer Hospital,Hebei Medical university,Hebei,china.

Hepatocellular carcinoma(HCC) is one of the most common human cancers worldwide, particularly in Southeast Asia and *** than 70-80%of HCC cases occur in high hepatitis B virus(HBV) endemic regions,and 50%of HCC cases worldwide are attributable to chronic infection with ***,the 5-year survival rate of HBV-related HCC patients remains poor,and approximately 600,000 HCC patients die each year despite recent advances in surgical techniques and medical *** previous studies identified many aberrantly expressed protein-coding genes in HCC,novel molecular markers that can help in early diagnosis and risk assessment are still urgently *** is of paramount importance to understand the relationships between clinical symptoms and molecular changes in HCC for developing new diagnosis and treatment strategies for HCC and improving the prognosis of diagnosed patients. The human transcriptome comprises not only large numbers of protein-coding messenger RNAs(mRNAs) but also a large set of non-protein coding transcripts that have structural,regulatory or unknown *** studies of small non-coding RNAs(18 to 200 nucleotides(nt)) have dominated the field of RNA biology in recent years,a surprisingly wide array of cellular functions has also been associated with long non-coding RNAs(IncRNAs).IncRNAs,tentatively defined as non-coding RNAs more than 200 nt in length,are characterized by the complexity and diversity of their sequences and mechanisms of action.A handful of studies have implicated IncRNAs in a variety of disease states,and altered IncRNA levels can result in aberrant expression of gene products that may contribute to cancer ***,there are only preliminary studies on the role of IncRNAs in HCC,and the overall pathophysiological contributions of IncRNAs to HCC remain largely unknown. In this study,we have identified non-overlapping signatures of a small number of IncRNAs that are aberrantly expressed in human HBV

关键词： hepatocellular carcinoma noncoding RNAs PRC2 IncRNAs cell cycle

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高压沼气对浅部砂质粉土工程性质的影响

同济大学学报（自然科学版） 2004年第10期32卷 1316-1319页

作者：唐益群刘冰洋赵书凯黄雨同济大学地下建筑与工程系上海200092

以长江口越江通道的盾构法施工隧道工程为背景 ,结合非饱和土双变量强度理论 ,研究在越江通道 (隧道 )施工过程中遇到的浅层 (砂性土层 )高压沼气地质灾害问题 .试验采用GDS系统 (geotechnicaldigitalsystems,岩土数字系统 ) ,进行非饱... 详细信息

以长江口越江通道的盾构法施工隧道工程为背景 ,结合非饱和土双变量强度理论 ,研究在越江通道 (隧道 )施工过程中遇到的浅层 (砂性土层 )高压沼气地质灾害问题 .试验采用GDS系统 (geotechnicaldigitalsystems,岩土数字系统 ) ,进行非饱和土三轴试验 ,模拟含高压沼气地层中气体的分带特征与高压沼气释放后气压力的变化对土体强度的影响 ,以及沼气释放后破坏轴应力的变化 .实验结果表明砂性土土体强度随着气体压力的升高而升高 ,到达某一气压时 ,强度达到峰值 ,然后土体强度随气压升高而下降 ,土体具有很强的流动性 .同时研究了高压沼气从砂性土层中缓慢释放和强烈喷发这

关键词：高压沼气地层非饱和土双变量强度理论岩土数字系统

人前列腺特异膜抗原膜外区基因的克隆表达及抗体的制备

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生物工程学报 2002年第1期18卷 35-39页

作者：叶传忠赵旭东张芳林林震许明张永康陈常庆复旦大学附属中山医院泌尿外科上海200032 中国科学院上海生物工程研究中心上海200042 上海第二医科大学附属瑞金医院上海内分泌研究所上海200025 福建医科大学附属协和医院泌尿外科福州350001

利用RT PCR技术 ,从前列腺癌组织总RNA中扩增人前列腺特异膜抗原 (PSMA)基因编码区序列 ,克隆至pcDNA3.1载体 ,以此为模板再次PCR扩增出PSMA膜外区cDNA(edPSMA) ,序列测定表明克隆获得的PSMA及edPSMA与基因库所登录的序列相一致。构建... 详细信息

利用RT PCR技术 ,从前列腺癌组织总RNA中扩增人前列腺特异膜抗原 (PSMA)基因编码区序列 ,克隆至pcDNA3.1载体 ,以此为模板再次PCR扩增出PSMA膜外区cDNA(edPSMA) ,序列测定表明克隆获得的PSMA及edPSMA与基因库所登录的序列相一致。构建原核表达质粒pMAL c2x edPSMA ,经IPTG诱导表达的MBP edPSMA融合蛋白分子量约 12 0kD ,Westernblot证实表达产物可特异地与PSMA单克隆抗体 4G5结合。用直链淀粉琼脂糖凝胶 (Amyloseresin)亲和层析纯化蛋白质可得到电泳均一的融合蛋白 ,免疫BALB C小鼠制备多抗 ,获得效价为 1∶12 80 0的多克隆抗体。

关键词：人前列腺特异膜抗原膜外区抗体制备原核表达亲和层析基因克隆前列腺癌