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MK-801 differentially alters the expression of mBDNF and proBDNF in the hippocampus of corticosterone-treated rats

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MK-801 differentially alters the expression of mBDNF and pro...

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：李建国 Ying Wang Na Ma Jing Chen Yu zhang ce zhang Key Laboratory of cellular Physiology Ministry of Educationand Department of PhysiologyShanxi Medical University

Background: NMDAR(N-methyl-D-aspartate receptor) uncompetitive antagonist dizocilpine(MK-801) produces antidepressant effects via the brain-derived neurotrophic factor(BDNF).However, the mechanism of MK-801-induced BDNF expression is ***: Corticosterone(CORT) was orally administrated to induce depressive-like behavior in SD *** the elevated plus maze test, sucrose preference test, open field test, and forced swimming test to observe the depressive-like *** Western blotting to analyze the expression of mature BDNF(mBDNF) and precursor(proBDNF).Results: Chronic administration of CORT induced depressive-like behaviors in rats and acute administration of MK-801 attenuated the depressive-like ***-801 increased the expression of mBDNF and decreased the expression of proBDNF in the ventral and dorsal hippocampal DG of ***, acute administration of deacetylases antagonist Suberoylanilide hydroxamic acid(SAHA) increased the mBDNF expression, decreased the proBDNF expression, and attenuated depressive-like behaviors in CORT-treated ***,SAHA treatment after MK-801 showed no more mBDNF expression and no less proBDNF expression in hippocampal ***: Our findings suggest that the antidepressant effects of MK-801 may be associated with the increased mBDNF expression and decreased proBDNF expression via histone acetylation in hippocampal *** mBDNF and proBDNF may provide new targets for antidepressant therapy.

关键词： MK-801 mature BDNF proBDNF depression hippocampus

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计入内齿板变形的环式减速器弹性动力分析

机械工程学报 2006年第9期42卷 29-32页

作者：宋轶民张俊张永新张策天津大学机械工程学院天津300032

环式减速器是一类新型的少齿差行星传动装置,具有传动比大、承载能力高、结构紧凑、制造成本低和适应性广等诸多优点。为改善系统的动力学性能,建立了环式减速器的弹性动力学方程,计入了高速轴、内齿板、啮合轮齿及轴承等的弹性变形。利... 详细信息

环式减速器是一类新型的少齿差行星传动装置,具有传动比大、承载能力高、结构紧凑、制造成本低和适应性广等诸多优点。为改善系统的动力学性能,建立了环式减速器的弹性动力学方程,计入了高速轴、内齿板、啮合轮齿及轴承等的弹性变形。利用ANSYS软件创建了内齿板的有限元模型,以具有等效刚度的弹簧约束内齿板的刚体运动,求解了一个机构运动周期内各相内齿板的应力、位移与弹性变形。将基于ANSYS的内齿板有限元分析与环式减速器的弹性动力分析相结合,经迭代计算,揭示了系统中各零部件的真实受力情况。研究表明,内齿板的拉压变形与弯曲变形均对环式减速器的动力学性能具有重要影响,内齿板的弹性变形将导致行星轴承的实际使用寿命低于预期的设计寿命。

关键词：环式减速器内齿板有限元分析弹性动力分析

双子季铵盐改善聚羧酸减水剂对黏土的敏感性能

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建筑材料学报 2019年第1期22卷 81-86页

作者：张光华王爽张策崔鸿跃陕西科技大学陕西省轻化工助剂重点实验室陕西西安710021 陕西科技大学陕西省轻化工助剂化学与技术协同创新中心陕西西安710021 山西省运城市泓翔建材有限公司山西运城044000

针对黏土对含聚羧酸系减水剂水泥浆体流变性能的负面影响,以三乙胺分别与1,4-二溴丁烷、1,5-二溴戊烷和对二溴苄反应合成了3种阳离子双子季铵盐(分别标记为KN1,KN2和KN3),并将其与聚羧酸盐减水剂RS-1复配.KN1,KN2和KN3的分子结构采用傅... 详细信息

针对黏土对含聚羧酸系减水剂水泥浆体流变性能的负面影响,以三乙胺分别与1,4-二溴丁烷、1,5-二溴戊烷和对二溴苄反应合成了3种阳离子双子季铵盐(分别标记为KN1,KN2和KN3),并将其与聚羧酸盐减水剂RS-1复配.KN1,KN2和KN3的分子结构采用傅里叶红外光谱(FTIR)和核磁共振氢谱(~1H NMR)测试和证实.双子季铵盐和减水剂复配体系的抗泥效果通过测定水泥净浆流动度进行评价.同时,综合运用X射线衍射(XRD)、水接触角和总有机碳(TOC)等表征手段,考察了双子季铵盐和减水剂复配体系对水泥分散、亲疏水性和吸附性能的影响.结果表明:当蒙脱土的含量为3%(质量分数)时,KN1,KN2和KN3均可显著提高水泥净浆的流动度,并能保持良好的稳定性,且KN3表现出更优异的抗泥性能.

关键词：双子季铵盐聚羧酸系减水剂蒙脱土抗泥

The signal pathway of SIRT1 underlying the neuroprotection in NMDA-induced excitotoxicity

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The signal pathway of SIRT1 underlying the neuroprotection i...

中国神经科学学会第十届全国学术会议

作者： Xue-Fei SUN Pei-Pei SI Yu zhang Xiao-Rong YANG ce zhang Department of Physiology Shanxi Medical University

Objective The silent information regulator the factor 2 enzyme 1(silent information regulator 2 homolog 1,SIRT1) is one of the members of the Sirtuin family,widely presents in mammalian *** recent years,people have paid more and more attention on the neuroprotective effect of *** researches have suggested that many factors can regulate SIRT1 ***,specific intracellular signaling mechanism does not *** The study was divided into three *** NMDA-induced Excitotoxicity cell model,apphed to Gene silencing technology,Genetic mutations,Western blotting(WB),Real Time PCR,immunoprecipitation(IP),the enzyme activity detection experiments and so on to observe(1) the effects of HuR phosphorylation to SIRT1 in NMDA-induced Excitotoxicity,(2) the effects of PKC kinase activity to HuR in NMDA-induced Excitotoxicity,(3) the effects of influx of Ca to PKC kinase activity in NMDA-induced *** In NMDA-induced excitotoxicity cell model,NMDA induces extracellular Ca influx,intracellular increased Ca activates PKC,activation of PKC phosphorylates HuR,the phosphorylated HuR with SIRT1 mRNA combines reduces,so that SIRT1 mRNA decreases stability,SITR1downregulates,causing cell damages and even to *** Ca-PKC-HuR-SIRTl pathway may be the access to regulating SIRT1 function in neurons.

关键词： NMDA excitatory neurotoxicity SIRT1 neuroprotection signaling pathways

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双子季铵盐对聚羧酸减水剂抗泥性能的影响

硅酸盐学报 2019年第2期47卷 178-183页

作者：张光华王爽张策崔鸿跃陕西科技大学陕西省轻化工助剂重点实验室西安710021 陕西科技大学陕西省轻化工助剂化学与技术协同创新中心西安710021 山西省运城市泓翔建材有限公司山西运城044000

针对含泥量对水泥浆体的负面影响,以三甲胺(或三乙胺)与1, 3-二溴丙烷作为反应物,通过季铵化反应制备出短链双子季铵盐抗泥剂(三甲胺型标记为G-KN1,三乙胺型标记为G-KN2),将其与聚羧酸盐减水剂RS-1复配以增强水泥浆体的抗泥效果。抗泥剂... 详细信息

针对含泥量对水泥浆体的负面影响,以三甲胺(或三乙胺)与1, 3-二溴丙烷作为反应物,通过季铵化反应制备出短链双子季铵盐抗泥剂(三甲胺型标记为G-KN1,三乙胺型标记为G-KN2),将其与聚羧酸盐减水剂RS-1复配以增强水泥浆体的抗泥效果。抗泥剂G-KN1和G-KN2的分子结构采用FT-IR和1H NMR进行测定。抗泥剂和减水剂复配体系的抗泥效果通过测定水泥净浆流动度进行评价。同时,综合运用X射线衍射和总有机碳(TOC)表征手段,考察了抗泥剂和减水剂复配体系对水泥分散和吸附性能的影响。结果表明,当蒙脱土的含量为2%或3%时,G-KN1和G-KN2的加入均可明显提高水泥的净浆流动度,并能保持良好的稳定性,且G-KN2表现出更优异的抗泥性能。

关键词：双子季铵盐聚羧酸减水剂抗泥剂蒙脱土抗泥性能

新时代背景下新媒体融入高校思想政治教育的价值、原则及路径

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国家教育行政学院学报 2020年第8期 60-65页

作者：张策张耀元山西大同大学山西大同037009

新媒体融入思想政治教育工作是新时代高校思想政治教育工作“因时而进、因势而新”的重要举措。新媒体融入高校思想政治教育工作,有助于高校思想政治教育工作“活起来”,有助于高校“三全育人”工作机制的完善,有助于高校思想政治教育... 详细信息

新媒体融入思想政治教育工作是新时代高校思想政治教育工作“因时而进、因势而新”的重要举措。新媒体融入高校思想政治教育工作,有助于高校思想政治教育工作“活起来”,有助于高校“三全育人”工作机制的完善,有助于高校思想政治教育的个体化开展。新媒体服务于高校思想政治教育,要始终坚持以育“时代新人”为根本指向,要契合新媒体传播的规律和特点,要坚持体系化、系统化的思政育人原则,要积极打造线上教学与线下育人双向融合的“智慧课堂”,建立健全高校“三全育人”的“智慧平台”,打造具有时代气息的“智慧团建”,从而全面提升校园新媒体平台的服务力、吸引力和黏合度,充分发挥出新媒体平台对高校思想政治教育工作的促进作用。

关键词：新媒体高校思想政治教育

Prognostic Values of Serum Chloride and Sodium Levels in Patients with Three-vessel Disease

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Biomedical and Environmental Sciences 2019年第4期32卷 250-259页

作者： zhang ce WANG Dong HOU Bing Jie JIANG Lin XU Lian Jun TIAN Jian ZHAO Yan Yan ZHAO Xue Yan FENG Xin Xing zhang Yin SUN Kai XU Bo ZHAO Wei HUI Ru Tai GAO Run Lin LOU Hui Ling YUAN Jin Qing SONG Lei Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Internal Medicine The People's Hospital of Tang County Medical Research & Biometrics center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Endocrinology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Information center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Department of Geriatrics Guangzhou First People's HospitalSchool of MedicineSouth China University of Technology

Objective Identification of new risk factors is needed to improve prediction of adverse outcomes in patients with three-vessel disease(TVD). The present study aimed to evaluate the prognostic values of serum chloride and sodium levels in patients with TVD. Methods We used data from a prospective cohort of consecutive patients with angiographically confirmed TVD. The primary endpoint was all-cause death. Cox proportional hazard regression was used to analyze the relationship of serum chloride and sodium levels with long-term outcomes of TVD patients. Results A total of 8,318 participants with available serum chloride and sodium data were included in this analysis. At baseline, patients in the low tertiles group of serum chloride level(≤ 102.0 mmol/L) or serum sodium level(≤ 139.0 mmol/L) had more severe disease conditions. During a median follow-up of 7.5-year, both low serum chloride level and low serum sodium level were found to be associated with an increased risk for mortality in univariate analysis. However, when both parameters were incorporated into a multivariate model, only low serum sodium level remained to be an independent predictor of all-cause death(hazard ratio: 1.16, 95% confidence interval: 1.01-1.34, P = 0.041). Modest but significant improvement of discrimination was observed after incorporating serum sodium level into the Synergy between percutaneous coronary intervention(PCI) with Taxus and Cardiac Surgery score. Conclusion Serum sodium level is more strongly associated with long-term outcomes of TVD patients compared with serum chloride level. Low serum sodium level is an independent risk factor for mortality, but only provides modest prognostic information beyond an established risk model.

关键词： Coronary disease Prognosis Biomarkers

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基于结构属性的乌金体藏文古籍字符切分

激光与光电子学进展 2021年第20期58卷 252-267页

作者：张策王维兰西北民族大学中国民族语言文字信息技术教育部重点实验室甘肃兰州730030 重庆第二师范学院数学与信息工程学院重庆400065

字符切分是藏文古籍文档图像分析与识别中重要的一环,针对乌金体藏文古籍文本行倾斜,字符之间笔画交叠、交叉、粘连以及不同程度的笔画断裂、噪声干扰等问题,提出了一种基于结构属性的乌金体藏文字符切分方法。首先,建立了乌金体藏文古... 详细信息

字符切分是藏文古籍文档图像分析与识别中重要的一环,针对乌金体藏文古籍文本行倾斜,字符之间笔画交叠、交叉、粘连以及不同程度的笔画断裂、噪声干扰等问题,提出了一种基于结构属性的乌金体藏文字符切分方法。首先,建立了乌金体藏文古籍字符区块库。然后,利用音节点位置信息或结合水平投影与直线检测的方法检测出字符区块的局部基线,并根据基线将字符区块切分为上下两部分;利用改进的模板匹配算法检测基线上方笔画的粘连及其类型,利用多方向、多路径粘连切分算法切分交叉、粘连笔画。最后,根据藏文结构属性对各笔画进行归属,完成字符切分。实验结果表明,本方法能有效解决字符切分中遇到的问题,字符切分的召回率、精确率以及F-Measure可分别达到96.52%、98.24%、97.37%。

关键词：图像处理藏文古籍文档字符区块局部基线粘连检测与切分笔画归属

Using machine learning to aid treatment decision and risk assessment for severe three-vessel coronary artery disease

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Journal of Geriatric Cardiology 2022年第5期19卷 367-376页

作者： Liu JIE Xin-Xing FENG Yan-Feng DUAN Jun-Hao LIU ce zhang Lin JIANG Lian-Jun XU Jian TIAN Xue-Yan ZHAO Yin zhang Kai SUN Bo XU Wei ZHAO Ru-Tai HUI Run-Lin GAO Ji-Zheng WANG Jin-Qing YUAN Xin HUANG Lei SONG State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Endocrinology and Cardiovascular Disease centre Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Endocrinology Fuwai HospitalChinese Academy of Medical SciencesShenzhenChina Nanjing TooBoo Technology Co. Ltd.NanjingChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiomyopathy Ward Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Information center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research center for Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Solar activity Prediction center National Astronomical ObservatoriesChinese Academy of SciencesBeijingChina

BACKGROUND Three-vessel disease(TVD)with a SYNergy between PCI with TAXus and cardiac surgery(SYNTAX)score of≥23 is one of the most severe types of coronary artery *** aimed to take advantage of machine learning to help in de-cision-making and prognostic evaluation in such *** We analyzed 3786 patients who had TVD with a SYNTAX score of≥23,had no history of previous revascularization,and underwent either coronary artery bypass grafting(CABG)or percutaneous coronary intervention(PCI)after *** patients were randomly assigned to a training group and testing *** C4.5 decision tree algorithm was applied in the training group,and all-cause death after a median follow-up of 6.6 years was regarded as the class *** The decision tree algorithm selected age and left ventricular end-diastolic diameter(LVEDD)as splitting features and divided the patients into three subgroups:subgroup 1(age of≤67 years and LVEDD of≤53 mm),subgroup 2(age of≤67 years and LVEDD of>53 mm),and subgroup 3(age of>67 years).PCI conferred a patient survival benefit over CABG in sub-group *** was no significant difference in the risk of all-cause death between PCI and CABG in subgroup 1 and subgroup 3 in both the training data and testing *** the total study population,the multivariable analysis revealed significant dif-ferences in the risk of all-cause death among patients in three *** The combination of age and LVEDD identified by machine learning can contribute to decision-making and risk assessment of death in patients with severe *** present results suggest that PCI is a better choice for young patients with severe TVD characterized by left ventricular dilation.

关键词： coronary testing treatment