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红花黄色素对糖尿病小鼠足溃疡创面愈合的影响及机制

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新乡医学院学报 2024年第5期41卷 412-418页

作者：张杰刘自新贾炳学张爱新张卓北京市平谷区医院急诊科北京101200

目的探讨红花黄色素(SY)对糖尿病小鼠足溃疡(DFU)创面愈合的影响及分子机制。方法取45只C57BL/6小鼠腹腔注射链脲佐菌素建立糖尿病模型。将糖尿病小鼠随机分为假手术组、模型组、低剂量SY干预组、高剂量SY干预组及高剂量SY联合胰岛素样... 详细信息

目的探讨红花黄色素(SY)对糖尿病小鼠足溃疡(DFU)创面愈合的影响及分子机制。方法取45只C57BL/6小鼠腹腔注射链脲佐菌素建立糖尿病模型。将糖尿病小鼠随机分为假手术组、模型组、低剂量SY干预组、高剂量SY干预组及高剂量SY联合胰岛素样生长因子-1(IGF-1)组,每组9只。DFU模型制备前,模型组小鼠不给予干预处理,低剂量SY干预组和高剂量SY干预组分别腹腔注射5、20 mg·kg^(-1)SY,高剂量SY联合IGF-1组腹腔注射20 mg·kg^(-1)SY和0.03 mg·kg^(-1)IGF-1。除假手术组外,其余4组小鼠通过切开足背部皮肤制备DFU模型;假手术组不制作足背部皮肤伤口,余手术步骤与模型组一致。于造模后第14天,用电子秤测量各组小鼠的体质量,采集尾静脉血测定空腹血糖,并使用小型游标卡尺测量创面宽度,然后处死小鼠收集创面组织,采用苏木精-伊红染色检测各组小鼠创面组织病理学变化,反转录-实时荧光定量聚合酶链反应检测各组小鼠创面组织中血小板衍生生长因子(PDGF)、血管内皮生长因子(VEGF)、α-平滑肌肌动蛋白(α-SMA)和I型胶原蛋白(collagen I)、蛋白酪氨酸磷酸酶1B(PTP1B)、晚期糖基化终产物(AGEs)mRNA的相对表达量,蛋白质印迹法检测各组小鼠创面组织中增殖标志物Ki-67、增殖细胞核抗原(PCNA)、凋亡相关蛋白(caspase-3、caspase-6、caspase-7)、p85磷脂酰肌醇-3-激酶(PI3K)和磷酸化蛋白激酶B(p-AKT)蛋白的相对表达量,酶联免疫吸附试验检测各组小鼠创面组织中肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β及IL-6水平。结果假手术组、模型组、低剂量SY干预组、高剂量SY干预组及高剂量SY联合IGF-1组小鼠血糖和体质量比较差异均无统计学意义(P>0.05)。高剂量SY干预组小鼠创面组织愈合率显著大于模型组、低剂量SY干预组及高剂量SY联合IGF-1组(P0.05)。高剂量SY干预组小鼠创面组织中出现大量胶原纤维密集有序排列,并伴有大量新生血管;模型组、低剂量SY干预组及高剂量SY联合IGF-1组小鼠创面组织中胶原纤维稀疏,并伴有少量新生血管。高剂量SY干预组小鼠创面组织中PDGF、VEGF、α-SMA及collagen I mRNA相对表达量显著高于模型组、低剂量SY干预组、高剂量SY联合IGF-1组(P0.05)。高剂量SY干预组小鼠创面组织中Ki-67和PCNA蛋白相对表达量显著高于模型组、低剂量SY干预组、高剂量SY联合IGF-1组(P0.05)。高剂量SY干预组小鼠创面组织中TNF-α、IL-1β及IL-6水平显著低于模型组、低剂量SY干预组、高剂量SY联合IGF-1组(P0.05)。结论高剂量SY干预可通过提高血管生成、胶原形成及细胞增殖,降低胰岛素抵抗、炎症反应和细胞凋亡来促进小鼠DFU创面愈合,其机制可能与抑制PI3K/AKT通路有关。

关键词：红花黄色素糖尿病足溃疡创面愈合血管生成磷脂酰肌醇-3-激酶/蛋白激酶B通路

Pt3Ag alloy wavy nanowires as highly effective electrocatalysts for ethanol oxidation reaction

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Nano Research 2020年第5期13卷 1472-1478页

作者： Xiaoyang Fu Chengzhang Wan aixin zhang Zipeng Zhao Huaixun Huyan Xiaoqing Pan Shuaijing Du Xiangfeng Duan Yu Huang Department of Chemistry and Biochemistry University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA Department of Materials Science and Engineering University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA Department of Chemical Engineering and Materials Science University of CaliforniaIrvineIrvineCalifornia 92697USA Irvine Materials Research Institute(IMRI) University of CaliforniaIrvineIrvineCalifornia 92697USA Department of Physics and Astronomy University of CaliforniaIrvineIrvineCalifornia 92697USA California Nanosystems Institute University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA

Direct ethanol fuel cell(DEFC)has received tremendous research interests because of the more convenient storage and transportation of ethanol *** ***,the electrocatalytic ethanol oxidation reaction typically requires precious metal catalysts and is plagued with relatively high over potential and low mass *** we report the synthesis of Pt3Ag alloy wavy nanowires via a particle attachment mechanism in a facile solvothermal *** microscopy studies and elemental analyses show highly wavy nanowire structures with an average diameter of 4.6±1.0 nm and uniform Pt3Ag alloy *** studies demonstrate that the resulting alloy nanowires can function as highly effective electrocatalysts for ethanol oxidation reactions(EOR)with ultrahigh specific activity of 28.0 mA/cm^2 and mass activity of 6.1 A/mg,far exceeding that of the commercial Pt/carbon samples(1.10 A/mg).The improved electrocatalytic activity may be partly attributed to partial electron transfer from Ag to Pt in the Pt3Ag alloy,which weakens CO binding and the CO poisoning *** one-dimensional nanowire morphology also contributes to favorable charge transport properties that are critical for extracting charge from catalytic active sites to external *** chronoamperometry studies demonstrate considerably improved stability for long term operation compared with the commercial Pt/C samples,making the Pt3Ag wavy nanowires an attractive electrocatalyst for EOR.

关键词： platinum silver alloy wavy nanowires electrocatalysis ethanol oxidation reaction(EOR)

A Group-Based Fingerprinting Scheme for Digital Wholesale and Retail

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China Communications 2014年第10期11卷 126-135页

作者： ZHAO Yong zhang aixin LU Songnian School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Minhang 200240 Shanghai R R. China

Prior group-based fingerprinting achieves better detection performance when colluders are from the same group. But in digital wholesale and needs to be identified retail, the middleman as well as customers especially against group colluding attack. The group tracing is neglected in previous works. In this paper, we propose a novel multimedia group fingerprint to trace malicious middlemen along with customers. We explore the quality of the non degenerate linear shift register sequence （NDLSRS） which is convenient in group initialization and management. The theoretic analysis and simulation experiment results show that NDLSRS has good resistance against attacks from colluding groups/ members even after its volume expanded.

关键词： Group fingerprint non-degeneratelinear shift register sequence wholesale andretail group colluding attack

Analytical Models of on-Chip Hardware Trojan Detection Based on Radiated Emission Characteristics

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Chinese Journal of Electronics 2024年第2期33卷 385-392页

作者： Fan zhang Dongrong zhang Qiang REN aixin CHEN Donglin SU School of Electronics and Information Engineering Beihang University Zhongguancun Laboratory The Research Institute for Frontier Science Beihang University

Since many third parties involved in integrated circuit(IC) manufacturing, hardware Trojans malicious implantation have become a threat to the IC industry. Therefore, varieties of reliable hardware Trojan detection methods are needed. Since electromagnetic radiation is an inherent phenomenon of electronic devices, there are significant differences in the electromagnetic radiated characteristics for circuits with different structures and operating states. In this paper, a novel hardware Trojan detection method is proposed, which considers the electromagnetic radiation differences caused by hardware Trojan implantation. Experiments of detecting hardware Trojan in field programmable gate arrays show that the proposed method can effectively distinguish the ICs with Trojan from the ones without Trojan by the radiated emission.

关键词： Electromagnetic radiation Propagation losses Hardware System-on-chip Registers Manufacturing Trojan horses

A Mechanism Based on Reputation in P2P Networks to Counter Malicious Packet Dropping

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Wuhan University Journal of Natural Sciences 2011年第5期16卷 405-408页

作者： PENG Hao LU Songnian LI Jianhua zhang aixin ZHAO Dandan Electronic Engineering Department Shanghai Jiao TongUniversity Shanghai 200240 China School of Information Security Engineering Shanghai JiaoTong University Shanghai 200240 China

In P2P （Peer-to-Peer） networks, some malicious peers can impact on overall networks performance. One of the malicious behaviors of these peers is malicious packet dropping. In this paper, our focus is to detect and to exclude peers that misbehave by dropping some or all packets. Here, we propose a reputation-based mechanism for solving the problem efficiently. The proposed mechanism uses both direct reputation information and indirect reputation information to compute comprehensive reputation of a peer. At the same time, history reputation information is also taken into account to provide faults tolerance capability and we regulate the imprecision based on the fact that the cause of packet dropping can be complex. Finally, the peers with bad comprehensive reputation can be detected easily and then will be excluded from the network. In this way, our proposed mechanism improves the per- formance of P2P networks without increasing computational overhead.

关键词： P2P (Peer-to-Peer) reputation malicious peers packet dropping

An Anonymity Scheme Based on Pseudonym in P2P Networks

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China Communications 2010年第6期7卷 157-160页

作者： Peng Hao Lu Songnian Li Jianhua zhang aixin Zhao Dandan Electrical Engineering Department Shanghai Jiao Tong University Shanghai 200240 P. R. China Information Security Institute Shanghai Jiao Tong University Shanghai 200240 P. R. China

In this paper, we proposed an anonymity scheme based on pseudonym where peers are motivated not to share their identity. Compared with precious scheme such as RuP （Reputation using Pseudonyms）, our scheme can reduce... 详细信息

关键词： anonymity P2P networks pseudonym

Migration mechanism of atrazine in the simulated lake icing process at different freezing temperatures based on density function theory

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Journal of Environmental Sciences 2024年第10期144卷 45-54页

作者： Yan zhang Hao Lin aixin Yu Xiaozhuang Wang Yucan Liu Tongshuai Liu Chen Zhao Rui Mei School of Civil Engineering Yantai UniversityYantai 264005China

Atrazine causes concern due to its resistant to biodegradation and could be accumulated in aquatic organisms,causing pollution in *** study measured the concentration of atrazine in ice and the water under ice through a simulated icing experiment and calculated the distribution coefficient K to characterize its migration ability in the freezing ***,density functional theory(DFT)calculations were employed to expatiate the migration law of atrazine during icing *** to the results,it could release more energy into the environment when atrazine staying in water phase(-15.077 kcal/mol)than staying in ice phase(-14.388 kcal/mol),therefore it was beneficial for the migration of atrazine from ice to *** explains that during the freezing process,the concentration of atrazine in the ice was lower than that in the *** calculations indicated thatwhen the temperature decreases from268 to 248 K,the internal energy contribution of the compound of atrazine and ice molecule(water cluster)decreases at the same vibrational frequency,resulting in an increase in the free energy difference of the compound from-167.946 to-165.390 kcal/*** demonstrated the diminished migratory capacity of *** study revealed the environmental behavior of atrazine during lake freezing,which was beneficial for the management of atrazine and other pollutants during freezing and environmental protection.

关键词： Density functional theory(DFT) Icing process Atrazine Migration behavior Free energy

Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第6期22卷 512-520页

作者： Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong zhang Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin zhang Mingming FENG Yiwei GENG aixin zhang Sabina JANCIAUSKIENE Aiguo XU Department of Pulmonary and Critical Care Medicine Zhengzhou Second People's HospitalZhengzhou Affiliated Hospital of Jinan UniversityZhengzhou 450006China Department of Pulmonary and Critical Care Medicine First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Cell Biology School of Basic and Forensic MedicineBaotou Medical CollegeBaotou 014040China Department of Hematology First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Respiratory Medicine German Center for Lung ResearchHannover Medical SchoolHannover 30625Germany

Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of *** study aimed to investigate whether serum MIF reflects a therapeutic response in allergic ***:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic ***:Our study showed that all measured parameters in patients were at higher levels than those of *** one week of treatment,most parameter levels decreased significantly except for serum ***,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function *** operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic *** area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of ***:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations.

关键词： Macrophage migration inhibitory factor(MIF) Allergic asthma Eosinophilic inflammation Fractional exhaled nitric oxide Immunoglobulin E(IgE)

Study on the Clinical Application of Nutritional Management Combined with Clinical Monitoring of Glycated Albumin in Diabetic Nephropathy Dialysis Patients

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Journal of Clinical and Nursing Research 2024年第9期8卷 146-151页

作者： Hongliang Wang aixin Shen Shanshan zhang Na Jin People’s Hospital of Guandu District Kunming 650200Yunnan ProvinceChina

Objective:To explore the clinical application of nutritional management combined with clinical monitoring of glycated albumin(GA)in diabetic nephropathy(DN)dialysis ***:A total of 20 diabetic nephropathy dialysis patients admitted to the People’s Hospital of Guandu District from January 2022 to February 2023 were included in the *** were randomly divided into a conventional group(n=10)and an observation group(n=10).The study evaluated the blood glucose control,nutritional status,dialysis efficacy,and quality of life scores of both ***:Before the intervention,there were no significant differences in fasting plasma glucose(FPG),GA,serum albumin,body mass index(BMI),dialysis efficiency values,urea clearance rate,or quality-of-life scores between the two groups(P>0.05).After the intervention,the observation group showed significantly lower FPG and GA levels,higher serum albumin,dialysis efficiency values,urea clearance rate,and improved quality-of-life scores compared to the conventional group(P0.05).Conclusion:Nutritional management combined with clinical monitoring of glycated albumin has a significant effect on the clinical application of diabetic nephropathy dialysis *** can effectively improve patients’blood glucose control and nutritional status,reduce the risk of complications,and enhance the quality of life,demonstrating clinical value for broader application.

关键词： Nutritional management Glycated albumin Diabetic nephropathy Dialysis